Alcohol induces intrahepatic humoral immunity-related suppression and delays the clearance of HBV infection

Alcohol consumption is widespread. As the main organ of alcohol metabolism, the liver also has an immune tolerance function. However, little is known about how alcohol affects intrahepatic immune dysregulation and hepatitis B virus (HBV) infection. In a mice model, alcohol intake increased Fas expre...
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Autor*in:	Zhang, Daqian [verfasserIn] Liu, Zhenguo [verfasserIn] Zhou, Yang [verfasserIn] Tang, Libo [verfasserIn] Hou, Jinlin [verfasserIn] Li, Yongyin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Alcohol Intrahepatic humoral immunity suppression T peripheral helper cells T follicular helper cells hepatitis B virus

Übergeordnetes Werk:	Enthalten in: International immunopharmacology - Amsterdam [u.a.] : Elsevier Science, 2001, 116
Übergeordnetes Werk:	volume:116

DOI / URN:	10.1016/j.intimp.2023.109811

Katalog-ID:	ELV065075579

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520			\|a Alcohol consumption is widespread. As the main organ of alcohol metabolism, the liver also has an immune tolerance function. However, little is known about how alcohol affects intrahepatic immune dysregulation and hepatitis B virus (HBV) infection. In a mice model, alcohol intake increased Fas expression on intrahepatic B220+B cells and intrahepatic CD138+B cells, increased TGF-β and IL-10 production by intrahepatic CD19+B cells, and decreased frequencies of intrahepatic T peripheral helper (Tph) cells and intrahepatic T follicular helper (Tfh) cells. Tph cells, but not Tfh cells, were negatively correlated with the B-lineage cell-related apoptosis and the production of immunosuppressive cytokines. Besides, alcohol intake significantly reduced the production of IL-21 by Tfh-like cells and CD8+PD-1+ cells and reduced the area of the splenic germinal center B cells. After 4 weeks of alcohol intake, we induced HBV infection in mice by injecting plasmid pAAV-HBV1.2. Alcohol intake increased serum hepatitis B surface antigen (HBsAg) and hepatitis B envelope antigen levels, delayed HBsAg clearance and decreased anti-HBsAg antibodies production at 40 days post-injection. In conclusion, our study reveals that alcohol intake can suppress humoral immunity and impede HBV clearance, providing further evidence for alcohol abstinence in patients with HBV infection.
650		4	\|a Alcohol
650		4	\|a Intrahepatic humoral immunity suppression
650		4	\|a T peripheral helper cells
650		4	\|a T follicular helper cells
650		4	\|a hepatitis B virus
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700	1		\|a Zhou, Yang \|e verfasserin \|4 aut
700	1		\|a Tang, Libo \|e verfasserin \|4 aut
700	1		\|a Hou, Jinlin \|e verfasserin \|4 aut
700	1		\|a Li, Yongyin \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t International immunopharmacology \|d Amsterdam [u.a.] : Elsevier Science, 2001 \|g 116 \|h Online-Ressource \|w (DE-627)330614630 \|w (DE-600)2049924-3 \|w (DE-576)259272272 \|x 1878-1705 \|7 nnns
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912			\|a GBV_ILN_105
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912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
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912			\|a GBV_ILN_230
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
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912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
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912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
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912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2044
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912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
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936	b	k	\|a 44.38 \|j Pharmakologie \|q VZ
951			\|a AR
952			\|d 116

Indexfelder

author_variant	d z dz z l zl y z yz l t lt j h jh y l yl
matchkey_str	article:18781705:2023----::looidcsnrhptcuoaimntrltdupesoadeas
hierarchy_sort_str	2023
bklnumber	44.38
publishDate	2023
allfields	10.1016/j.intimp.2023.109811 doi (DE-627)ELV065075579 (ELSEVIER)S1567-5769(23)00134-0 DE-627 ger DE-627 rda eng 610 VZ PHARM DE-84 fid 44.38 bkl Zhang, Daqian verfasserin aut Alcohol induces intrahepatic humoral immunity-related suppression and delays the clearance of HBV infection 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Alcohol consumption is widespread. As the main organ of alcohol metabolism, the liver also has an immune tolerance function. However, little is known about how alcohol affects intrahepatic immune dysregulation and hepatitis B virus (HBV) infection. In a mice model, alcohol intake increased Fas expression on intrahepatic B220+B cells and intrahepatic CD138+B cells, increased TGF-β and IL-10 production by intrahepatic CD19+B cells, and decreased frequencies of intrahepatic T peripheral helper (Tph) cells and intrahepatic T follicular helper (Tfh) cells. Tph cells, but not Tfh cells, were negatively correlated with the B-lineage cell-related apoptosis and the production of immunosuppressive cytokines. Besides, alcohol intake significantly reduced the production of IL-21 by Tfh-like cells and CD8+PD-1+ cells and reduced the area of the splenic germinal center B cells. After 4 weeks of alcohol intake, we induced HBV infection in mice by injecting plasmid pAAV-HBV1.2. Alcohol intake increased serum hepatitis B surface antigen (HBsAg) and hepatitis B envelope antigen levels, delayed HBsAg clearance and decreased anti-HBsAg antibodies production at 40 days post-injection. In conclusion, our study reveals that alcohol intake can suppress humoral immunity and impede HBV clearance, providing further evidence for alcohol abstinence in patients with HBV infection. Alcohol Intrahepatic humoral immunity suppression T peripheral helper cells T follicular helper cells hepatitis B virus Liu, Zhenguo verfasserin aut Zhou, Yang verfasserin aut Tang, Libo verfasserin aut Hou, Jinlin verfasserin aut Li, Yongyin verfasserin aut Enthalten in International immunopharmacology Amsterdam [u.a.] : Elsevier Science, 2001 116 Online-Ressource (DE-627)330614630 (DE-600)2049924-3 (DE-576)259272272 1878-1705 nnns volume:116 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.38 Pharmakologie VZ AR 116
spelling	10.1016/j.intimp.2023.109811 doi (DE-627)ELV065075579 (ELSEVIER)S1567-5769(23)00134-0 DE-627 ger DE-627 rda eng 610 VZ PHARM DE-84 fid 44.38 bkl Zhang, Daqian verfasserin aut Alcohol induces intrahepatic humoral immunity-related suppression and delays the clearance of HBV infection 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Alcohol consumption is widespread. As the main organ of alcohol metabolism, the liver also has an immune tolerance function. However, little is known about how alcohol affects intrahepatic immune dysregulation and hepatitis B virus (HBV) infection. In a mice model, alcohol intake increased Fas expression on intrahepatic B220+B cells and intrahepatic CD138+B cells, increased TGF-β and IL-10 production by intrahepatic CD19+B cells, and decreased frequencies of intrahepatic T peripheral helper (Tph) cells and intrahepatic T follicular helper (Tfh) cells. Tph cells, but not Tfh cells, were negatively correlated with the B-lineage cell-related apoptosis and the production of immunosuppressive cytokines. Besides, alcohol intake significantly reduced the production of IL-21 by Tfh-like cells and CD8+PD-1+ cells and reduced the area of the splenic germinal center B cells. After 4 weeks of alcohol intake, we induced HBV infection in mice by injecting plasmid pAAV-HBV1.2. Alcohol intake increased serum hepatitis B surface antigen (HBsAg) and hepatitis B envelope antigen levels, delayed HBsAg clearance and decreased anti-HBsAg antibodies production at 40 days post-injection. In conclusion, our study reveals that alcohol intake can suppress humoral immunity and impede HBV clearance, providing further evidence for alcohol abstinence in patients with HBV infection. Alcohol Intrahepatic humoral immunity suppression T peripheral helper cells T follicular helper cells hepatitis B virus Liu, Zhenguo verfasserin aut Zhou, Yang verfasserin aut Tang, Libo verfasserin aut Hou, Jinlin verfasserin aut Li, Yongyin verfasserin aut Enthalten in International immunopharmacology Amsterdam [u.a.] : Elsevier Science, 2001 116 Online-Ressource (DE-627)330614630 (DE-600)2049924-3 (DE-576)259272272 1878-1705 nnns volume:116 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.38 Pharmakologie VZ AR 116
allfields_unstemmed	10.1016/j.intimp.2023.109811 doi (DE-627)ELV065075579 (ELSEVIER)S1567-5769(23)00134-0 DE-627 ger DE-627 rda eng 610 VZ PHARM DE-84 fid 44.38 bkl Zhang, Daqian verfasserin aut Alcohol induces intrahepatic humoral immunity-related suppression and delays the clearance of HBV infection 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Alcohol consumption is widespread. As the main organ of alcohol metabolism, the liver also has an immune tolerance function. However, little is known about how alcohol affects intrahepatic immune dysregulation and hepatitis B virus (HBV) infection. In a mice model, alcohol intake increased Fas expression on intrahepatic B220+B cells and intrahepatic CD138+B cells, increased TGF-β and IL-10 production by intrahepatic CD19+B cells, and decreased frequencies of intrahepatic T peripheral helper (Tph) cells and intrahepatic T follicular helper (Tfh) cells. Tph cells, but not Tfh cells, were negatively correlated with the B-lineage cell-related apoptosis and the production of immunosuppressive cytokines. Besides, alcohol intake significantly reduced the production of IL-21 by Tfh-like cells and CD8+PD-1+ cells and reduced the area of the splenic germinal center B cells. After 4 weeks of alcohol intake, we induced HBV infection in mice by injecting plasmid pAAV-HBV1.2. Alcohol intake increased serum hepatitis B surface antigen (HBsAg) and hepatitis B envelope antigen levels, delayed HBsAg clearance and decreased anti-HBsAg antibodies production at 40 days post-injection. In conclusion, our study reveals that alcohol intake can suppress humoral immunity and impede HBV clearance, providing further evidence for alcohol abstinence in patients with HBV infection. Alcohol Intrahepatic humoral immunity suppression T peripheral helper cells T follicular helper cells hepatitis B virus Liu, Zhenguo verfasserin aut Zhou, Yang verfasserin aut Tang, Libo verfasserin aut Hou, Jinlin verfasserin aut Li, Yongyin verfasserin aut Enthalten in International immunopharmacology Amsterdam [u.a.] : Elsevier Science, 2001 116 Online-Ressource (DE-627)330614630 (DE-600)2049924-3 (DE-576)259272272 1878-1705 nnns volume:116 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.38 Pharmakologie VZ AR 116
allfieldsGer	10.1016/j.intimp.2023.109811 doi (DE-627)ELV065075579 (ELSEVIER)S1567-5769(23)00134-0 DE-627 ger DE-627 rda eng 610 VZ PHARM DE-84 fid 44.38 bkl Zhang, Daqian verfasserin aut Alcohol induces intrahepatic humoral immunity-related suppression and delays the clearance of HBV infection 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Alcohol consumption is widespread. As the main organ of alcohol metabolism, the liver also has an immune tolerance function. However, little is known about how alcohol affects intrahepatic immune dysregulation and hepatitis B virus (HBV) infection. In a mice model, alcohol intake increased Fas expression on intrahepatic B220+B cells and intrahepatic CD138+B cells, increased TGF-β and IL-10 production by intrahepatic CD19+B cells, and decreased frequencies of intrahepatic T peripheral helper (Tph) cells and intrahepatic T follicular helper (Tfh) cells. Tph cells, but not Tfh cells, were negatively correlated with the B-lineage cell-related apoptosis and the production of immunosuppressive cytokines. Besides, alcohol intake significantly reduced the production of IL-21 by Tfh-like cells and CD8+PD-1+ cells and reduced the area of the splenic germinal center B cells. After 4 weeks of alcohol intake, we induced HBV infection in mice by injecting plasmid pAAV-HBV1.2. Alcohol intake increased serum hepatitis B surface antigen (HBsAg) and hepatitis B envelope antigen levels, delayed HBsAg clearance and decreased anti-HBsAg antibodies production at 40 days post-injection. In conclusion, our study reveals that alcohol intake can suppress humoral immunity and impede HBV clearance, providing further evidence for alcohol abstinence in patients with HBV infection. Alcohol Intrahepatic humoral immunity suppression T peripheral helper cells T follicular helper cells hepatitis B virus Liu, Zhenguo verfasserin aut Zhou, Yang verfasserin aut Tang, Libo verfasserin aut Hou, Jinlin verfasserin aut Li, Yongyin verfasserin aut Enthalten in International immunopharmacology Amsterdam [u.a.] : Elsevier Science, 2001 116 Online-Ressource (DE-627)330614630 (DE-600)2049924-3 (DE-576)259272272 1878-1705 nnns volume:116 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.38 Pharmakologie VZ AR 116
allfieldsSound	10.1016/j.intimp.2023.109811 doi (DE-627)ELV065075579 (ELSEVIER)S1567-5769(23)00134-0 DE-627 ger DE-627 rda eng 610 VZ PHARM DE-84 fid 44.38 bkl Zhang, Daqian verfasserin aut Alcohol induces intrahepatic humoral immunity-related suppression and delays the clearance of HBV infection 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Alcohol consumption is widespread. As the main organ of alcohol metabolism, the liver also has an immune tolerance function. However, little is known about how alcohol affects intrahepatic immune dysregulation and hepatitis B virus (HBV) infection. In a mice model, alcohol intake increased Fas expression on intrahepatic B220+B cells and intrahepatic CD138+B cells, increased TGF-β and IL-10 production by intrahepatic CD19+B cells, and decreased frequencies of intrahepatic T peripheral helper (Tph) cells and intrahepatic T follicular helper (Tfh) cells. Tph cells, but not Tfh cells, were negatively correlated with the B-lineage cell-related apoptosis and the production of immunosuppressive cytokines. Besides, alcohol intake significantly reduced the production of IL-21 by Tfh-like cells and CD8+PD-1+ cells and reduced the area of the splenic germinal center B cells. After 4 weeks of alcohol intake, we induced HBV infection in mice by injecting plasmid pAAV-HBV1.2. Alcohol intake increased serum hepatitis B surface antigen (HBsAg) and hepatitis B envelope antigen levels, delayed HBsAg clearance and decreased anti-HBsAg antibodies production at 40 days post-injection. In conclusion, our study reveals that alcohol intake can suppress humoral immunity and impede HBV clearance, providing further evidence for alcohol abstinence in patients with HBV infection. Alcohol Intrahepatic humoral immunity suppression T peripheral helper cells T follicular helper cells hepatitis B virus Liu, Zhenguo verfasserin aut Zhou, Yang verfasserin aut Tang, Libo verfasserin aut Hou, Jinlin verfasserin aut Li, Yongyin verfasserin aut Enthalten in International immunopharmacology Amsterdam [u.a.] : Elsevier Science, 2001 116 Online-Ressource (DE-627)330614630 (DE-600)2049924-3 (DE-576)259272272 1878-1705 nnns volume:116 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.38 Pharmakologie VZ AR 116
language	English
source	Enthalten in International immunopharmacology 116 volume:116
sourceStr	Enthalten in International immunopharmacology 116 volume:116
format_phy_str_mv	Article
bklname	Pharmakologie
institution	findex.gbv.de
topic_facet	Alcohol Intrahepatic humoral immunity suppression T peripheral helper cells T follicular helper cells hepatitis B virus
dewey-raw	610
isfreeaccess_bool	false
container_title	International immunopharmacology
authorswithroles_txt_mv	Zhang, Daqian @@aut@@ Liu, Zhenguo @@aut@@ Zhou, Yang @@aut@@ Tang, Libo @@aut@@ Hou, Jinlin @@aut@@ Li, Yongyin @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	330614630
dewey-sort	3610
id	ELV065075579
language_de	englisch
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As the main organ of alcohol metabolism, the liver also has an immune tolerance function. However, little is known about how alcohol affects intrahepatic immune dysregulation and hepatitis B virus (HBV) infection. In a mice model, alcohol intake increased Fas expression on intrahepatic B220+B cells and intrahepatic CD138+B cells, increased TGF-β and IL-10 production by intrahepatic CD19+B cells, and decreased frequencies of intrahepatic T peripheral helper (Tph) cells and intrahepatic T follicular helper (Tfh) cells. Tph cells, but not Tfh cells, were negatively correlated with the B-lineage cell-related apoptosis and the production of immunosuppressive cytokines. Besides, alcohol intake significantly reduced the production of IL-21 by Tfh-like cells and CD8+PD-1+ cells and reduced the area of the splenic germinal center B cells. After 4 weeks of alcohol intake, we induced HBV infection in mice by injecting plasmid pAAV-HBV1.2. Alcohol intake increased serum hepatitis B surface antigen (HBsAg) and hepatitis B envelope antigen levels, delayed HBsAg clearance and decreased anti-HBsAg antibodies production at 40 days post-injection. 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author	Zhang, Daqian
spellingShingle	Zhang, Daqian ddc 610 fid PHARM bkl 44.38 misc Alcohol misc Intrahepatic humoral immunity suppression misc T peripheral helper cells misc T follicular helper cells misc hepatitis B virus Alcohol induces intrahepatic humoral immunity-related suppression and delays the clearance of HBV infection
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topic_title	610 VZ PHARM DE-84 fid 44.38 bkl Alcohol induces intrahepatic humoral immunity-related suppression and delays the clearance of HBV infection Alcohol Intrahepatic humoral immunity suppression T peripheral helper cells T follicular helper cells hepatitis B virus
topic	ddc 610 fid PHARM bkl 44.38 misc Alcohol misc Intrahepatic humoral immunity suppression misc T peripheral helper cells misc T follicular helper cells misc hepatitis B virus
topic_unstemmed	ddc 610 fid PHARM bkl 44.38 misc Alcohol misc Intrahepatic humoral immunity suppression misc T peripheral helper cells misc T follicular helper cells misc hepatitis B virus
topic_browse	ddc 610 fid PHARM bkl 44.38 misc Alcohol misc Intrahepatic humoral immunity suppression misc T peripheral helper cells misc T follicular helper cells misc hepatitis B virus
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title	Alcohol induces intrahepatic humoral immunity-related suppression and delays the clearance of HBV infection
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title_full	Alcohol induces intrahepatic humoral immunity-related suppression and delays the clearance of HBV infection
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author_browse	Zhang, Daqian Liu, Zhenguo Zhou, Yang Tang, Libo Hou, Jinlin Li, Yongyin
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title_sort	alcohol induces intrahepatic humoral immunity-related suppression and delays the clearance of hbv infection
title_auth	Alcohol induces intrahepatic humoral immunity-related suppression and delays the clearance of HBV infection
abstract	Alcohol consumption is widespread. As the main organ of alcohol metabolism, the liver also has an immune tolerance function. However, little is known about how alcohol affects intrahepatic immune dysregulation and hepatitis B virus (HBV) infection. In a mice model, alcohol intake increased Fas expression on intrahepatic B220+B cells and intrahepatic CD138+B cells, increased TGF-β and IL-10 production by intrahepatic CD19+B cells, and decreased frequencies of intrahepatic T peripheral helper (Tph) cells and intrahepatic T follicular helper (Tfh) cells. Tph cells, but not Tfh cells, were negatively correlated with the B-lineage cell-related apoptosis and the production of immunosuppressive cytokines. Besides, alcohol intake significantly reduced the production of IL-21 by Tfh-like cells and CD8+PD-1+ cells and reduced the area of the splenic germinal center B cells. After 4 weeks of alcohol intake, we induced HBV infection in mice by injecting plasmid pAAV-HBV1.2. Alcohol intake increased serum hepatitis B surface antigen (HBsAg) and hepatitis B envelope antigen levels, delayed HBsAg clearance and decreased anti-HBsAg antibodies production at 40 days post-injection. In conclusion, our study reveals that alcohol intake can suppress humoral immunity and impede HBV clearance, providing further evidence for alcohol abstinence in patients with HBV infection.
abstractGer	Alcohol consumption is widespread. As the main organ of alcohol metabolism, the liver also has an immune tolerance function. However, little is known about how alcohol affects intrahepatic immune dysregulation and hepatitis B virus (HBV) infection. In a mice model, alcohol intake increased Fas expression on intrahepatic B220+B cells and intrahepatic CD138+B cells, increased TGF-β and IL-10 production by intrahepatic CD19+B cells, and decreased frequencies of intrahepatic T peripheral helper (Tph) cells and intrahepatic T follicular helper (Tfh) cells. Tph cells, but not Tfh cells, were negatively correlated with the B-lineage cell-related apoptosis and the production of immunosuppressive cytokines. Besides, alcohol intake significantly reduced the production of IL-21 by Tfh-like cells and CD8+PD-1+ cells and reduced the area of the splenic germinal center B cells. After 4 weeks of alcohol intake, we induced HBV infection in mice by injecting plasmid pAAV-HBV1.2. Alcohol intake increased serum hepatitis B surface antigen (HBsAg) and hepatitis B envelope antigen levels, delayed HBsAg clearance and decreased anti-HBsAg antibodies production at 40 days post-injection. In conclusion, our study reveals that alcohol intake can suppress humoral immunity and impede HBV clearance, providing further evidence for alcohol abstinence in patients with HBV infection.
abstract_unstemmed	Alcohol consumption is widespread. As the main organ of alcohol metabolism, the liver also has an immune tolerance function. However, little is known about how alcohol affects intrahepatic immune dysregulation and hepatitis B virus (HBV) infection. In a mice model, alcohol intake increased Fas expression on intrahepatic B220+B cells and intrahepatic CD138+B cells, increased TGF-β and IL-10 production by intrahepatic CD19+B cells, and decreased frequencies of intrahepatic T peripheral helper (Tph) cells and intrahepatic T follicular helper (Tfh) cells. Tph cells, but not Tfh cells, were negatively correlated with the B-lineage cell-related apoptosis and the production of immunosuppressive cytokines. Besides, alcohol intake significantly reduced the production of IL-21 by Tfh-like cells and CD8+PD-1+ cells and reduced the area of the splenic germinal center B cells. After 4 weeks of alcohol intake, we induced HBV infection in mice by injecting plasmid pAAV-HBV1.2. Alcohol intake increased serum hepatitis B surface antigen (HBsAg) and hepatitis B envelope antigen levels, delayed HBsAg clearance and decreased anti-HBsAg antibodies production at 40 days post-injection. In conclusion, our study reveals that alcohol intake can suppress humoral immunity and impede HBV clearance, providing further evidence for alcohol abstinence in patients with HBV infection.
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title_short	Alcohol induces intrahepatic humoral immunity-related suppression and delays the clearance of HBV infection
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author2	Liu, Zhenguo Zhou, Yang Tang, Libo Hou, Jinlin Li, Yongyin
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doi_str	10.1016/j.intimp.2023.109811
up_date	2024-07-06T21:44:37.806Z
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Alcohol induces intrahepatic humoral immunity-related suppression and delays the clearance of HBV infection

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