Photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing

Diabetic wound healing is affected by insufficient angiogenesis, oxidative damage, and bacterial infection, resulting in a delayed healing process. There is an urgent need to design a novel multifunctional wound dressing for promoting diabetic wound healing. Nitric oxide (NO) represents a promising...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	He, Jiahui [verfasserIn] Li, Zhenlong [verfasserIn] Wang, Jiaxin [verfasserIn] Li, Tongyang [verfasserIn] Chen, Jueying [verfasserIn] Duan, Xianglong [verfasserIn] Guo, Baolin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Diabetic wound Nitric oxide Antioxidant Photothermal antibacterial Conductivity

Übergeordnetes Werk:	Enthalten in: Composites / B - Amsterdam [u.a.] : Elsevier, 1996, 266
Übergeordnetes Werk:	volume:266

DOI / URN:	10.1016/j.compositesb.2023.110985

Katalog-ID:	ELV065193342

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245	1	0	\|a Photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing
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520			\|a Diabetic wound healing is affected by insufficient angiogenesis, oxidative damage, and bacterial infection, resulting in a delayed healing process. There is an urgent need to design a novel multifunctional wound dressing for promoting diabetic wound healing. Nitric oxide (NO) represents a promising wound healing agent because of its positive role in angiogenesis. Here, a series of antibacterial antioxidant self-healing conductive multifunctional hydrogels integrating near-infrared (NIR) laser irradiation NO release behavior, were developed based on carboxymethyl chitosan (CMCS), 2,3,4-trihydroxybenzaldehyde (THB), copper chloride (CuCl2), and graphene oxide (GO)-N, N′-di-sec-butyl-N, N′-dinitroso-1,4-phenylenediamine (BNN6) (GO-BNN6, abbreviated as GB), to promote wound healing in Type I diabetes (TID). CMCS/THB/Cu/GB hydrogels show stable mechanical properties, self-healing ability, conductivity, antioxidant properties, intrinsic antibacterial properties, biocompatibility, etc. The addition of GB enabled the hydrogel to exhibit photothermal properties and photothermal-induced antibacterial activity in vitro. More importantly, the CMCS/THB/Cu/GB2 (2 mg/mL of GB in the hydrogel) was able to release NO under NIR laser irradiation. In a full-thickness skin wound model in diabetic mice, CMCS/THB/Cu/GB2 hydrogel combined with NIR laser treatment (CMCS/THB/Cu/GB2+NIR) can significantly accelerate wound contraction, collagen content, and angiogenesis. In conclusion, these multifunctional photothermal conductive antioxidant self-healing hydrogels with integrated NO-releasing behavior show great potential for treating type I diabetic wounds.
650		4	\|a Diabetic wound
650		4	\|a Nitric oxide
650		4	\|a Antioxidant
650		4	\|a Photothermal antibacterial
650		4	\|a Conductivity
700	1		\|a Li, Zhenlong \|e verfasserin \|4 aut
700	1		\|a Wang, Jiaxin \|e verfasserin \|4 aut
700	1		\|a Li, Tongyang \|e verfasserin \|4 aut
700	1		\|a Chen, Jueying \|e verfasserin \|4 aut
700	1		\|a Duan, Xianglong \|e verfasserin \|4 aut
700	1		\|a Guo, Baolin \|e verfasserin \|0 (orcid)0000-0001-6756-1441 \|4 aut
773	0	8	\|i Enthalten in \|t Composites / B \|d Amsterdam [u.a.] : Elsevier, 1996 \|g 266 \|h Online-Ressource \|w (DE-627)32050235X \|w (DE-600)2012385-1 \|w (DE-576)094531420 \|x 1879-1069 \|7 nnns
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912			\|a GBV_USEFLAG_U
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912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_32
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_95
912			\|a GBV_ILN_100
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
936	b	k	\|a 51.75 \|j Verbundwerkstoffe \|j Schichtstoffe \|q VZ
951			\|a AR
952			\|d 266

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publishDate	2023
allfields	10.1016/j.compositesb.2023.110985 doi (DE-627)ELV065193342 (ELSEVIER)S1359-8368(23)00488-2 DE-627 ger DE-627 rda eng 660 VZ 51.75 bkl He, Jiahui verfasserin aut Photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Diabetic wound healing is affected by insufficient angiogenesis, oxidative damage, and bacterial infection, resulting in a delayed healing process. There is an urgent need to design a novel multifunctional wound dressing for promoting diabetic wound healing. Nitric oxide (NO) represents a promising wound healing agent because of its positive role in angiogenesis. Here, a series of antibacterial antioxidant self-healing conductive multifunctional hydrogels integrating near-infrared (NIR) laser irradiation NO release behavior, were developed based on carboxymethyl chitosan (CMCS), 2,3,4-trihydroxybenzaldehyde (THB), copper chloride (CuCl2), and graphene oxide (GO)-N, N′-di-sec-butyl-N, N′-dinitroso-1,4-phenylenediamine (BNN6) (GO-BNN6, abbreviated as GB), to promote wound healing in Type I diabetes (TID). CMCS/THB/Cu/GB hydrogels show stable mechanical properties, self-healing ability, conductivity, antioxidant properties, intrinsic antibacterial properties, biocompatibility, etc. The addition of GB enabled the hydrogel to exhibit photothermal properties and photothermal-induced antibacterial activity in vitro. More importantly, the CMCS/THB/Cu/GB2 (2 mg/mL of GB in the hydrogel) was able to release NO under NIR laser irradiation. In a full-thickness skin wound model in diabetic mice, CMCS/THB/Cu/GB2 hydrogel combined with NIR laser treatment (CMCS/THB/Cu/GB2+NIR) can significantly accelerate wound contraction, collagen content, and angiogenesis. In conclusion, these multifunctional photothermal conductive antioxidant self-healing hydrogels with integrated NO-releasing behavior show great potential for treating type I diabetic wounds. Diabetic wound Nitric oxide Antioxidant Photothermal antibacterial Conductivity Li, Zhenlong verfasserin aut Wang, Jiaxin verfasserin aut Li, Tongyang verfasserin aut Chen, Jueying verfasserin aut Duan, Xianglong verfasserin aut Guo, Baolin verfasserin (orcid)0000-0001-6756-1441 aut Enthalten in Composites / B Amsterdam [u.a.] : Elsevier, 1996 266 Online-Ressource (DE-627)32050235X (DE-600)2012385-1 (DE-576)094531420 1879-1069 nnns volume:266 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.75 Verbundwerkstoffe Schichtstoffe VZ AR 266
spelling	10.1016/j.compositesb.2023.110985 doi (DE-627)ELV065193342 (ELSEVIER)S1359-8368(23)00488-2 DE-627 ger DE-627 rda eng 660 VZ 51.75 bkl He, Jiahui verfasserin aut Photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Diabetic wound healing is affected by insufficient angiogenesis, oxidative damage, and bacterial infection, resulting in a delayed healing process. There is an urgent need to design a novel multifunctional wound dressing for promoting diabetic wound healing. Nitric oxide (NO) represents a promising wound healing agent because of its positive role in angiogenesis. Here, a series of antibacterial antioxidant self-healing conductive multifunctional hydrogels integrating near-infrared (NIR) laser irradiation NO release behavior, were developed based on carboxymethyl chitosan (CMCS), 2,3,4-trihydroxybenzaldehyde (THB), copper chloride (CuCl2), and graphene oxide (GO)-N, N′-di-sec-butyl-N, N′-dinitroso-1,4-phenylenediamine (BNN6) (GO-BNN6, abbreviated as GB), to promote wound healing in Type I diabetes (TID). CMCS/THB/Cu/GB hydrogels show stable mechanical properties, self-healing ability, conductivity, antioxidant properties, intrinsic antibacterial properties, biocompatibility, etc. The addition of GB enabled the hydrogel to exhibit photothermal properties and photothermal-induced antibacterial activity in vitro. More importantly, the CMCS/THB/Cu/GB2 (2 mg/mL of GB in the hydrogel) was able to release NO under NIR laser irradiation. In a full-thickness skin wound model in diabetic mice, CMCS/THB/Cu/GB2 hydrogel combined with NIR laser treatment (CMCS/THB/Cu/GB2+NIR) can significantly accelerate wound contraction, collagen content, and angiogenesis. In conclusion, these multifunctional photothermal conductive antioxidant self-healing hydrogels with integrated NO-releasing behavior show great potential for treating type I diabetic wounds. Diabetic wound Nitric oxide Antioxidant Photothermal antibacterial Conductivity Li, Zhenlong verfasserin aut Wang, Jiaxin verfasserin aut Li, Tongyang verfasserin aut Chen, Jueying verfasserin aut Duan, Xianglong verfasserin aut Guo, Baolin verfasserin (orcid)0000-0001-6756-1441 aut Enthalten in Composites / B Amsterdam [u.a.] : Elsevier, 1996 266 Online-Ressource (DE-627)32050235X (DE-600)2012385-1 (DE-576)094531420 1879-1069 nnns volume:266 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.75 Verbundwerkstoffe Schichtstoffe VZ AR 266
allfields_unstemmed	10.1016/j.compositesb.2023.110985 doi (DE-627)ELV065193342 (ELSEVIER)S1359-8368(23)00488-2 DE-627 ger DE-627 rda eng 660 VZ 51.75 bkl He, Jiahui verfasserin aut Photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Diabetic wound healing is affected by insufficient angiogenesis, oxidative damage, and bacterial infection, resulting in a delayed healing process. There is an urgent need to design a novel multifunctional wound dressing for promoting diabetic wound healing. Nitric oxide (NO) represents a promising wound healing agent because of its positive role in angiogenesis. Here, a series of antibacterial antioxidant self-healing conductive multifunctional hydrogels integrating near-infrared (NIR) laser irradiation NO release behavior, were developed based on carboxymethyl chitosan (CMCS), 2,3,4-trihydroxybenzaldehyde (THB), copper chloride (CuCl2), and graphene oxide (GO)-N, N′-di-sec-butyl-N, N′-dinitroso-1,4-phenylenediamine (BNN6) (GO-BNN6, abbreviated as GB), to promote wound healing in Type I diabetes (TID). CMCS/THB/Cu/GB hydrogels show stable mechanical properties, self-healing ability, conductivity, antioxidant properties, intrinsic antibacterial properties, biocompatibility, etc. The addition of GB enabled the hydrogel to exhibit photothermal properties and photothermal-induced antibacterial activity in vitro. More importantly, the CMCS/THB/Cu/GB2 (2 mg/mL of GB in the hydrogel) was able to release NO under NIR laser irradiation. In a full-thickness skin wound model in diabetic mice, CMCS/THB/Cu/GB2 hydrogel combined with NIR laser treatment (CMCS/THB/Cu/GB2+NIR) can significantly accelerate wound contraction, collagen content, and angiogenesis. In conclusion, these multifunctional photothermal conductive antioxidant self-healing hydrogels with integrated NO-releasing behavior show great potential for treating type I diabetic wounds. Diabetic wound Nitric oxide Antioxidant Photothermal antibacterial Conductivity Li, Zhenlong verfasserin aut Wang, Jiaxin verfasserin aut Li, Tongyang verfasserin aut Chen, Jueying verfasserin aut Duan, Xianglong verfasserin aut Guo, Baolin verfasserin (orcid)0000-0001-6756-1441 aut Enthalten in Composites / B Amsterdam [u.a.] : Elsevier, 1996 266 Online-Ressource (DE-627)32050235X (DE-600)2012385-1 (DE-576)094531420 1879-1069 nnns volume:266 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.75 Verbundwerkstoffe Schichtstoffe VZ AR 266
allfieldsGer	10.1016/j.compositesb.2023.110985 doi (DE-627)ELV065193342 (ELSEVIER)S1359-8368(23)00488-2 DE-627 ger DE-627 rda eng 660 VZ 51.75 bkl He, Jiahui verfasserin aut Photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Diabetic wound healing is affected by insufficient angiogenesis, oxidative damage, and bacterial infection, resulting in a delayed healing process. There is an urgent need to design a novel multifunctional wound dressing for promoting diabetic wound healing. Nitric oxide (NO) represents a promising wound healing agent because of its positive role in angiogenesis. Here, a series of antibacterial antioxidant self-healing conductive multifunctional hydrogels integrating near-infrared (NIR) laser irradiation NO release behavior, were developed based on carboxymethyl chitosan (CMCS), 2,3,4-trihydroxybenzaldehyde (THB), copper chloride (CuCl2), and graphene oxide (GO)-N, N′-di-sec-butyl-N, N′-dinitroso-1,4-phenylenediamine (BNN6) (GO-BNN6, abbreviated as GB), to promote wound healing in Type I diabetes (TID). CMCS/THB/Cu/GB hydrogels show stable mechanical properties, self-healing ability, conductivity, antioxidant properties, intrinsic antibacterial properties, biocompatibility, etc. The addition of GB enabled the hydrogel to exhibit photothermal properties and photothermal-induced antibacterial activity in vitro. More importantly, the CMCS/THB/Cu/GB2 (2 mg/mL of GB in the hydrogel) was able to release NO under NIR laser irradiation. In a full-thickness skin wound model in diabetic mice, CMCS/THB/Cu/GB2 hydrogel combined with NIR laser treatment (CMCS/THB/Cu/GB2+NIR) can significantly accelerate wound contraction, collagen content, and angiogenesis. In conclusion, these multifunctional photothermal conductive antioxidant self-healing hydrogels with integrated NO-releasing behavior show great potential for treating type I diabetic wounds. Diabetic wound Nitric oxide Antioxidant Photothermal antibacterial Conductivity Li, Zhenlong verfasserin aut Wang, Jiaxin verfasserin aut Li, Tongyang verfasserin aut Chen, Jueying verfasserin aut Duan, Xianglong verfasserin aut Guo, Baolin verfasserin (orcid)0000-0001-6756-1441 aut Enthalten in Composites / B Amsterdam [u.a.] : Elsevier, 1996 266 Online-Ressource (DE-627)32050235X (DE-600)2012385-1 (DE-576)094531420 1879-1069 nnns volume:266 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.75 Verbundwerkstoffe Schichtstoffe VZ AR 266
allfieldsSound	10.1016/j.compositesb.2023.110985 doi (DE-627)ELV065193342 (ELSEVIER)S1359-8368(23)00488-2 DE-627 ger DE-627 rda eng 660 VZ 51.75 bkl He, Jiahui verfasserin aut Photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Diabetic wound healing is affected by insufficient angiogenesis, oxidative damage, and bacterial infection, resulting in a delayed healing process. There is an urgent need to design a novel multifunctional wound dressing for promoting diabetic wound healing. Nitric oxide (NO) represents a promising wound healing agent because of its positive role in angiogenesis. Here, a series of antibacterial antioxidant self-healing conductive multifunctional hydrogels integrating near-infrared (NIR) laser irradiation NO release behavior, were developed based on carboxymethyl chitosan (CMCS), 2,3,4-trihydroxybenzaldehyde (THB), copper chloride (CuCl2), and graphene oxide (GO)-N, N′-di-sec-butyl-N, N′-dinitroso-1,4-phenylenediamine (BNN6) (GO-BNN6, abbreviated as GB), to promote wound healing in Type I diabetes (TID). CMCS/THB/Cu/GB hydrogels show stable mechanical properties, self-healing ability, conductivity, antioxidant properties, intrinsic antibacterial properties, biocompatibility, etc. The addition of GB enabled the hydrogel to exhibit photothermal properties and photothermal-induced antibacterial activity in vitro. More importantly, the CMCS/THB/Cu/GB2 (2 mg/mL of GB in the hydrogel) was able to release NO under NIR laser irradiation. In a full-thickness skin wound model in diabetic mice, CMCS/THB/Cu/GB2 hydrogel combined with NIR laser treatment (CMCS/THB/Cu/GB2+NIR) can significantly accelerate wound contraction, collagen content, and angiogenesis. In conclusion, these multifunctional photothermal conductive antioxidant self-healing hydrogels with integrated NO-releasing behavior show great potential for treating type I diabetic wounds. Diabetic wound Nitric oxide Antioxidant Photothermal antibacterial Conductivity Li, Zhenlong verfasserin aut Wang, Jiaxin verfasserin aut Li, Tongyang verfasserin aut Chen, Jueying verfasserin aut Duan, Xianglong verfasserin aut Guo, Baolin verfasserin (orcid)0000-0001-6756-1441 aut Enthalten in Composites / B Amsterdam [u.a.] : Elsevier, 1996 266 Online-Ressource (DE-627)32050235X (DE-600)2012385-1 (DE-576)094531420 1879-1069 nnns volume:266 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.75 Verbundwerkstoffe Schichtstoffe VZ AR 266
language	English
source	Enthalten in Composites / B 266 volume:266
sourceStr	Enthalten in Composites / B 266 volume:266
format_phy_str_mv	Article
bklname	Verbundwerkstoffe Schichtstoffe
institution	findex.gbv.de
topic_facet	Diabetic wound Nitric oxide Antioxidant Photothermal antibacterial Conductivity
dewey-raw	660
isfreeaccess_bool	false
container_title	Composites / B
authorswithroles_txt_mv	He, Jiahui @@aut@@ Li, Zhenlong @@aut@@ Wang, Jiaxin @@aut@@ Li, Tongyang @@aut@@ Chen, Jueying @@aut@@ Duan, Xianglong @@aut@@ Guo, Baolin @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	32050235X
dewey-sort	3660
id	ELV065193342
language_de	englisch
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author	He, Jiahui
spellingShingle	He, Jiahui ddc 660 bkl 51.75 misc Diabetic wound misc Nitric oxide misc Antioxidant misc Photothermal antibacterial misc Conductivity Photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing
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topic_title	660 VZ 51.75 bkl Photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing Diabetic wound Nitric oxide Antioxidant Photothermal antibacterial Conductivity
topic	ddc 660 bkl 51.75 misc Diabetic wound misc Nitric oxide misc Antioxidant misc Photothermal antibacterial misc Conductivity
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title	Photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing
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title_full	Photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing
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author_browse	He, Jiahui Li, Zhenlong Wang, Jiaxin Li, Tongyang Chen, Jueying Duan, Xianglong Guo, Baolin
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title_sort	photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing
title_auth	Photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing
abstract	Diabetic wound healing is affected by insufficient angiogenesis, oxidative damage, and bacterial infection, resulting in a delayed healing process. There is an urgent need to design a novel multifunctional wound dressing for promoting diabetic wound healing. Nitric oxide (NO) represents a promising wound healing agent because of its positive role in angiogenesis. Here, a series of antibacterial antioxidant self-healing conductive multifunctional hydrogels integrating near-infrared (NIR) laser irradiation NO release behavior, were developed based on carboxymethyl chitosan (CMCS), 2,3,4-trihydroxybenzaldehyde (THB), copper chloride (CuCl2), and graphene oxide (GO)-N, N′-di-sec-butyl-N, N′-dinitroso-1,4-phenylenediamine (BNN6) (GO-BNN6, abbreviated as GB), to promote wound healing in Type I diabetes (TID). CMCS/THB/Cu/GB hydrogels show stable mechanical properties, self-healing ability, conductivity, antioxidant properties, intrinsic antibacterial properties, biocompatibility, etc. The addition of GB enabled the hydrogel to exhibit photothermal properties and photothermal-induced antibacterial activity in vitro. More importantly, the CMCS/THB/Cu/GB2 (2 mg/mL of GB in the hydrogel) was able to release NO under NIR laser irradiation. In a full-thickness skin wound model in diabetic mice, CMCS/THB/Cu/GB2 hydrogel combined with NIR laser treatment (CMCS/THB/Cu/GB2+NIR) can significantly accelerate wound contraction, collagen content, and angiogenesis. In conclusion, these multifunctional photothermal conductive antioxidant self-healing hydrogels with integrated NO-releasing behavior show great potential for treating type I diabetic wounds.
abstractGer	Diabetic wound healing is affected by insufficient angiogenesis, oxidative damage, and bacterial infection, resulting in a delayed healing process. There is an urgent need to design a novel multifunctional wound dressing for promoting diabetic wound healing. Nitric oxide (NO) represents a promising wound healing agent because of its positive role in angiogenesis. Here, a series of antibacterial antioxidant self-healing conductive multifunctional hydrogels integrating near-infrared (NIR) laser irradiation NO release behavior, were developed based on carboxymethyl chitosan (CMCS), 2,3,4-trihydroxybenzaldehyde (THB), copper chloride (CuCl2), and graphene oxide (GO)-N, N′-di-sec-butyl-N, N′-dinitroso-1,4-phenylenediamine (BNN6) (GO-BNN6, abbreviated as GB), to promote wound healing in Type I diabetes (TID). CMCS/THB/Cu/GB hydrogels show stable mechanical properties, self-healing ability, conductivity, antioxidant properties, intrinsic antibacterial properties, biocompatibility, etc. The addition of GB enabled the hydrogel to exhibit photothermal properties and photothermal-induced antibacterial activity in vitro. More importantly, the CMCS/THB/Cu/GB2 (2 mg/mL of GB in the hydrogel) was able to release NO under NIR laser irradiation. In a full-thickness skin wound model in diabetic mice, CMCS/THB/Cu/GB2 hydrogel combined with NIR laser treatment (CMCS/THB/Cu/GB2+NIR) can significantly accelerate wound contraction, collagen content, and angiogenesis. In conclusion, these multifunctional photothermal conductive antioxidant self-healing hydrogels with integrated NO-releasing behavior show great potential for treating type I diabetic wounds.
abstract_unstemmed	Diabetic wound healing is affected by insufficient angiogenesis, oxidative damage, and bacterial infection, resulting in a delayed healing process. There is an urgent need to design a novel multifunctional wound dressing for promoting diabetic wound healing. Nitric oxide (NO) represents a promising wound healing agent because of its positive role in angiogenesis. Here, a series of antibacterial antioxidant self-healing conductive multifunctional hydrogels integrating near-infrared (NIR) laser irradiation NO release behavior, were developed based on carboxymethyl chitosan (CMCS), 2,3,4-trihydroxybenzaldehyde (THB), copper chloride (CuCl2), and graphene oxide (GO)-N, N′-di-sec-butyl-N, N′-dinitroso-1,4-phenylenediamine (BNN6) (GO-BNN6, abbreviated as GB), to promote wound healing in Type I diabetes (TID). CMCS/THB/Cu/GB hydrogels show stable mechanical properties, self-healing ability, conductivity, antioxidant properties, intrinsic antibacterial properties, biocompatibility, etc. The addition of GB enabled the hydrogel to exhibit photothermal properties and photothermal-induced antibacterial activity in vitro. More importantly, the CMCS/THB/Cu/GB2 (2 mg/mL of GB in the hydrogel) was able to release NO under NIR laser irradiation. In a full-thickness skin wound model in diabetic mice, CMCS/THB/Cu/GB2 hydrogel combined with NIR laser treatment (CMCS/THB/Cu/GB2+NIR) can significantly accelerate wound contraction, collagen content, and angiogenesis. In conclusion, these multifunctional photothermal conductive antioxidant self-healing hydrogels with integrated NO-releasing behavior show great potential for treating type I diabetic wounds.
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title_short	Photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing
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author2	Li, Zhenlong Wang, Jiaxin Li, Tongyang Chen, Jueying Duan, Xianglong Guo, Baolin
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doi_str	10.1016/j.compositesb.2023.110985
up_date	2024-07-06T22:09:55.609Z
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There is an urgent need to design a novel multifunctional wound dressing for promoting diabetic wound healing. Nitric oxide (NO) represents a promising wound healing agent because of its positive role in angiogenesis. Here, a series of antibacterial antioxidant self-healing conductive multifunctional hydrogels integrating near-infrared (NIR) laser irradiation NO release behavior, were developed based on carboxymethyl chitosan (CMCS), 2,3,4-trihydroxybenzaldehyde (THB), copper chloride (CuCl2), and graphene oxide (GO)-N, N′-di-sec-butyl-N, N′-dinitroso-1,4-phenylenediamine (BNN6) (GO-BNN6, abbreviated as GB), to promote wound healing in Type I diabetes (TID). CMCS/THB/Cu/GB hydrogels show stable mechanical properties, self-healing ability, conductivity, antioxidant properties, intrinsic antibacterial properties, biocompatibility, etc. The addition of GB enabled the hydrogel to exhibit photothermal properties and photothermal-induced antibacterial activity in vitro. More importantly, the CMCS/THB/Cu/GB2 (2 mg/mL of GB in the hydrogel) was able to release NO under NIR laser irradiation. In a full-thickness skin wound model in diabetic mice, CMCS/THB/Cu/GB2 hydrogel combined with NIR laser treatment (CMCS/THB/Cu/GB2+NIR) can significantly accelerate wound contraction, collagen content, and angiogenesis. In conclusion, these multifunctional photothermal conductive antioxidant self-healing hydrogels with integrated NO-releasing behavior show great potential for treating type I diabetic wounds.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Diabetic wound</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nitric oxide</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Antioxidant</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Photothermal antibacterial</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Conductivity</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Li, Zhenlong</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wang, Jiaxin</subfield><subfield code="e">verfasserin</subfield><subfield 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Photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing

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