Ohne Titel
Background and study aims: Colorectal cancer (CRC) is the second most common cancer in Malaysia and mostly detected at advanced stages due to lack of awareness of CRC symptoms and signs. CRC pathogenesis is multifactorial, and there is ambiguous evidence on association of Streptococcus gallolyticus...
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| Autor*in: |
Bin Ismail, Che Muhammad Khairul Hisyam [verfasserIn] Bin Mohammad Aidid, Edre [verfasserIn] Binti Hamzah, Hairul Aini [verfasserIn] Bin Shalihin, Mohd Shaiful Ehsan [verfasserIn] Bin Md Nor, Azmi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: No title available - 24, Seite 163-167 |
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| Übergeordnetes Werk: |
volume:24 ; pages:163-167 |
| DOI / URN: |
10.1016/j.ajg.2023.02.002 |
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ELV064958612 |
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| 520 | |a Background and study aims: Colorectal cancer (CRC) is the second most common cancer in Malaysia and mostly detected at advanced stages due to lack of awareness of CRC symptoms and signs. CRC pathogenesis is multifactorial, and there is ambiguous evidence on association of Streptococcus gallolyticus infection with CRC that needs further attention.Patients and methods: A total of 33 stool samples from patients diagnosed with CRC and 80 from patients without CRC attending surgical clinic of SASMECIIUM were collected and analyzed with iFOBT test and PCR assay to detect S. gallolyticus.Results: In this study, the proportion of S. gallolyticus infection was higher among patients with CRC (48.5%) compared with the control group (20%). Univariate analysis shows that occult blood in stool, S. gallolyticus infection and family history were significantly associated with the development of CRC (P < 0.05). Using the multivariate logistic regression model, positive stool PCR for S. gallolyticus had the lowest relative standard error and almost five times the odds of developing CRC after adjusting other factors (adjusted odds ratio = 4.7, 95% confidence interval = 1.7–12.6, relative standard error = 59.6%).Conclusion: This finding suggests that S. gallolyticus infection was the strongest predictor of CRC’s development in our study and potentially serves as a predictive marker for early detection of disease progression. | ||
| 650 | 4 | |a Case-control study | |
| 650 | 4 | |a Colorectal cancer | |
| 650 | 4 | |a Multivariate logistic regression | |
| 650 | 4 | |a Predictors | |
| 650 | 4 | |a Stool PCR | |
| 700 | 1 | |a Bin Mohammad Aidid, Edre |e verfasserin |4 aut | |
| 700 | 1 | |a Binti Hamzah, Hairul Aini |e verfasserin |4 aut | |
| 700 | 1 | |a Bin Shalihin, Mohd Shaiful Ehsan |e verfasserin |4 aut | |
| 700 | 1 | |a Bin Md Nor, Azmi |e verfasserin |4 aut | |
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10.1016/j.ajg.2023.02.002 doi (DE-627)ELV064958612 (ELSEVIER)S1687-1979(23)00011-4 DE-627 ger DE-627 rda eng Bin Ismail, Che Muhammad Khairul Hisyam verfasserin aut 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and study aims: Colorectal cancer (CRC) is the second most common cancer in Malaysia and mostly detected at advanced stages due to lack of awareness of CRC symptoms and signs. CRC pathogenesis is multifactorial, and there is ambiguous evidence on association of Streptococcus gallolyticus infection with CRC that needs further attention.Patients and methods: A total of 33 stool samples from patients diagnosed with CRC and 80 from patients without CRC attending surgical clinic of SASMECIIUM were collected and analyzed with iFOBT test and PCR assay to detect S. gallolyticus.Results: In this study, the proportion of S. gallolyticus infection was higher among patients with CRC (48.5%) compared with the control group (20%). Univariate analysis shows that occult blood in stool, S. gallolyticus infection and family history were significantly associated with the development of CRC (P < 0.05). Using the multivariate logistic regression model, positive stool PCR for S. gallolyticus had the lowest relative standard error and almost five times the odds of developing CRC after adjusting other factors (adjusted odds ratio = 4.7, 95% confidence interval = 1.7–12.6, relative standard error = 59.6%).Conclusion: This finding suggests that S. gallolyticus infection was the strongest predictor of CRC’s development in our study and potentially serves as a predictive marker for early detection of disease progression. Case-control study Colorectal cancer Multivariate logistic regression Predictors Stool PCR Bin Mohammad Aidid, Edre verfasserin aut Binti Hamzah, Hairul Aini verfasserin aut Bin Shalihin, Mohd Shaiful Ehsan verfasserin aut Bin Md Nor, Azmi verfasserin aut Enthalten in No title available 24, Seite 163-167 (DE-627)ELV001249401 1687-1979 nnns volume:24 pages:163-167 GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 24 163-167 |
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10.1016/j.ajg.2023.02.002 doi (DE-627)ELV064958612 (ELSEVIER)S1687-1979(23)00011-4 DE-627 ger DE-627 rda eng Bin Ismail, Che Muhammad Khairul Hisyam verfasserin aut 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and study aims: Colorectal cancer (CRC) is the second most common cancer in Malaysia and mostly detected at advanced stages due to lack of awareness of CRC symptoms and signs. CRC pathogenesis is multifactorial, and there is ambiguous evidence on association of Streptococcus gallolyticus infection with CRC that needs further attention.Patients and methods: A total of 33 stool samples from patients diagnosed with CRC and 80 from patients without CRC attending surgical clinic of SASMECIIUM were collected and analyzed with iFOBT test and PCR assay to detect S. gallolyticus.Results: In this study, the proportion of S. gallolyticus infection was higher among patients with CRC (48.5%) compared with the control group (20%). Univariate analysis shows that occult blood in stool, S. gallolyticus infection and family history were significantly associated with the development of CRC (P < 0.05). Using the multivariate logistic regression model, positive stool PCR for S. gallolyticus had the lowest relative standard error and almost five times the odds of developing CRC after adjusting other factors (adjusted odds ratio = 4.7, 95% confidence interval = 1.7–12.6, relative standard error = 59.6%).Conclusion: This finding suggests that S. gallolyticus infection was the strongest predictor of CRC’s development in our study and potentially serves as a predictive marker for early detection of disease progression. Case-control study Colorectal cancer Multivariate logistic regression Predictors Stool PCR Bin Mohammad Aidid, Edre verfasserin aut Binti Hamzah, Hairul Aini verfasserin aut Bin Shalihin, Mohd Shaiful Ehsan verfasserin aut Bin Md Nor, Azmi verfasserin aut Enthalten in No title available 24, Seite 163-167 (DE-627)ELV001249401 1687-1979 nnns volume:24 pages:163-167 GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 24 163-167 |
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10.1016/j.ajg.2023.02.002 doi (DE-627)ELV064958612 (ELSEVIER)S1687-1979(23)00011-4 DE-627 ger DE-627 rda eng Bin Ismail, Che Muhammad Khairul Hisyam verfasserin aut 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and study aims: Colorectal cancer (CRC) is the second most common cancer in Malaysia and mostly detected at advanced stages due to lack of awareness of CRC symptoms and signs. CRC pathogenesis is multifactorial, and there is ambiguous evidence on association of Streptococcus gallolyticus infection with CRC that needs further attention.Patients and methods: A total of 33 stool samples from patients diagnosed with CRC and 80 from patients without CRC attending surgical clinic of SASMECIIUM were collected and analyzed with iFOBT test and PCR assay to detect S. gallolyticus.Results: In this study, the proportion of S. gallolyticus infection was higher among patients with CRC (48.5%) compared with the control group (20%). Univariate analysis shows that occult blood in stool, S. gallolyticus infection and family history were significantly associated with the development of CRC (P < 0.05). Using the multivariate logistic regression model, positive stool PCR for S. gallolyticus had the lowest relative standard error and almost five times the odds of developing CRC after adjusting other factors (adjusted odds ratio = 4.7, 95% confidence interval = 1.7–12.6, relative standard error = 59.6%).Conclusion: This finding suggests that S. gallolyticus infection was the strongest predictor of CRC’s development in our study and potentially serves as a predictive marker for early detection of disease progression. Case-control study Colorectal cancer Multivariate logistic regression Predictors Stool PCR Bin Mohammad Aidid, Edre verfasserin aut Binti Hamzah, Hairul Aini verfasserin aut Bin Shalihin, Mohd Shaiful Ehsan verfasserin aut Bin Md Nor, Azmi verfasserin aut Enthalten in No title available 24, Seite 163-167 (DE-627)ELV001249401 1687-1979 nnns volume:24 pages:163-167 GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 24 163-167 |
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10.1016/j.ajg.2023.02.002 doi (DE-627)ELV064958612 (ELSEVIER)S1687-1979(23)00011-4 DE-627 ger DE-627 rda eng Bin Ismail, Che Muhammad Khairul Hisyam verfasserin aut 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and study aims: Colorectal cancer (CRC) is the second most common cancer in Malaysia and mostly detected at advanced stages due to lack of awareness of CRC symptoms and signs. CRC pathogenesis is multifactorial, and there is ambiguous evidence on association of Streptococcus gallolyticus infection with CRC that needs further attention.Patients and methods: A total of 33 stool samples from patients diagnosed with CRC and 80 from patients without CRC attending surgical clinic of SASMECIIUM were collected and analyzed with iFOBT test and PCR assay to detect S. gallolyticus.Results: In this study, the proportion of S. gallolyticus infection was higher among patients with CRC (48.5%) compared with the control group (20%). Univariate analysis shows that occult blood in stool, S. gallolyticus infection and family history were significantly associated with the development of CRC (P < 0.05). Using the multivariate logistic regression model, positive stool PCR for S. gallolyticus had the lowest relative standard error and almost five times the odds of developing CRC after adjusting other factors (adjusted odds ratio = 4.7, 95% confidence interval = 1.7–12.6, relative standard error = 59.6%).Conclusion: This finding suggests that S. gallolyticus infection was the strongest predictor of CRC’s development in our study and potentially serves as a predictive marker for early detection of disease progression. Case-control study Colorectal cancer Multivariate logistic regression Predictors Stool PCR Bin Mohammad Aidid, Edre verfasserin aut Binti Hamzah, Hairul Aini verfasserin aut Bin Shalihin, Mohd Shaiful Ehsan verfasserin aut Bin Md Nor, Azmi verfasserin aut Enthalten in No title available 24, Seite 163-167 (DE-627)ELV001249401 1687-1979 nnns volume:24 pages:163-167 GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 24 163-167 |
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10.1016/j.ajg.2023.02.002 doi (DE-627)ELV064958612 (ELSEVIER)S1687-1979(23)00011-4 DE-627 ger DE-627 rda eng Bin Ismail, Che Muhammad Khairul Hisyam verfasserin aut 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and study aims: Colorectal cancer (CRC) is the second most common cancer in Malaysia and mostly detected at advanced stages due to lack of awareness of CRC symptoms and signs. CRC pathogenesis is multifactorial, and there is ambiguous evidence on association of Streptococcus gallolyticus infection with CRC that needs further attention.Patients and methods: A total of 33 stool samples from patients diagnosed with CRC and 80 from patients without CRC attending surgical clinic of SASMECIIUM were collected and analyzed with iFOBT test and PCR assay to detect S. gallolyticus.Results: In this study, the proportion of S. gallolyticus infection was higher among patients with CRC (48.5%) compared with the control group (20%). Univariate analysis shows that occult blood in stool, S. gallolyticus infection and family history were significantly associated with the development of CRC (P < 0.05). Using the multivariate logistic regression model, positive stool PCR for S. gallolyticus had the lowest relative standard error and almost five times the odds of developing CRC after adjusting other factors (adjusted odds ratio = 4.7, 95% confidence interval = 1.7–12.6, relative standard error = 59.6%).Conclusion: This finding suggests that S. gallolyticus infection was the strongest predictor of CRC’s development in our study and potentially serves as a predictive marker for early detection of disease progression. Case-control study Colorectal cancer Multivariate logistic regression Predictors Stool PCR Bin Mohammad Aidid, Edre verfasserin aut Binti Hamzah, Hairul Aini verfasserin aut Bin Shalihin, Mohd Shaiful Ehsan verfasserin aut Bin Md Nor, Azmi verfasserin aut Enthalten in No title available 24, Seite 163-167 (DE-627)ELV001249401 1687-1979 nnns volume:24 pages:163-167 GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 24 163-167 |
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Background and study aims: Colorectal cancer (CRC) is the second most common cancer in Malaysia and mostly detected at advanced stages due to lack of awareness of CRC symptoms and signs. CRC pathogenesis is multifactorial, and there is ambiguous evidence on association of Streptococcus gallolyticus infection with CRC that needs further attention.Patients and methods: A total of 33 stool samples from patients diagnosed with CRC and 80 from patients without CRC attending surgical clinic of SASMECIIUM were collected and analyzed with iFOBT test and PCR assay to detect S. gallolyticus.Results: In this study, the proportion of S. gallolyticus infection was higher among patients with CRC (48.5%) compared with the control group (20%). Univariate analysis shows that occult blood in stool, S. gallolyticus infection and family history were significantly associated with the development of CRC (P < 0.05). Using the multivariate logistic regression model, positive stool PCR for S. gallolyticus had the lowest relative standard error and almost five times the odds of developing CRC after adjusting other factors (adjusted odds ratio = 4.7, 95% confidence interval = 1.7–12.6, relative standard error = 59.6%).Conclusion: This finding suggests that S. gallolyticus infection was the strongest predictor of CRC’s development in our study and potentially serves as a predictive marker for early detection of disease progression. |
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Background and study aims: Colorectal cancer (CRC) is the second most common cancer in Malaysia and mostly detected at advanced stages due to lack of awareness of CRC symptoms and signs. CRC pathogenesis is multifactorial, and there is ambiguous evidence on association of Streptococcus gallolyticus infection with CRC that needs further attention.Patients and methods: A total of 33 stool samples from patients diagnosed with CRC and 80 from patients without CRC attending surgical clinic of SASMECIIUM were collected and analyzed with iFOBT test and PCR assay to detect S. gallolyticus.Results: In this study, the proportion of S. gallolyticus infection was higher among patients with CRC (48.5%) compared with the control group (20%). Univariate analysis shows that occult blood in stool, S. gallolyticus infection and family history were significantly associated with the development of CRC (P < 0.05). Using the multivariate logistic regression model, positive stool PCR for S. gallolyticus had the lowest relative standard error and almost five times the odds of developing CRC after adjusting other factors (adjusted odds ratio = 4.7, 95% confidence interval = 1.7–12.6, relative standard error = 59.6%).Conclusion: This finding suggests that S. gallolyticus infection was the strongest predictor of CRC’s development in our study and potentially serves as a predictive marker for early detection of disease progression. |
| abstract_unstemmed |
Background and study aims: Colorectal cancer (CRC) is the second most common cancer in Malaysia and mostly detected at advanced stages due to lack of awareness of CRC symptoms and signs. CRC pathogenesis is multifactorial, and there is ambiguous evidence on association of Streptococcus gallolyticus infection with CRC that needs further attention.Patients and methods: A total of 33 stool samples from patients diagnosed with CRC and 80 from patients without CRC attending surgical clinic of SASMECIIUM were collected and analyzed with iFOBT test and PCR assay to detect S. gallolyticus.Results: In this study, the proportion of S. gallolyticus infection was higher among patients with CRC (48.5%) compared with the control group (20%). Univariate analysis shows that occult blood in stool, S. gallolyticus infection and family history were significantly associated with the development of CRC (P < 0.05). Using the multivariate logistic regression model, positive stool PCR for S. gallolyticus had the lowest relative standard error and almost five times the odds of developing CRC after adjusting other factors (adjusted odds ratio = 4.7, 95% confidence interval = 1.7–12.6, relative standard error = 59.6%).Conclusion: This finding suggests that S. gallolyticus infection was the strongest predictor of CRC’s development in our study and potentially serves as a predictive marker for early detection of disease progression. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">ELV064958612</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20231005073047.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">231005s2023 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.ajg.2023.02.002</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV064958612</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1687-1979(23)00011-4</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Bin Ismail, Che Muhammad Khairul Hisyam</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background and study aims: Colorectal cancer (CRC) is the second most common cancer in Malaysia and mostly detected at advanced stages due to lack of awareness of CRC symptoms and signs. CRC pathogenesis is multifactorial, and there is ambiguous evidence on association of Streptococcus gallolyticus infection with CRC that needs further attention.Patients and methods: A total of 33 stool samples from patients diagnosed with CRC and 80 from patients without CRC attending surgical clinic of SASMECIIUM were collected and analyzed with iFOBT test and PCR assay to detect S. gallolyticus.Results: In this study, the proportion of S. gallolyticus infection was higher among patients with CRC (48.5%) compared with the control group (20%). Univariate analysis shows that occult blood in stool, S. gallolyticus infection and family history were significantly associated with the development of CRC (P < 0.05). Using the multivariate logistic regression model, positive stool PCR for S. gallolyticus had the lowest relative standard error and almost five times the odds of developing CRC after adjusting other factors (adjusted odds ratio = 4.7, 95% confidence interval = 1.7–12.6, relative standard error = 59.6%).Conclusion: This finding suggests that S. gallolyticus infection was the strongest predictor of CRC’s development in our study and potentially serves as a predictive marker for early detection of disease progression.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Case-control study</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Colorectal cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Multivariate logistic regression</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Predictors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Stool PCR</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bin Mohammad Aidid, Edre</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Binti Hamzah, Hairul Aini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bin Shalihin, Mohd Shaiful Ehsan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bin Md Nor, Azmi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">No title available</subfield><subfield code="g">24, Seite 163-167</subfield><subfield code="w">(DE-627)ELV001249401</subfield><subfield code="x">1687-1979</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:24</subfield><subfield code="g">pages:163-167</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">24</subfield><subfield code="h">163-167</subfield></datafield></record></collection>
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