Nucleic acid-assisted CRISPR-Cas systems for advanced biosensing and bioimaging

Nucleic acid molecules possess many superior properties, including high designability and structural predictability, making them attractive biosensing and bioimaging tools. The CRISPR-Cas systems can recognize and cleave nucleic acid targets with high programmability and flexibility, and have been e...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Chen, Siyu [verfasserIn] Gong, Bo [verfasserIn] Zhu, Cong [verfasserIn] Lei, Chunyang [verfasserIn] Nie, Zhou [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Functional nucleic acid Nucleic acid amplification Nucleic acid circuit CRISPR-Cas Biosensing Bioimaging

Übergeordnetes Werk:	Enthalten in: Trends in analytical chemistry - Amsterdam : Elsevier, 1981, 159
Übergeordnetes Werk:	volume:159

DOI / URN:	10.1016/j.trac.2023.116931

Katalog-ID:	ELV064754278

Internformat


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520			\|a Nucleic acid molecules possess many superior properties, including high designability and structural predictability, making them attractive biosensing and bioimaging tools. The CRISPR-Cas systems can recognize and cleave nucleic acid targets with high programmability and flexibility, and have been engineered as a multifunctional bimolecular toolbox. Target recognition by CRISPR-Cas systems strictly follows the Watson-Crick base pairing principle, providing a natural interface for coupling with nucleic acids. Such integration has advanced the biosensing and bioimaging methodologies, holding great promise in basic biochemical research and clinical diagnosis. Here, we summarized the latest research progress in integrating nucleic acids with CRISPR-Cas systems for advanced biosensing and bioimaging, including nucleic acid amplification and DNA circuit-coupled CRISPR methods for molecular diagnostics, functional nucleic acid-regulated CRISPR assays for biochemical analysis, and functional nucleic acid-mediated CRISPR bioimaging. We also discussed the challenges and prospects of nucleic acid-assisted CRISPR-Cas systems in biosensing and bioimaging.
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650		4	\|a Nucleic acid amplification
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650		4	\|a CRISPR-Cas
650		4	\|a Biosensing
650		4	\|a Bioimaging
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700	1		\|a Zhu, Cong \|e verfasserin \|4 aut
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912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
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912			\|a GBV_ILN_2014
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912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
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912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
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912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
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Indexfelder

author_variant	s c sc b g bg c z cz c l cl z n zn
matchkey_str	chensiyugongbozhucongleichunyangniezhou:2023----:uliaiassecipcsytmfrdacdis
hierarchy_sort_str	2023
bklnumber	35.23
publishDate	2023
allfields	10.1016/j.trac.2023.116931 doi (DE-627)ELV064754278 (ELSEVIER)S0165-9936(23)00018-3 DE-627 ger DE-627 rda eng 540 VZ 35.23 bkl Chen, Siyu verfasserin aut Nucleic acid-assisted CRISPR-Cas systems for advanced biosensing and bioimaging 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nucleic acid molecules possess many superior properties, including high designability and structural predictability, making them attractive biosensing and bioimaging tools. The CRISPR-Cas systems can recognize and cleave nucleic acid targets with high programmability and flexibility, and have been engineered as a multifunctional bimolecular toolbox. Target recognition by CRISPR-Cas systems strictly follows the Watson-Crick base pairing principle, providing a natural interface for coupling with nucleic acids. Such integration has advanced the biosensing and bioimaging methodologies, holding great promise in basic biochemical research and clinical diagnosis. Here, we summarized the latest research progress in integrating nucleic acids with CRISPR-Cas systems for advanced biosensing and bioimaging, including nucleic acid amplification and DNA circuit-coupled CRISPR methods for molecular diagnostics, functional nucleic acid-regulated CRISPR assays for biochemical analysis, and functional nucleic acid-mediated CRISPR bioimaging. We also discussed the challenges and prospects of nucleic acid-assisted CRISPR-Cas systems in biosensing and bioimaging. Functional nucleic acid Nucleic acid amplification Nucleic acid circuit CRISPR-Cas Biosensing Bioimaging Gong, Bo verfasserin aut Zhu, Cong verfasserin aut Lei, Chunyang verfasserin aut Nie, Zhou verfasserin (orcid)0000-0001-9864-2965 aut Enthalten in Trends in analytical chemistry Amsterdam : Elsevier, 1981 159 Online-Ressource (DE-627)320516601 (DE-600)2014041-1 (DE-576)098253344 nnns volume:159 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.23 Analytische Chemie: Allgemeines VZ AR 159
spelling	10.1016/j.trac.2023.116931 doi (DE-627)ELV064754278 (ELSEVIER)S0165-9936(23)00018-3 DE-627 ger DE-627 rda eng 540 VZ 35.23 bkl Chen, Siyu verfasserin aut Nucleic acid-assisted CRISPR-Cas systems for advanced biosensing and bioimaging 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nucleic acid molecules possess many superior properties, including high designability and structural predictability, making them attractive biosensing and bioimaging tools. The CRISPR-Cas systems can recognize and cleave nucleic acid targets with high programmability and flexibility, and have been engineered as a multifunctional bimolecular toolbox. Target recognition by CRISPR-Cas systems strictly follows the Watson-Crick base pairing principle, providing a natural interface for coupling with nucleic acids. Such integration has advanced the biosensing and bioimaging methodologies, holding great promise in basic biochemical research and clinical diagnosis. Here, we summarized the latest research progress in integrating nucleic acids with CRISPR-Cas systems for advanced biosensing and bioimaging, including nucleic acid amplification and DNA circuit-coupled CRISPR methods for molecular diagnostics, functional nucleic acid-regulated CRISPR assays for biochemical analysis, and functional nucleic acid-mediated CRISPR bioimaging. We also discussed the challenges and prospects of nucleic acid-assisted CRISPR-Cas systems in biosensing and bioimaging. Functional nucleic acid Nucleic acid amplification Nucleic acid circuit CRISPR-Cas Biosensing Bioimaging Gong, Bo verfasserin aut Zhu, Cong verfasserin aut Lei, Chunyang verfasserin aut Nie, Zhou verfasserin (orcid)0000-0001-9864-2965 aut Enthalten in Trends in analytical chemistry Amsterdam : Elsevier, 1981 159 Online-Ressource (DE-627)320516601 (DE-600)2014041-1 (DE-576)098253344 nnns volume:159 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.23 Analytische Chemie: Allgemeines VZ AR 159
allfields_unstemmed	10.1016/j.trac.2023.116931 doi (DE-627)ELV064754278 (ELSEVIER)S0165-9936(23)00018-3 DE-627 ger DE-627 rda eng 540 VZ 35.23 bkl Chen, Siyu verfasserin aut Nucleic acid-assisted CRISPR-Cas systems for advanced biosensing and bioimaging 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nucleic acid molecules possess many superior properties, including high designability and structural predictability, making them attractive biosensing and bioimaging tools. The CRISPR-Cas systems can recognize and cleave nucleic acid targets with high programmability and flexibility, and have been engineered as a multifunctional bimolecular toolbox. Target recognition by CRISPR-Cas systems strictly follows the Watson-Crick base pairing principle, providing a natural interface for coupling with nucleic acids. Such integration has advanced the biosensing and bioimaging methodologies, holding great promise in basic biochemical research and clinical diagnosis. Here, we summarized the latest research progress in integrating nucleic acids with CRISPR-Cas systems for advanced biosensing and bioimaging, including nucleic acid amplification and DNA circuit-coupled CRISPR methods for molecular diagnostics, functional nucleic acid-regulated CRISPR assays for biochemical analysis, and functional nucleic acid-mediated CRISPR bioimaging. We also discussed the challenges and prospects of nucleic acid-assisted CRISPR-Cas systems in biosensing and bioimaging. Functional nucleic acid Nucleic acid amplification Nucleic acid circuit CRISPR-Cas Biosensing Bioimaging Gong, Bo verfasserin aut Zhu, Cong verfasserin aut Lei, Chunyang verfasserin aut Nie, Zhou verfasserin (orcid)0000-0001-9864-2965 aut Enthalten in Trends in analytical chemistry Amsterdam : Elsevier, 1981 159 Online-Ressource (DE-627)320516601 (DE-600)2014041-1 (DE-576)098253344 nnns volume:159 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.23 Analytische Chemie: Allgemeines VZ AR 159
allfieldsGer	10.1016/j.trac.2023.116931 doi (DE-627)ELV064754278 (ELSEVIER)S0165-9936(23)00018-3 DE-627 ger DE-627 rda eng 540 VZ 35.23 bkl Chen, Siyu verfasserin aut Nucleic acid-assisted CRISPR-Cas systems for advanced biosensing and bioimaging 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nucleic acid molecules possess many superior properties, including high designability and structural predictability, making them attractive biosensing and bioimaging tools. The CRISPR-Cas systems can recognize and cleave nucleic acid targets with high programmability and flexibility, and have been engineered as a multifunctional bimolecular toolbox. Target recognition by CRISPR-Cas systems strictly follows the Watson-Crick base pairing principle, providing a natural interface for coupling with nucleic acids. Such integration has advanced the biosensing and bioimaging methodologies, holding great promise in basic biochemical research and clinical diagnosis. Here, we summarized the latest research progress in integrating nucleic acids with CRISPR-Cas systems for advanced biosensing and bioimaging, including nucleic acid amplification and DNA circuit-coupled CRISPR methods for molecular diagnostics, functional nucleic acid-regulated CRISPR assays for biochemical analysis, and functional nucleic acid-mediated CRISPR bioimaging. We also discussed the challenges and prospects of nucleic acid-assisted CRISPR-Cas systems in biosensing and bioimaging. Functional nucleic acid Nucleic acid amplification Nucleic acid circuit CRISPR-Cas Biosensing Bioimaging Gong, Bo verfasserin aut Zhu, Cong verfasserin aut Lei, Chunyang verfasserin aut Nie, Zhou verfasserin (orcid)0000-0001-9864-2965 aut Enthalten in Trends in analytical chemistry Amsterdam : Elsevier, 1981 159 Online-Ressource (DE-627)320516601 (DE-600)2014041-1 (DE-576)098253344 nnns volume:159 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.23 Analytische Chemie: Allgemeines VZ AR 159
allfieldsSound	10.1016/j.trac.2023.116931 doi (DE-627)ELV064754278 (ELSEVIER)S0165-9936(23)00018-3 DE-627 ger DE-627 rda eng 540 VZ 35.23 bkl Chen, Siyu verfasserin aut Nucleic acid-assisted CRISPR-Cas systems for advanced biosensing and bioimaging 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nucleic acid molecules possess many superior properties, including high designability and structural predictability, making them attractive biosensing and bioimaging tools. The CRISPR-Cas systems can recognize and cleave nucleic acid targets with high programmability and flexibility, and have been engineered as a multifunctional bimolecular toolbox. Target recognition by CRISPR-Cas systems strictly follows the Watson-Crick base pairing principle, providing a natural interface for coupling with nucleic acids. Such integration has advanced the biosensing and bioimaging methodologies, holding great promise in basic biochemical research and clinical diagnosis. Here, we summarized the latest research progress in integrating nucleic acids with CRISPR-Cas systems for advanced biosensing and bioimaging, including nucleic acid amplification and DNA circuit-coupled CRISPR methods for molecular diagnostics, functional nucleic acid-regulated CRISPR assays for biochemical analysis, and functional nucleic acid-mediated CRISPR bioimaging. We also discussed the challenges and prospects of nucleic acid-assisted CRISPR-Cas systems in biosensing and bioimaging. Functional nucleic acid Nucleic acid amplification Nucleic acid circuit CRISPR-Cas Biosensing Bioimaging Gong, Bo verfasserin aut Zhu, Cong verfasserin aut Lei, Chunyang verfasserin aut Nie, Zhou verfasserin (orcid)0000-0001-9864-2965 aut Enthalten in Trends in analytical chemistry Amsterdam : Elsevier, 1981 159 Online-Ressource (DE-627)320516601 (DE-600)2014041-1 (DE-576)098253344 nnns volume:159 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.23 Analytische Chemie: Allgemeines VZ AR 159
language	English
source	Enthalten in Trends in analytical chemistry 159 volume:159
sourceStr	Enthalten in Trends in analytical chemistry 159 volume:159
format_phy_str_mv	Article
bklname	Analytische Chemie: Allgemeines
institution	findex.gbv.de
topic_facet	Functional nucleic acid Nucleic acid amplification Nucleic acid circuit CRISPR-Cas Biosensing Bioimaging
dewey-raw	540
isfreeaccess_bool	false
container_title	Trends in analytical chemistry
authorswithroles_txt_mv	Chen, Siyu @@aut@@ Gong, Bo @@aut@@ Zhu, Cong @@aut@@ Lei, Chunyang @@aut@@ Nie, Zhou @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	320516601
dewey-sort	3540
id	ELV064754278
language_de	englisch
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author	Chen, Siyu
spellingShingle	Chen, Siyu ddc 540 bkl 35.23 misc Functional nucleic acid misc Nucleic acid amplification misc Nucleic acid circuit misc CRISPR-Cas misc Biosensing misc Bioimaging Nucleic acid-assisted CRISPR-Cas systems for advanced biosensing and bioimaging
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topic_title	540 VZ 35.23 bkl Nucleic acid-assisted CRISPR-Cas systems for advanced biosensing and bioimaging Functional nucleic acid Nucleic acid amplification Nucleic acid circuit CRISPR-Cas Biosensing Bioimaging
topic	ddc 540 bkl 35.23 misc Functional nucleic acid misc Nucleic acid amplification misc Nucleic acid circuit misc CRISPR-Cas misc Biosensing misc Bioimaging
topic_unstemmed	ddc 540 bkl 35.23 misc Functional nucleic acid misc Nucleic acid amplification misc Nucleic acid circuit misc CRISPR-Cas misc Biosensing misc Bioimaging
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title	Nucleic acid-assisted CRISPR-Cas systems for advanced biosensing and bioimaging
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title_full	Nucleic acid-assisted CRISPR-Cas systems for advanced biosensing and bioimaging
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author_browse	Chen, Siyu Gong, Bo Zhu, Cong Lei, Chunyang Nie, Zhou
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title_sort	nucleic acid-assisted crispr-cas systems for advanced biosensing and bioimaging
title_auth	Nucleic acid-assisted CRISPR-Cas systems for advanced biosensing and bioimaging
abstract	Nucleic acid molecules possess many superior properties, including high designability and structural predictability, making them attractive biosensing and bioimaging tools. The CRISPR-Cas systems can recognize and cleave nucleic acid targets with high programmability and flexibility, and have been engineered as a multifunctional bimolecular toolbox. Target recognition by CRISPR-Cas systems strictly follows the Watson-Crick base pairing principle, providing a natural interface for coupling with nucleic acids. Such integration has advanced the biosensing and bioimaging methodologies, holding great promise in basic biochemical research and clinical diagnosis. Here, we summarized the latest research progress in integrating nucleic acids with CRISPR-Cas systems for advanced biosensing and bioimaging, including nucleic acid amplification and DNA circuit-coupled CRISPR methods for molecular diagnostics, functional nucleic acid-regulated CRISPR assays for biochemical analysis, and functional nucleic acid-mediated CRISPR bioimaging. We also discussed the challenges and prospects of nucleic acid-assisted CRISPR-Cas systems in biosensing and bioimaging.
abstractGer	Nucleic acid molecules possess many superior properties, including high designability and structural predictability, making them attractive biosensing and bioimaging tools. The CRISPR-Cas systems can recognize and cleave nucleic acid targets with high programmability and flexibility, and have been engineered as a multifunctional bimolecular toolbox. Target recognition by CRISPR-Cas systems strictly follows the Watson-Crick base pairing principle, providing a natural interface for coupling with nucleic acids. Such integration has advanced the biosensing and bioimaging methodologies, holding great promise in basic biochemical research and clinical diagnosis. Here, we summarized the latest research progress in integrating nucleic acids with CRISPR-Cas systems for advanced biosensing and bioimaging, including nucleic acid amplification and DNA circuit-coupled CRISPR methods for molecular diagnostics, functional nucleic acid-regulated CRISPR assays for biochemical analysis, and functional nucleic acid-mediated CRISPR bioimaging. We also discussed the challenges and prospects of nucleic acid-assisted CRISPR-Cas systems in biosensing and bioimaging.
abstract_unstemmed	Nucleic acid molecules possess many superior properties, including high designability and structural predictability, making them attractive biosensing and bioimaging tools. The CRISPR-Cas systems can recognize and cleave nucleic acid targets with high programmability and flexibility, and have been engineered as a multifunctional bimolecular toolbox. Target recognition by CRISPR-Cas systems strictly follows the Watson-Crick base pairing principle, providing a natural interface for coupling with nucleic acids. Such integration has advanced the biosensing and bioimaging methodologies, holding great promise in basic biochemical research and clinical diagnosis. Here, we summarized the latest research progress in integrating nucleic acids with CRISPR-Cas systems for advanced biosensing and bioimaging, including nucleic acid amplification and DNA circuit-coupled CRISPR methods for molecular diagnostics, functional nucleic acid-regulated CRISPR assays for biochemical analysis, and functional nucleic acid-mediated CRISPR bioimaging. We also discussed the challenges and prospects of nucleic acid-assisted CRISPR-Cas systems in biosensing and bioimaging.
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title_short	Nucleic acid-assisted CRISPR-Cas systems for advanced biosensing and bioimaging
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author2	Gong, Bo Zhu, Cong Lei, Chunyang Nie, Zhou
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up_date	2024-07-06T20:40:36.391Z
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Nucleic acid-assisted CRISPR-Cas systems for advanced biosensing and bioimaging

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