Construction of a dual-signal sensing platform based on DNA enhanced peroxidase-activity of iron cobalt oxide nanosheets for thrombin detection
Thrombin played important roles for the diagnosis of neurodegenerative and cardiovascular diseases. Herein, we successfully constructed a rapid and sensitive fluorescence and colorimetric dual-signal sensing strategy for the detection of thrombin by taking advantage of the DNA-enhanced peroxidase li...
Ausführliche Beschreibung
Autor*in: |
Zhang, Jiabao [verfasserIn] Wang, Mengke [verfasserIn] Liu, Jinying [verfasserIn] Lv, Yuntai [verfasserIn] Su, Xingguang [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2023 |
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Schlagwörter: |
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Übergeordnetes Werk: |
Enthalten in: Sensors and actuators |
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Übergeordnetes Werk: |
volume:396 |
DOI / URN: |
10.1016/j.snb.2023.134526 |
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Katalog-ID: |
ELV064868230 |
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245 | 1 | 0 | |a Construction of a dual-signal sensing platform based on DNA enhanced peroxidase-activity of iron cobalt oxide nanosheets for thrombin detection |
264 | 1 | |c 2023 | |
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520 | |a Thrombin played important roles for the diagnosis of neurodegenerative and cardiovascular diseases. Herein, we successfully constructed a rapid and sensitive fluorescence and colorimetric dual-signal sensing strategy for the detection of thrombin by taking advantage of the DNA-enhanced peroxidase like activity FeCo-ONSs and magnetic separation. In this work, single-stranded DNA S1 with thrombin aptamer was used to enhance the catalytic activity of FeCo-ONSs, and single-stranded DNA S2 with different thrombin aptamer was modified on the surface of magnetic beads (MBs) to construct MBs-S2 for subsequent magnetic separation. In the presence of thrombin, S1 and MBs-S2 quickly combined with thrombin and the amount of S1 decreased in the solution after magnetic separation. The enhancement of peroxidase like activity of S1/FeCo-ONSs was weakened, resulting in the inhibition of the catalytic oxidation process of substrate TMB. The formation of oxTMB and the fluorescence quenching efficiency of MoS2 QDs were further affected. Therefore, the quantitative detection of thrombin can be achieved by measuring the absorption signal of oxTMB and the fluorescence signal of MoS2 QDs. The limits of detection for thrombin were 0.67 pM and 2.36 pM by the outputting fluorometric and colorimetric dual signals, respectively. This sensing strategy not only has high specificity, but also can be expanded as a more universal platform for sensitive detection of different proteins by changing the aptamer probe pairs. | ||
650 | 4 | |a FeCo-ONSs | |
650 | 4 | |a MoS | |
650 | 4 | |a Thrombin | |
650 | 4 | |a Aptamers | |
650 | 4 | |a Dual-signal | |
650 | 4 | |a Magnetic separation | |
700 | 1 | |a Wang, Mengke |e verfasserin |4 aut | |
700 | 1 | |a Liu, Jinying |e verfasserin |4 aut | |
700 | 1 | |a Lv, Yuntai |e verfasserin |4 aut | |
700 | 1 | |a Su, Xingguang |e verfasserin |4 aut | |
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912 | |a GBV_ILN_2048 | ||
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912 | |a GBV_ILN_4338 | ||
912 | |a GBV_ILN_4393 | ||
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2023 |
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2023 |
allfields |
10.1016/j.snb.2023.134526 doi (DE-627)ELV064868230 (ELSEVIER)S0925-4005(23)01241-8 DE-627 ger DE-627 rda eng 530 620 VZ 50.22 bkl 35.07 bkl Zhang, Jiabao verfasserin aut Construction of a dual-signal sensing platform based on DNA enhanced peroxidase-activity of iron cobalt oxide nanosheets for thrombin detection 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Thrombin played important roles for the diagnosis of neurodegenerative and cardiovascular diseases. Herein, we successfully constructed a rapid and sensitive fluorescence and colorimetric dual-signal sensing strategy for the detection of thrombin by taking advantage of the DNA-enhanced peroxidase like activity FeCo-ONSs and magnetic separation. In this work, single-stranded DNA S1 with thrombin aptamer was used to enhance the catalytic activity of FeCo-ONSs, and single-stranded DNA S2 with different thrombin aptamer was modified on the surface of magnetic beads (MBs) to construct MBs-S2 for subsequent magnetic separation. In the presence of thrombin, S1 and MBs-S2 quickly combined with thrombin and the amount of S1 decreased in the solution after magnetic separation. The enhancement of peroxidase like activity of S1/FeCo-ONSs was weakened, resulting in the inhibition of the catalytic oxidation process of substrate TMB. The formation of oxTMB and the fluorescence quenching efficiency of MoS2 QDs were further affected. Therefore, the quantitative detection of thrombin can be achieved by measuring the absorption signal of oxTMB and the fluorescence signal of MoS2 QDs. The limits of detection for thrombin were 0.67 pM and 2.36 pM by the outputting fluorometric and colorimetric dual signals, respectively. This sensing strategy not only has high specificity, but also can be expanded as a more universal platform for sensitive detection of different proteins by changing the aptamer probe pairs. FeCo-ONSs MoS Thrombin Aptamers Dual-signal Magnetic separation Wang, Mengke verfasserin aut Liu, Jinying verfasserin aut Lv, Yuntai verfasserin aut Su, Xingguang verfasserin aut Enthalten in Sensors and actuators <Lausanne> / B Amsterdam [u.a.] : Elsevier Science, 1990 396 Online-Ressource (DE-627)306710358 (DE-600)1500731-5 (DE-576)082435855 0925-4005 nnns volume:396 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 50.22 Sensorik VZ 35.07 Chemisches Labor chemische Methoden VZ AR 396 |
spelling |
10.1016/j.snb.2023.134526 doi (DE-627)ELV064868230 (ELSEVIER)S0925-4005(23)01241-8 DE-627 ger DE-627 rda eng 530 620 VZ 50.22 bkl 35.07 bkl Zhang, Jiabao verfasserin aut Construction of a dual-signal sensing platform based on DNA enhanced peroxidase-activity of iron cobalt oxide nanosheets for thrombin detection 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Thrombin played important roles for the diagnosis of neurodegenerative and cardiovascular diseases. Herein, we successfully constructed a rapid and sensitive fluorescence and colorimetric dual-signal sensing strategy for the detection of thrombin by taking advantage of the DNA-enhanced peroxidase like activity FeCo-ONSs and magnetic separation. In this work, single-stranded DNA S1 with thrombin aptamer was used to enhance the catalytic activity of FeCo-ONSs, and single-stranded DNA S2 with different thrombin aptamer was modified on the surface of magnetic beads (MBs) to construct MBs-S2 for subsequent magnetic separation. In the presence of thrombin, S1 and MBs-S2 quickly combined with thrombin and the amount of S1 decreased in the solution after magnetic separation. The enhancement of peroxidase like activity of S1/FeCo-ONSs was weakened, resulting in the inhibition of the catalytic oxidation process of substrate TMB. The formation of oxTMB and the fluorescence quenching efficiency of MoS2 QDs were further affected. Therefore, the quantitative detection of thrombin can be achieved by measuring the absorption signal of oxTMB and the fluorescence signal of MoS2 QDs. The limits of detection for thrombin were 0.67 pM and 2.36 pM by the outputting fluorometric and colorimetric dual signals, respectively. This sensing strategy not only has high specificity, but also can be expanded as a more universal platform for sensitive detection of different proteins by changing the aptamer probe pairs. FeCo-ONSs MoS Thrombin Aptamers Dual-signal Magnetic separation Wang, Mengke verfasserin aut Liu, Jinying verfasserin aut Lv, Yuntai verfasserin aut Su, Xingguang verfasserin aut Enthalten in Sensors and actuators <Lausanne> / B Amsterdam [u.a.] : Elsevier Science, 1990 396 Online-Ressource (DE-627)306710358 (DE-600)1500731-5 (DE-576)082435855 0925-4005 nnns volume:396 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 50.22 Sensorik VZ 35.07 Chemisches Labor chemische Methoden VZ AR 396 |
allfields_unstemmed |
10.1016/j.snb.2023.134526 doi (DE-627)ELV064868230 (ELSEVIER)S0925-4005(23)01241-8 DE-627 ger DE-627 rda eng 530 620 VZ 50.22 bkl 35.07 bkl Zhang, Jiabao verfasserin aut Construction of a dual-signal sensing platform based on DNA enhanced peroxidase-activity of iron cobalt oxide nanosheets for thrombin detection 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Thrombin played important roles for the diagnosis of neurodegenerative and cardiovascular diseases. Herein, we successfully constructed a rapid and sensitive fluorescence and colorimetric dual-signal sensing strategy for the detection of thrombin by taking advantage of the DNA-enhanced peroxidase like activity FeCo-ONSs and magnetic separation. In this work, single-stranded DNA S1 with thrombin aptamer was used to enhance the catalytic activity of FeCo-ONSs, and single-stranded DNA S2 with different thrombin aptamer was modified on the surface of magnetic beads (MBs) to construct MBs-S2 for subsequent magnetic separation. In the presence of thrombin, S1 and MBs-S2 quickly combined with thrombin and the amount of S1 decreased in the solution after magnetic separation. The enhancement of peroxidase like activity of S1/FeCo-ONSs was weakened, resulting in the inhibition of the catalytic oxidation process of substrate TMB. The formation of oxTMB and the fluorescence quenching efficiency of MoS2 QDs were further affected. Therefore, the quantitative detection of thrombin can be achieved by measuring the absorption signal of oxTMB and the fluorescence signal of MoS2 QDs. The limits of detection for thrombin were 0.67 pM and 2.36 pM by the outputting fluorometric and colorimetric dual signals, respectively. This sensing strategy not only has high specificity, but also can be expanded as a more universal platform for sensitive detection of different proteins by changing the aptamer probe pairs. FeCo-ONSs MoS Thrombin Aptamers Dual-signal Magnetic separation Wang, Mengke verfasserin aut Liu, Jinying verfasserin aut Lv, Yuntai verfasserin aut Su, Xingguang verfasserin aut Enthalten in Sensors and actuators <Lausanne> / B Amsterdam [u.a.] : Elsevier Science, 1990 396 Online-Ressource (DE-627)306710358 (DE-600)1500731-5 (DE-576)082435855 0925-4005 nnns volume:396 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 50.22 Sensorik VZ 35.07 Chemisches Labor chemische Methoden VZ AR 396 |
allfieldsGer |
10.1016/j.snb.2023.134526 doi (DE-627)ELV064868230 (ELSEVIER)S0925-4005(23)01241-8 DE-627 ger DE-627 rda eng 530 620 VZ 50.22 bkl 35.07 bkl Zhang, Jiabao verfasserin aut Construction of a dual-signal sensing platform based on DNA enhanced peroxidase-activity of iron cobalt oxide nanosheets for thrombin detection 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Thrombin played important roles for the diagnosis of neurodegenerative and cardiovascular diseases. Herein, we successfully constructed a rapid and sensitive fluorescence and colorimetric dual-signal sensing strategy for the detection of thrombin by taking advantage of the DNA-enhanced peroxidase like activity FeCo-ONSs and magnetic separation. In this work, single-stranded DNA S1 with thrombin aptamer was used to enhance the catalytic activity of FeCo-ONSs, and single-stranded DNA S2 with different thrombin aptamer was modified on the surface of magnetic beads (MBs) to construct MBs-S2 for subsequent magnetic separation. In the presence of thrombin, S1 and MBs-S2 quickly combined with thrombin and the amount of S1 decreased in the solution after magnetic separation. The enhancement of peroxidase like activity of S1/FeCo-ONSs was weakened, resulting in the inhibition of the catalytic oxidation process of substrate TMB. The formation of oxTMB and the fluorescence quenching efficiency of MoS2 QDs were further affected. Therefore, the quantitative detection of thrombin can be achieved by measuring the absorption signal of oxTMB and the fluorescence signal of MoS2 QDs. The limits of detection for thrombin were 0.67 pM and 2.36 pM by the outputting fluorometric and colorimetric dual signals, respectively. This sensing strategy not only has high specificity, but also can be expanded as a more universal platform for sensitive detection of different proteins by changing the aptamer probe pairs. FeCo-ONSs MoS Thrombin Aptamers Dual-signal Magnetic separation Wang, Mengke verfasserin aut Liu, Jinying verfasserin aut Lv, Yuntai verfasserin aut Su, Xingguang verfasserin aut Enthalten in Sensors and actuators <Lausanne> / B Amsterdam [u.a.] : Elsevier Science, 1990 396 Online-Ressource (DE-627)306710358 (DE-600)1500731-5 (DE-576)082435855 0925-4005 nnns volume:396 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 50.22 Sensorik VZ 35.07 Chemisches Labor chemische Methoden VZ AR 396 |
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10.1016/j.snb.2023.134526 doi (DE-627)ELV064868230 (ELSEVIER)S0925-4005(23)01241-8 DE-627 ger DE-627 rda eng 530 620 VZ 50.22 bkl 35.07 bkl Zhang, Jiabao verfasserin aut Construction of a dual-signal sensing platform based on DNA enhanced peroxidase-activity of iron cobalt oxide nanosheets for thrombin detection 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Thrombin played important roles for the diagnosis of neurodegenerative and cardiovascular diseases. Herein, we successfully constructed a rapid and sensitive fluorescence and colorimetric dual-signal sensing strategy for the detection of thrombin by taking advantage of the DNA-enhanced peroxidase like activity FeCo-ONSs and magnetic separation. In this work, single-stranded DNA S1 with thrombin aptamer was used to enhance the catalytic activity of FeCo-ONSs, and single-stranded DNA S2 with different thrombin aptamer was modified on the surface of magnetic beads (MBs) to construct MBs-S2 for subsequent magnetic separation. In the presence of thrombin, S1 and MBs-S2 quickly combined with thrombin and the amount of S1 decreased in the solution after magnetic separation. The enhancement of peroxidase like activity of S1/FeCo-ONSs was weakened, resulting in the inhibition of the catalytic oxidation process of substrate TMB. The formation of oxTMB and the fluorescence quenching efficiency of MoS2 QDs were further affected. Therefore, the quantitative detection of thrombin can be achieved by measuring the absorption signal of oxTMB and the fluorescence signal of MoS2 QDs. The limits of detection for thrombin were 0.67 pM and 2.36 pM by the outputting fluorometric and colorimetric dual signals, respectively. This sensing strategy not only has high specificity, but also can be expanded as a more universal platform for sensitive detection of different proteins by changing the aptamer probe pairs. FeCo-ONSs MoS Thrombin Aptamers Dual-signal Magnetic separation Wang, Mengke verfasserin aut Liu, Jinying verfasserin aut Lv, Yuntai verfasserin aut Su, Xingguang verfasserin aut Enthalten in Sensors and actuators <Lausanne> / B Amsterdam [u.a.] : Elsevier Science, 1990 396 Online-Ressource (DE-627)306710358 (DE-600)1500731-5 (DE-576)082435855 0925-4005 nnns volume:396 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 50.22 Sensorik VZ 35.07 Chemisches Labor chemische Methoden VZ AR 396 |
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Enthalten in Sensors and actuators <Lausanne> / B 396 volume:396 |
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FeCo-ONSs MoS Thrombin Aptamers Dual-signal Magnetic separation |
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Zhang, Jiabao @@aut@@ Wang, Mengke @@aut@@ Liu, Jinying @@aut@@ Lv, Yuntai @@aut@@ Su, Xingguang @@aut@@ |
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author |
Zhang, Jiabao |
spellingShingle |
Zhang, Jiabao ddc 530 bkl 50.22 bkl 35.07 misc FeCo-ONSs misc MoS misc Thrombin misc Aptamers misc Dual-signal misc Magnetic separation Construction of a dual-signal sensing platform based on DNA enhanced peroxidase-activity of iron cobalt oxide nanosheets for thrombin detection |
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530 620 VZ 50.22 bkl 35.07 bkl Construction of a dual-signal sensing platform based on DNA enhanced peroxidase-activity of iron cobalt oxide nanosheets for thrombin detection FeCo-ONSs MoS Thrombin Aptamers Dual-signal Magnetic separation |
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Construction of a dual-signal sensing platform based on DNA enhanced peroxidase-activity of iron cobalt oxide nanosheets for thrombin detection |
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Construction of a dual-signal sensing platform based on DNA enhanced peroxidase-activity of iron cobalt oxide nanosheets for thrombin detection |
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construction of a dual-signal sensing platform based on dna enhanced peroxidase-activity of iron cobalt oxide nanosheets for thrombin detection |
title_auth |
Construction of a dual-signal sensing platform based on DNA enhanced peroxidase-activity of iron cobalt oxide nanosheets for thrombin detection |
abstract |
Thrombin played important roles for the diagnosis of neurodegenerative and cardiovascular diseases. Herein, we successfully constructed a rapid and sensitive fluorescence and colorimetric dual-signal sensing strategy for the detection of thrombin by taking advantage of the DNA-enhanced peroxidase like activity FeCo-ONSs and magnetic separation. In this work, single-stranded DNA S1 with thrombin aptamer was used to enhance the catalytic activity of FeCo-ONSs, and single-stranded DNA S2 with different thrombin aptamer was modified on the surface of magnetic beads (MBs) to construct MBs-S2 for subsequent magnetic separation. In the presence of thrombin, S1 and MBs-S2 quickly combined with thrombin and the amount of S1 decreased in the solution after magnetic separation. The enhancement of peroxidase like activity of S1/FeCo-ONSs was weakened, resulting in the inhibition of the catalytic oxidation process of substrate TMB. The formation of oxTMB and the fluorescence quenching efficiency of MoS2 QDs were further affected. Therefore, the quantitative detection of thrombin can be achieved by measuring the absorption signal of oxTMB and the fluorescence signal of MoS2 QDs. The limits of detection for thrombin were 0.67 pM and 2.36 pM by the outputting fluorometric and colorimetric dual signals, respectively. This sensing strategy not only has high specificity, but also can be expanded as a more universal platform for sensitive detection of different proteins by changing the aptamer probe pairs. |
abstractGer |
Thrombin played important roles for the diagnosis of neurodegenerative and cardiovascular diseases. Herein, we successfully constructed a rapid and sensitive fluorescence and colorimetric dual-signal sensing strategy for the detection of thrombin by taking advantage of the DNA-enhanced peroxidase like activity FeCo-ONSs and magnetic separation. In this work, single-stranded DNA S1 with thrombin aptamer was used to enhance the catalytic activity of FeCo-ONSs, and single-stranded DNA S2 with different thrombin aptamer was modified on the surface of magnetic beads (MBs) to construct MBs-S2 for subsequent magnetic separation. In the presence of thrombin, S1 and MBs-S2 quickly combined with thrombin and the amount of S1 decreased in the solution after magnetic separation. The enhancement of peroxidase like activity of S1/FeCo-ONSs was weakened, resulting in the inhibition of the catalytic oxidation process of substrate TMB. The formation of oxTMB and the fluorescence quenching efficiency of MoS2 QDs were further affected. Therefore, the quantitative detection of thrombin can be achieved by measuring the absorption signal of oxTMB and the fluorescence signal of MoS2 QDs. The limits of detection for thrombin were 0.67 pM and 2.36 pM by the outputting fluorometric and colorimetric dual signals, respectively. This sensing strategy not only has high specificity, but also can be expanded as a more universal platform for sensitive detection of different proteins by changing the aptamer probe pairs. |
abstract_unstemmed |
Thrombin played important roles for the diagnosis of neurodegenerative and cardiovascular diseases. Herein, we successfully constructed a rapid and sensitive fluorescence and colorimetric dual-signal sensing strategy for the detection of thrombin by taking advantage of the DNA-enhanced peroxidase like activity FeCo-ONSs and magnetic separation. In this work, single-stranded DNA S1 with thrombin aptamer was used to enhance the catalytic activity of FeCo-ONSs, and single-stranded DNA S2 with different thrombin aptamer was modified on the surface of magnetic beads (MBs) to construct MBs-S2 for subsequent magnetic separation. In the presence of thrombin, S1 and MBs-S2 quickly combined with thrombin and the amount of S1 decreased in the solution after magnetic separation. The enhancement of peroxidase like activity of S1/FeCo-ONSs was weakened, resulting in the inhibition of the catalytic oxidation process of substrate TMB. The formation of oxTMB and the fluorescence quenching efficiency of MoS2 QDs were further affected. Therefore, the quantitative detection of thrombin can be achieved by measuring the absorption signal of oxTMB and the fluorescence signal of MoS2 QDs. The limits of detection for thrombin were 0.67 pM and 2.36 pM by the outputting fluorometric and colorimetric dual signals, respectively. This sensing strategy not only has high specificity, but also can be expanded as a more universal platform for sensitive detection of different proteins by changing the aptamer probe pairs. |
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title_short |
Construction of a dual-signal sensing platform based on DNA enhanced peroxidase-activity of iron cobalt oxide nanosheets for thrombin detection |
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|
score |
7.40007 |