Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity

Primary progressive aphasia (PPA) is comprised of three subtypes: logopenic (lvPPA), non-fluent (nfvPPA), and semantic (svPPA). We used magnetic resonance spectroscopy (MRS) to measure tissue-corrected metabolite levels in the left inferior frontal gyrus (IFG) and right sensorimotor cortex (SMC) fro...
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Autor*in:	Hupfeld, Kathleen E. [verfasserIn] Zöllner, Helge J. [verfasserIn] Oeltzschner, Georg [verfasserIn] Hyatt, Hayden W. [verfasserIn] Herrmann, Olivia [verfasserIn] Gallegos, Jessica [verfasserIn] Hui, Steve C.N. [verfasserIn] Harris, Ashley D. [verfasserIn] Edden, Richard A.E. [verfasserIn] Tsapkini, Kyrana [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Primary Progressive Aphasia (PPA) Creatine (tCr) Glutamate+glutamine (Glx) Magnetic resonance spectroscopy (MRS) Point RESolved Spectroscopy (PRESS)

Übergeordnetes Werk:	Enthalten in: Neurobiology of aging - Amsterdam [u.a.] : Elsevier Science, 1980, 122, Seite 65-75
Übergeordnetes Werk:	volume:122 ; pages:65-75

DOI / URN:	10.1016/j.neurobiolaging.2022.11.006

Katalog-ID:	ELV065091949

Internformat


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100	1		\|a Hupfeld, Kathleen E. \|e verfasserin \|4 aut
245	1	0	\|a Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity
264		1	\|c 2022
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520			\|a Primary progressive aphasia (PPA) is comprised of three subtypes: logopenic (lvPPA), non-fluent (nfvPPA), and semantic (svPPA). We used magnetic resonance spectroscopy (MRS) to measure tissue-corrected metabolite levels in the left inferior frontal gyrus (IFG) and right sensorimotor cortex (SMC) from 61 PPA patients. We aimed to: (1) characterize subtype differences in metabolites; and (2) test for metabolite associations with symptom severity. tCr differed by subtype across the left IFG and right SMC. tCr levels were lowest in lvPPA and highest in svPPA. tCr levels predicted lvPPA versus svPPA diagnosis. Higher IFG tCr and lower Glx correlated with greater disease severity. As tCr is involved in brain energy metabolism, svPPA pathology might involve changes in specific cellular energy processes. Perturbations to cellular energy homeostasis in language areas may contribute to symptoms. Reduced cortical excitatory capacity (i.e. lower Glx) in language regions may also contribute to symptoms. Thus, tCr may be useful for differentiating between PPA subtypes, and both tCr and Glx might have utility in understanding PPA mechanisms and tracking progression.
650		4	\|a Primary Progressive Aphasia (PPA)
650		4	\|a Creatine (tCr)
650		4	\|a Glutamate+glutamine (Glx)
650		4	\|a Magnetic resonance spectroscopy (MRS)
650		4	\|a Point RESolved Spectroscopy (PRESS)
700	1		\|a Zöllner, Helge J. \|e verfasserin \|4 aut
700	1		\|a Oeltzschner, Georg \|e verfasserin \|4 aut
700	1		\|a Hyatt, Hayden W. \|e verfasserin \|4 aut
700	1		\|a Herrmann, Olivia \|e verfasserin \|4 aut
700	1		\|a Gallegos, Jessica \|e verfasserin \|4 aut
700	1		\|a Hui, Steve C.N. \|e verfasserin \|4 aut
700	1		\|a Harris, Ashley D. \|e verfasserin \|4 aut
700	1		\|a Edden, Richard A.E. \|e verfasserin \|4 aut
700	1		\|a Tsapkini, Kyrana \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Neurobiology of aging \|d Amsterdam [u.a.] : Elsevier Science, 1980 \|g 122, Seite 65-75 \|h Online-Ressource \|w (DE-627)306588552 \|w (DE-600)1498414-3 \|w (DE-576)081953062 \|x 1558-1497 \|7 nnns
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936	b	k	\|a 44.90 \|j Neurologie \|q VZ
936	b	k	\|a 44.68 \|j Gerontologie \|j Geriatrie \|q VZ
951			\|a AR
952			\|d 122 \|h 65-75

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publishDate	2022
allfields	10.1016/j.neurobiolaging.2022.11.006 doi (DE-627)ELV065091949 (ELSEVIER)S0197-4580(22)00236-6 DE-627 ger DE-627 rda eng 610 VZ 44.90 bkl 44.68 bkl Hupfeld, Kathleen E. verfasserin aut Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Primary progressive aphasia (PPA) is comprised of three subtypes: logopenic (lvPPA), non-fluent (nfvPPA), and semantic (svPPA). We used magnetic resonance spectroscopy (MRS) to measure tissue-corrected metabolite levels in the left inferior frontal gyrus (IFG) and right sensorimotor cortex (SMC) from 61 PPA patients. We aimed to: (1) characterize subtype differences in metabolites; and (2) test for metabolite associations with symptom severity. tCr differed by subtype across the left IFG and right SMC. tCr levels were lowest in lvPPA and highest in svPPA. tCr levels predicted lvPPA versus svPPA diagnosis. Higher IFG tCr and lower Glx correlated with greater disease severity. As tCr is involved in brain energy metabolism, svPPA pathology might involve changes in specific cellular energy processes. Perturbations to cellular energy homeostasis in language areas may contribute to symptoms. Reduced cortical excitatory capacity (i.e. lower Glx) in language regions may also contribute to symptoms. Thus, tCr may be useful for differentiating between PPA subtypes, and both tCr and Glx might have utility in understanding PPA mechanisms and tracking progression. Primary Progressive Aphasia (PPA) Creatine (tCr) Glutamate+glutamine (Glx) Magnetic resonance spectroscopy (MRS) Point RESolved Spectroscopy (PRESS) Zöllner, Helge J. verfasserin aut Oeltzschner, Georg verfasserin aut Hyatt, Hayden W. verfasserin aut Herrmann, Olivia verfasserin aut Gallegos, Jessica verfasserin aut Hui, Steve C.N. verfasserin aut Harris, Ashley D. verfasserin aut Edden, Richard A.E. verfasserin aut Tsapkini, Kyrana verfasserin aut Enthalten in Neurobiology of aging Amsterdam [u.a.] : Elsevier Science, 1980 122, Seite 65-75 Online-Ressource (DE-627)306588552 (DE-600)1498414-3 (DE-576)081953062 1558-1497 nnns volume:122 pages:65-75 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie VZ 44.68 Gerontologie Geriatrie VZ AR 122 65-75
spelling	10.1016/j.neurobiolaging.2022.11.006 doi (DE-627)ELV065091949 (ELSEVIER)S0197-4580(22)00236-6 DE-627 ger DE-627 rda eng 610 VZ 44.90 bkl 44.68 bkl Hupfeld, Kathleen E. verfasserin aut Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Primary progressive aphasia (PPA) is comprised of three subtypes: logopenic (lvPPA), non-fluent (nfvPPA), and semantic (svPPA). We used magnetic resonance spectroscopy (MRS) to measure tissue-corrected metabolite levels in the left inferior frontal gyrus (IFG) and right sensorimotor cortex (SMC) from 61 PPA patients. We aimed to: (1) characterize subtype differences in metabolites; and (2) test for metabolite associations with symptom severity. tCr differed by subtype across the left IFG and right SMC. tCr levels were lowest in lvPPA and highest in svPPA. tCr levels predicted lvPPA versus svPPA diagnosis. Higher IFG tCr and lower Glx correlated with greater disease severity. As tCr is involved in brain energy metabolism, svPPA pathology might involve changes in specific cellular energy processes. Perturbations to cellular energy homeostasis in language areas may contribute to symptoms. Reduced cortical excitatory capacity (i.e. lower Glx) in language regions may also contribute to symptoms. Thus, tCr may be useful for differentiating between PPA subtypes, and both tCr and Glx might have utility in understanding PPA mechanisms and tracking progression. Primary Progressive Aphasia (PPA) Creatine (tCr) Glutamate+glutamine (Glx) Magnetic resonance spectroscopy (MRS) Point RESolved Spectroscopy (PRESS) Zöllner, Helge J. verfasserin aut Oeltzschner, Georg verfasserin aut Hyatt, Hayden W. verfasserin aut Herrmann, Olivia verfasserin aut Gallegos, Jessica verfasserin aut Hui, Steve C.N. verfasserin aut Harris, Ashley D. verfasserin aut Edden, Richard A.E. verfasserin aut Tsapkini, Kyrana verfasserin aut Enthalten in Neurobiology of aging Amsterdam [u.a.] : Elsevier Science, 1980 122, Seite 65-75 Online-Ressource (DE-627)306588552 (DE-600)1498414-3 (DE-576)081953062 1558-1497 nnns volume:122 pages:65-75 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie VZ 44.68 Gerontologie Geriatrie VZ AR 122 65-75
allfields_unstemmed	10.1016/j.neurobiolaging.2022.11.006 doi (DE-627)ELV065091949 (ELSEVIER)S0197-4580(22)00236-6 DE-627 ger DE-627 rda eng 610 VZ 44.90 bkl 44.68 bkl Hupfeld, Kathleen E. verfasserin aut Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Primary progressive aphasia (PPA) is comprised of three subtypes: logopenic (lvPPA), non-fluent (nfvPPA), and semantic (svPPA). We used magnetic resonance spectroscopy (MRS) to measure tissue-corrected metabolite levels in the left inferior frontal gyrus (IFG) and right sensorimotor cortex (SMC) from 61 PPA patients. We aimed to: (1) characterize subtype differences in metabolites; and (2) test for metabolite associations with symptom severity. tCr differed by subtype across the left IFG and right SMC. tCr levels were lowest in lvPPA and highest in svPPA. tCr levels predicted lvPPA versus svPPA diagnosis. Higher IFG tCr and lower Glx correlated with greater disease severity. As tCr is involved in brain energy metabolism, svPPA pathology might involve changes in specific cellular energy processes. Perturbations to cellular energy homeostasis in language areas may contribute to symptoms. Reduced cortical excitatory capacity (i.e. lower Glx) in language regions may also contribute to symptoms. Thus, tCr may be useful for differentiating between PPA subtypes, and both tCr and Glx might have utility in understanding PPA mechanisms and tracking progression. Primary Progressive Aphasia (PPA) Creatine (tCr) Glutamate+glutamine (Glx) Magnetic resonance spectroscopy (MRS) Point RESolved Spectroscopy (PRESS) Zöllner, Helge J. verfasserin aut Oeltzschner, Georg verfasserin aut Hyatt, Hayden W. verfasserin aut Herrmann, Olivia verfasserin aut Gallegos, Jessica verfasserin aut Hui, Steve C.N. verfasserin aut Harris, Ashley D. verfasserin aut Edden, Richard A.E. verfasserin aut Tsapkini, Kyrana verfasserin aut Enthalten in Neurobiology of aging Amsterdam [u.a.] : Elsevier Science, 1980 122, Seite 65-75 Online-Ressource (DE-627)306588552 (DE-600)1498414-3 (DE-576)081953062 1558-1497 nnns volume:122 pages:65-75 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie VZ 44.68 Gerontologie Geriatrie VZ AR 122 65-75
allfieldsGer	10.1016/j.neurobiolaging.2022.11.006 doi (DE-627)ELV065091949 (ELSEVIER)S0197-4580(22)00236-6 DE-627 ger DE-627 rda eng 610 VZ 44.90 bkl 44.68 bkl Hupfeld, Kathleen E. verfasserin aut Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Primary progressive aphasia (PPA) is comprised of three subtypes: logopenic (lvPPA), non-fluent (nfvPPA), and semantic (svPPA). We used magnetic resonance spectroscopy (MRS) to measure tissue-corrected metabolite levels in the left inferior frontal gyrus (IFG) and right sensorimotor cortex (SMC) from 61 PPA patients. We aimed to: (1) characterize subtype differences in metabolites; and (2) test for metabolite associations with symptom severity. tCr differed by subtype across the left IFG and right SMC. tCr levels were lowest in lvPPA and highest in svPPA. tCr levels predicted lvPPA versus svPPA diagnosis. Higher IFG tCr and lower Glx correlated with greater disease severity. As tCr is involved in brain energy metabolism, svPPA pathology might involve changes in specific cellular energy processes. Perturbations to cellular energy homeostasis in language areas may contribute to symptoms. Reduced cortical excitatory capacity (i.e. lower Glx) in language regions may also contribute to symptoms. Thus, tCr may be useful for differentiating between PPA subtypes, and both tCr and Glx might have utility in understanding PPA mechanisms and tracking progression. Primary Progressive Aphasia (PPA) Creatine (tCr) Glutamate+glutamine (Glx) Magnetic resonance spectroscopy (MRS) Point RESolved Spectroscopy (PRESS) Zöllner, Helge J. verfasserin aut Oeltzschner, Georg verfasserin aut Hyatt, Hayden W. verfasserin aut Herrmann, Olivia verfasserin aut Gallegos, Jessica verfasserin aut Hui, Steve C.N. verfasserin aut Harris, Ashley D. verfasserin aut Edden, Richard A.E. verfasserin aut Tsapkini, Kyrana verfasserin aut Enthalten in Neurobiology of aging Amsterdam [u.a.] : Elsevier Science, 1980 122, Seite 65-75 Online-Ressource (DE-627)306588552 (DE-600)1498414-3 (DE-576)081953062 1558-1497 nnns volume:122 pages:65-75 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie VZ 44.68 Gerontologie Geriatrie VZ AR 122 65-75
allfieldsSound	10.1016/j.neurobiolaging.2022.11.006 doi (DE-627)ELV065091949 (ELSEVIER)S0197-4580(22)00236-6 DE-627 ger DE-627 rda eng 610 VZ 44.90 bkl 44.68 bkl Hupfeld, Kathleen E. verfasserin aut Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Primary progressive aphasia (PPA) is comprised of three subtypes: logopenic (lvPPA), non-fluent (nfvPPA), and semantic (svPPA). We used magnetic resonance spectroscopy (MRS) to measure tissue-corrected metabolite levels in the left inferior frontal gyrus (IFG) and right sensorimotor cortex (SMC) from 61 PPA patients. We aimed to: (1) characterize subtype differences in metabolites; and (2) test for metabolite associations with symptom severity. tCr differed by subtype across the left IFG and right SMC. tCr levels were lowest in lvPPA and highest in svPPA. tCr levels predicted lvPPA versus svPPA diagnosis. Higher IFG tCr and lower Glx correlated with greater disease severity. As tCr is involved in brain energy metabolism, svPPA pathology might involve changes in specific cellular energy processes. Perturbations to cellular energy homeostasis in language areas may contribute to symptoms. Reduced cortical excitatory capacity (i.e. lower Glx) in language regions may also contribute to symptoms. Thus, tCr may be useful for differentiating between PPA subtypes, and both tCr and Glx might have utility in understanding PPA mechanisms and tracking progression. Primary Progressive Aphasia (PPA) Creatine (tCr) Glutamate+glutamine (Glx) Magnetic resonance spectroscopy (MRS) Point RESolved Spectroscopy (PRESS) Zöllner, Helge J. verfasserin aut Oeltzschner, Georg verfasserin aut Hyatt, Hayden W. verfasserin aut Herrmann, Olivia verfasserin aut Gallegos, Jessica verfasserin aut Hui, Steve C.N. verfasserin aut Harris, Ashley D. verfasserin aut Edden, Richard A.E. verfasserin aut Tsapkini, Kyrana verfasserin aut Enthalten in Neurobiology of aging Amsterdam [u.a.] : Elsevier Science, 1980 122, Seite 65-75 Online-Ressource (DE-627)306588552 (DE-600)1498414-3 (DE-576)081953062 1558-1497 nnns volume:122 pages:65-75 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie VZ 44.68 Gerontologie Geriatrie VZ AR 122 65-75
language	English
source	Enthalten in Neurobiology of aging 122, Seite 65-75 volume:122 pages:65-75
sourceStr	Enthalten in Neurobiology of aging 122, Seite 65-75 volume:122 pages:65-75
format_phy_str_mv	Article
bklname	Neurologie Gerontologie Geriatrie
institution	findex.gbv.de
topic_facet	Primary Progressive Aphasia (PPA) Creatine (tCr) Glutamate+glutamine (Glx) Magnetic resonance spectroscopy (MRS) Point RESolved Spectroscopy (PRESS)
dewey-raw	610
isfreeaccess_bool	false
container_title	Neurobiology of aging
authorswithroles_txt_mv	Hupfeld, Kathleen E. @@aut@@ Zöllner, Helge J. @@aut@@ Oeltzschner, Georg @@aut@@ Hyatt, Hayden W. @@aut@@ Herrmann, Olivia @@aut@@ Gallegos, Jessica @@aut@@ Hui, Steve C.N. @@aut@@ Harris, Ashley D. @@aut@@ Edden, Richard A.E. @@aut@@ Tsapkini, Kyrana @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	306588552
dewey-sort	3610
id	ELV065091949
language_de	englisch
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author	Hupfeld, Kathleen E.
spellingShingle	Hupfeld, Kathleen E. ddc 610 bkl 44.90 bkl 44.68 misc Primary Progressive Aphasia (PPA) misc Creatine (tCr) misc Glutamate+glutamine (Glx) misc Magnetic resonance spectroscopy (MRS) misc Point RESolved Spectroscopy (PRESS) Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity
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topic_title	610 VZ 44.90 bkl 44.68 bkl Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity Primary Progressive Aphasia (PPA) Creatine (tCr) Glutamate+glutamine (Glx) Magnetic resonance spectroscopy (MRS) Point RESolved Spectroscopy (PRESS)
topic	ddc 610 bkl 44.90 bkl 44.68 misc Primary Progressive Aphasia (PPA) misc Creatine (tCr) misc Glutamate+glutamine (Glx) misc Magnetic resonance spectroscopy (MRS) misc Point RESolved Spectroscopy (PRESS)
topic_unstemmed	ddc 610 bkl 44.90 bkl 44.68 misc Primary Progressive Aphasia (PPA) misc Creatine (tCr) misc Glutamate+glutamine (Glx) misc Magnetic resonance spectroscopy (MRS) misc Point RESolved Spectroscopy (PRESS)
topic_browse	ddc 610 bkl 44.90 bkl 44.68 misc Primary Progressive Aphasia (PPA) misc Creatine (tCr) misc Glutamate+glutamine (Glx) misc Magnetic resonance spectroscopy (MRS) misc Point RESolved Spectroscopy (PRESS)
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title	Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity
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title_full	Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity
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author_browse	Hupfeld, Kathleen E. Zöllner, Helge J. Oeltzschner, Georg Hyatt, Hayden W. Herrmann, Olivia Gallegos, Jessica Hui, Steve C.N. Harris, Ashley D. Edden, Richard A.E. Tsapkini, Kyrana
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author-letter	Hupfeld, Kathleen E.
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title_sort	brain total creatine differs between primary progressive aphasia (ppa) subtypes and correlates with disease severity
title_auth	Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity
abstract	Primary progressive aphasia (PPA) is comprised of three subtypes: logopenic (lvPPA), non-fluent (nfvPPA), and semantic (svPPA). We used magnetic resonance spectroscopy (MRS) to measure tissue-corrected metabolite levels in the left inferior frontal gyrus (IFG) and right sensorimotor cortex (SMC) from 61 PPA patients. We aimed to: (1) characterize subtype differences in metabolites; and (2) test for metabolite associations with symptom severity. tCr differed by subtype across the left IFG and right SMC. tCr levels were lowest in lvPPA and highest in svPPA. tCr levels predicted lvPPA versus svPPA diagnosis. Higher IFG tCr and lower Glx correlated with greater disease severity. As tCr is involved in brain energy metabolism, svPPA pathology might involve changes in specific cellular energy processes. Perturbations to cellular energy homeostasis in language areas may contribute to symptoms. Reduced cortical excitatory capacity (i.e. lower Glx) in language regions may also contribute to symptoms. Thus, tCr may be useful for differentiating between PPA subtypes, and both tCr and Glx might have utility in understanding PPA mechanisms and tracking progression.
abstractGer	Primary progressive aphasia (PPA) is comprised of three subtypes: logopenic (lvPPA), non-fluent (nfvPPA), and semantic (svPPA). We used magnetic resonance spectroscopy (MRS) to measure tissue-corrected metabolite levels in the left inferior frontal gyrus (IFG) and right sensorimotor cortex (SMC) from 61 PPA patients. We aimed to: (1) characterize subtype differences in metabolites; and (2) test for metabolite associations with symptom severity. tCr differed by subtype across the left IFG and right SMC. tCr levels were lowest in lvPPA and highest in svPPA. tCr levels predicted lvPPA versus svPPA diagnosis. Higher IFG tCr and lower Glx correlated with greater disease severity. As tCr is involved in brain energy metabolism, svPPA pathology might involve changes in specific cellular energy processes. Perturbations to cellular energy homeostasis in language areas may contribute to symptoms. Reduced cortical excitatory capacity (i.e. lower Glx) in language regions may also contribute to symptoms. Thus, tCr may be useful for differentiating between PPA subtypes, and both tCr and Glx might have utility in understanding PPA mechanisms and tracking progression.
abstract_unstemmed	Primary progressive aphasia (PPA) is comprised of three subtypes: logopenic (lvPPA), non-fluent (nfvPPA), and semantic (svPPA). We used magnetic resonance spectroscopy (MRS) to measure tissue-corrected metabolite levels in the left inferior frontal gyrus (IFG) and right sensorimotor cortex (SMC) from 61 PPA patients. We aimed to: (1) characterize subtype differences in metabolites; and (2) test for metabolite associations with symptom severity. tCr differed by subtype across the left IFG and right SMC. tCr levels were lowest in lvPPA and highest in svPPA. tCr levels predicted lvPPA versus svPPA diagnosis. Higher IFG tCr and lower Glx correlated with greater disease severity. As tCr is involved in brain energy metabolism, svPPA pathology might involve changes in specific cellular energy processes. Perturbations to cellular energy homeostasis in language areas may contribute to symptoms. Reduced cortical excitatory capacity (i.e. lower Glx) in language regions may also contribute to symptoms. Thus, tCr may be useful for differentiating between PPA subtypes, and both tCr and Glx might have utility in understanding PPA mechanisms and tracking progression.
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title_short	Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity
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author2	Zöllner, Helge J. Oeltzschner, Georg Hyatt, Hayden W. Herrmann, Olivia Gallegos, Jessica Hui, Steve C.N. Harris, Ashley D. Edden, Richard A.E. Tsapkini, Kyrana
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up_date	2024-07-06T21:48:02.209Z
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Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity

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