Neural oscillations modulation during working memory in pre-manifest and early Huntington’s disease
Introduction: We recently demonstrated specific spectral signatures associated with updating of memory information, working memory (WM) maintenance and readout, with relatively high spatial resolution by means of high-density electroencephalography (hdEEG). WM is impaired already in early symptomati...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Bonassi, Gaia [verfasserIn] Semprini, Marianna [verfasserIn] Mandich, Paola [verfasserIn] Trevisan, Lucia [verfasserIn] Marchese, Roberta [verfasserIn] Lagravinese, Giovanna [verfasserIn] Barban, Federico [verfasserIn] Pelosin, Elisa [verfasserIn] Chiappalone, Michela [verfasserIn] Mantini, Dante [verfasserIn] Avanzino, Laura [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Brain research - Amsterdam : Elsevier, 1966, 1820 |
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| Übergeordnetes Werk: |
volume:1820 |
| DOI / URN: |
10.1016/j.brainres.2023.148540 |
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| Katalog-ID: |
ELV065127447 |
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| 100 | 1 | |a Bonassi, Gaia |e verfasserin |0 (orcid)0000-0003-2697-4113 |4 aut | |
| 245 | 1 | 0 | |a Neural oscillations modulation during working memory in pre-manifest and early Huntington’s disease |
| 264 | 1 | |c 2023 | |
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| 520 | |a Introduction: We recently demonstrated specific spectral signatures associated with updating of memory information, working memory (WM) maintenance and readout, with relatively high spatial resolution by means of high-density electroencephalography (hdEEG). WM is impaired already in early symptomatic HD (early-HD) and in pre-manifest HD (pre-HD). The aim of this study was to test whether hdEEG coupled to source localization allows for the identification of neuronal oscillations in specific frequency bands in 16 pre-HD and early-HD during different phases of a WM task.Methods: We examined modulation of neural oscillations by event-related synchronization and desynchronization (ERS/ERD) of θ, β, gamma low, γLOW and γHIGH EEG bands in a-priori selected large fronto-parietal network, including the insula and the cerebellum.Results: We found: (i) Reduced θ oscillations in HD with respect to controls in almost all the areas of the WM network during the update and readout phases; (ii) Modulation of β oscillations, which increased during the maintenance phase of the WM task in both groups; (iii) correlation of γHIGH oscillations during WM task with disease burden score in HD patients.Conclusions: Our data show reduced phase-specific modulation of oscillations in pre-HD and early-HD, even in the presence of preserved dynamic of modulation. Particularly, reduced synchronization in the θ band in the areas of the WM network, consistent with abnormal long-range coordination of neuronal activity within this network, was found in update and readout phases in HD groups. | ||
| 650 | 4 | |a Huntington disease | |
| 650 | 4 | |a hd-EEG | |
| 650 | 4 | |a Working memory | |
| 650 | 4 | |a Neural oscillations | |
| 650 | 4 | |a Network | |
| 700 | 1 | |a Semprini, Marianna |e verfasserin |0 (orcid)0000-0001-5504-0251 |4 aut | |
| 700 | 1 | |a Mandich, Paola |e verfasserin |4 aut | |
| 700 | 1 | |a Trevisan, Lucia |e verfasserin |0 (orcid)0000-0002-8608-4342 |4 aut | |
| 700 | 1 | |a Marchese, Roberta |e verfasserin |4 aut | |
| 700 | 1 | |a Lagravinese, Giovanna |e verfasserin |4 aut | |
| 700 | 1 | |a Barban, Federico |e verfasserin |4 aut | |
| 700 | 1 | |a Pelosin, Elisa |e verfasserin |0 (orcid)0000-0002-9880-2241 |4 aut | |
| 700 | 1 | |a Chiappalone, Michela |e verfasserin |0 (orcid)0000-0003-1427-5147 |4 aut | |
| 700 | 1 | |a Mantini, Dante |e verfasserin |4 aut | |
| 700 | 1 | |a Avanzino, Laura |e verfasserin |0 (orcid)0000-0001-6286-1509 |4 aut | |
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10.1016/j.brainres.2023.148540 doi (DE-627)ELV065127447 (ELSEVIER)S0006-8993(23)00311-6 DE-627 ger DE-627 rda eng 150 610 VZ 44.90 bkl Bonassi, Gaia verfasserin (orcid)0000-0003-2697-4113 aut Neural oscillations modulation during working memory in pre-manifest and early Huntington’s disease 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: We recently demonstrated specific spectral signatures associated with updating of memory information, working memory (WM) maintenance and readout, with relatively high spatial resolution by means of high-density electroencephalography (hdEEG). WM is impaired already in early symptomatic HD (early-HD) and in pre-manifest HD (pre-HD). The aim of this study was to test whether hdEEG coupled to source localization allows for the identification of neuronal oscillations in specific frequency bands in 16 pre-HD and early-HD during different phases of a WM task.Methods: We examined modulation of neural oscillations by event-related synchronization and desynchronization (ERS/ERD) of θ, β, gamma low, γLOW and γHIGH EEG bands in a-priori selected large fronto-parietal network, including the insula and the cerebellum.Results: We found: (i) Reduced θ oscillations in HD with respect to controls in almost all the areas of the WM network during the update and readout phases; (ii) Modulation of β oscillations, which increased during the maintenance phase of the WM task in both groups; (iii) correlation of γHIGH oscillations during WM task with disease burden score in HD patients.Conclusions: Our data show reduced phase-specific modulation of oscillations in pre-HD and early-HD, even in the presence of preserved dynamic of modulation. Particularly, reduced synchronization in the θ band in the areas of the WM network, consistent with abnormal long-range coordination of neuronal activity within this network, was found in update and readout phases in HD groups. Huntington disease hd-EEG Working memory Neural oscillations Network Semprini, Marianna verfasserin (orcid)0000-0001-5504-0251 aut Mandich, Paola verfasserin aut Trevisan, Lucia verfasserin (orcid)0000-0002-8608-4342 aut Marchese, Roberta verfasserin aut Lagravinese, Giovanna verfasserin aut Barban, Federico verfasserin aut Pelosin, Elisa verfasserin (orcid)0000-0002-9880-2241 aut Chiappalone, Michela verfasserin (orcid)0000-0003-1427-5147 aut Mantini, Dante verfasserin aut Avanzino, Laura verfasserin (orcid)0000-0001-6286-1509 aut Enthalten in Brain research Amsterdam : Elsevier, 1966 1820 Online-Ressource (DE-627)254635776 (DE-600)1462674-3 (DE-576)074530976 1872-6240 nnns volume:1820 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie VZ AR 1820 |
| spelling |
10.1016/j.brainres.2023.148540 doi (DE-627)ELV065127447 (ELSEVIER)S0006-8993(23)00311-6 DE-627 ger DE-627 rda eng 150 610 VZ 44.90 bkl Bonassi, Gaia verfasserin (orcid)0000-0003-2697-4113 aut Neural oscillations modulation during working memory in pre-manifest and early Huntington’s disease 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: We recently demonstrated specific spectral signatures associated with updating of memory information, working memory (WM) maintenance and readout, with relatively high spatial resolution by means of high-density electroencephalography (hdEEG). WM is impaired already in early symptomatic HD (early-HD) and in pre-manifest HD (pre-HD). The aim of this study was to test whether hdEEG coupled to source localization allows for the identification of neuronal oscillations in specific frequency bands in 16 pre-HD and early-HD during different phases of a WM task.Methods: We examined modulation of neural oscillations by event-related synchronization and desynchronization (ERS/ERD) of θ, β, gamma low, γLOW and γHIGH EEG bands in a-priori selected large fronto-parietal network, including the insula and the cerebellum.Results: We found: (i) Reduced θ oscillations in HD with respect to controls in almost all the areas of the WM network during the update and readout phases; (ii) Modulation of β oscillations, which increased during the maintenance phase of the WM task in both groups; (iii) correlation of γHIGH oscillations during WM task with disease burden score in HD patients.Conclusions: Our data show reduced phase-specific modulation of oscillations in pre-HD and early-HD, even in the presence of preserved dynamic of modulation. Particularly, reduced synchronization in the θ band in the areas of the WM network, consistent with abnormal long-range coordination of neuronal activity within this network, was found in update and readout phases in HD groups. Huntington disease hd-EEG Working memory Neural oscillations Network Semprini, Marianna verfasserin (orcid)0000-0001-5504-0251 aut Mandich, Paola verfasserin aut Trevisan, Lucia verfasserin (orcid)0000-0002-8608-4342 aut Marchese, Roberta verfasserin aut Lagravinese, Giovanna verfasserin aut Barban, Federico verfasserin aut Pelosin, Elisa verfasserin (orcid)0000-0002-9880-2241 aut Chiappalone, Michela verfasserin (orcid)0000-0003-1427-5147 aut Mantini, Dante verfasserin aut Avanzino, Laura verfasserin (orcid)0000-0001-6286-1509 aut Enthalten in Brain research Amsterdam : Elsevier, 1966 1820 Online-Ressource (DE-627)254635776 (DE-600)1462674-3 (DE-576)074530976 1872-6240 nnns volume:1820 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie VZ AR 1820 |
| allfields_unstemmed |
10.1016/j.brainres.2023.148540 doi (DE-627)ELV065127447 (ELSEVIER)S0006-8993(23)00311-6 DE-627 ger DE-627 rda eng 150 610 VZ 44.90 bkl Bonassi, Gaia verfasserin (orcid)0000-0003-2697-4113 aut Neural oscillations modulation during working memory in pre-manifest and early Huntington’s disease 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: We recently demonstrated specific spectral signatures associated with updating of memory information, working memory (WM) maintenance and readout, with relatively high spatial resolution by means of high-density electroencephalography (hdEEG). WM is impaired already in early symptomatic HD (early-HD) and in pre-manifest HD (pre-HD). The aim of this study was to test whether hdEEG coupled to source localization allows for the identification of neuronal oscillations in specific frequency bands in 16 pre-HD and early-HD during different phases of a WM task.Methods: We examined modulation of neural oscillations by event-related synchronization and desynchronization (ERS/ERD) of θ, β, gamma low, γLOW and γHIGH EEG bands in a-priori selected large fronto-parietal network, including the insula and the cerebellum.Results: We found: (i) Reduced θ oscillations in HD with respect to controls in almost all the areas of the WM network during the update and readout phases; (ii) Modulation of β oscillations, which increased during the maintenance phase of the WM task in both groups; (iii) correlation of γHIGH oscillations during WM task with disease burden score in HD patients.Conclusions: Our data show reduced phase-specific modulation of oscillations in pre-HD and early-HD, even in the presence of preserved dynamic of modulation. Particularly, reduced synchronization in the θ band in the areas of the WM network, consistent with abnormal long-range coordination of neuronal activity within this network, was found in update and readout phases in HD groups. Huntington disease hd-EEG Working memory Neural oscillations Network Semprini, Marianna verfasserin (orcid)0000-0001-5504-0251 aut Mandich, Paola verfasserin aut Trevisan, Lucia verfasserin (orcid)0000-0002-8608-4342 aut Marchese, Roberta verfasserin aut Lagravinese, Giovanna verfasserin aut Barban, Federico verfasserin aut Pelosin, Elisa verfasserin (orcid)0000-0002-9880-2241 aut Chiappalone, Michela verfasserin (orcid)0000-0003-1427-5147 aut Mantini, Dante verfasserin aut Avanzino, Laura verfasserin (orcid)0000-0001-6286-1509 aut Enthalten in Brain research Amsterdam : Elsevier, 1966 1820 Online-Ressource (DE-627)254635776 (DE-600)1462674-3 (DE-576)074530976 1872-6240 nnns volume:1820 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie VZ AR 1820 |
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10.1016/j.brainres.2023.148540 doi (DE-627)ELV065127447 (ELSEVIER)S0006-8993(23)00311-6 DE-627 ger DE-627 rda eng 150 610 VZ 44.90 bkl Bonassi, Gaia verfasserin (orcid)0000-0003-2697-4113 aut Neural oscillations modulation during working memory in pre-manifest and early Huntington’s disease 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: We recently demonstrated specific spectral signatures associated with updating of memory information, working memory (WM) maintenance and readout, with relatively high spatial resolution by means of high-density electroencephalography (hdEEG). WM is impaired already in early symptomatic HD (early-HD) and in pre-manifest HD (pre-HD). The aim of this study was to test whether hdEEG coupled to source localization allows for the identification of neuronal oscillations in specific frequency bands in 16 pre-HD and early-HD during different phases of a WM task.Methods: We examined modulation of neural oscillations by event-related synchronization and desynchronization (ERS/ERD) of θ, β, gamma low, γLOW and γHIGH EEG bands in a-priori selected large fronto-parietal network, including the insula and the cerebellum.Results: We found: (i) Reduced θ oscillations in HD with respect to controls in almost all the areas of the WM network during the update and readout phases; (ii) Modulation of β oscillations, which increased during the maintenance phase of the WM task in both groups; (iii) correlation of γHIGH oscillations during WM task with disease burden score in HD patients.Conclusions: Our data show reduced phase-specific modulation of oscillations in pre-HD and early-HD, even in the presence of preserved dynamic of modulation. Particularly, reduced synchronization in the θ band in the areas of the WM network, consistent with abnormal long-range coordination of neuronal activity within this network, was found in update and readout phases in HD groups. Huntington disease hd-EEG Working memory Neural oscillations Network Semprini, Marianna verfasserin (orcid)0000-0001-5504-0251 aut Mandich, Paola verfasserin aut Trevisan, Lucia verfasserin (orcid)0000-0002-8608-4342 aut Marchese, Roberta verfasserin aut Lagravinese, Giovanna verfasserin aut Barban, Federico verfasserin aut Pelosin, Elisa verfasserin (orcid)0000-0002-9880-2241 aut Chiappalone, Michela verfasserin (orcid)0000-0003-1427-5147 aut Mantini, Dante verfasserin aut Avanzino, Laura verfasserin (orcid)0000-0001-6286-1509 aut Enthalten in Brain research Amsterdam : Elsevier, 1966 1820 Online-Ressource (DE-627)254635776 (DE-600)1462674-3 (DE-576)074530976 1872-6240 nnns volume:1820 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie VZ AR 1820 |
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10.1016/j.brainres.2023.148540 doi (DE-627)ELV065127447 (ELSEVIER)S0006-8993(23)00311-6 DE-627 ger DE-627 rda eng 150 610 VZ 44.90 bkl Bonassi, Gaia verfasserin (orcid)0000-0003-2697-4113 aut Neural oscillations modulation during working memory in pre-manifest and early Huntington’s disease 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: We recently demonstrated specific spectral signatures associated with updating of memory information, working memory (WM) maintenance and readout, with relatively high spatial resolution by means of high-density electroencephalography (hdEEG). WM is impaired already in early symptomatic HD (early-HD) and in pre-manifest HD (pre-HD). The aim of this study was to test whether hdEEG coupled to source localization allows for the identification of neuronal oscillations in specific frequency bands in 16 pre-HD and early-HD during different phases of a WM task.Methods: We examined modulation of neural oscillations by event-related synchronization and desynchronization (ERS/ERD) of θ, β, gamma low, γLOW and γHIGH EEG bands in a-priori selected large fronto-parietal network, including the insula and the cerebellum.Results: We found: (i) Reduced θ oscillations in HD with respect to controls in almost all the areas of the WM network during the update and readout phases; (ii) Modulation of β oscillations, which increased during the maintenance phase of the WM task in both groups; (iii) correlation of γHIGH oscillations during WM task with disease burden score in HD patients.Conclusions: Our data show reduced phase-specific modulation of oscillations in pre-HD and early-HD, even in the presence of preserved dynamic of modulation. Particularly, reduced synchronization in the θ band in the areas of the WM network, consistent with abnormal long-range coordination of neuronal activity within this network, was found in update and readout phases in HD groups. Huntington disease hd-EEG Working memory Neural oscillations Network Semprini, Marianna verfasserin (orcid)0000-0001-5504-0251 aut Mandich, Paola verfasserin aut Trevisan, Lucia verfasserin (orcid)0000-0002-8608-4342 aut Marchese, Roberta verfasserin aut Lagravinese, Giovanna verfasserin aut Barban, Federico verfasserin aut Pelosin, Elisa verfasserin (orcid)0000-0002-9880-2241 aut Chiappalone, Michela verfasserin (orcid)0000-0003-1427-5147 aut Mantini, Dante verfasserin aut Avanzino, Laura verfasserin (orcid)0000-0001-6286-1509 aut Enthalten in Brain research Amsterdam : Elsevier, 1966 1820 Online-Ressource (DE-627)254635776 (DE-600)1462674-3 (DE-576)074530976 1872-6240 nnns volume:1820 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie VZ AR 1820 |
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Bonassi, Gaia @@aut@@ Semprini, Marianna @@aut@@ Mandich, Paola @@aut@@ Trevisan, Lucia @@aut@@ Marchese, Roberta @@aut@@ Lagravinese, Giovanna @@aut@@ Barban, Federico @@aut@@ Pelosin, Elisa @@aut@@ Chiappalone, Michela @@aut@@ Mantini, Dante @@aut@@ Avanzino, Laura @@aut@@ |
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2023-01-01T00:00:00Z |
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The aim of this study was to test whether hdEEG coupled to source localization allows for the identification of neuronal oscillations in specific frequency bands in 16 pre-HD and early-HD during different phases of a WM task.Methods: We examined modulation of neural oscillations by event-related synchronization and desynchronization (ERS/ERD) of θ, β, gamma low, γLOW and γHIGH EEG bands in a-priori selected large fronto-parietal network, including the insula and the cerebellum.Results: We found: (i) Reduced θ oscillations in HD with respect to controls in almost all the areas of the WM network during the update and readout phases; (ii) Modulation of β oscillations, which increased during the maintenance phase of the WM task in both groups; (iii) correlation of γHIGH oscillations during WM task with disease burden score in HD patients.Conclusions: Our data show reduced phase-specific modulation of oscillations in pre-HD and early-HD, even in the presence of preserved dynamic of modulation. 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Bonassi, Gaia |
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150 610 VZ 44.90 bkl Neural oscillations modulation during working memory in pre-manifest and early Huntington’s disease Huntington disease hd-EEG Working memory Neural oscillations Network |
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Neural oscillations modulation during working memory in pre-manifest and early Huntington’s disease |
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Bonassi, Gaia Semprini, Marianna Mandich, Paola Trevisan, Lucia Marchese, Roberta Lagravinese, Giovanna Barban, Federico Pelosin, Elisa Chiappalone, Michela Mantini, Dante Avanzino, Laura |
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10.1016/j.brainres.2023.148540 |
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neural oscillations modulation during working memory in pre-manifest and early huntington’s disease |
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Neural oscillations modulation during working memory in pre-manifest and early Huntington’s disease |
| abstract |
Introduction: We recently demonstrated specific spectral signatures associated with updating of memory information, working memory (WM) maintenance and readout, with relatively high spatial resolution by means of high-density electroencephalography (hdEEG). WM is impaired already in early symptomatic HD (early-HD) and in pre-manifest HD (pre-HD). The aim of this study was to test whether hdEEG coupled to source localization allows for the identification of neuronal oscillations in specific frequency bands in 16 pre-HD and early-HD during different phases of a WM task.Methods: We examined modulation of neural oscillations by event-related synchronization and desynchronization (ERS/ERD) of θ, β, gamma low, γLOW and γHIGH EEG bands in a-priori selected large fronto-parietal network, including the insula and the cerebellum.Results: We found: (i) Reduced θ oscillations in HD with respect to controls in almost all the areas of the WM network during the update and readout phases; (ii) Modulation of β oscillations, which increased during the maintenance phase of the WM task in both groups; (iii) correlation of γHIGH oscillations during WM task with disease burden score in HD patients.Conclusions: Our data show reduced phase-specific modulation of oscillations in pre-HD and early-HD, even in the presence of preserved dynamic of modulation. Particularly, reduced synchronization in the θ band in the areas of the WM network, consistent with abnormal long-range coordination of neuronal activity within this network, was found in update and readout phases in HD groups. |
| abstractGer |
Introduction: We recently demonstrated specific spectral signatures associated with updating of memory information, working memory (WM) maintenance and readout, with relatively high spatial resolution by means of high-density electroencephalography (hdEEG). WM is impaired already in early symptomatic HD (early-HD) and in pre-manifest HD (pre-HD). The aim of this study was to test whether hdEEG coupled to source localization allows for the identification of neuronal oscillations in specific frequency bands in 16 pre-HD and early-HD during different phases of a WM task.Methods: We examined modulation of neural oscillations by event-related synchronization and desynchronization (ERS/ERD) of θ, β, gamma low, γLOW and γHIGH EEG bands in a-priori selected large fronto-parietal network, including the insula and the cerebellum.Results: We found: (i) Reduced θ oscillations in HD with respect to controls in almost all the areas of the WM network during the update and readout phases; (ii) Modulation of β oscillations, which increased during the maintenance phase of the WM task in both groups; (iii) correlation of γHIGH oscillations during WM task with disease burden score in HD patients.Conclusions: Our data show reduced phase-specific modulation of oscillations in pre-HD and early-HD, even in the presence of preserved dynamic of modulation. Particularly, reduced synchronization in the θ band in the areas of the WM network, consistent with abnormal long-range coordination of neuronal activity within this network, was found in update and readout phases in HD groups. |
| abstract_unstemmed |
Introduction: We recently demonstrated specific spectral signatures associated with updating of memory information, working memory (WM) maintenance and readout, with relatively high spatial resolution by means of high-density electroencephalography (hdEEG). WM is impaired already in early symptomatic HD (early-HD) and in pre-manifest HD (pre-HD). The aim of this study was to test whether hdEEG coupled to source localization allows for the identification of neuronal oscillations in specific frequency bands in 16 pre-HD and early-HD during different phases of a WM task.Methods: We examined modulation of neural oscillations by event-related synchronization and desynchronization (ERS/ERD) of θ, β, gamma low, γLOW and γHIGH EEG bands in a-priori selected large fronto-parietal network, including the insula and the cerebellum.Results: We found: (i) Reduced θ oscillations in HD with respect to controls in almost all the areas of the WM network during the update and readout phases; (ii) Modulation of β oscillations, which increased during the maintenance phase of the WM task in both groups; (iii) correlation of γHIGH oscillations during WM task with disease burden score in HD patients.Conclusions: Our data show reduced phase-specific modulation of oscillations in pre-HD and early-HD, even in the presence of preserved dynamic of modulation. Particularly, reduced synchronization in the θ band in the areas of the WM network, consistent with abnormal long-range coordination of neuronal activity within this network, was found in update and readout phases in HD groups. |
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Neural oscillations modulation during working memory in pre-manifest and early Huntington’s disease |
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Semprini, Marianna Mandich, Paola Trevisan, Lucia Marchese, Roberta Lagravinese, Giovanna Barban, Federico Pelosin, Elisa Chiappalone, Michela Mantini, Dante Avanzino, Laura |
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| score |
7.401595 |