Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy

Background: Implantable cardioverter-defibrillator (ICD) therapy is the most effective prophylactic strategy against sudden cardiac death (SCD) in patients with ischemic cardiomyopathy (ICM) and left ventricle ejection fraction (LVEF) ≤35% as detected by transthoracic echocardiograpgy (TTE). This ap...
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Autor*in:	Pontone, Gianluca [verfasserIn] Guaricci, Andrea Igoren [verfasserIn] Fusini, Laura [verfasserIn] Baggiano, Andrea [verfasserIn] Guglielmo, Marco [verfasserIn] Muscogiuri, Giuseppe [verfasserIn] Volpe, Alessandra [verfasserIn] Abete, Raffaele [verfasserIn] Aquaro, Giovanni [verfasserIn] Barison, Andrea [verfasserIn] Bogaert, Jan [verfasserIn] Camastra, Giovanni [verfasserIn] Carigi, Samuela [verfasserIn] Carrabba, Nazario [verfasserIn] Casavecchia, Grazia [verfasserIn] Censi, Stefano [verfasserIn] Cicala, Gloria [verfasserIn] De Cecco, Carlo N. [verfasserIn] De Lazzari, Manuel [verfasserIn] Di Giovine, Gabriella [verfasserIn] Di Roma, Mauro [verfasserIn] Dobrovie, Monica [verfasserIn] Focardi, Marta [verfasserIn] Gaibazzi, Nicola [verfasserIn] Gismondi, Annalaura [verfasserIn] Gravina, Matteo [verfasserIn] Lanzillo, Chiara [verfasserIn] Lombardi, Massimo [verfasserIn] Lorenzoni, Valentina [verfasserIn] Lozano-Torres, Jordi [verfasserIn] Martini, Chiara [verfasserIn] Marzo, Francesca [verfasserIn] Masi, Ambra [verfasserIn] Memeo, Riccardo [verfasserIn] Moro, Claudio [verfasserIn] Nese, Alberto [verfasserIn] Palumbo, Alessandro [verfasserIn] Pavon, Anna Giulia [verfasserIn] Pedrotti, Patrizia [verfasserIn] Marra, Martina Perazzolo [verfasserIn] Pica, Silvia [verfasserIn] Pradella, Silvia [verfasserIn] Presicci, Cristina [verfasserIn] Rabbat, Mark G. [verfasserIn] Raineri, Claudia [verfasserIn] Rodriguez-Palomares, José F. [verfasserIn] Sbarbati, Stefano [verfasserIn] Schoepf, U. Joseph [verfasserIn] Squeri, Angelo [verfasserIn] Sverzellati, Nicola [verfasserIn] Symons, Rolf [verfasserIn] Tat, Emily [verfasserIn] Timpani, Mauro [verfasserIn] Todiere, Giancarlo [verfasserIn] Valentini, Adele [verfasserIn] Varga-Szemes, Akos [verfasserIn] Masci, Pier-Giorgio [verfasserIn] Schwitter, Juerg [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	cardiac magnetic resonance heart failure implantable cardioverter-defibrillator ischemic dilated cardiomyopathy primary prevention

Übergeordnetes Werk:	Enthalten in: JACC Cardiovascular imaging - American College of Cardiology ; ID: gnd/1017722-X, Amsterdam : Elsevier, 2008, 16, Seite 1387-1400
Übergeordnetes Werk:	volume:16 ; pages:1387-1400

DOI / URN:	10.1016/j.jcmg.2023.03.015

Katalog-ID:	ELV065466683

Internformat


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024	7		\|a 10.1016/j.jcmg.2023.03.015 \|2 doi
035			\|a (DE-627)ELV065466683
035			\|a (ELSEVIER)S1936-878X(23)00181-X
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041			\|a eng
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084			\|a 44.85 \|2 bkl
084			\|a 44.64 \|2 bkl
100	1		\|a Pontone, Gianluca \|e verfasserin \|4 aut
245	1	0	\|a Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy
264		1	\|c 2023
336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Background: Implantable cardioverter-defibrillator (ICD) therapy is the most effective prophylactic strategy against sudden cardiac death (SCD) in patients with ischemic cardiomyopathy (ICM) and left ventricle ejection fraction (LVEF) ≤35% as detected by transthoracic echocardiograpgy (TTE). This approach has been recently questioned because of the low rate of ICD interventions in patients who received implantation and the not-negligible percentage of patients who experienced SCD despite not fulfilling criteria for implantation.Objectives: The DERIVATE-ICM registry (CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DebrillAtor ThErapy; NCT03352648) is an international, multicenter, and multivendor study to assess the net reclassification improvement (NRI) for the indication of ICD implantation by the use of cardiac magnetic resonance (CMR) as compared to TTE in patients with ICM.Methods: A total of 861 patients with ICM (mean age 65 ± 11 years, 86% male) with chronic heart failure and TTE-LVEF <50% participated. Major adverse arrhythmic cardiac events (MAACE) were the primary endpoints.Results: During a median follow-up of 1,054 days, MAACE occurred in 88 (10.2%). Left ventricular end-diastolic volume index (HR: 1.007 [95% CI: 1.000-1.011]; P = 0.05), CMR-LVEF (HR: 0.972 [95% CI: 0.945-0.999]; P = 0.045) and late gadolinium enhancement (LGE) mass (HR: 1.010 [95% CI: 1.002-1.018]; P = 0.015) were independent predictors of MAACE. A multiparametric CMR weighted predictive derived score identifies subjects at high risk for MAACE compared with TTE-LVEF cutoff of 35% with a NRI of 31.7% (P = 0.007).Conclusions: The DERIVATE-ICM registry is a large multicenter registry showing the additional value of CMR to stratify the risk for MAACE in a large cohort of patients with ICM compared with standard of care.
650		4	\|a cardiac magnetic resonance
650		4	\|a heart failure
650		4	\|a implantable cardioverter-defibrillator
650		4	\|a ischemic dilated cardiomyopathy
650		4	\|a primary prevention
700	1		\|a Guaricci, Andrea Igoren \|e verfasserin \|0 (orcid)0000-0001-7133-4401 \|4 aut
700	1		\|a Fusini, Laura \|e verfasserin \|0 (orcid)0000-0003-0309-6231 \|4 aut
700	1		\|a Baggiano, Andrea \|e verfasserin \|4 aut
700	1		\|a Guglielmo, Marco \|e verfasserin \|4 aut
700	1		\|a Muscogiuri, Giuseppe \|e verfasserin \|4 aut
700	1		\|a Volpe, Alessandra \|e verfasserin \|4 aut
700	1		\|a Abete, Raffaele \|e verfasserin \|4 aut
700	1		\|a Aquaro, Giovanni \|e verfasserin \|4 aut
700	1		\|a Barison, Andrea \|e verfasserin \|0 (orcid)0000-0001-9042-340X \|4 aut
700	1		\|a Bogaert, Jan \|e verfasserin \|4 aut
700	1		\|a Camastra, Giovanni \|e verfasserin \|4 aut
700	1		\|a Carigi, Samuela \|e verfasserin \|4 aut
700	1		\|a Carrabba, Nazario \|e verfasserin \|0 (orcid)0000-0002-5190-5227 \|4 aut
700	1		\|a Casavecchia, Grazia \|e verfasserin \|4 aut
700	1		\|a Censi, Stefano \|e verfasserin \|4 aut
700	1		\|a Cicala, Gloria \|e verfasserin \|4 aut
700	1		\|a De Cecco, Carlo N. \|e verfasserin \|4 aut
700	1		\|a De Lazzari, Manuel \|e verfasserin \|4 aut
700	1		\|a Di Giovine, Gabriella \|e verfasserin \|4 aut
700	1		\|a Di Roma, Mauro \|e verfasserin \|4 aut
700	1		\|a Dobrovie, Monica \|e verfasserin \|4 aut
700	1		\|a Focardi, Marta \|e verfasserin \|4 aut
700	1		\|a Gaibazzi, Nicola \|e verfasserin \|4 aut
700	1		\|a Gismondi, Annalaura \|e verfasserin \|4 aut
700	1		\|a Gravina, Matteo \|e verfasserin \|4 aut
700	1		\|a Lanzillo, Chiara \|e verfasserin \|4 aut
700	1		\|a Lombardi, Massimo \|e verfasserin \|4 aut
700	1		\|a Lorenzoni, Valentina \|e verfasserin \|4 aut
700	1		\|a Lozano-Torres, Jordi \|e verfasserin \|4 aut
700	1		\|a Martini, Chiara \|e verfasserin \|4 aut
700	1		\|a Marzo, Francesca \|e verfasserin \|4 aut
700	1		\|a Masi, Ambra \|e verfasserin \|4 aut
700	1		\|a Memeo, Riccardo \|e verfasserin \|4 aut
700	1		\|a Moro, Claudio \|e verfasserin \|4 aut
700	1		\|a Nese, Alberto \|e verfasserin \|4 aut
700	1		\|a Palumbo, Alessandro \|e verfasserin \|4 aut
700	1		\|a Pavon, Anna Giulia \|e verfasserin \|4 aut
700	1		\|a Pedrotti, Patrizia \|e verfasserin \|4 aut
700	1		\|a Marra, Martina Perazzolo \|e verfasserin \|4 aut
700	1		\|a Pica, Silvia \|e verfasserin \|4 aut
700	1		\|a Pradella, Silvia \|e verfasserin \|4 aut
700	1		\|a Presicci, Cristina \|e verfasserin \|4 aut
700	1		\|a Rabbat, Mark G. \|e verfasserin \|4 aut
700	1		\|a Raineri, Claudia \|e verfasserin \|4 aut
700	1		\|a Rodriguez-Palomares, José F. \|e verfasserin \|0 (orcid)0000-0002-7229-9780 \|4 aut
700	1		\|a Sbarbati, Stefano \|e verfasserin \|4 aut
700	1		\|a Schoepf, U. Joseph \|e verfasserin \|4 aut
700	1		\|a Squeri, Angelo \|e verfasserin \|4 aut
700	1		\|a Sverzellati, Nicola \|e verfasserin \|4 aut
700	1		\|a Symons, Rolf \|e verfasserin \|4 aut
700	1		\|a Tat, Emily \|e verfasserin \|4 aut
700	1		\|a Timpani, Mauro \|e verfasserin \|4 aut
700	1		\|a Todiere, Giancarlo \|e verfasserin \|4 aut
700	1		\|a Valentini, Adele \|e verfasserin \|4 aut
700	1		\|a Varga-Szemes, Akos \|e verfasserin \|4 aut
700	1		\|a Masci, Pier-Giorgio \|e verfasserin \|4 aut
700	1		\|a Schwitter, Juerg \|e verfasserin \|0 (orcid)0000-0002-9966-6149 \|4 aut
773	0	8	\|i Enthalten in \|a American College of Cardiology ; ID: gnd/1017722-X \|t JACC Cardiovascular imaging \|d Amsterdam : Elsevier, 2008 \|g 16, Seite 1387-1400 \|h Online-Ressource \|w (DE-627)559427239 \|w (DE-600)2412441-2 \|w (DE-576)294402861 \|x 1876-7591 \|7 nnns
773	1	8	\|g volume:16 \|g pages:1387-1400
912			\|a GBV_USEFLAG_U
912			\|a GBV_ELV
912			\|a SYSFLAG_U
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912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_32
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_95
912			\|a GBV_ILN_100
912			\|a GBV_ILN_101
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_187
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2190
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912			\|a GBV_ILN_2507
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4035
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912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
936	b	k	\|a 44.85 \|j Kardiologie \|j Angiologie \|q VZ
936	b	k	\|a 44.64 \|j Radiologie \|q VZ
951			\|a AR
952			\|d 16 \|h 1387-1400

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author_variant	g p gp a i g ai aig l f lf a b ab m g mg g m gm a v av r a ra g a ga a b ab j b jb g c gc s c sc n c nc g c gc s c sc g c gc c c n d ccn ccnd l m d lm lmd g g d gg ggd r m d rm rmd m d md m f mf n g ng a g ag m g mg c l cl m l ml v l vl j l t jlt c m cm f m fm a m am r m rm c m cm a n an a p ap a g p ag agp p p pp m p m mp mpm s p sp s p sp c p cp m g r mg mgr c r cr j f r p jfr jfrp s s ss u j s uj ujs a s as n s ns r s rs e t et m t mt g t gt a v av a v s avs p g m pgm j s js
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publishDate	2023
allfields	10.1016/j.jcmg.2023.03.015 doi (DE-627)ELV065466683 (ELSEVIER)S1936-878X(23)00181-X DE-627 ger DE-627 rda eng 610 VZ 44.85 bkl 44.64 bkl Pontone, Gianluca verfasserin aut Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Implantable cardioverter-defibrillator (ICD) therapy is the most effective prophylactic strategy against sudden cardiac death (SCD) in patients with ischemic cardiomyopathy (ICM) and left ventricle ejection fraction (LVEF) ≤35% as detected by transthoracic echocardiograpgy (TTE). This approach has been recently questioned because of the low rate of ICD interventions in patients who received implantation and the not-negligible percentage of patients who experienced SCD despite not fulfilling criteria for implantation.Objectives: The DERIVATE-ICM registry (CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DebrillAtor ThErapy; NCT03352648) is an international, multicenter, and multivendor study to assess the net reclassification improvement (NRI) for the indication of ICD implantation by the use of cardiac magnetic resonance (CMR) as compared to TTE in patients with ICM.Methods: A total of 861 patients with ICM (mean age 65 ± 11 years, 86% male) with chronic heart failure and TTE-LVEF <50% participated. Major adverse arrhythmic cardiac events (MAACE) were the primary endpoints.Results: During a median follow-up of 1,054 days, MAACE occurred in 88 (10.2%). Left ventricular end-diastolic volume index (HR: 1.007 [95% CI: 1.000-1.011]; P = 0.05), CMR-LVEF (HR: 0.972 [95% CI: 0.945-0.999]; P = 0.045) and late gadolinium enhancement (LGE) mass (HR: 1.010 [95% CI: 1.002-1.018]; P = 0.015) were independent predictors of MAACE. A multiparametric CMR weighted predictive derived score identifies subjects at high risk for MAACE compared with TTE-LVEF cutoff of 35% with a NRI of 31.7% (P = 0.007).Conclusions: The DERIVATE-ICM registry is a large multicenter registry showing the additional value of CMR to stratify the risk for MAACE in a large cohort of patients with ICM compared with standard of care. cardiac magnetic resonance heart failure implantable cardioverter-defibrillator ischemic dilated cardiomyopathy primary prevention Guaricci, Andrea Igoren verfasserin (orcid)0000-0001-7133-4401 aut Fusini, Laura verfasserin (orcid)0000-0003-0309-6231 aut Baggiano, Andrea verfasserin aut Guglielmo, Marco verfasserin aut Muscogiuri, Giuseppe verfasserin aut Volpe, Alessandra verfasserin aut Abete, Raffaele verfasserin aut Aquaro, Giovanni verfasserin aut Barison, Andrea verfasserin (orcid)0000-0001-9042-340X aut Bogaert, Jan verfasserin aut Camastra, Giovanni verfasserin aut Carigi, Samuela verfasserin aut Carrabba, Nazario verfasserin (orcid)0000-0002-5190-5227 aut Casavecchia, Grazia verfasserin aut Censi, Stefano verfasserin aut Cicala, Gloria verfasserin aut De Cecco, Carlo N. verfasserin aut De Lazzari, Manuel verfasserin aut Di Giovine, Gabriella verfasserin aut Di Roma, Mauro verfasserin aut Dobrovie, Monica verfasserin aut Focardi, Marta verfasserin aut Gaibazzi, Nicola verfasserin aut Gismondi, Annalaura verfasserin aut Gravina, Matteo verfasserin aut Lanzillo, Chiara verfasserin aut Lombardi, Massimo verfasserin aut Lorenzoni, Valentina verfasserin aut Lozano-Torres, Jordi verfasserin aut Martini, Chiara verfasserin aut Marzo, Francesca verfasserin aut Masi, Ambra verfasserin aut Memeo, Riccardo verfasserin aut Moro, Claudio verfasserin aut Nese, Alberto verfasserin aut Palumbo, Alessandro verfasserin aut Pavon, Anna Giulia verfasserin aut Pedrotti, Patrizia verfasserin aut Marra, Martina Perazzolo verfasserin aut Pica, Silvia verfasserin aut Pradella, Silvia verfasserin aut Presicci, Cristina verfasserin aut Rabbat, Mark G. verfasserin aut Raineri, Claudia verfasserin aut Rodriguez-Palomares, José F. verfasserin (orcid)0000-0002-7229-9780 aut Sbarbati, Stefano verfasserin aut Schoepf, U. Joseph verfasserin aut Squeri, Angelo verfasserin aut Sverzellati, Nicola verfasserin aut Symons, Rolf verfasserin aut Tat, Emily verfasserin aut Timpani, Mauro verfasserin aut Todiere, Giancarlo verfasserin aut Valentini, Adele verfasserin aut Varga-Szemes, Akos verfasserin aut Masci, Pier-Giorgio verfasserin aut Schwitter, Juerg verfasserin (orcid)0000-0002-9966-6149 aut Enthalten in American College of Cardiology ; ID: gnd/1017722-X JACC Cardiovascular imaging Amsterdam : Elsevier, 2008 16, Seite 1387-1400 Online-Ressource (DE-627)559427239 (DE-600)2412441-2 (DE-576)294402861 1876-7591 nnns volume:16 pages:1387-1400 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.85 Kardiologie Angiologie VZ 44.64 Radiologie VZ AR 16 1387-1400
spelling	10.1016/j.jcmg.2023.03.015 doi (DE-627)ELV065466683 (ELSEVIER)S1936-878X(23)00181-X DE-627 ger DE-627 rda eng 610 VZ 44.85 bkl 44.64 bkl Pontone, Gianluca verfasserin aut Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Implantable cardioverter-defibrillator (ICD) therapy is the most effective prophylactic strategy against sudden cardiac death (SCD) in patients with ischemic cardiomyopathy (ICM) and left ventricle ejection fraction (LVEF) ≤35% as detected by transthoracic echocardiograpgy (TTE). This approach has been recently questioned because of the low rate of ICD interventions in patients who received implantation and the not-negligible percentage of patients who experienced SCD despite not fulfilling criteria for implantation.Objectives: The DERIVATE-ICM registry (CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DebrillAtor ThErapy; NCT03352648) is an international, multicenter, and multivendor study to assess the net reclassification improvement (NRI) for the indication of ICD implantation by the use of cardiac magnetic resonance (CMR) as compared to TTE in patients with ICM.Methods: A total of 861 patients with ICM (mean age 65 ± 11 years, 86% male) with chronic heart failure and TTE-LVEF <50% participated. Major adverse arrhythmic cardiac events (MAACE) were the primary endpoints.Results: During a median follow-up of 1,054 days, MAACE occurred in 88 (10.2%). Left ventricular end-diastolic volume index (HR: 1.007 [95% CI: 1.000-1.011]; P = 0.05), CMR-LVEF (HR: 0.972 [95% CI: 0.945-0.999]; P = 0.045) and late gadolinium enhancement (LGE) mass (HR: 1.010 [95% CI: 1.002-1.018]; P = 0.015) were independent predictors of MAACE. A multiparametric CMR weighted predictive derived score identifies subjects at high risk for MAACE compared with TTE-LVEF cutoff of 35% with a NRI of 31.7% (P = 0.007).Conclusions: The DERIVATE-ICM registry is a large multicenter registry showing the additional value of CMR to stratify the risk for MAACE in a large cohort of patients with ICM compared with standard of care. cardiac magnetic resonance heart failure implantable cardioverter-defibrillator ischemic dilated cardiomyopathy primary prevention Guaricci, Andrea Igoren verfasserin (orcid)0000-0001-7133-4401 aut Fusini, Laura verfasserin (orcid)0000-0003-0309-6231 aut Baggiano, Andrea verfasserin aut Guglielmo, Marco verfasserin aut Muscogiuri, Giuseppe verfasserin aut Volpe, Alessandra verfasserin aut Abete, Raffaele verfasserin aut Aquaro, Giovanni verfasserin aut Barison, Andrea verfasserin (orcid)0000-0001-9042-340X aut Bogaert, Jan verfasserin aut Camastra, Giovanni verfasserin aut Carigi, Samuela verfasserin aut Carrabba, Nazario verfasserin (orcid)0000-0002-5190-5227 aut Casavecchia, Grazia verfasserin aut Censi, Stefano verfasserin aut Cicala, Gloria verfasserin aut De Cecco, Carlo N. verfasserin aut De Lazzari, Manuel verfasserin aut Di Giovine, Gabriella verfasserin aut Di Roma, Mauro verfasserin aut Dobrovie, Monica verfasserin aut Focardi, Marta verfasserin aut Gaibazzi, Nicola verfasserin aut Gismondi, Annalaura verfasserin aut Gravina, Matteo verfasserin aut Lanzillo, Chiara verfasserin aut Lombardi, Massimo verfasserin aut Lorenzoni, Valentina verfasserin aut Lozano-Torres, Jordi verfasserin aut Martini, Chiara verfasserin aut Marzo, Francesca verfasserin aut Masi, Ambra verfasserin aut Memeo, Riccardo verfasserin aut Moro, Claudio verfasserin aut Nese, Alberto verfasserin aut Palumbo, Alessandro verfasserin aut Pavon, Anna Giulia verfasserin aut Pedrotti, Patrizia verfasserin aut Marra, Martina Perazzolo verfasserin aut Pica, Silvia verfasserin aut Pradella, Silvia verfasserin aut Presicci, Cristina verfasserin aut Rabbat, Mark G. verfasserin aut Raineri, Claudia verfasserin aut Rodriguez-Palomares, José F. verfasserin (orcid)0000-0002-7229-9780 aut Sbarbati, Stefano verfasserin aut Schoepf, U. Joseph verfasserin aut Squeri, Angelo verfasserin aut Sverzellati, Nicola verfasserin aut Symons, Rolf verfasserin aut Tat, Emily verfasserin aut Timpani, Mauro verfasserin aut Todiere, Giancarlo verfasserin aut Valentini, Adele verfasserin aut Varga-Szemes, Akos verfasserin aut Masci, Pier-Giorgio verfasserin aut Schwitter, Juerg verfasserin (orcid)0000-0002-9966-6149 aut Enthalten in American College of Cardiology ; ID: gnd/1017722-X JACC Cardiovascular imaging Amsterdam : Elsevier, 2008 16, Seite 1387-1400 Online-Ressource (DE-627)559427239 (DE-600)2412441-2 (DE-576)294402861 1876-7591 nnns volume:16 pages:1387-1400 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.85 Kardiologie Angiologie VZ 44.64 Radiologie VZ AR 16 1387-1400
allfields_unstemmed	10.1016/j.jcmg.2023.03.015 doi (DE-627)ELV065466683 (ELSEVIER)S1936-878X(23)00181-X DE-627 ger DE-627 rda eng 610 VZ 44.85 bkl 44.64 bkl Pontone, Gianluca verfasserin aut Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Implantable cardioverter-defibrillator (ICD) therapy is the most effective prophylactic strategy against sudden cardiac death (SCD) in patients with ischemic cardiomyopathy (ICM) and left ventricle ejection fraction (LVEF) ≤35% as detected by transthoracic echocardiograpgy (TTE). This approach has been recently questioned because of the low rate of ICD interventions in patients who received implantation and the not-negligible percentage of patients who experienced SCD despite not fulfilling criteria for implantation.Objectives: The DERIVATE-ICM registry (CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DebrillAtor ThErapy; NCT03352648) is an international, multicenter, and multivendor study to assess the net reclassification improvement (NRI) for the indication of ICD implantation by the use of cardiac magnetic resonance (CMR) as compared to TTE in patients with ICM.Methods: A total of 861 patients with ICM (mean age 65 ± 11 years, 86% male) with chronic heart failure and TTE-LVEF <50% participated. Major adverse arrhythmic cardiac events (MAACE) were the primary endpoints.Results: During a median follow-up of 1,054 days, MAACE occurred in 88 (10.2%). Left ventricular end-diastolic volume index (HR: 1.007 [95% CI: 1.000-1.011]; P = 0.05), CMR-LVEF (HR: 0.972 [95% CI: 0.945-0.999]; P = 0.045) and late gadolinium enhancement (LGE) mass (HR: 1.010 [95% CI: 1.002-1.018]; P = 0.015) were independent predictors of MAACE. A multiparametric CMR weighted predictive derived score identifies subjects at high risk for MAACE compared with TTE-LVEF cutoff of 35% with a NRI of 31.7% (P = 0.007).Conclusions: The DERIVATE-ICM registry is a large multicenter registry showing the additional value of CMR to stratify the risk for MAACE in a large cohort of patients with ICM compared with standard of care. cardiac magnetic resonance heart failure implantable cardioverter-defibrillator ischemic dilated cardiomyopathy primary prevention Guaricci, Andrea Igoren verfasserin (orcid)0000-0001-7133-4401 aut Fusini, Laura verfasserin (orcid)0000-0003-0309-6231 aut Baggiano, Andrea verfasserin aut Guglielmo, Marco verfasserin aut Muscogiuri, Giuseppe verfasserin aut Volpe, Alessandra verfasserin aut Abete, Raffaele verfasserin aut Aquaro, Giovanni verfasserin aut Barison, Andrea verfasserin (orcid)0000-0001-9042-340X aut Bogaert, Jan verfasserin aut Camastra, Giovanni verfasserin aut Carigi, Samuela verfasserin aut Carrabba, Nazario verfasserin (orcid)0000-0002-5190-5227 aut Casavecchia, Grazia verfasserin aut Censi, Stefano verfasserin aut Cicala, Gloria verfasserin aut De Cecco, Carlo N. verfasserin aut De Lazzari, Manuel verfasserin aut Di Giovine, Gabriella verfasserin aut Di Roma, Mauro verfasserin aut Dobrovie, Monica verfasserin aut Focardi, Marta verfasserin aut Gaibazzi, Nicola verfasserin aut Gismondi, Annalaura verfasserin aut Gravina, Matteo verfasserin aut Lanzillo, Chiara verfasserin aut Lombardi, Massimo verfasserin aut Lorenzoni, Valentina verfasserin aut Lozano-Torres, Jordi verfasserin aut Martini, Chiara verfasserin aut Marzo, Francesca verfasserin aut Masi, Ambra verfasserin aut Memeo, Riccardo verfasserin aut Moro, Claudio verfasserin aut Nese, Alberto verfasserin aut Palumbo, Alessandro verfasserin aut Pavon, Anna Giulia verfasserin aut Pedrotti, Patrizia verfasserin aut Marra, Martina Perazzolo verfasserin aut Pica, Silvia verfasserin aut Pradella, Silvia verfasserin aut Presicci, Cristina verfasserin aut Rabbat, Mark G. verfasserin aut Raineri, Claudia verfasserin aut Rodriguez-Palomares, José F. verfasserin (orcid)0000-0002-7229-9780 aut Sbarbati, Stefano verfasserin aut Schoepf, U. Joseph verfasserin aut Squeri, Angelo verfasserin aut Sverzellati, Nicola verfasserin aut Symons, Rolf verfasserin aut Tat, Emily verfasserin aut Timpani, Mauro verfasserin aut Todiere, Giancarlo verfasserin aut Valentini, Adele verfasserin aut Varga-Szemes, Akos verfasserin aut Masci, Pier-Giorgio verfasserin aut Schwitter, Juerg verfasserin (orcid)0000-0002-9966-6149 aut Enthalten in American College of Cardiology ; ID: gnd/1017722-X JACC Cardiovascular imaging Amsterdam : Elsevier, 2008 16, Seite 1387-1400 Online-Ressource (DE-627)559427239 (DE-600)2412441-2 (DE-576)294402861 1876-7591 nnns volume:16 pages:1387-1400 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.85 Kardiologie Angiologie VZ 44.64 Radiologie VZ AR 16 1387-1400
allfieldsGer	10.1016/j.jcmg.2023.03.015 doi (DE-627)ELV065466683 (ELSEVIER)S1936-878X(23)00181-X DE-627 ger DE-627 rda eng 610 VZ 44.85 bkl 44.64 bkl Pontone, Gianluca verfasserin aut Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Implantable cardioverter-defibrillator (ICD) therapy is the most effective prophylactic strategy against sudden cardiac death (SCD) in patients with ischemic cardiomyopathy (ICM) and left ventricle ejection fraction (LVEF) ≤35% as detected by transthoracic echocardiograpgy (TTE). This approach has been recently questioned because of the low rate of ICD interventions in patients who received implantation and the not-negligible percentage of patients who experienced SCD despite not fulfilling criteria for implantation.Objectives: The DERIVATE-ICM registry (CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DebrillAtor ThErapy; NCT03352648) is an international, multicenter, and multivendor study to assess the net reclassification improvement (NRI) for the indication of ICD implantation by the use of cardiac magnetic resonance (CMR) as compared to TTE in patients with ICM.Methods: A total of 861 patients with ICM (mean age 65 ± 11 years, 86% male) with chronic heart failure and TTE-LVEF <50% participated. Major adverse arrhythmic cardiac events (MAACE) were the primary endpoints.Results: During a median follow-up of 1,054 days, MAACE occurred in 88 (10.2%). Left ventricular end-diastolic volume index (HR: 1.007 [95% CI: 1.000-1.011]; P = 0.05), CMR-LVEF (HR: 0.972 [95% CI: 0.945-0.999]; P = 0.045) and late gadolinium enhancement (LGE) mass (HR: 1.010 [95% CI: 1.002-1.018]; P = 0.015) were independent predictors of MAACE. A multiparametric CMR weighted predictive derived score identifies subjects at high risk for MAACE compared with TTE-LVEF cutoff of 35% with a NRI of 31.7% (P = 0.007).Conclusions: The DERIVATE-ICM registry is a large multicenter registry showing the additional value of CMR to stratify the risk for MAACE in a large cohort of patients with ICM compared with standard of care. cardiac magnetic resonance heart failure implantable cardioverter-defibrillator ischemic dilated cardiomyopathy primary prevention Guaricci, Andrea Igoren verfasserin (orcid)0000-0001-7133-4401 aut Fusini, Laura verfasserin (orcid)0000-0003-0309-6231 aut Baggiano, Andrea verfasserin aut Guglielmo, Marco verfasserin aut Muscogiuri, Giuseppe verfasserin aut Volpe, Alessandra verfasserin aut Abete, Raffaele verfasserin aut Aquaro, Giovanni verfasserin aut Barison, Andrea verfasserin (orcid)0000-0001-9042-340X aut Bogaert, Jan verfasserin aut Camastra, Giovanni verfasserin aut Carigi, Samuela verfasserin aut Carrabba, Nazario verfasserin (orcid)0000-0002-5190-5227 aut Casavecchia, Grazia verfasserin aut Censi, Stefano verfasserin aut Cicala, Gloria verfasserin aut De Cecco, Carlo N. verfasserin aut De Lazzari, Manuel verfasserin aut Di Giovine, Gabriella verfasserin aut Di Roma, Mauro verfasserin aut Dobrovie, Monica verfasserin aut Focardi, Marta verfasserin aut Gaibazzi, Nicola verfasserin aut Gismondi, Annalaura verfasserin aut Gravina, Matteo verfasserin aut Lanzillo, Chiara verfasserin aut Lombardi, Massimo verfasserin aut Lorenzoni, Valentina verfasserin aut Lozano-Torres, Jordi verfasserin aut Martini, Chiara verfasserin aut Marzo, Francesca verfasserin aut Masi, Ambra verfasserin aut Memeo, Riccardo verfasserin aut Moro, Claudio verfasserin aut Nese, Alberto verfasserin aut Palumbo, Alessandro verfasserin aut Pavon, Anna Giulia verfasserin aut Pedrotti, Patrizia verfasserin aut Marra, Martina Perazzolo verfasserin aut Pica, Silvia verfasserin aut Pradella, Silvia verfasserin aut Presicci, Cristina verfasserin aut Rabbat, Mark G. verfasserin aut Raineri, Claudia verfasserin aut Rodriguez-Palomares, José F. verfasserin (orcid)0000-0002-7229-9780 aut Sbarbati, Stefano verfasserin aut Schoepf, U. Joseph verfasserin aut Squeri, Angelo verfasserin aut Sverzellati, Nicola verfasserin aut Symons, Rolf verfasserin aut Tat, Emily verfasserin aut Timpani, Mauro verfasserin aut Todiere, Giancarlo verfasserin aut Valentini, Adele verfasserin aut Varga-Szemes, Akos verfasserin aut Masci, Pier-Giorgio verfasserin aut Schwitter, Juerg verfasserin (orcid)0000-0002-9966-6149 aut Enthalten in American College of Cardiology ; ID: gnd/1017722-X JACC Cardiovascular imaging Amsterdam : Elsevier, 2008 16, Seite 1387-1400 Online-Ressource (DE-627)559427239 (DE-600)2412441-2 (DE-576)294402861 1876-7591 nnns volume:16 pages:1387-1400 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.85 Kardiologie Angiologie VZ 44.64 Radiologie VZ AR 16 1387-1400
allfieldsSound	10.1016/j.jcmg.2023.03.015 doi (DE-627)ELV065466683 (ELSEVIER)S1936-878X(23)00181-X DE-627 ger DE-627 rda eng 610 VZ 44.85 bkl 44.64 bkl Pontone, Gianluca verfasserin aut Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Implantable cardioverter-defibrillator (ICD) therapy is the most effective prophylactic strategy against sudden cardiac death (SCD) in patients with ischemic cardiomyopathy (ICM) and left ventricle ejection fraction (LVEF) ≤35% as detected by transthoracic echocardiograpgy (TTE). This approach has been recently questioned because of the low rate of ICD interventions in patients who received implantation and the not-negligible percentage of patients who experienced SCD despite not fulfilling criteria for implantation.Objectives: The DERIVATE-ICM registry (CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DebrillAtor ThErapy; NCT03352648) is an international, multicenter, and multivendor study to assess the net reclassification improvement (NRI) for the indication of ICD implantation by the use of cardiac magnetic resonance (CMR) as compared to TTE in patients with ICM.Methods: A total of 861 patients with ICM (mean age 65 ± 11 years, 86% male) with chronic heart failure and TTE-LVEF <50% participated. Major adverse arrhythmic cardiac events (MAACE) were the primary endpoints.Results: During a median follow-up of 1,054 days, MAACE occurred in 88 (10.2%). Left ventricular end-diastolic volume index (HR: 1.007 [95% CI: 1.000-1.011]; P = 0.05), CMR-LVEF (HR: 0.972 [95% CI: 0.945-0.999]; P = 0.045) and late gadolinium enhancement (LGE) mass (HR: 1.010 [95% CI: 1.002-1.018]; P = 0.015) were independent predictors of MAACE. A multiparametric CMR weighted predictive derived score identifies subjects at high risk for MAACE compared with TTE-LVEF cutoff of 35% with a NRI of 31.7% (P = 0.007).Conclusions: The DERIVATE-ICM registry is a large multicenter registry showing the additional value of CMR to stratify the risk for MAACE in a large cohort of patients with ICM compared with standard of care. cardiac magnetic resonance heart failure implantable cardioverter-defibrillator ischemic dilated cardiomyopathy primary prevention Guaricci, Andrea Igoren verfasserin (orcid)0000-0001-7133-4401 aut Fusini, Laura verfasserin (orcid)0000-0003-0309-6231 aut Baggiano, Andrea verfasserin aut Guglielmo, Marco verfasserin aut Muscogiuri, Giuseppe verfasserin aut Volpe, Alessandra verfasserin aut Abete, Raffaele verfasserin aut Aquaro, Giovanni verfasserin aut Barison, Andrea verfasserin (orcid)0000-0001-9042-340X aut Bogaert, Jan verfasserin aut Camastra, Giovanni verfasserin aut Carigi, Samuela verfasserin aut Carrabba, Nazario verfasserin (orcid)0000-0002-5190-5227 aut Casavecchia, Grazia verfasserin aut Censi, Stefano verfasserin aut Cicala, Gloria verfasserin aut De Cecco, Carlo N. verfasserin aut De Lazzari, Manuel verfasserin aut Di Giovine, Gabriella verfasserin aut Di Roma, Mauro verfasserin aut Dobrovie, Monica verfasserin aut Focardi, Marta verfasserin aut Gaibazzi, Nicola verfasserin aut Gismondi, Annalaura verfasserin aut Gravina, Matteo verfasserin aut Lanzillo, Chiara verfasserin aut Lombardi, Massimo verfasserin aut Lorenzoni, Valentina verfasserin aut Lozano-Torres, Jordi verfasserin aut Martini, Chiara verfasserin aut Marzo, Francesca verfasserin aut Masi, Ambra verfasserin aut Memeo, Riccardo verfasserin aut Moro, Claudio verfasserin aut Nese, Alberto verfasserin aut Palumbo, Alessandro verfasserin aut Pavon, Anna Giulia verfasserin aut Pedrotti, Patrizia verfasserin aut Marra, Martina Perazzolo verfasserin aut Pica, Silvia verfasserin aut Pradella, Silvia verfasserin aut Presicci, Cristina verfasserin aut Rabbat, Mark G. verfasserin aut Raineri, Claudia verfasserin aut Rodriguez-Palomares, José F. verfasserin (orcid)0000-0002-7229-9780 aut Sbarbati, Stefano verfasserin aut Schoepf, U. Joseph verfasserin aut Squeri, Angelo verfasserin aut Sverzellati, Nicola verfasserin aut Symons, Rolf verfasserin aut Tat, Emily verfasserin aut Timpani, Mauro verfasserin aut Todiere, Giancarlo verfasserin aut Valentini, Adele verfasserin aut Varga-Szemes, Akos verfasserin aut Masci, Pier-Giorgio verfasserin aut Schwitter, Juerg verfasserin (orcid)0000-0002-9966-6149 aut Enthalten in American College of Cardiology ; ID: gnd/1017722-X JACC Cardiovascular imaging Amsterdam : Elsevier, 2008 16, Seite 1387-1400 Online-Ressource (DE-627)559427239 (DE-600)2412441-2 (DE-576)294402861 1876-7591 nnns volume:16 pages:1387-1400 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.85 Kardiologie Angiologie VZ 44.64 Radiologie VZ AR 16 1387-1400
language	English
source	Enthalten in JACC Cardiovascular imaging 16, Seite 1387-1400 volume:16 pages:1387-1400
sourceStr	Enthalten in JACC Cardiovascular imaging 16, Seite 1387-1400 volume:16 pages:1387-1400
format_phy_str_mv	Article
bklname	Kardiologie Angiologie Radiologie
institution	findex.gbv.de
topic_facet	cardiac magnetic resonance heart failure implantable cardioverter-defibrillator ischemic dilated cardiomyopathy primary prevention
dewey-raw	610
isfreeaccess_bool	false
container_title	JACC Cardiovascular imaging
authorswithroles_txt_mv	Pontone, Gianluca @@aut@@ Guaricci, Andrea Igoren @@aut@@ Fusini, Laura @@aut@@ Baggiano, Andrea @@aut@@ Guglielmo, Marco @@aut@@ Muscogiuri, Giuseppe @@aut@@ Volpe, Alessandra @@aut@@ Abete, Raffaele @@aut@@ Aquaro, Giovanni @@aut@@ Barison, Andrea @@aut@@ Bogaert, Jan @@aut@@ Camastra, Giovanni @@aut@@ Carigi, Samuela @@aut@@ Carrabba, Nazario @@aut@@ Casavecchia, Grazia @@aut@@ Censi, Stefano @@aut@@ Cicala, Gloria @@aut@@ De Cecco, Carlo N. @@aut@@ De Lazzari, Manuel @@aut@@ Di Giovine, Gabriella @@aut@@ Di Roma, Mauro @@aut@@ Dobrovie, Monica @@aut@@ Focardi, Marta @@aut@@ Gaibazzi, Nicola @@aut@@ Gismondi, Annalaura @@aut@@ Gravina, Matteo @@aut@@ Lanzillo, Chiara @@aut@@ Lombardi, Massimo @@aut@@ Lorenzoni, Valentina @@aut@@ Lozano-Torres, Jordi @@aut@@ Martini, Chiara @@aut@@ Marzo, Francesca @@aut@@ Masi, Ambra @@aut@@ Memeo, Riccardo @@aut@@ Moro, Claudio @@aut@@ Nese, Alberto @@aut@@ Palumbo, Alessandro @@aut@@ Pavon, Anna Giulia @@aut@@ Pedrotti, Patrizia @@aut@@ Marra, Martina Perazzolo @@aut@@ Pica, Silvia @@aut@@ Pradella, Silvia @@aut@@ Presicci, Cristina @@aut@@ Rabbat, Mark G. @@aut@@ Raineri, Claudia @@aut@@ Rodriguez-Palomares, José F. @@aut@@ Sbarbati, Stefano @@aut@@ Schoepf, U. Joseph @@aut@@ Squeri, Angelo @@aut@@ Sverzellati, Nicola @@aut@@ Symons, Rolf @@aut@@ Tat, Emily @@aut@@ Timpani, Mauro @@aut@@ Todiere, Giancarlo @@aut@@ Valentini, Adele @@aut@@ Varga-Szemes, Akos @@aut@@ Masci, Pier-Giorgio @@aut@@ Schwitter, Juerg @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	559427239
dewey-sort	3610
id	ELV065466683
language_de	englisch
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This approach has been recently questioned because of the low rate of ICD interventions in patients who received implantation and the not-negligible percentage of patients who experienced SCD despite not fulfilling criteria for implantation.Objectives: The DERIVATE-ICM registry (CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DebrillAtor ThErapy; NCT03352648) is an international, multicenter, and multivendor study to assess the net reclassification improvement (NRI) for the indication of ICD implantation by the use of cardiac magnetic resonance (CMR) as compared to TTE in patients with ICM.Methods: A total of 861 patients with ICM (mean age 65 ± 11 years, 86% male) with chronic heart failure and TTE-LVEF <50% participated. Major adverse arrhythmic cardiac events (MAACE) were the primary endpoints.Results: During a median follow-up of 1,054 days, MAACE occurred in 88 (10.2%). Left ventricular end-diastolic volume index (HR: 1.007 [95% CI: 1.000-1.011]; P = 0.05), CMR-LVEF (HR: 0.972 [95% CI: 0.945-0.999]; P = 0.045) and late gadolinium enhancement (LGE) mass (HR: 1.010 [95% CI: 1.002-1.018]; P = 0.015) were independent predictors of MAACE. A multiparametric CMR weighted predictive derived score identifies subjects at high risk for MAACE compared with TTE-LVEF cutoff of 35% with a NRI of 31.7% (P = 0.007).Conclusions: The DERIVATE-ICM registry is a large multicenter registry showing the additional value of CMR to stratify the risk for MAACE in a large cohort of patients with ICM compared with standard of care.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cardiac magnetic resonance</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">heart failure</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">implantable cardioverter-defibrillator</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ischemic dilated cardiomyopathy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">primary prevention</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Guaricci, 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author	Pontone, Gianluca
spellingShingle	Pontone, Gianluca ddc 610 bkl 44.85 bkl 44.64 misc cardiac magnetic resonance misc heart failure misc implantable cardioverter-defibrillator misc ischemic dilated cardiomyopathy misc primary prevention Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy
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topic_title	610 VZ 44.85 bkl 44.64 bkl Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy cardiac magnetic resonance heart failure implantable cardioverter-defibrillator ischemic dilated cardiomyopathy primary prevention
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title	Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy
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title_full	Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy
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author_browse	Pontone, Gianluca Guaricci, Andrea Igoren Fusini, Laura Baggiano, Andrea Guglielmo, Marco Muscogiuri, Giuseppe Volpe, Alessandra Abete, Raffaele Aquaro, Giovanni Barison, Andrea Bogaert, Jan Camastra, Giovanni Carigi, Samuela Carrabba, Nazario Casavecchia, Grazia Censi, Stefano Cicala, Gloria De Cecco, Carlo N. De Lazzari, Manuel Di Giovine, Gabriella Di Roma, Mauro Dobrovie, Monica Focardi, Marta Gaibazzi, Nicola Gismondi, Annalaura Gravina, Matteo Lanzillo, Chiara Lombardi, Massimo Lorenzoni, Valentina Lozano-Torres, Jordi Martini, Chiara Marzo, Francesca Masi, Ambra Memeo, Riccardo Moro, Claudio Nese, Alberto Palumbo, Alessandro Pavon, Anna Giulia Pedrotti, Patrizia Marra, Martina Perazzolo Pica, Silvia Pradella, Silvia Presicci, Cristina Rabbat, Mark G. Raineri, Claudia Rodriguez-Palomares, José F. Sbarbati, Stefano Schoepf, U. Joseph Squeri, Angelo Sverzellati, Nicola Symons, Rolf Tat, Emily Timpani, Mauro Todiere, Giancarlo Valentini, Adele Varga-Szemes, Akos Masci, Pier-Giorgio Schwitter, Juerg
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title_sort	cardiac magnetic resonance for prophylactic implantable-cardioverter defibrillator therapy in ischemic cardiomyopathy
title_auth	Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy
abstract	Background: Implantable cardioverter-defibrillator (ICD) therapy is the most effective prophylactic strategy against sudden cardiac death (SCD) in patients with ischemic cardiomyopathy (ICM) and left ventricle ejection fraction (LVEF) ≤35% as detected by transthoracic echocardiograpgy (TTE). This approach has been recently questioned because of the low rate of ICD interventions in patients who received implantation and the not-negligible percentage of patients who experienced SCD despite not fulfilling criteria for implantation.Objectives: The DERIVATE-ICM registry (CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DebrillAtor ThErapy; NCT03352648) is an international, multicenter, and multivendor study to assess the net reclassification improvement (NRI) for the indication of ICD implantation by the use of cardiac magnetic resonance (CMR) as compared to TTE in patients with ICM.Methods: A total of 861 patients with ICM (mean age 65 ± 11 years, 86% male) with chronic heart failure and TTE-LVEF <50% participated. Major adverse arrhythmic cardiac events (MAACE) were the primary endpoints.Results: During a median follow-up of 1,054 days, MAACE occurred in 88 (10.2%). Left ventricular end-diastolic volume index (HR: 1.007 [95% CI: 1.000-1.011]; P = 0.05), CMR-LVEF (HR: 0.972 [95% CI: 0.945-0.999]; P = 0.045) and late gadolinium enhancement (LGE) mass (HR: 1.010 [95% CI: 1.002-1.018]; P = 0.015) were independent predictors of MAACE. A multiparametric CMR weighted predictive derived score identifies subjects at high risk for MAACE compared with TTE-LVEF cutoff of 35% with a NRI of 31.7% (P = 0.007).Conclusions: The DERIVATE-ICM registry is a large multicenter registry showing the additional value of CMR to stratify the risk for MAACE in a large cohort of patients with ICM compared with standard of care.
abstractGer	Background: Implantable cardioverter-defibrillator (ICD) therapy is the most effective prophylactic strategy against sudden cardiac death (SCD) in patients with ischemic cardiomyopathy (ICM) and left ventricle ejection fraction (LVEF) ≤35% as detected by transthoracic echocardiograpgy (TTE). This approach has been recently questioned because of the low rate of ICD interventions in patients who received implantation and the not-negligible percentage of patients who experienced SCD despite not fulfilling criteria for implantation.Objectives: The DERIVATE-ICM registry (CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DebrillAtor ThErapy; NCT03352648) is an international, multicenter, and multivendor study to assess the net reclassification improvement (NRI) for the indication of ICD implantation by the use of cardiac magnetic resonance (CMR) as compared to TTE in patients with ICM.Methods: A total of 861 patients with ICM (mean age 65 ± 11 years, 86% male) with chronic heart failure and TTE-LVEF <50% participated. Major adverse arrhythmic cardiac events (MAACE) were the primary endpoints.Results: During a median follow-up of 1,054 days, MAACE occurred in 88 (10.2%). Left ventricular end-diastolic volume index (HR: 1.007 [95% CI: 1.000-1.011]; P = 0.05), CMR-LVEF (HR: 0.972 [95% CI: 0.945-0.999]; P = 0.045) and late gadolinium enhancement (LGE) mass (HR: 1.010 [95% CI: 1.002-1.018]; P = 0.015) were independent predictors of MAACE. A multiparametric CMR weighted predictive derived score identifies subjects at high risk for MAACE compared with TTE-LVEF cutoff of 35% with a NRI of 31.7% (P = 0.007).Conclusions: The DERIVATE-ICM registry is a large multicenter registry showing the additional value of CMR to stratify the risk for MAACE in a large cohort of patients with ICM compared with standard of care.
abstract_unstemmed	Background: Implantable cardioverter-defibrillator (ICD) therapy is the most effective prophylactic strategy against sudden cardiac death (SCD) in patients with ischemic cardiomyopathy (ICM) and left ventricle ejection fraction (LVEF) ≤35% as detected by transthoracic echocardiograpgy (TTE). This approach has been recently questioned because of the low rate of ICD interventions in patients who received implantation and the not-negligible percentage of patients who experienced SCD despite not fulfilling criteria for implantation.Objectives: The DERIVATE-ICM registry (CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DebrillAtor ThErapy; NCT03352648) is an international, multicenter, and multivendor study to assess the net reclassification improvement (NRI) for the indication of ICD implantation by the use of cardiac magnetic resonance (CMR) as compared to TTE in patients with ICM.Methods: A total of 861 patients with ICM (mean age 65 ± 11 years, 86% male) with chronic heart failure and TTE-LVEF <50% participated. Major adverse arrhythmic cardiac events (MAACE) were the primary endpoints.Results: During a median follow-up of 1,054 days, MAACE occurred in 88 (10.2%). Left ventricular end-diastolic volume index (HR: 1.007 [95% CI: 1.000-1.011]; P = 0.05), CMR-LVEF (HR: 0.972 [95% CI: 0.945-0.999]; P = 0.045) and late gadolinium enhancement (LGE) mass (HR: 1.010 [95% CI: 1.002-1.018]; P = 0.015) were independent predictors of MAACE. A multiparametric CMR weighted predictive derived score identifies subjects at high risk for MAACE compared with TTE-LVEF cutoff of 35% with a NRI of 31.7% (P = 0.007).Conclusions: The DERIVATE-ICM registry is a large multicenter registry showing the additional value of CMR to stratify the risk for MAACE in a large cohort of patients with ICM compared with standard of care.
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title_short	Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy
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author2	Guaricci, Andrea Igoren Fusini, Laura Baggiano, Andrea Guglielmo, Marco Muscogiuri, Giuseppe Volpe, Alessandra Abete, Raffaele Aquaro, Giovanni Barison, Andrea Bogaert, Jan Camastra, Giovanni Carigi, Samuela Carrabba, Nazario Casavecchia, Grazia Censi, Stefano Cicala, Gloria De Cecco, Carlo N. De Lazzari, Manuel Di Giovine, Gabriella Di Roma, Mauro Dobrovie, Monica Focardi, Marta Gaibazzi, Nicola Gismondi, Annalaura Gravina, Matteo Lanzillo, Chiara Lombardi, Massimo Lorenzoni, Valentina Lozano-Torres, Jordi Martini, Chiara Marzo, Francesca Masi, Ambra Memeo, Riccardo Moro, Claudio Nese, Alberto Palumbo, Alessandro Pavon, Anna Giulia Pedrotti, Patrizia Marra, Martina Perazzolo Pica, Silvia Pradella, Silvia Presicci, Cristina Rabbat, Mark G. Raineri, Claudia Rodriguez-Palomares, José F. Sbarbati, Stefano Schoepf, U. Joseph Squeri, Angelo Sverzellati, Nicola Symons, Rolf Tat, Emily Timpani, Mauro Todiere, Giancarlo Valentini, Adele Varga-Szemes, Akos Masci, Pier-Giorgio Schwitter, Juerg
author2Str	Guaricci, Andrea Igoren Fusini, Laura Baggiano, Andrea Guglielmo, Marco Muscogiuri, Giuseppe Volpe, Alessandra Abete, Raffaele Aquaro, Giovanni Barison, Andrea Bogaert, Jan Camastra, Giovanni Carigi, Samuela Carrabba, Nazario Casavecchia, Grazia Censi, Stefano Cicala, Gloria De Cecco, Carlo N. De Lazzari, Manuel Di Giovine, Gabriella Di Roma, Mauro Dobrovie, Monica Focardi, Marta Gaibazzi, Nicola Gismondi, Annalaura Gravina, Matteo Lanzillo, Chiara Lombardi, Massimo Lorenzoni, Valentina Lozano-Torres, Jordi Martini, Chiara Marzo, Francesca Masi, Ambra Memeo, Riccardo Moro, Claudio Nese, Alberto Palumbo, Alessandro Pavon, Anna Giulia Pedrotti, Patrizia Marra, Martina Perazzolo Pica, Silvia Pradella, Silvia Presicci, Cristina Rabbat, Mark G. Raineri, Claudia Rodriguez-Palomares, José F. Sbarbati, Stefano Schoepf, U. Joseph Squeri, Angelo Sverzellati, Nicola Symons, Rolf Tat, Emily Timpani, Mauro Todiere, Giancarlo Valentini, Adele Varga-Szemes, Akos Masci, Pier-Giorgio Schwitter, Juerg
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doi_str	10.1016/j.jcmg.2023.03.015
up_date	2024-07-06T23:07:51.977Z
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This approach has been recently questioned because of the low rate of ICD interventions in patients who received implantation and the not-negligible percentage of patients who experienced SCD despite not fulfilling criteria for implantation.Objectives: The DERIVATE-ICM registry (CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DebrillAtor ThErapy; NCT03352648) is an international, multicenter, and multivendor study to assess the net reclassification improvement (NRI) for the indication of ICD implantation by the use of cardiac magnetic resonance (CMR) as compared to TTE in patients with ICM.Methods: A total of 861 patients with ICM (mean age 65 ± 11 years, 86% male) with chronic heart failure and TTE-LVEF <50% participated. Major adverse arrhythmic cardiac events (MAACE) were the primary endpoints.Results: During a median follow-up of 1,054 days, MAACE occurred in 88 (10.2%). Left ventricular end-diastolic volume index (HR: 1.007 [95% CI: 1.000-1.011]; P = 0.05), CMR-LVEF (HR: 0.972 [95% CI: 0.945-0.999]; P = 0.045) and late gadolinium enhancement (LGE) mass (HR: 1.010 [95% CI: 1.002-1.018]; P = 0.015) were independent predictors of MAACE. A multiparametric CMR weighted predictive derived score identifies subjects at high risk for MAACE compared with TTE-LVEF cutoff of 35% with a NRI of 31.7% (P = 0.007).Conclusions: The DERIVATE-ICM registry is a large multicenter registry showing the additional value of CMR to stratify the risk for MAACE in a large cohort of patients with ICM compared with standard of care.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cardiac magnetic resonance</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">heart failure</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">implantable cardioverter-defibrillator</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ischemic dilated cardiomyopathy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">primary prevention</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Guaricci, 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Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy

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