miRNAs: novel noninvasive biomarkers as diagnostic and prognostic tools in neonatal sepsis

The study aimed to assess the diagnostic and prognostic value of 3 specific microRNAs (miRNAs) in early-onset neonatal sepsis (NS). We examined miR-1, miR-124, and miR-34a in 70 NS patients upon admission and compared them to 70 healthy controls by RT-PCR. The main finding of the study was the diffe...
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Autor*in:	El-Khazragy, Nashwa [verfasserIn] Mohamed, Noura Mostafa [verfasserIn] Mostafa, Mohamed Fathalla [verfasserIn] Elnakib, Mostafa [verfasserIn] Hemida, Eman H.A. [verfasserIn] Salah, Amira [verfasserIn] Fawzy, Nesma Mohamed [verfasserIn] Safwat, Gehan [verfasserIn] Emam, Mennatallah M. [verfasserIn] Mahran, Nievin Ahmed [verfasserIn] Rabie, Dina [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	miRNA miR-1 miR-124 miR-34a mortality neonatal sepsis

Übergeordnetes Werk:	Enthalten in: Diagnostic microbiology and infectious disease - Amsterdam [u.a.] : Elsevier Science, 1983, 107
Übergeordnetes Werk:	volume:107

DOI / URN:	10.1016/j.diagmicrobio.2023.116053

Katalog-ID:	ELV064916243

Internformat


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024	7		\|a 10.1016/j.diagmicrobio.2023.116053 \|2 doi
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100	1		\|a El-Khazragy, Nashwa \|e verfasserin \|0 (orcid)0000-0001-6646-4674 \|4 aut
245	1	0	\|a miRNAs: novel noninvasive biomarkers as diagnostic and prognostic tools in neonatal sepsis
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336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
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520			\|a The study aimed to assess the diagnostic and prognostic value of 3 specific microRNAs (miRNAs) in early-onset neonatal sepsis (NS). We examined miR-1, miR-124, and miR-34a in 70 NS patients upon admission and compared them to 70 healthy controls by RT-PCR. The main finding of the study was the difference in miRNA expression levels between NS patients and controls. Higher expression levels of miR-1 and miR-124 were significantly associated with NS, while miR-34a expression was reduced. Among the studied miRNAs, miR-34a exhibited the highest specificity (97%) as a confirmatory test for NS. In the multivariate model, miR-1 and miR-124 were found to be significant predictors of disease progression or mortality. Overall, the study suggests that miR-1, miR-124, and miR-34a could serve as potential biomarkers for diagnosing and predicting outcomes in early-onset NS.
650		4	\|a miRNA
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650		4	\|a miR-124
650		4	\|a miR-34a
650		4	\|a mortality
650		4	\|a neonatal sepsis
700	1		\|a Mohamed, Noura Mostafa \|e verfasserin \|4 aut
700	1		\|a Mostafa, Mohamed Fathalla \|e verfasserin \|4 aut
700	1		\|a Elnakib, Mostafa \|e verfasserin \|4 aut
700	1		\|a Hemida, Eman H.A. \|e verfasserin \|4 aut
700	1		\|a Salah, Amira \|e verfasserin \|4 aut
700	1		\|a Fawzy, Nesma Mohamed \|e verfasserin \|4 aut
700	1		\|a Safwat, Gehan \|e verfasserin \|4 aut
700	1		\|a Emam, Mennatallah M. \|e verfasserin \|4 aut
700	1		\|a Mahran, Nievin Ahmed \|e verfasserin \|4 aut
700	1		\|a Rabie, Dina \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Diagnostic microbiology and infectious disease \|d Amsterdam [u.a.] : Elsevier Science, 1983 \|g 107 \|h Online-Ressource \|w (DE-627)32360479X \|w (DE-600)2026024-6 \|w (DE-576)264424107 \|x 1879-0070 \|7 nnns
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912			\|a GBV_ILN_32
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_65
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912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_100
912			\|a GBV_ILN_101
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912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_252
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
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912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2110
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912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
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912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
936	b	k	\|a 44.43 \|j Medizinische Mikrobiologie \|q VZ
936	b	k	\|a 44.75 \|j Infektionskrankheiten \|j parasitäre Krankheiten \|x Medizin \|q VZ
951			\|a AR
952			\|d 107

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publishDate	2023
allfields	10.1016/j.diagmicrobio.2023.116053 doi (DE-627)ELV064916243 (ELSEVIER)S0732-8893(23)00163-3 DE-627 ger DE-627 rda eng 610 VZ 44.43 bkl 44.75 bkl El-Khazragy, Nashwa verfasserin (orcid)0000-0001-6646-4674 aut miRNAs: novel noninvasive biomarkers as diagnostic and prognostic tools in neonatal sepsis 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The study aimed to assess the diagnostic and prognostic value of 3 specific microRNAs (miRNAs) in early-onset neonatal sepsis (NS). We examined miR-1, miR-124, and miR-34a in 70 NS patients upon admission and compared them to 70 healthy controls by RT-PCR. The main finding of the study was the difference in miRNA expression levels between NS patients and controls. Higher expression levels of miR-1 and miR-124 were significantly associated with NS, while miR-34a expression was reduced. Among the studied miRNAs, miR-34a exhibited the highest specificity (97%) as a confirmatory test for NS. In the multivariate model, miR-1 and miR-124 were found to be significant predictors of disease progression or mortality. Overall, the study suggests that miR-1, miR-124, and miR-34a could serve as potential biomarkers for diagnosing and predicting outcomes in early-onset NS. miRNA miR-1 miR-124 miR-34a mortality neonatal sepsis Mohamed, Noura Mostafa verfasserin aut Mostafa, Mohamed Fathalla verfasserin aut Elnakib, Mostafa verfasserin aut Hemida, Eman H.A. verfasserin aut Salah, Amira verfasserin aut Fawzy, Nesma Mohamed verfasserin aut Safwat, Gehan verfasserin aut Emam, Mennatallah M. verfasserin aut Mahran, Nievin Ahmed verfasserin aut Rabie, Dina verfasserin aut Enthalten in Diagnostic microbiology and infectious disease Amsterdam [u.a.] : Elsevier Science, 1983 107 Online-Ressource (DE-627)32360479X (DE-600)2026024-6 (DE-576)264424107 1879-0070 nnns volume:107 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 Medizinische Mikrobiologie VZ 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin VZ AR 107
spelling	10.1016/j.diagmicrobio.2023.116053 doi (DE-627)ELV064916243 (ELSEVIER)S0732-8893(23)00163-3 DE-627 ger DE-627 rda eng 610 VZ 44.43 bkl 44.75 bkl El-Khazragy, Nashwa verfasserin (orcid)0000-0001-6646-4674 aut miRNAs: novel noninvasive biomarkers as diagnostic and prognostic tools in neonatal sepsis 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The study aimed to assess the diagnostic and prognostic value of 3 specific microRNAs (miRNAs) in early-onset neonatal sepsis (NS). We examined miR-1, miR-124, and miR-34a in 70 NS patients upon admission and compared them to 70 healthy controls by RT-PCR. The main finding of the study was the difference in miRNA expression levels between NS patients and controls. Higher expression levels of miR-1 and miR-124 were significantly associated with NS, while miR-34a expression was reduced. Among the studied miRNAs, miR-34a exhibited the highest specificity (97%) as a confirmatory test for NS. In the multivariate model, miR-1 and miR-124 were found to be significant predictors of disease progression or mortality. Overall, the study suggests that miR-1, miR-124, and miR-34a could serve as potential biomarkers for diagnosing and predicting outcomes in early-onset NS. miRNA miR-1 miR-124 miR-34a mortality neonatal sepsis Mohamed, Noura Mostafa verfasserin aut Mostafa, Mohamed Fathalla verfasserin aut Elnakib, Mostafa verfasserin aut Hemida, Eman H.A. verfasserin aut Salah, Amira verfasserin aut Fawzy, Nesma Mohamed verfasserin aut Safwat, Gehan verfasserin aut Emam, Mennatallah M. verfasserin aut Mahran, Nievin Ahmed verfasserin aut Rabie, Dina verfasserin aut Enthalten in Diagnostic microbiology and infectious disease Amsterdam [u.a.] : Elsevier Science, 1983 107 Online-Ressource (DE-627)32360479X (DE-600)2026024-6 (DE-576)264424107 1879-0070 nnns volume:107 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 Medizinische Mikrobiologie VZ 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin VZ AR 107
allfields_unstemmed	10.1016/j.diagmicrobio.2023.116053 doi (DE-627)ELV064916243 (ELSEVIER)S0732-8893(23)00163-3 DE-627 ger DE-627 rda eng 610 VZ 44.43 bkl 44.75 bkl El-Khazragy, Nashwa verfasserin (orcid)0000-0001-6646-4674 aut miRNAs: novel noninvasive biomarkers as diagnostic and prognostic tools in neonatal sepsis 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The study aimed to assess the diagnostic and prognostic value of 3 specific microRNAs (miRNAs) in early-onset neonatal sepsis (NS). We examined miR-1, miR-124, and miR-34a in 70 NS patients upon admission and compared them to 70 healthy controls by RT-PCR. The main finding of the study was the difference in miRNA expression levels between NS patients and controls. Higher expression levels of miR-1 and miR-124 were significantly associated with NS, while miR-34a expression was reduced. Among the studied miRNAs, miR-34a exhibited the highest specificity (97%) as a confirmatory test for NS. In the multivariate model, miR-1 and miR-124 were found to be significant predictors of disease progression or mortality. Overall, the study suggests that miR-1, miR-124, and miR-34a could serve as potential biomarkers for diagnosing and predicting outcomes in early-onset NS. miRNA miR-1 miR-124 miR-34a mortality neonatal sepsis Mohamed, Noura Mostafa verfasserin aut Mostafa, Mohamed Fathalla verfasserin aut Elnakib, Mostafa verfasserin aut Hemida, Eman H.A. verfasserin aut Salah, Amira verfasserin aut Fawzy, Nesma Mohamed verfasserin aut Safwat, Gehan verfasserin aut Emam, Mennatallah M. verfasserin aut Mahran, Nievin Ahmed verfasserin aut Rabie, Dina verfasserin aut Enthalten in Diagnostic microbiology and infectious disease Amsterdam [u.a.] : Elsevier Science, 1983 107 Online-Ressource (DE-627)32360479X (DE-600)2026024-6 (DE-576)264424107 1879-0070 nnns volume:107 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 Medizinische Mikrobiologie VZ 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin VZ AR 107
allfieldsGer	10.1016/j.diagmicrobio.2023.116053 doi (DE-627)ELV064916243 (ELSEVIER)S0732-8893(23)00163-3 DE-627 ger DE-627 rda eng 610 VZ 44.43 bkl 44.75 bkl El-Khazragy, Nashwa verfasserin (orcid)0000-0001-6646-4674 aut miRNAs: novel noninvasive biomarkers as diagnostic and prognostic tools in neonatal sepsis 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The study aimed to assess the diagnostic and prognostic value of 3 specific microRNAs (miRNAs) in early-onset neonatal sepsis (NS). We examined miR-1, miR-124, and miR-34a in 70 NS patients upon admission and compared them to 70 healthy controls by RT-PCR. The main finding of the study was the difference in miRNA expression levels between NS patients and controls. Higher expression levels of miR-1 and miR-124 were significantly associated with NS, while miR-34a expression was reduced. Among the studied miRNAs, miR-34a exhibited the highest specificity (97%) as a confirmatory test for NS. In the multivariate model, miR-1 and miR-124 were found to be significant predictors of disease progression or mortality. Overall, the study suggests that miR-1, miR-124, and miR-34a could serve as potential biomarkers for diagnosing and predicting outcomes in early-onset NS. miRNA miR-1 miR-124 miR-34a mortality neonatal sepsis Mohamed, Noura Mostafa verfasserin aut Mostafa, Mohamed Fathalla verfasserin aut Elnakib, Mostafa verfasserin aut Hemida, Eman H.A. verfasserin aut Salah, Amira verfasserin aut Fawzy, Nesma Mohamed verfasserin aut Safwat, Gehan verfasserin aut Emam, Mennatallah M. verfasserin aut Mahran, Nievin Ahmed verfasserin aut Rabie, Dina verfasserin aut Enthalten in Diagnostic microbiology and infectious disease Amsterdam [u.a.] : Elsevier Science, 1983 107 Online-Ressource (DE-627)32360479X (DE-600)2026024-6 (DE-576)264424107 1879-0070 nnns volume:107 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 Medizinische Mikrobiologie VZ 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin VZ AR 107
allfieldsSound	10.1016/j.diagmicrobio.2023.116053 doi (DE-627)ELV064916243 (ELSEVIER)S0732-8893(23)00163-3 DE-627 ger DE-627 rda eng 610 VZ 44.43 bkl 44.75 bkl El-Khazragy, Nashwa verfasserin (orcid)0000-0001-6646-4674 aut miRNAs: novel noninvasive biomarkers as diagnostic and prognostic tools in neonatal sepsis 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The study aimed to assess the diagnostic and prognostic value of 3 specific microRNAs (miRNAs) in early-onset neonatal sepsis (NS). We examined miR-1, miR-124, and miR-34a in 70 NS patients upon admission and compared them to 70 healthy controls by RT-PCR. The main finding of the study was the difference in miRNA expression levels between NS patients and controls. Higher expression levels of miR-1 and miR-124 were significantly associated with NS, while miR-34a expression was reduced. Among the studied miRNAs, miR-34a exhibited the highest specificity (97%) as a confirmatory test for NS. In the multivariate model, miR-1 and miR-124 were found to be significant predictors of disease progression or mortality. Overall, the study suggests that miR-1, miR-124, and miR-34a could serve as potential biomarkers for diagnosing and predicting outcomes in early-onset NS. miRNA miR-1 miR-124 miR-34a mortality neonatal sepsis Mohamed, Noura Mostafa verfasserin aut Mostafa, Mohamed Fathalla verfasserin aut Elnakib, Mostafa verfasserin aut Hemida, Eman H.A. verfasserin aut Salah, Amira verfasserin aut Fawzy, Nesma Mohamed verfasserin aut Safwat, Gehan verfasserin aut Emam, Mennatallah M. verfasserin aut Mahran, Nievin Ahmed verfasserin aut Rabie, Dina verfasserin aut Enthalten in Diagnostic microbiology and infectious disease Amsterdam [u.a.] : Elsevier Science, 1983 107 Online-Ressource (DE-627)32360479X (DE-600)2026024-6 (DE-576)264424107 1879-0070 nnns volume:107 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 Medizinische Mikrobiologie VZ 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin VZ AR 107
language	English
source	Enthalten in Diagnostic microbiology and infectious disease 107 volume:107
sourceStr	Enthalten in Diagnostic microbiology and infectious disease 107 volume:107
format_phy_str_mv	Article
bklname	Medizinische Mikrobiologie Infektionskrankheiten parasitäre Krankheiten
institution	findex.gbv.de
topic_facet	miRNA miR-1 miR-124 miR-34a mortality neonatal sepsis
dewey-raw	610
isfreeaccess_bool	false
container_title	Diagnostic microbiology and infectious disease
authorswithroles_txt_mv	El-Khazragy, Nashwa @@aut@@ Mohamed, Noura Mostafa @@aut@@ Mostafa, Mohamed Fathalla @@aut@@ Elnakib, Mostafa @@aut@@ Hemida, Eman H.A. @@aut@@ Salah, Amira @@aut@@ Fawzy, Nesma Mohamed @@aut@@ Safwat, Gehan @@aut@@ Emam, Mennatallah M. @@aut@@ Mahran, Nievin Ahmed @@aut@@ Rabie, Dina @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	32360479X
dewey-sort	3610
id	ELV064916243
language_de	englisch
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author	El-Khazragy, Nashwa
spellingShingle	El-Khazragy, Nashwa ddc 610 bkl 44.43 bkl 44.75 misc miRNA misc miR-1 misc miR-124 misc miR-34a misc mortality misc neonatal sepsis miRNAs: novel noninvasive biomarkers as diagnostic and prognostic tools in neonatal sepsis
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topic_title	610 VZ 44.43 bkl 44.75 bkl miRNAs: novel noninvasive biomarkers as diagnostic and prognostic tools in neonatal sepsis miRNA miR-1 miR-124 miR-34a mortality neonatal sepsis
topic	ddc 610 bkl 44.43 bkl 44.75 misc miRNA misc miR-1 misc miR-124 misc miR-34a misc mortality misc neonatal sepsis
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title	miRNAs: novel noninvasive biomarkers as diagnostic and prognostic tools in neonatal sepsis
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title_full	miRNAs: novel noninvasive biomarkers as diagnostic and prognostic tools in neonatal sepsis
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author_browse	El-Khazragy, Nashwa Mohamed, Noura Mostafa Mostafa, Mohamed Fathalla Elnakib, Mostafa Hemida, Eman H.A. Salah, Amira Fawzy, Nesma Mohamed Safwat, Gehan Emam, Mennatallah M. Mahran, Nievin Ahmed Rabie, Dina
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title_sort	mirnas: novel noninvasive biomarkers as diagnostic and prognostic tools in neonatal sepsis
title_auth	miRNAs: novel noninvasive biomarkers as diagnostic and prognostic tools in neonatal sepsis
abstract	The study aimed to assess the diagnostic and prognostic value of 3 specific microRNAs (miRNAs) in early-onset neonatal sepsis (NS). We examined miR-1, miR-124, and miR-34a in 70 NS patients upon admission and compared them to 70 healthy controls by RT-PCR. The main finding of the study was the difference in miRNA expression levels between NS patients and controls. Higher expression levels of miR-1 and miR-124 were significantly associated with NS, while miR-34a expression was reduced. Among the studied miRNAs, miR-34a exhibited the highest specificity (97%) as a confirmatory test for NS. In the multivariate model, miR-1 and miR-124 were found to be significant predictors of disease progression or mortality. Overall, the study suggests that miR-1, miR-124, and miR-34a could serve as potential biomarkers for diagnosing and predicting outcomes in early-onset NS.
abstractGer	The study aimed to assess the diagnostic and prognostic value of 3 specific microRNAs (miRNAs) in early-onset neonatal sepsis (NS). We examined miR-1, miR-124, and miR-34a in 70 NS patients upon admission and compared them to 70 healthy controls by RT-PCR. The main finding of the study was the difference in miRNA expression levels between NS patients and controls. Higher expression levels of miR-1 and miR-124 were significantly associated with NS, while miR-34a expression was reduced. Among the studied miRNAs, miR-34a exhibited the highest specificity (97%) as a confirmatory test for NS. In the multivariate model, miR-1 and miR-124 were found to be significant predictors of disease progression or mortality. Overall, the study suggests that miR-1, miR-124, and miR-34a could serve as potential biomarkers for diagnosing and predicting outcomes in early-onset NS.
abstract_unstemmed	The study aimed to assess the diagnostic and prognostic value of 3 specific microRNAs (miRNAs) in early-onset neonatal sepsis (NS). We examined miR-1, miR-124, and miR-34a in 70 NS patients upon admission and compared them to 70 healthy controls by RT-PCR. The main finding of the study was the difference in miRNA expression levels between NS patients and controls. Higher expression levels of miR-1 and miR-124 were significantly associated with NS, while miR-34a expression was reduced. Among the studied miRNAs, miR-34a exhibited the highest specificity (97%) as a confirmatory test for NS. In the multivariate model, miR-1 and miR-124 were found to be significant predictors of disease progression or mortality. Overall, the study suggests that miR-1, miR-124, and miR-34a could serve as potential biomarkers for diagnosing and predicting outcomes in early-onset NS.
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title_short	miRNAs: novel noninvasive biomarkers as diagnostic and prognostic tools in neonatal sepsis
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author2	Mohamed, Noura Mostafa Mostafa, Mohamed Fathalla Elnakib, Mostafa Hemida, Eman H.A. Salah, Amira Fawzy, Nesma Mohamed Safwat, Gehan Emam, Mennatallah M. Mahran, Nievin Ahmed Rabie, Dina
author2Str	Mohamed, Noura Mostafa Mostafa, Mohamed Fathalla Elnakib, Mostafa Hemida, Eman H.A. Salah, Amira Fawzy, Nesma Mohamed Safwat, Gehan Emam, Mennatallah M. Mahran, Nievin Ahmed Rabie, Dina
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up_date	2024-07-06T21:11:18.059Z
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