Appraisals on the chemical characterization and biological potentials of
In this context, phytochemicals were extracted from Ranunculus constantinopolitanus using ethyl acetate (EA), ethanol, ethanol/water (70%), and water solvent. The analysis encompassed quantification of total phenolic and flavonoid content using spectrophotometric assays, chemical profiling via high...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Lazarova, Irina [verfasserIn] Zengin, Gokhan [verfasserIn] Piatti, Diletta [verfasserIn] Uba, Abdullahi Ibrahim [verfasserIn] Sagratini, Gianni [verfasserIn] Caprioli, Giovanni [verfasserIn] Emre, Gizem [verfasserIn] Ponniya, Sathish Kumar M. [verfasserIn] Rengasamy, Kannan RR. [verfasserIn] Paradis, Nicholas Joseph [verfasserIn] Koyuncu, Ismail [verfasserIn] Şeker, Fatma [verfasserIn] Wu, Chun [verfasserIn] Nilofar [verfasserIn] Flores, Giancarlo Angeles [verfasserIn] Cusumano, Gaia [verfasserIn] Angelini, Paola [verfasserIn] Venanzoni, Roberto [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Food and chemical toxicology - New York, NY [u.a.] : Elsevier, 1982, 181 |
|---|---|
| Übergeordnetes Werk: |
volume:181 |
| DOI / URN: |
10.1016/j.fct.2023.114064 |
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| Katalog-ID: |
ELV065413938 |
|---|
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| 245 | 1 | 0 | |a Appraisals on the chemical characterization and biological potentials of |
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| 520 | |a In this context, phytochemicals were extracted from Ranunculus constantinopolitanus using ethyl acetate (EA), ethanol, ethanol/water (70%), and water solvent. The analysis encompassed quantification of total phenolic and flavonoid content using spectrophotometric assays, chemical profiling via high performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) for the extracts, and assessment of antioxidant activity via 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), Cupric reducing antioxidant capacity (CUPRAC), ferric reducing antioxidant power (FRAP), metal chelating (MCA), and phosphomolybdenum (PBD) assays. Moreover, antimicrobial activity was assessed against four different bacterial strains, as well as various yeasts. Enzyme inhibitory activities were evaluated against five types of enzymes. Additionally, the extracts were examined for their anticancer and protective effects on several cancer cell lines and the human normal cell line. All of the extracts exhibited significant levels of ferulic acid, kaempferol, and caffeic acid. All tested extracts demonstrated antimicrobial activity, with Escherichia coli and Pseudomonas aeruginosa being most sensitive to EA and ethanol extracts. Molecular docking studies revealed that kaempferol-3-O-glucoside strong interactions with AChE, BChE and tyrosinase. In addition, network pharmacology showed an association between gastric cancer and kaempferol-3-O-glucoside. Based on the results, R. constantinopolitanus can be a potential reservoir of bioactive compounds for future bioproduct innovation and pharmaceutical industries. | ||
| 650 | 4 | |a Flavonoids | |
| 650 | 4 | |a Computational analysis | |
| 650 | 4 | |a Antifungal | |
| 650 | 4 | |a Network pharmacology | |
| 650 | 4 | |a Novel pharmaceutics | |
| 700 | 1 | |a Zengin, Gokhan |e verfasserin |4 aut | |
| 700 | 1 | |a Piatti, Diletta |e verfasserin |0 (orcid)0009-0001-9590-5560 |4 aut | |
| 700 | 1 | |a Uba, Abdullahi Ibrahim |e verfasserin |4 aut | |
| 700 | 1 | |a Sagratini, Gianni |e verfasserin |4 aut | |
| 700 | 1 | |a Caprioli, Giovanni |e verfasserin |4 aut | |
| 700 | 1 | |a Emre, Gizem |e verfasserin |4 aut | |
| 700 | 1 | |a Ponniya, Sathish Kumar M. |e verfasserin |4 aut | |
| 700 | 1 | |a Rengasamy, Kannan RR. |e verfasserin |4 aut | |
| 700 | 1 | |a Paradis, Nicholas Joseph |e verfasserin |0 (orcid)0000-0002-4402-7315 |4 aut | |
| 700 | 1 | |a Koyuncu, Ismail |e verfasserin |4 aut | |
| 700 | 1 | |a Şeker, Fatma |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Chun |e verfasserin |4 aut | |
| 700 | 1 | |a Nilofar |e verfasserin |0 (orcid)0000-0002-4254-4140 |4 aut | |
| 700 | 1 | |a Flores, Giancarlo Angeles |e verfasserin |4 aut | |
| 700 | 1 | |a Cusumano, Gaia |e verfasserin |4 aut | |
| 700 | 1 | |a Angelini, Paola |e verfasserin |4 aut | |
| 700 | 1 | |a Venanzoni, Roberto |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Food and chemical toxicology |d New York, NY [u.a.] : Elsevier, 1982 |g 181 |h Online-Ressource |w (DE-627)300898487 |w (DE-600)1483645-2 |w (DE-576)259270849 |x 1873-6351 |7 nnns |
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10.1016/j.fct.2023.114064 doi (DE-627)ELV065413938 (ELSEVIER)S0278-6915(23)00466-0 DE-627 ger DE-627 rda eng 630 640 610 VZ 44.21 bkl Lazarova, Irina verfasserin (orcid)0000-0002-8966-545X aut Appraisals on the chemical characterization and biological potentials of 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this context, phytochemicals were extracted from Ranunculus constantinopolitanus using ethyl acetate (EA), ethanol, ethanol/water (70%), and water solvent. The analysis encompassed quantification of total phenolic and flavonoid content using spectrophotometric assays, chemical profiling via high performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) for the extracts, and assessment of antioxidant activity via 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), Cupric reducing antioxidant capacity (CUPRAC), ferric reducing antioxidant power (FRAP), metal chelating (MCA), and phosphomolybdenum (PBD) assays. Moreover, antimicrobial activity was assessed against four different bacterial strains, as well as various yeasts. Enzyme inhibitory activities were evaluated against five types of enzymes. Additionally, the extracts were examined for their anticancer and protective effects on several cancer cell lines and the human normal cell line. All of the extracts exhibited significant levels of ferulic acid, kaempferol, and caffeic acid. All tested extracts demonstrated antimicrobial activity, with Escherichia coli and Pseudomonas aeruginosa being most sensitive to EA and ethanol extracts. Molecular docking studies revealed that kaempferol-3-O-glucoside strong interactions with AChE, BChE and tyrosinase. In addition, network pharmacology showed an association between gastric cancer and kaempferol-3-O-glucoside. Based on the results, R. constantinopolitanus can be a potential reservoir of bioactive compounds for future bioproduct innovation and pharmaceutical industries. Flavonoids Computational analysis Antifungal Network pharmacology Novel pharmaceutics Zengin, Gokhan verfasserin aut Piatti, Diletta verfasserin (orcid)0009-0001-9590-5560 aut Uba, Abdullahi Ibrahim verfasserin aut Sagratini, Gianni verfasserin aut Caprioli, Giovanni verfasserin aut Emre, Gizem verfasserin aut Ponniya, Sathish Kumar M. verfasserin aut Rengasamy, Kannan RR. verfasserin aut Paradis, Nicholas Joseph verfasserin (orcid)0000-0002-4402-7315 aut Koyuncu, Ismail verfasserin aut Şeker, Fatma verfasserin aut Wu, Chun verfasserin aut Nilofar verfasserin (orcid)0000-0002-4254-4140 aut Flores, Giancarlo Angeles verfasserin aut Cusumano, Gaia verfasserin aut Angelini, Paola verfasserin aut Venanzoni, Roberto verfasserin aut Enthalten in Food and chemical toxicology New York, NY [u.a.] : Elsevier, 1982 181 Online-Ressource (DE-627)300898487 (DE-600)1483645-2 (DE-576)259270849 1873-6351 nnns volume:181 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.21 Ernährung Medizin VZ AR 181 |
| spelling |
10.1016/j.fct.2023.114064 doi (DE-627)ELV065413938 (ELSEVIER)S0278-6915(23)00466-0 DE-627 ger DE-627 rda eng 630 640 610 VZ 44.21 bkl Lazarova, Irina verfasserin (orcid)0000-0002-8966-545X aut Appraisals on the chemical characterization and biological potentials of 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this context, phytochemicals were extracted from Ranunculus constantinopolitanus using ethyl acetate (EA), ethanol, ethanol/water (70%), and water solvent. The analysis encompassed quantification of total phenolic and flavonoid content using spectrophotometric assays, chemical profiling via high performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) for the extracts, and assessment of antioxidant activity via 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), Cupric reducing antioxidant capacity (CUPRAC), ferric reducing antioxidant power (FRAP), metal chelating (MCA), and phosphomolybdenum (PBD) assays. Moreover, antimicrobial activity was assessed against four different bacterial strains, as well as various yeasts. Enzyme inhibitory activities were evaluated against five types of enzymes. Additionally, the extracts were examined for their anticancer and protective effects on several cancer cell lines and the human normal cell line. All of the extracts exhibited significant levels of ferulic acid, kaempferol, and caffeic acid. All tested extracts demonstrated antimicrobial activity, with Escherichia coli and Pseudomonas aeruginosa being most sensitive to EA and ethanol extracts. Molecular docking studies revealed that kaempferol-3-O-glucoside strong interactions with AChE, BChE and tyrosinase. In addition, network pharmacology showed an association between gastric cancer and kaempferol-3-O-glucoside. Based on the results, R. constantinopolitanus can be a potential reservoir of bioactive compounds for future bioproduct innovation and pharmaceutical industries. Flavonoids Computational analysis Antifungal Network pharmacology Novel pharmaceutics Zengin, Gokhan verfasserin aut Piatti, Diletta verfasserin (orcid)0009-0001-9590-5560 aut Uba, Abdullahi Ibrahim verfasserin aut Sagratini, Gianni verfasserin aut Caprioli, Giovanni verfasserin aut Emre, Gizem verfasserin aut Ponniya, Sathish Kumar M. verfasserin aut Rengasamy, Kannan RR. verfasserin aut Paradis, Nicholas Joseph verfasserin (orcid)0000-0002-4402-7315 aut Koyuncu, Ismail verfasserin aut Şeker, Fatma verfasserin aut Wu, Chun verfasserin aut Nilofar verfasserin (orcid)0000-0002-4254-4140 aut Flores, Giancarlo Angeles verfasserin aut Cusumano, Gaia verfasserin aut Angelini, Paola verfasserin aut Venanzoni, Roberto verfasserin aut Enthalten in Food and chemical toxicology New York, NY [u.a.] : Elsevier, 1982 181 Online-Ressource (DE-627)300898487 (DE-600)1483645-2 (DE-576)259270849 1873-6351 nnns volume:181 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.21 Ernährung Medizin VZ AR 181 |
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10.1016/j.fct.2023.114064 doi (DE-627)ELV065413938 (ELSEVIER)S0278-6915(23)00466-0 DE-627 ger DE-627 rda eng 630 640 610 VZ 44.21 bkl Lazarova, Irina verfasserin (orcid)0000-0002-8966-545X aut Appraisals on the chemical characterization and biological potentials of 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this context, phytochemicals were extracted from Ranunculus constantinopolitanus using ethyl acetate (EA), ethanol, ethanol/water (70%), and water solvent. The analysis encompassed quantification of total phenolic and flavonoid content using spectrophotometric assays, chemical profiling via high performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) for the extracts, and assessment of antioxidant activity via 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), Cupric reducing antioxidant capacity (CUPRAC), ferric reducing antioxidant power (FRAP), metal chelating (MCA), and phosphomolybdenum (PBD) assays. Moreover, antimicrobial activity was assessed against four different bacterial strains, as well as various yeasts. Enzyme inhibitory activities were evaluated against five types of enzymes. Additionally, the extracts were examined for their anticancer and protective effects on several cancer cell lines and the human normal cell line. All of the extracts exhibited significant levels of ferulic acid, kaempferol, and caffeic acid. All tested extracts demonstrated antimicrobial activity, with Escherichia coli and Pseudomonas aeruginosa being most sensitive to EA and ethanol extracts. Molecular docking studies revealed that kaempferol-3-O-glucoside strong interactions with AChE, BChE and tyrosinase. In addition, network pharmacology showed an association between gastric cancer and kaempferol-3-O-glucoside. Based on the results, R. constantinopolitanus can be a potential reservoir of bioactive compounds for future bioproduct innovation and pharmaceutical industries. Flavonoids Computational analysis Antifungal Network pharmacology Novel pharmaceutics Zengin, Gokhan verfasserin aut Piatti, Diletta verfasserin (orcid)0009-0001-9590-5560 aut Uba, Abdullahi Ibrahim verfasserin aut Sagratini, Gianni verfasserin aut Caprioli, Giovanni verfasserin aut Emre, Gizem verfasserin aut Ponniya, Sathish Kumar M. verfasserin aut Rengasamy, Kannan RR. verfasserin aut Paradis, Nicholas Joseph verfasserin (orcid)0000-0002-4402-7315 aut Koyuncu, Ismail verfasserin aut Şeker, Fatma verfasserin aut Wu, Chun verfasserin aut Nilofar verfasserin (orcid)0000-0002-4254-4140 aut Flores, Giancarlo Angeles verfasserin aut Cusumano, Gaia verfasserin aut Angelini, Paola verfasserin aut Venanzoni, Roberto verfasserin aut Enthalten in Food and chemical toxicology New York, NY [u.a.] : Elsevier, 1982 181 Online-Ressource (DE-627)300898487 (DE-600)1483645-2 (DE-576)259270849 1873-6351 nnns volume:181 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.21 Ernährung Medizin VZ AR 181 |
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10.1016/j.fct.2023.114064 doi (DE-627)ELV065413938 (ELSEVIER)S0278-6915(23)00466-0 DE-627 ger DE-627 rda eng 630 640 610 VZ 44.21 bkl Lazarova, Irina verfasserin (orcid)0000-0002-8966-545X aut Appraisals on the chemical characterization and biological potentials of 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this context, phytochemicals were extracted from Ranunculus constantinopolitanus using ethyl acetate (EA), ethanol, ethanol/water (70%), and water solvent. The analysis encompassed quantification of total phenolic and flavonoid content using spectrophotometric assays, chemical profiling via high performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) for the extracts, and assessment of antioxidant activity via 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), Cupric reducing antioxidant capacity (CUPRAC), ferric reducing antioxidant power (FRAP), metal chelating (MCA), and phosphomolybdenum (PBD) assays. Moreover, antimicrobial activity was assessed against four different bacterial strains, as well as various yeasts. Enzyme inhibitory activities were evaluated against five types of enzymes. Additionally, the extracts were examined for their anticancer and protective effects on several cancer cell lines and the human normal cell line. All of the extracts exhibited significant levels of ferulic acid, kaempferol, and caffeic acid. All tested extracts demonstrated antimicrobial activity, with Escherichia coli and Pseudomonas aeruginosa being most sensitive to EA and ethanol extracts. Molecular docking studies revealed that kaempferol-3-O-glucoside strong interactions with AChE, BChE and tyrosinase. In addition, network pharmacology showed an association between gastric cancer and kaempferol-3-O-glucoside. Based on the results, R. constantinopolitanus can be a potential reservoir of bioactive compounds for future bioproduct innovation and pharmaceutical industries. Flavonoids Computational analysis Antifungal Network pharmacology Novel pharmaceutics Zengin, Gokhan verfasserin aut Piatti, Diletta verfasserin (orcid)0009-0001-9590-5560 aut Uba, Abdullahi Ibrahim verfasserin aut Sagratini, Gianni verfasserin aut Caprioli, Giovanni verfasserin aut Emre, Gizem verfasserin aut Ponniya, Sathish Kumar M. verfasserin aut Rengasamy, Kannan RR. verfasserin aut Paradis, Nicholas Joseph verfasserin (orcid)0000-0002-4402-7315 aut Koyuncu, Ismail verfasserin aut Şeker, Fatma verfasserin aut Wu, Chun verfasserin aut Nilofar verfasserin (orcid)0000-0002-4254-4140 aut Flores, Giancarlo Angeles verfasserin aut Cusumano, Gaia verfasserin aut Angelini, Paola verfasserin aut Venanzoni, Roberto verfasserin aut Enthalten in Food and chemical toxicology New York, NY [u.a.] : Elsevier, 1982 181 Online-Ressource (DE-627)300898487 (DE-600)1483645-2 (DE-576)259270849 1873-6351 nnns volume:181 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.21 Ernährung Medizin VZ AR 181 |
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10.1016/j.fct.2023.114064 doi (DE-627)ELV065413938 (ELSEVIER)S0278-6915(23)00466-0 DE-627 ger DE-627 rda eng 630 640 610 VZ 44.21 bkl Lazarova, Irina verfasserin (orcid)0000-0002-8966-545X aut Appraisals on the chemical characterization and biological potentials of 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this context, phytochemicals were extracted from Ranunculus constantinopolitanus using ethyl acetate (EA), ethanol, ethanol/water (70%), and water solvent. The analysis encompassed quantification of total phenolic and flavonoid content using spectrophotometric assays, chemical profiling via high performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) for the extracts, and assessment of antioxidant activity via 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), Cupric reducing antioxidant capacity (CUPRAC), ferric reducing antioxidant power (FRAP), metal chelating (MCA), and phosphomolybdenum (PBD) assays. Moreover, antimicrobial activity was assessed against four different bacterial strains, as well as various yeasts. Enzyme inhibitory activities were evaluated against five types of enzymes. Additionally, the extracts were examined for their anticancer and protective effects on several cancer cell lines and the human normal cell line. All of the extracts exhibited significant levels of ferulic acid, kaempferol, and caffeic acid. All tested extracts demonstrated antimicrobial activity, with Escherichia coli and Pseudomonas aeruginosa being most sensitive to EA and ethanol extracts. Molecular docking studies revealed that kaempferol-3-O-glucoside strong interactions with AChE, BChE and tyrosinase. In addition, network pharmacology showed an association between gastric cancer and kaempferol-3-O-glucoside. Based on the results, R. constantinopolitanus can be a potential reservoir of bioactive compounds for future bioproduct innovation and pharmaceutical industries. Flavonoids Computational analysis Antifungal Network pharmacology Novel pharmaceutics Zengin, Gokhan verfasserin aut Piatti, Diletta verfasserin (orcid)0009-0001-9590-5560 aut Uba, Abdullahi Ibrahim verfasserin aut Sagratini, Gianni verfasserin aut Caprioli, Giovanni verfasserin aut Emre, Gizem verfasserin aut Ponniya, Sathish Kumar M. verfasserin aut Rengasamy, Kannan RR. verfasserin aut Paradis, Nicholas Joseph verfasserin (orcid)0000-0002-4402-7315 aut Koyuncu, Ismail verfasserin aut Şeker, Fatma verfasserin aut Wu, Chun verfasserin aut Nilofar verfasserin (orcid)0000-0002-4254-4140 aut Flores, Giancarlo Angeles verfasserin aut Cusumano, Gaia verfasserin aut Angelini, Paola verfasserin aut Venanzoni, Roberto verfasserin aut Enthalten in Food and chemical toxicology New York, NY [u.a.] : Elsevier, 1982 181 Online-Ressource (DE-627)300898487 (DE-600)1483645-2 (DE-576)259270849 1873-6351 nnns volume:181 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.21 Ernährung Medizin VZ AR 181 |
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Lazarova, Irina @@aut@@ Zengin, Gokhan @@aut@@ Piatti, Diletta @@aut@@ Uba, Abdullahi Ibrahim @@aut@@ Sagratini, Gianni @@aut@@ Caprioli, Giovanni @@aut@@ Emre, Gizem @@aut@@ Ponniya, Sathish Kumar M. @@aut@@ Rengasamy, Kannan RR. @@aut@@ Paradis, Nicholas Joseph @@aut@@ Koyuncu, Ismail @@aut@@ Şeker, Fatma @@aut@@ Wu, Chun @@aut@@ Nilofar @@aut@@ Flores, Giancarlo Angeles @@aut@@ Cusumano, Gaia @@aut@@ Angelini, Paola @@aut@@ Venanzoni, Roberto @@aut@@ |
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Lazarova, Irina |
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Lazarova, Irina Zengin, Gokhan Piatti, Diletta Uba, Abdullahi Ibrahim Sagratini, Gianni Caprioli, Giovanni Emre, Gizem Ponniya, Sathish Kumar M. Rengasamy, Kannan RR. Paradis, Nicholas Joseph Koyuncu, Ismail Şeker, Fatma Wu, Chun Nilofar Flores, Giancarlo Angeles Cusumano, Gaia Angelini, Paola Venanzoni, Roberto |
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10.1016/j.fct.2023.114064 |
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appraisals on the chemical characterization and biological potentials of |
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Appraisals on the chemical characterization and biological potentials of |
| abstract |
In this context, phytochemicals were extracted from Ranunculus constantinopolitanus using ethyl acetate (EA), ethanol, ethanol/water (70%), and water solvent. The analysis encompassed quantification of total phenolic and flavonoid content using spectrophotometric assays, chemical profiling via high performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) for the extracts, and assessment of antioxidant activity via 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), Cupric reducing antioxidant capacity (CUPRAC), ferric reducing antioxidant power (FRAP), metal chelating (MCA), and phosphomolybdenum (PBD) assays. Moreover, antimicrobial activity was assessed against four different bacterial strains, as well as various yeasts. Enzyme inhibitory activities were evaluated against five types of enzymes. Additionally, the extracts were examined for their anticancer and protective effects on several cancer cell lines and the human normal cell line. All of the extracts exhibited significant levels of ferulic acid, kaempferol, and caffeic acid. All tested extracts demonstrated antimicrobial activity, with Escherichia coli and Pseudomonas aeruginosa being most sensitive to EA and ethanol extracts. Molecular docking studies revealed that kaempferol-3-O-glucoside strong interactions with AChE, BChE and tyrosinase. In addition, network pharmacology showed an association between gastric cancer and kaempferol-3-O-glucoside. Based on the results, R. constantinopolitanus can be a potential reservoir of bioactive compounds for future bioproduct innovation and pharmaceutical industries. |
| abstractGer |
In this context, phytochemicals were extracted from Ranunculus constantinopolitanus using ethyl acetate (EA), ethanol, ethanol/water (70%), and water solvent. The analysis encompassed quantification of total phenolic and flavonoid content using spectrophotometric assays, chemical profiling via high performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) for the extracts, and assessment of antioxidant activity via 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), Cupric reducing antioxidant capacity (CUPRAC), ferric reducing antioxidant power (FRAP), metal chelating (MCA), and phosphomolybdenum (PBD) assays. Moreover, antimicrobial activity was assessed against four different bacterial strains, as well as various yeasts. Enzyme inhibitory activities were evaluated against five types of enzymes. Additionally, the extracts were examined for their anticancer and protective effects on several cancer cell lines and the human normal cell line. All of the extracts exhibited significant levels of ferulic acid, kaempferol, and caffeic acid. All tested extracts demonstrated antimicrobial activity, with Escherichia coli and Pseudomonas aeruginosa being most sensitive to EA and ethanol extracts. Molecular docking studies revealed that kaempferol-3-O-glucoside strong interactions with AChE, BChE and tyrosinase. In addition, network pharmacology showed an association between gastric cancer and kaempferol-3-O-glucoside. Based on the results, R. constantinopolitanus can be a potential reservoir of bioactive compounds for future bioproduct innovation and pharmaceutical industries. |
| abstract_unstemmed |
In this context, phytochemicals were extracted from Ranunculus constantinopolitanus using ethyl acetate (EA), ethanol, ethanol/water (70%), and water solvent. The analysis encompassed quantification of total phenolic and flavonoid content using spectrophotometric assays, chemical profiling via high performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) for the extracts, and assessment of antioxidant activity via 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), Cupric reducing antioxidant capacity (CUPRAC), ferric reducing antioxidant power (FRAP), metal chelating (MCA), and phosphomolybdenum (PBD) assays. Moreover, antimicrobial activity was assessed against four different bacterial strains, as well as various yeasts. Enzyme inhibitory activities were evaluated against five types of enzymes. Additionally, the extracts were examined for their anticancer and protective effects on several cancer cell lines and the human normal cell line. All of the extracts exhibited significant levels of ferulic acid, kaempferol, and caffeic acid. All tested extracts demonstrated antimicrobial activity, with Escherichia coli and Pseudomonas aeruginosa being most sensitive to EA and ethanol extracts. Molecular docking studies revealed that kaempferol-3-O-glucoside strong interactions with AChE, BChE and tyrosinase. In addition, network pharmacology showed an association between gastric cancer and kaempferol-3-O-glucoside. Based on the results, R. constantinopolitanus can be a potential reservoir of bioactive compounds for future bioproduct innovation and pharmaceutical industries. |
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Zengin, Gokhan Piatti, Diletta Uba, Abdullahi Ibrahim Sagratini, Gianni Caprioli, Giovanni Emre, Gizem Ponniya, Sathish Kumar M. Rengasamy, Kannan RR Paradis, Nicholas Joseph Koyuncu, Ismail Şeker, Fatma Wu, Chun Nilofar Flores, Giancarlo Angeles Cusumano, Gaia Angelini, Paola Venanzoni, Roberto |
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10.1016/j.fct.2023.114064 |
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2024-07-06T22:56:55.509Z |
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