Deformation of nucleated cells driven by ultrasonic standing waves

The deformation of nucleated cells driven by ultrasonic standing waves in fluid environment is investigated by theoretical analysis and numerical simulation. The nucleated cells are considered to consist of cell membrane, cytoplasm and nucleus The cell membrane is assumed to have in-plane deformatio...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Liu, Yifan [verfasserIn] Xin, Fengxian [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Cell deformation Nucleated cell Acoustic radiation stress Ultrasonic standing wave

Übergeordnetes Werk:	Enthalten in: Mechanics of materials - Amsterdam : Elsevier, 1982, 186
Übergeordnetes Werk:	volume:186

DOI / URN:	10.1016/j.mechmat.2023.104805

Katalog-ID:	ELV065127765

Internformat


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520			\|a The deformation of nucleated cells driven by ultrasonic standing waves in fluid environment is investigated by theoretical analysis and numerical simulation. The nucleated cells are considered to consist of cell membrane, cytoplasm and nucleus The cell membrane is assumed to have in-plane deformation and bending resistances, in which the in-plane deformation is modeled by the generalized Hooke's law, and the bending resistance is modeled by the Helfrich bending energy formula. Due to the acoustic mismatch between the media inside and outside the cell, the generated acoustic radiation stress on the cell membrane causes the nucleated cell to deform. Considering the acoustic scattering of the nucleus, the acoustic radiation stress is formulated by applying the acoustic radiation stress tensor theory. Based on the proposed theoretical model, a finite element model is established to solve the coupling problem of ultrasonic propagation and cell deformation. The analytical solution for the acoustic induced deformation of nucleated cells in the limits of long wavelength and small deformation is given and successfully verifies the finite element model. The results show that the deformation of nucleated cells is much larger than that of enucleated cells due to the effect of the nucleus on wave propagation. The deformation of nucleated cells is significantly affected by nuclear size and nuclear density. This study is helpful to accurately extract the mechanical properties of nucleated cells and further promote the detection of cell-related diseases by acoustic deformation technology.
650		4	\|a Cell deformation
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650		4	\|a Acoustic radiation stress
650		4	\|a Ultrasonic standing wave
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publishDate	2023
allfields	10.1016/j.mechmat.2023.104805 doi (DE-627)ELV065127765 (ELSEVIER)S0167-6636(23)00251-X DE-627 ger DE-627 rda eng 550 VZ 51.32 bkl Liu, Yifan verfasserin (orcid)0000-0003-0484-7906 aut Deformation of nucleated cells driven by ultrasonic standing waves 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The deformation of nucleated cells driven by ultrasonic standing waves in fluid environment is investigated by theoretical analysis and numerical simulation. The nucleated cells are considered to consist of cell membrane, cytoplasm and nucleus The cell membrane is assumed to have in-plane deformation and bending resistances, in which the in-plane deformation is modeled by the generalized Hooke's law, and the bending resistance is modeled by the Helfrich bending energy formula. Due to the acoustic mismatch between the media inside and outside the cell, the generated acoustic radiation stress on the cell membrane causes the nucleated cell to deform. Considering the acoustic scattering of the nucleus, the acoustic radiation stress is formulated by applying the acoustic radiation stress tensor theory. Based on the proposed theoretical model, a finite element model is established to solve the coupling problem of ultrasonic propagation and cell deformation. The analytical solution for the acoustic induced deformation of nucleated cells in the limits of long wavelength and small deformation is given and successfully verifies the finite element model. The results show that the deformation of nucleated cells is much larger than that of enucleated cells due to the effect of the nucleus on wave propagation. The deformation of nucleated cells is significantly affected by nuclear size and nuclear density. This study is helpful to accurately extract the mechanical properties of nucleated cells and further promote the detection of cell-related diseases by acoustic deformation technology. Cell deformation Nucleated cell Acoustic radiation stress Ultrasonic standing wave Xin, Fengxian verfasserin aut Enthalten in Mechanics of materials Amsterdam : Elsevier, 1982 186 Online-Ressource (DE-627)32051398X (DE-600)2013735-7 (DE-576)259484806 1872-7743 nnns volume:186 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GEO SSG-OPC-GGO GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.32 Werkstoffmechanik VZ AR 186
spelling	10.1016/j.mechmat.2023.104805 doi (DE-627)ELV065127765 (ELSEVIER)S0167-6636(23)00251-X DE-627 ger DE-627 rda eng 550 VZ 51.32 bkl Liu, Yifan verfasserin (orcid)0000-0003-0484-7906 aut Deformation of nucleated cells driven by ultrasonic standing waves 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The deformation of nucleated cells driven by ultrasonic standing waves in fluid environment is investigated by theoretical analysis and numerical simulation. The nucleated cells are considered to consist of cell membrane, cytoplasm and nucleus The cell membrane is assumed to have in-plane deformation and bending resistances, in which the in-plane deformation is modeled by the generalized Hooke's law, and the bending resistance is modeled by the Helfrich bending energy formula. Due to the acoustic mismatch between the media inside and outside the cell, the generated acoustic radiation stress on the cell membrane causes the nucleated cell to deform. Considering the acoustic scattering of the nucleus, the acoustic radiation stress is formulated by applying the acoustic radiation stress tensor theory. Based on the proposed theoretical model, a finite element model is established to solve the coupling problem of ultrasonic propagation and cell deformation. The analytical solution for the acoustic induced deformation of nucleated cells in the limits of long wavelength and small deformation is given and successfully verifies the finite element model. The results show that the deformation of nucleated cells is much larger than that of enucleated cells due to the effect of the nucleus on wave propagation. The deformation of nucleated cells is significantly affected by nuclear size and nuclear density. This study is helpful to accurately extract the mechanical properties of nucleated cells and further promote the detection of cell-related diseases by acoustic deformation technology. Cell deformation Nucleated cell Acoustic radiation stress Ultrasonic standing wave Xin, Fengxian verfasserin aut Enthalten in Mechanics of materials Amsterdam : Elsevier, 1982 186 Online-Ressource (DE-627)32051398X (DE-600)2013735-7 (DE-576)259484806 1872-7743 nnns volume:186 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GEO SSG-OPC-GGO GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.32 Werkstoffmechanik VZ AR 186
allfields_unstemmed	10.1016/j.mechmat.2023.104805 doi (DE-627)ELV065127765 (ELSEVIER)S0167-6636(23)00251-X DE-627 ger DE-627 rda eng 550 VZ 51.32 bkl Liu, Yifan verfasserin (orcid)0000-0003-0484-7906 aut Deformation of nucleated cells driven by ultrasonic standing waves 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The deformation of nucleated cells driven by ultrasonic standing waves in fluid environment is investigated by theoretical analysis and numerical simulation. The nucleated cells are considered to consist of cell membrane, cytoplasm and nucleus The cell membrane is assumed to have in-plane deformation and bending resistances, in which the in-plane deformation is modeled by the generalized Hooke's law, and the bending resistance is modeled by the Helfrich bending energy formula. Due to the acoustic mismatch between the media inside and outside the cell, the generated acoustic radiation stress on the cell membrane causes the nucleated cell to deform. Considering the acoustic scattering of the nucleus, the acoustic radiation stress is formulated by applying the acoustic radiation stress tensor theory. Based on the proposed theoretical model, a finite element model is established to solve the coupling problem of ultrasonic propagation and cell deformation. The analytical solution for the acoustic induced deformation of nucleated cells in the limits of long wavelength and small deformation is given and successfully verifies the finite element model. The results show that the deformation of nucleated cells is much larger than that of enucleated cells due to the effect of the nucleus on wave propagation. The deformation of nucleated cells is significantly affected by nuclear size and nuclear density. This study is helpful to accurately extract the mechanical properties of nucleated cells and further promote the detection of cell-related diseases by acoustic deformation technology. Cell deformation Nucleated cell Acoustic radiation stress Ultrasonic standing wave Xin, Fengxian verfasserin aut Enthalten in Mechanics of materials Amsterdam : Elsevier, 1982 186 Online-Ressource (DE-627)32051398X (DE-600)2013735-7 (DE-576)259484806 1872-7743 nnns volume:186 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GEO SSG-OPC-GGO GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.32 Werkstoffmechanik VZ AR 186
allfieldsGer	10.1016/j.mechmat.2023.104805 doi (DE-627)ELV065127765 (ELSEVIER)S0167-6636(23)00251-X DE-627 ger DE-627 rda eng 550 VZ 51.32 bkl Liu, Yifan verfasserin (orcid)0000-0003-0484-7906 aut Deformation of nucleated cells driven by ultrasonic standing waves 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The deformation of nucleated cells driven by ultrasonic standing waves in fluid environment is investigated by theoretical analysis and numerical simulation. The nucleated cells are considered to consist of cell membrane, cytoplasm and nucleus The cell membrane is assumed to have in-plane deformation and bending resistances, in which the in-plane deformation is modeled by the generalized Hooke's law, and the bending resistance is modeled by the Helfrich bending energy formula. Due to the acoustic mismatch between the media inside and outside the cell, the generated acoustic radiation stress on the cell membrane causes the nucleated cell to deform. Considering the acoustic scattering of the nucleus, the acoustic radiation stress is formulated by applying the acoustic radiation stress tensor theory. Based on the proposed theoretical model, a finite element model is established to solve the coupling problem of ultrasonic propagation and cell deformation. The analytical solution for the acoustic induced deformation of nucleated cells in the limits of long wavelength and small deformation is given and successfully verifies the finite element model. The results show that the deformation of nucleated cells is much larger than that of enucleated cells due to the effect of the nucleus on wave propagation. The deformation of nucleated cells is significantly affected by nuclear size and nuclear density. This study is helpful to accurately extract the mechanical properties of nucleated cells and further promote the detection of cell-related diseases by acoustic deformation technology. Cell deformation Nucleated cell Acoustic radiation stress Ultrasonic standing wave Xin, Fengxian verfasserin aut Enthalten in Mechanics of materials Amsterdam : Elsevier, 1982 186 Online-Ressource (DE-627)32051398X (DE-600)2013735-7 (DE-576)259484806 1872-7743 nnns volume:186 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GEO SSG-OPC-GGO GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.32 Werkstoffmechanik VZ AR 186
allfieldsSound	10.1016/j.mechmat.2023.104805 doi (DE-627)ELV065127765 (ELSEVIER)S0167-6636(23)00251-X DE-627 ger DE-627 rda eng 550 VZ 51.32 bkl Liu, Yifan verfasserin (orcid)0000-0003-0484-7906 aut Deformation of nucleated cells driven by ultrasonic standing waves 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The deformation of nucleated cells driven by ultrasonic standing waves in fluid environment is investigated by theoretical analysis and numerical simulation. The nucleated cells are considered to consist of cell membrane, cytoplasm and nucleus The cell membrane is assumed to have in-plane deformation and bending resistances, in which the in-plane deformation is modeled by the generalized Hooke's law, and the bending resistance is modeled by the Helfrich bending energy formula. Due to the acoustic mismatch between the media inside and outside the cell, the generated acoustic radiation stress on the cell membrane causes the nucleated cell to deform. Considering the acoustic scattering of the nucleus, the acoustic radiation stress is formulated by applying the acoustic radiation stress tensor theory. Based on the proposed theoretical model, a finite element model is established to solve the coupling problem of ultrasonic propagation and cell deformation. The analytical solution for the acoustic induced deformation of nucleated cells in the limits of long wavelength and small deformation is given and successfully verifies the finite element model. The results show that the deformation of nucleated cells is much larger than that of enucleated cells due to the effect of the nucleus on wave propagation. The deformation of nucleated cells is significantly affected by nuclear size and nuclear density. This study is helpful to accurately extract the mechanical properties of nucleated cells and further promote the detection of cell-related diseases by acoustic deformation technology. Cell deformation Nucleated cell Acoustic radiation stress Ultrasonic standing wave Xin, Fengxian verfasserin aut Enthalten in Mechanics of materials Amsterdam : Elsevier, 1982 186 Online-Ressource (DE-627)32051398X (DE-600)2013735-7 (DE-576)259484806 1872-7743 nnns volume:186 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GEO SSG-OPC-GGO GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.32 Werkstoffmechanik VZ AR 186
language	English
source	Enthalten in Mechanics of materials 186 volume:186
sourceStr	Enthalten in Mechanics of materials 186 volume:186
format_phy_str_mv	Article
bklname	Werkstoffmechanik
institution	findex.gbv.de
topic_facet	Cell deformation Nucleated cell Acoustic radiation stress Ultrasonic standing wave
dewey-raw	550
isfreeaccess_bool	false
container_title	Mechanics of materials
authorswithroles_txt_mv	Liu, Yifan @@aut@@ Xin, Fengxian @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	32051398X
dewey-sort	3550
id	ELV065127765
language_de	englisch
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The nucleated cells are considered to consist of cell membrane, cytoplasm and nucleus The cell membrane is assumed to have in-plane deformation and bending resistances, in which the in-plane deformation is modeled by the generalized Hooke's law, and the bending resistance is modeled by the Helfrich bending energy formula. Due to the acoustic mismatch between the media inside and outside the cell, the generated acoustic radiation stress on the cell membrane causes the nucleated cell to deform. Considering the acoustic scattering of the nucleus, the acoustic radiation stress is formulated by applying the acoustic radiation stress tensor theory. Based on the proposed theoretical model, a finite element model is established to solve the coupling problem of ultrasonic propagation and cell deformation. The analytical solution for the acoustic induced deformation of nucleated cells in the limits of long wavelength and small deformation is given and successfully verifies the finite element model. The results show that the deformation of nucleated cells is much larger than that of enucleated cells due to the effect of the nucleus on wave propagation. The deformation of nucleated cells is significantly affected by nuclear size and nuclear density. 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author	Liu, Yifan
spellingShingle	Liu, Yifan ddc 550 bkl 51.32 misc Cell deformation misc Nucleated cell misc Acoustic radiation stress misc Ultrasonic standing wave Deformation of nucleated cells driven by ultrasonic standing waves
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topic_title	550 VZ 51.32 bkl Deformation of nucleated cells driven by ultrasonic standing waves Cell deformation Nucleated cell Acoustic radiation stress Ultrasonic standing wave
topic	ddc 550 bkl 51.32 misc Cell deformation misc Nucleated cell misc Acoustic radiation stress misc Ultrasonic standing wave
topic_unstemmed	ddc 550 bkl 51.32 misc Cell deformation misc Nucleated cell misc Acoustic radiation stress misc Ultrasonic standing wave
topic_browse	ddc 550 bkl 51.32 misc Cell deformation misc Nucleated cell misc Acoustic radiation stress misc Ultrasonic standing wave
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title	Deformation of nucleated cells driven by ultrasonic standing waves
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title_full	Deformation of nucleated cells driven by ultrasonic standing waves
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title_sort	deformation of nucleated cells driven by ultrasonic standing waves
title_auth	Deformation of nucleated cells driven by ultrasonic standing waves
abstract	The deformation of nucleated cells driven by ultrasonic standing waves in fluid environment is investigated by theoretical analysis and numerical simulation. The nucleated cells are considered to consist of cell membrane, cytoplasm and nucleus The cell membrane is assumed to have in-plane deformation and bending resistances, in which the in-plane deformation is modeled by the generalized Hooke's law, and the bending resistance is modeled by the Helfrich bending energy formula. Due to the acoustic mismatch between the media inside and outside the cell, the generated acoustic radiation stress on the cell membrane causes the nucleated cell to deform. Considering the acoustic scattering of the nucleus, the acoustic radiation stress is formulated by applying the acoustic radiation stress tensor theory. Based on the proposed theoretical model, a finite element model is established to solve the coupling problem of ultrasonic propagation and cell deformation. The analytical solution for the acoustic induced deformation of nucleated cells in the limits of long wavelength and small deformation is given and successfully verifies the finite element model. The results show that the deformation of nucleated cells is much larger than that of enucleated cells due to the effect of the nucleus on wave propagation. The deformation of nucleated cells is significantly affected by nuclear size and nuclear density. This study is helpful to accurately extract the mechanical properties of nucleated cells and further promote the detection of cell-related diseases by acoustic deformation technology.
abstractGer	The deformation of nucleated cells driven by ultrasonic standing waves in fluid environment is investigated by theoretical analysis and numerical simulation. The nucleated cells are considered to consist of cell membrane, cytoplasm and nucleus The cell membrane is assumed to have in-plane deformation and bending resistances, in which the in-plane deformation is modeled by the generalized Hooke's law, and the bending resistance is modeled by the Helfrich bending energy formula. Due to the acoustic mismatch between the media inside and outside the cell, the generated acoustic radiation stress on the cell membrane causes the nucleated cell to deform. Considering the acoustic scattering of the nucleus, the acoustic radiation stress is formulated by applying the acoustic radiation stress tensor theory. Based on the proposed theoretical model, a finite element model is established to solve the coupling problem of ultrasonic propagation and cell deformation. The analytical solution for the acoustic induced deformation of nucleated cells in the limits of long wavelength and small deformation is given and successfully verifies the finite element model. The results show that the deformation of nucleated cells is much larger than that of enucleated cells due to the effect of the nucleus on wave propagation. The deformation of nucleated cells is significantly affected by nuclear size and nuclear density. This study is helpful to accurately extract the mechanical properties of nucleated cells and further promote the detection of cell-related diseases by acoustic deformation technology.
abstract_unstemmed	The deformation of nucleated cells driven by ultrasonic standing waves in fluid environment is investigated by theoretical analysis and numerical simulation. The nucleated cells are considered to consist of cell membrane, cytoplasm and nucleus The cell membrane is assumed to have in-plane deformation and bending resistances, in which the in-plane deformation is modeled by the generalized Hooke's law, and the bending resistance is modeled by the Helfrich bending energy formula. Due to the acoustic mismatch between the media inside and outside the cell, the generated acoustic radiation stress on the cell membrane causes the nucleated cell to deform. Considering the acoustic scattering of the nucleus, the acoustic radiation stress is formulated by applying the acoustic radiation stress tensor theory. Based on the proposed theoretical model, a finite element model is established to solve the coupling problem of ultrasonic propagation and cell deformation. The analytical solution for the acoustic induced deformation of nucleated cells in the limits of long wavelength and small deformation is given and successfully verifies the finite element model. The results show that the deformation of nucleated cells is much larger than that of enucleated cells due to the effect of the nucleus on wave propagation. The deformation of nucleated cells is significantly affected by nuclear size and nuclear density. This study is helpful to accurately extract the mechanical properties of nucleated cells and further promote the detection of cell-related diseases by acoustic deformation technology.
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title_short	Deformation of nucleated cells driven by ultrasonic standing waves
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up_date	2024-07-06T21:55:50.666Z
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Deformation of nucleated cells driven by ultrasonic standing waves

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