Well-established immunotherapy with R837-loaded boron neutron capture-shocked tumor cells
Although boron neutron capture therapy (BNCT) has been regarded as a curative therapy for aggressive tumors, the frequency of tumor recurrence and metastasis remains high mainly due to the adventitious nature of the immune response. Here, we explore the process of the immune response cascade after B...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Chen, Kui [verfasserIn] Liu, Sen [verfasserIn] Lv, Linwen [verfasserIn] Tong, Jianfei [verfasserIn] Chen, Junyang [verfasserIn] Liang, Haojun [verfasserIn] Wang, Yujiao [verfasserIn] Hu, Fan [verfasserIn] Liu, Qiuyang [verfasserIn] Li, Hao [verfasserIn] Chen, Ziteng [verfasserIn] Li, Jiacheng [verfasserIn] Wang, Zhijie [verfasserIn] Chang, Ya-nan [verfasserIn] Li, Juan [verfasserIn] Yuan, Hui [verfasserIn] Fu, Shinian [verfasserIn] Liang, Tianjiao [verfasserIn] Xing, Gengmei [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Nano today - Amsterdam [u.a.] : Elsevier, 2006, 52 |
|---|---|
| Übergeordnetes Werk: |
volume:52 |
| DOI / URN: |
10.1016/j.nantod.2023.101995 |
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| Katalog-ID: |
ELV065048482 |
|---|
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| 520 | |a Although boron neutron capture therapy (BNCT) has been regarded as a curative therapy for aggressive tumors, the frequency of tumor recurrence and metastasis remains high mainly due to the adventitious nature of the immune response. Here, we explore the process of the immune response cascade after BNCT and find that the rate-limiting step is antigen presentation. To overcome this barrier, we develop a carrier-free nano-boron agent (BN-R837 PVP), comprising hydrophilic 10B-boron nitride nanostructures loading with an immune agonist imiquimod (R837). The nano-boron agent can be internalized and cloaked into tumor cells and then following neutron irradiation, obtain the R837-loaded BNCT-shocked tumor cells (BTCs). When the BTCs are injected subcutaneously, the antigen pool and R837 are co-delivered into the draining lymph nodes, boosting immune responses as well as preventing R837 from entering the systemic circulation. This eventually results in significant inhibition of distal tumor growth and metastasis with a high rate of complete tumor regression in vivo. Moreover, memory T lymphocytes exist in these immunized mice and exhibit potent long-term anti-tumor. | ||
| 650 | 4 | |a Boron neutron capture therapy | |
| 650 | 4 | |a Immunotherapy | |
| 650 | 4 | |a Nano-boron agent | |
| 650 | 4 | |a R837 | |
| 650 | 4 | |a T lymphocytes | |
| 700 | 1 | |a Liu, Sen |e verfasserin |4 aut | |
| 700 | 1 | |a Lv, Linwen |e verfasserin |4 aut | |
| 700 | 1 | |a Tong, Jianfei |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Junyang |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Haojun |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yujiao |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Fan |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Qiuyang |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Hao |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Ziteng |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Jiacheng |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Zhijie |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Ya-nan |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Yuan, Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Fu, Shinian |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Tianjiao |e verfasserin |4 aut | |
| 700 | 1 | |a Xing, Gengmei |e verfasserin |4 aut | |
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10.1016/j.nantod.2023.101995 doi (DE-627)ELV065048482 (ELSEVIER)S1748-0132(23)00244-X DE-627 ger DE-627 rda eng 540 660 VZ 35.18 bkl 51.45 bkl 50.94 bkl 33.68 bkl Chen, Kui verfasserin (orcid)0000-0001-6754-4940 aut Well-established immunotherapy with R837-loaded boron neutron capture-shocked tumor cells 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although boron neutron capture therapy (BNCT) has been regarded as a curative therapy for aggressive tumors, the frequency of tumor recurrence and metastasis remains high mainly due to the adventitious nature of the immune response. Here, we explore the process of the immune response cascade after BNCT and find that the rate-limiting step is antigen presentation. To overcome this barrier, we develop a carrier-free nano-boron agent (BN-R837 PVP), comprising hydrophilic 10B-boron nitride nanostructures loading with an immune agonist imiquimod (R837). The nano-boron agent can be internalized and cloaked into tumor cells and then following neutron irradiation, obtain the R837-loaded BNCT-shocked tumor cells (BTCs). When the BTCs are injected subcutaneously, the antigen pool and R837 are co-delivered into the draining lymph nodes, boosting immune responses as well as preventing R837 from entering the systemic circulation. This eventually results in significant inhibition of distal tumor growth and metastasis with a high rate of complete tumor regression in vivo. Moreover, memory T lymphocytes exist in these immunized mice and exhibit potent long-term anti-tumor. Boron neutron capture therapy Immunotherapy Nano-boron agent R837 T lymphocytes Liu, Sen verfasserin aut Lv, Linwen verfasserin aut Tong, Jianfei verfasserin aut Chen, Junyang verfasserin aut Liang, Haojun verfasserin aut Wang, Yujiao verfasserin aut Hu, Fan verfasserin aut Liu, Qiuyang verfasserin aut Li, Hao verfasserin aut Chen, Ziteng verfasserin aut Li, Jiacheng verfasserin aut Wang, Zhijie verfasserin aut Chang, Ya-nan verfasserin aut Li, Juan verfasserin aut Yuan, Hui verfasserin aut Fu, Shinian verfasserin aut Liang, Tianjiao verfasserin aut Xing, Gengmei verfasserin aut Enthalten in Nano today Amsterdam [u.a.] : Elsevier, 2006 52 Online-Ressource (DE-627)508725259 (DE-600)2224882-1 (DE-576)258762047 1878-044X nnns volume:52 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.18 Kolloidchemie Grenzflächenchemie VZ 51.45 Werkstoffe mit besonderen Eigenschaften VZ 50.94 Mikrosystemtechnik Nanotechnologie VZ 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ AR 52 |
| spelling |
10.1016/j.nantod.2023.101995 doi (DE-627)ELV065048482 (ELSEVIER)S1748-0132(23)00244-X DE-627 ger DE-627 rda eng 540 660 VZ 35.18 bkl 51.45 bkl 50.94 bkl 33.68 bkl Chen, Kui verfasserin (orcid)0000-0001-6754-4940 aut Well-established immunotherapy with R837-loaded boron neutron capture-shocked tumor cells 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although boron neutron capture therapy (BNCT) has been regarded as a curative therapy for aggressive tumors, the frequency of tumor recurrence and metastasis remains high mainly due to the adventitious nature of the immune response. Here, we explore the process of the immune response cascade after BNCT and find that the rate-limiting step is antigen presentation. To overcome this barrier, we develop a carrier-free nano-boron agent (BN-R837 PVP), comprising hydrophilic 10B-boron nitride nanostructures loading with an immune agonist imiquimod (R837). The nano-boron agent can be internalized and cloaked into tumor cells and then following neutron irradiation, obtain the R837-loaded BNCT-shocked tumor cells (BTCs). When the BTCs are injected subcutaneously, the antigen pool and R837 are co-delivered into the draining lymph nodes, boosting immune responses as well as preventing R837 from entering the systemic circulation. This eventually results in significant inhibition of distal tumor growth and metastasis with a high rate of complete tumor regression in vivo. Moreover, memory T lymphocytes exist in these immunized mice and exhibit potent long-term anti-tumor. Boron neutron capture therapy Immunotherapy Nano-boron agent R837 T lymphocytes Liu, Sen verfasserin aut Lv, Linwen verfasserin aut Tong, Jianfei verfasserin aut Chen, Junyang verfasserin aut Liang, Haojun verfasserin aut Wang, Yujiao verfasserin aut Hu, Fan verfasserin aut Liu, Qiuyang verfasserin aut Li, Hao verfasserin aut Chen, Ziteng verfasserin aut Li, Jiacheng verfasserin aut Wang, Zhijie verfasserin aut Chang, Ya-nan verfasserin aut Li, Juan verfasserin aut Yuan, Hui verfasserin aut Fu, Shinian verfasserin aut Liang, Tianjiao verfasserin aut Xing, Gengmei verfasserin aut Enthalten in Nano today Amsterdam [u.a.] : Elsevier, 2006 52 Online-Ressource (DE-627)508725259 (DE-600)2224882-1 (DE-576)258762047 1878-044X nnns volume:52 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.18 Kolloidchemie Grenzflächenchemie VZ 51.45 Werkstoffe mit besonderen Eigenschaften VZ 50.94 Mikrosystemtechnik Nanotechnologie VZ 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ AR 52 |
| allfields_unstemmed |
10.1016/j.nantod.2023.101995 doi (DE-627)ELV065048482 (ELSEVIER)S1748-0132(23)00244-X DE-627 ger DE-627 rda eng 540 660 VZ 35.18 bkl 51.45 bkl 50.94 bkl 33.68 bkl Chen, Kui verfasserin (orcid)0000-0001-6754-4940 aut Well-established immunotherapy with R837-loaded boron neutron capture-shocked tumor cells 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although boron neutron capture therapy (BNCT) has been regarded as a curative therapy for aggressive tumors, the frequency of tumor recurrence and metastasis remains high mainly due to the adventitious nature of the immune response. Here, we explore the process of the immune response cascade after BNCT and find that the rate-limiting step is antigen presentation. To overcome this barrier, we develop a carrier-free nano-boron agent (BN-R837 PVP), comprising hydrophilic 10B-boron nitride nanostructures loading with an immune agonist imiquimod (R837). The nano-boron agent can be internalized and cloaked into tumor cells and then following neutron irradiation, obtain the R837-loaded BNCT-shocked tumor cells (BTCs). When the BTCs are injected subcutaneously, the antigen pool and R837 are co-delivered into the draining lymph nodes, boosting immune responses as well as preventing R837 from entering the systemic circulation. This eventually results in significant inhibition of distal tumor growth and metastasis with a high rate of complete tumor regression in vivo. Moreover, memory T lymphocytes exist in these immunized mice and exhibit potent long-term anti-tumor. Boron neutron capture therapy Immunotherapy Nano-boron agent R837 T lymphocytes Liu, Sen verfasserin aut Lv, Linwen verfasserin aut Tong, Jianfei verfasserin aut Chen, Junyang verfasserin aut Liang, Haojun verfasserin aut Wang, Yujiao verfasserin aut Hu, Fan verfasserin aut Liu, Qiuyang verfasserin aut Li, Hao verfasserin aut Chen, Ziteng verfasserin aut Li, Jiacheng verfasserin aut Wang, Zhijie verfasserin aut Chang, Ya-nan verfasserin aut Li, Juan verfasserin aut Yuan, Hui verfasserin aut Fu, Shinian verfasserin aut Liang, Tianjiao verfasserin aut Xing, Gengmei verfasserin aut Enthalten in Nano today Amsterdam [u.a.] : Elsevier, 2006 52 Online-Ressource (DE-627)508725259 (DE-600)2224882-1 (DE-576)258762047 1878-044X nnns volume:52 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.18 Kolloidchemie Grenzflächenchemie VZ 51.45 Werkstoffe mit besonderen Eigenschaften VZ 50.94 Mikrosystemtechnik Nanotechnologie VZ 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ AR 52 |
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10.1016/j.nantod.2023.101995 doi (DE-627)ELV065048482 (ELSEVIER)S1748-0132(23)00244-X DE-627 ger DE-627 rda eng 540 660 VZ 35.18 bkl 51.45 bkl 50.94 bkl 33.68 bkl Chen, Kui verfasserin (orcid)0000-0001-6754-4940 aut Well-established immunotherapy with R837-loaded boron neutron capture-shocked tumor cells 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although boron neutron capture therapy (BNCT) has been regarded as a curative therapy for aggressive tumors, the frequency of tumor recurrence and metastasis remains high mainly due to the adventitious nature of the immune response. Here, we explore the process of the immune response cascade after BNCT and find that the rate-limiting step is antigen presentation. To overcome this barrier, we develop a carrier-free nano-boron agent (BN-R837 PVP), comprising hydrophilic 10B-boron nitride nanostructures loading with an immune agonist imiquimod (R837). The nano-boron agent can be internalized and cloaked into tumor cells and then following neutron irradiation, obtain the R837-loaded BNCT-shocked tumor cells (BTCs). When the BTCs are injected subcutaneously, the antigen pool and R837 are co-delivered into the draining lymph nodes, boosting immune responses as well as preventing R837 from entering the systemic circulation. This eventually results in significant inhibition of distal tumor growth and metastasis with a high rate of complete tumor regression in vivo. Moreover, memory T lymphocytes exist in these immunized mice and exhibit potent long-term anti-tumor. Boron neutron capture therapy Immunotherapy Nano-boron agent R837 T lymphocytes Liu, Sen verfasserin aut Lv, Linwen verfasserin aut Tong, Jianfei verfasserin aut Chen, Junyang verfasserin aut Liang, Haojun verfasserin aut Wang, Yujiao verfasserin aut Hu, Fan verfasserin aut Liu, Qiuyang verfasserin aut Li, Hao verfasserin aut Chen, Ziteng verfasserin aut Li, Jiacheng verfasserin aut Wang, Zhijie verfasserin aut Chang, Ya-nan verfasserin aut Li, Juan verfasserin aut Yuan, Hui verfasserin aut Fu, Shinian verfasserin aut Liang, Tianjiao verfasserin aut Xing, Gengmei verfasserin aut Enthalten in Nano today Amsterdam [u.a.] : Elsevier, 2006 52 Online-Ressource (DE-627)508725259 (DE-600)2224882-1 (DE-576)258762047 1878-044X nnns volume:52 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.18 Kolloidchemie Grenzflächenchemie VZ 51.45 Werkstoffe mit besonderen Eigenschaften VZ 50.94 Mikrosystemtechnik Nanotechnologie VZ 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ AR 52 |
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10.1016/j.nantod.2023.101995 doi (DE-627)ELV065048482 (ELSEVIER)S1748-0132(23)00244-X DE-627 ger DE-627 rda eng 540 660 VZ 35.18 bkl 51.45 bkl 50.94 bkl 33.68 bkl Chen, Kui verfasserin (orcid)0000-0001-6754-4940 aut Well-established immunotherapy with R837-loaded boron neutron capture-shocked tumor cells 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although boron neutron capture therapy (BNCT) has been regarded as a curative therapy for aggressive tumors, the frequency of tumor recurrence and metastasis remains high mainly due to the adventitious nature of the immune response. Here, we explore the process of the immune response cascade after BNCT and find that the rate-limiting step is antigen presentation. To overcome this barrier, we develop a carrier-free nano-boron agent (BN-R837 PVP), comprising hydrophilic 10B-boron nitride nanostructures loading with an immune agonist imiquimod (R837). The nano-boron agent can be internalized and cloaked into tumor cells and then following neutron irradiation, obtain the R837-loaded BNCT-shocked tumor cells (BTCs). When the BTCs are injected subcutaneously, the antigen pool and R837 are co-delivered into the draining lymph nodes, boosting immune responses as well as preventing R837 from entering the systemic circulation. This eventually results in significant inhibition of distal tumor growth and metastasis with a high rate of complete tumor regression in vivo. Moreover, memory T lymphocytes exist in these immunized mice and exhibit potent long-term anti-tumor. Boron neutron capture therapy Immunotherapy Nano-boron agent R837 T lymphocytes Liu, Sen verfasserin aut Lv, Linwen verfasserin aut Tong, Jianfei verfasserin aut Chen, Junyang verfasserin aut Liang, Haojun verfasserin aut Wang, Yujiao verfasserin aut Hu, Fan verfasserin aut Liu, Qiuyang verfasserin aut Li, Hao verfasserin aut Chen, Ziteng verfasserin aut Li, Jiacheng verfasserin aut Wang, Zhijie verfasserin aut Chang, Ya-nan verfasserin aut Li, Juan verfasserin aut Yuan, Hui verfasserin aut Fu, Shinian verfasserin aut Liang, Tianjiao verfasserin aut Xing, Gengmei verfasserin aut Enthalten in Nano today Amsterdam [u.a.] : Elsevier, 2006 52 Online-Ressource (DE-627)508725259 (DE-600)2224882-1 (DE-576)258762047 1878-044X nnns volume:52 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.18 Kolloidchemie Grenzflächenchemie VZ 51.45 Werkstoffe mit besonderen Eigenschaften VZ 50.94 Mikrosystemtechnik Nanotechnologie VZ 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ AR 52 |
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Enthalten in Nano today 52 volume:52 |
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Kolloidchemie Grenzflächenchemie Werkstoffe mit besonderen Eigenschaften Mikrosystemtechnik Nanotechnologie Oberflächen Dünne Schichten Grenzflächen |
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Boron neutron capture therapy Immunotherapy Nano-boron agent R837 T lymphocytes |
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Chen, Kui @@aut@@ Liu, Sen @@aut@@ Lv, Linwen @@aut@@ Tong, Jianfei @@aut@@ Chen, Junyang @@aut@@ Liang, Haojun @@aut@@ Wang, Yujiao @@aut@@ Hu, Fan @@aut@@ Liu, Qiuyang @@aut@@ Li, Hao @@aut@@ Chen, Ziteng @@aut@@ Li, Jiacheng @@aut@@ Wang, Zhijie @@aut@@ Chang, Ya-nan @@aut@@ Li, Juan @@aut@@ Yuan, Hui @@aut@@ Fu, Shinian @@aut@@ Liang, Tianjiao @@aut@@ Xing, Gengmei @@aut@@ |
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2023-01-01T00:00:00Z |
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3540 |
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Chen, Kui ddc 540 bkl 35.18 bkl 51.45 bkl 50.94 bkl 33.68 misc Boron neutron capture therapy misc Immunotherapy misc Nano-boron agent misc R837 misc T lymphocytes Well-established immunotherapy with R837-loaded boron neutron capture-shocked tumor cells |
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540 660 VZ 35.18 bkl 51.45 bkl 50.94 bkl 33.68 bkl Well-established immunotherapy with R837-loaded boron neutron capture-shocked tumor cells Boron neutron capture therapy Immunotherapy Nano-boron agent R837 T lymphocytes |
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Chen, Kui Liu, Sen Lv, Linwen Tong, Jianfei Chen, Junyang Liang, Haojun Wang, Yujiao Hu, Fan Liu, Qiuyang Li, Hao Chen, Ziteng Li, Jiacheng Wang, Zhijie Chang, Ya-nan Li, Juan Yuan, Hui Fu, Shinian Liang, Tianjiao Xing, Gengmei |
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well-established immunotherapy with r837-loaded boron neutron capture-shocked tumor cells |
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Well-established immunotherapy with R837-loaded boron neutron capture-shocked tumor cells |
| abstract |
Although boron neutron capture therapy (BNCT) has been regarded as a curative therapy for aggressive tumors, the frequency of tumor recurrence and metastasis remains high mainly due to the adventitious nature of the immune response. Here, we explore the process of the immune response cascade after BNCT and find that the rate-limiting step is antigen presentation. To overcome this barrier, we develop a carrier-free nano-boron agent (BN-R837 PVP), comprising hydrophilic 10B-boron nitride nanostructures loading with an immune agonist imiquimod (R837). The nano-boron agent can be internalized and cloaked into tumor cells and then following neutron irradiation, obtain the R837-loaded BNCT-shocked tumor cells (BTCs). When the BTCs are injected subcutaneously, the antigen pool and R837 are co-delivered into the draining lymph nodes, boosting immune responses as well as preventing R837 from entering the systemic circulation. This eventually results in significant inhibition of distal tumor growth and metastasis with a high rate of complete tumor regression in vivo. Moreover, memory T lymphocytes exist in these immunized mice and exhibit potent long-term anti-tumor. |
| abstractGer |
Although boron neutron capture therapy (BNCT) has been regarded as a curative therapy for aggressive tumors, the frequency of tumor recurrence and metastasis remains high mainly due to the adventitious nature of the immune response. Here, we explore the process of the immune response cascade after BNCT and find that the rate-limiting step is antigen presentation. To overcome this barrier, we develop a carrier-free nano-boron agent (BN-R837 PVP), comprising hydrophilic 10B-boron nitride nanostructures loading with an immune agonist imiquimod (R837). The nano-boron agent can be internalized and cloaked into tumor cells and then following neutron irradiation, obtain the R837-loaded BNCT-shocked tumor cells (BTCs). When the BTCs are injected subcutaneously, the antigen pool and R837 are co-delivered into the draining lymph nodes, boosting immune responses as well as preventing R837 from entering the systemic circulation. This eventually results in significant inhibition of distal tumor growth and metastasis with a high rate of complete tumor regression in vivo. Moreover, memory T lymphocytes exist in these immunized mice and exhibit potent long-term anti-tumor. |
| abstract_unstemmed |
Although boron neutron capture therapy (BNCT) has been regarded as a curative therapy for aggressive tumors, the frequency of tumor recurrence and metastasis remains high mainly due to the adventitious nature of the immune response. Here, we explore the process of the immune response cascade after BNCT and find that the rate-limiting step is antigen presentation. To overcome this barrier, we develop a carrier-free nano-boron agent (BN-R837 PVP), comprising hydrophilic 10B-boron nitride nanostructures loading with an immune agonist imiquimod (R837). The nano-boron agent can be internalized and cloaked into tumor cells and then following neutron irradiation, obtain the R837-loaded BNCT-shocked tumor cells (BTCs). When the BTCs are injected subcutaneously, the antigen pool and R837 are co-delivered into the draining lymph nodes, boosting immune responses as well as preventing R837 from entering the systemic circulation. This eventually results in significant inhibition of distal tumor growth and metastasis with a high rate of complete tumor regression in vivo. Moreover, memory T lymphocytes exist in these immunized mice and exhibit potent long-term anti-tumor. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV065048482</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20231015093012.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">231009s2023 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.nantod.2023.101995</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV065048482</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1748-0132(23)00244-X</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">540</subfield><subfield code="a">660</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">35.18</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">51.45</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">50.94</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">33.68</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Chen, Kui</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0001-6754-4940</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Well-established immunotherapy with R837-loaded boron neutron capture-shocked tumor cells</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Although boron neutron capture therapy (BNCT) has been regarded as a curative therapy for aggressive tumors, the frequency of tumor recurrence and metastasis remains high mainly due to the adventitious nature of the immune response. 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Moreover, memory T lymphocytes exist in these immunized mice and exhibit potent long-term anti-tumor.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Boron neutron capture therapy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunotherapy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nano-boron agent</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">R837</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">T lymphocytes</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Liu, Sen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lv, Linwen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tong, Jianfei</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chen, Junyang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Liang, Haojun</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wang, Yujiao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hu, Fan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Liu, Qiuyang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Li, 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7.39849 |