Disentangling the effects of depression and perceived stress on cortisol levels in individuals with obesity: Preliminary results from a cross-sectional study

Background: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been suggested to play a role in the association between depression and obesity. The study aimed to investigate differences in cortisol levels in individuals with obesity with and without depression and the role of perceived str...
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Autor*in:	Mariani, Nicole [verfasserIn] McLaughlin, Anna [verfasserIn] Lambert, Ellen [verfasserIn] Kose, Melisa [verfasserIn] Nikkheslat, Naghmeh [verfasserIn] Patsalos, Olivia [verfasserIn] Bogdanova, Anna [verfasserIn] Chamseddine, Ghassan [verfasserIn] Panagiotopoulos, Spyros [verfasserIn] Chang, Avril [verfasserIn] Rubino, Francesco [verfasserIn] Mondelli, Valeria [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Depression Obesity Cortisol levels Perceived stress

Übergeordnetes Werk:	Enthalten in: Psychoneuroendocrinology - Amsterdam [u.a.] : Elsevier Science, 1975, 158
Übergeordnetes Werk:	volume:158

DOI / URN:	10.1016/j.psyneuen.2023.106387

Katalog-ID:	ELV065483480

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100	1		\|a Mariani, Nicole \|e verfasserin \|0 (orcid)0000-0001-7918-3492 \|4 aut
245	1	0	\|a Disentangling the effects of depression and perceived stress on cortisol levels in individuals with obesity: Preliminary results from a cross-sectional study
264		1	\|c 2023
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520			\|a Background: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been suggested to play a role in the association between depression and obesity. The study aimed to investigate differences in cortisol levels in individuals with obesity with and without depression and the role of perceived stress on these differences.Methods: Saliva samples were collected at awakening, 15-, 30- and 60-minutes post-awakening from 66 individuals with obesity (30 with major depressive disorder and 36 without major depressive disorder). Salivary cortisol was analysed using ELISA technique. Linear Mixed Models were used for group differences in cortisol awakening response (CAR) with adjustment for socio-demographic confounders and binge eating.Results: Individuals with obesity and depression had lower CAR compared with individuals with obesity without depression (β = −0.44; p = 0.036). When controlling for perceived stress, CAR was no longer influenced by depression (β = −0.09; p = 0.75), but individuals with moderate/high stress had lower CAR compared with those with low stress (β = −0.63; p = 0.036).Conclusions: Our results suggest that differences in CAR between individuals with obesity with and without depression could be due to higher levels of perceived stress in the depressed subjects.
650		4	\|a Depression
650		4	\|a Obesity
650		4	\|a Cortisol levels
650		4	\|a Perceived stress
700	1		\|a McLaughlin, Anna \|e verfasserin \|0 (orcid)0000-0002-2965-8215 \|4 aut
700	1		\|a Lambert, Ellen \|e verfasserin \|0 (orcid)0000-0001-5609-2942 \|4 aut
700	1		\|a Kose, Melisa \|e verfasserin \|0 (orcid)0000-0002-3046-3597 \|4 aut
700	1		\|a Nikkheslat, Naghmeh \|e verfasserin \|4 aut
700	1		\|a Patsalos, Olivia \|e verfasserin \|0 (orcid)0000-0001-7867-5110 \|4 aut
700	1		\|a Bogdanova, Anna \|e verfasserin \|4 aut
700	1		\|a Chamseddine, Ghassan \|e verfasserin \|0 (orcid)0000-0002-3467-9563 \|4 aut
700	1		\|a Panagiotopoulos, Spyros \|e verfasserin \|4 aut
700	1		\|a Chang, Avril \|e verfasserin \|4 aut
700	1		\|a Rubino, Francesco \|e verfasserin \|4 aut
700	1		\|a Mondelli, Valeria \|e verfasserin \|0 (orcid)0000-0001-8690-6839 \|4 aut
773	0	8	\|i Enthalten in \|t Psychoneuroendocrinology \|d Amsterdam [u.a.] : Elsevier Science, 1975 \|g 158 \|h Online-Ressource \|w (DE-627)306710102 \|w (DE-600)1500706-6 \|w (DE-576)264423631 \|x 1873-3360 \|7 nnns
773	1	8	\|g volume:158
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936	b	k	\|a 44.90 \|j Neurologie \|q VZ
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publishDate	2023
allfields	10.1016/j.psyneuen.2023.106387 doi (DE-627)ELV065483480 (ELSEVIER)S0306-4530(23)00365-7 DE-627 ger DE-627 rda eng 610 VZ 44.90 bkl 44.89 bkl Mariani, Nicole verfasserin (orcid)0000-0001-7918-3492 aut Disentangling the effects of depression and perceived stress on cortisol levels in individuals with obesity: Preliminary results from a cross-sectional study 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been suggested to play a role in the association between depression and obesity. The study aimed to investigate differences in cortisol levels in individuals with obesity with and without depression and the role of perceived stress on these differences.Methods: Saliva samples were collected at awakening, 15-, 30- and 60-minutes post-awakening from 66 individuals with obesity (30 with major depressive disorder and 36 without major depressive disorder). Salivary cortisol was analysed using ELISA technique. Linear Mixed Models were used for group differences in cortisol awakening response (CAR) with adjustment for socio-demographic confounders and binge eating.Results: Individuals with obesity and depression had lower CAR compared with individuals with obesity without depression (β = −0.44; p = 0.036). When controlling for perceived stress, CAR was no longer influenced by depression (β = −0.09; p = 0.75), but individuals with moderate/high stress had lower CAR compared with those with low stress (β = −0.63; p = 0.036).Conclusions: Our results suggest that differences in CAR between individuals with obesity with and without depression could be due to higher levels of perceived stress in the depressed subjects. Depression Obesity Cortisol levels Perceived stress McLaughlin, Anna verfasserin (orcid)0000-0002-2965-8215 aut Lambert, Ellen verfasserin (orcid)0000-0001-5609-2942 aut Kose, Melisa verfasserin (orcid)0000-0002-3046-3597 aut Nikkheslat, Naghmeh verfasserin aut Patsalos, Olivia verfasserin (orcid)0000-0001-7867-5110 aut Bogdanova, Anna verfasserin aut Chamseddine, Ghassan verfasserin (orcid)0000-0002-3467-9563 aut Panagiotopoulos, Spyros verfasserin aut Chang, Avril verfasserin aut Rubino, Francesco verfasserin aut Mondelli, Valeria verfasserin (orcid)0000-0001-8690-6839 aut Enthalten in Psychoneuroendocrinology Amsterdam [u.a.] : Elsevier Science, 1975 158 Online-Ressource (DE-627)306710102 (DE-600)1500706-6 (DE-576)264423631 1873-3360 nnns volume:158 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie VZ 44.89 Endokrinologie VZ AR 158
spelling	10.1016/j.psyneuen.2023.106387 doi (DE-627)ELV065483480 (ELSEVIER)S0306-4530(23)00365-7 DE-627 ger DE-627 rda eng 610 VZ 44.90 bkl 44.89 bkl Mariani, Nicole verfasserin (orcid)0000-0001-7918-3492 aut Disentangling the effects of depression and perceived stress on cortisol levels in individuals with obesity: Preliminary results from a cross-sectional study 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been suggested to play a role in the association between depression and obesity. The study aimed to investigate differences in cortisol levels in individuals with obesity with and without depression and the role of perceived stress on these differences.Methods: Saliva samples were collected at awakening, 15-, 30- and 60-minutes post-awakening from 66 individuals with obesity (30 with major depressive disorder and 36 without major depressive disorder). Salivary cortisol was analysed using ELISA technique. Linear Mixed Models were used for group differences in cortisol awakening response (CAR) with adjustment for socio-demographic confounders and binge eating.Results: Individuals with obesity and depression had lower CAR compared with individuals with obesity without depression (β = −0.44; p = 0.036). When controlling for perceived stress, CAR was no longer influenced by depression (β = −0.09; p = 0.75), but individuals with moderate/high stress had lower CAR compared with those with low stress (β = −0.63; p = 0.036).Conclusions: Our results suggest that differences in CAR between individuals with obesity with and without depression could be due to higher levels of perceived stress in the depressed subjects. Depression Obesity Cortisol levels Perceived stress McLaughlin, Anna verfasserin (orcid)0000-0002-2965-8215 aut Lambert, Ellen verfasserin (orcid)0000-0001-5609-2942 aut Kose, Melisa verfasserin (orcid)0000-0002-3046-3597 aut Nikkheslat, Naghmeh verfasserin aut Patsalos, Olivia verfasserin (orcid)0000-0001-7867-5110 aut Bogdanova, Anna verfasserin aut Chamseddine, Ghassan verfasserin (orcid)0000-0002-3467-9563 aut Panagiotopoulos, Spyros verfasserin aut Chang, Avril verfasserin aut Rubino, Francesco verfasserin aut Mondelli, Valeria verfasserin (orcid)0000-0001-8690-6839 aut Enthalten in Psychoneuroendocrinology Amsterdam [u.a.] : Elsevier Science, 1975 158 Online-Ressource (DE-627)306710102 (DE-600)1500706-6 (DE-576)264423631 1873-3360 nnns volume:158 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie VZ 44.89 Endokrinologie VZ AR 158
allfields_unstemmed	10.1016/j.psyneuen.2023.106387 doi (DE-627)ELV065483480 (ELSEVIER)S0306-4530(23)00365-7 DE-627 ger DE-627 rda eng 610 VZ 44.90 bkl 44.89 bkl Mariani, Nicole verfasserin (orcid)0000-0001-7918-3492 aut Disentangling the effects of depression and perceived stress on cortisol levels in individuals with obesity: Preliminary results from a cross-sectional study 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been suggested to play a role in the association between depression and obesity. The study aimed to investigate differences in cortisol levels in individuals with obesity with and without depression and the role of perceived stress on these differences.Methods: Saliva samples were collected at awakening, 15-, 30- and 60-minutes post-awakening from 66 individuals with obesity (30 with major depressive disorder and 36 without major depressive disorder). Salivary cortisol was analysed using ELISA technique. Linear Mixed Models were used for group differences in cortisol awakening response (CAR) with adjustment for socio-demographic confounders and binge eating.Results: Individuals with obesity and depression had lower CAR compared with individuals with obesity without depression (β = −0.44; p = 0.036). When controlling for perceived stress, CAR was no longer influenced by depression (β = −0.09; p = 0.75), but individuals with moderate/high stress had lower CAR compared with those with low stress (β = −0.63; p = 0.036).Conclusions: Our results suggest that differences in CAR between individuals with obesity with and without depression could be due to higher levels of perceived stress in the depressed subjects. Depression Obesity Cortisol levels Perceived stress McLaughlin, Anna verfasserin (orcid)0000-0002-2965-8215 aut Lambert, Ellen verfasserin (orcid)0000-0001-5609-2942 aut Kose, Melisa verfasserin (orcid)0000-0002-3046-3597 aut Nikkheslat, Naghmeh verfasserin aut Patsalos, Olivia verfasserin (orcid)0000-0001-7867-5110 aut Bogdanova, Anna verfasserin aut Chamseddine, Ghassan verfasserin (orcid)0000-0002-3467-9563 aut Panagiotopoulos, Spyros verfasserin aut Chang, Avril verfasserin aut Rubino, Francesco verfasserin aut Mondelli, Valeria verfasserin (orcid)0000-0001-8690-6839 aut Enthalten in Psychoneuroendocrinology Amsterdam [u.a.] : Elsevier Science, 1975 158 Online-Ressource (DE-627)306710102 (DE-600)1500706-6 (DE-576)264423631 1873-3360 nnns volume:158 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie VZ 44.89 Endokrinologie VZ AR 158
allfieldsGer	10.1016/j.psyneuen.2023.106387 doi (DE-627)ELV065483480 (ELSEVIER)S0306-4530(23)00365-7 DE-627 ger DE-627 rda eng 610 VZ 44.90 bkl 44.89 bkl Mariani, Nicole verfasserin (orcid)0000-0001-7918-3492 aut Disentangling the effects of depression and perceived stress on cortisol levels in individuals with obesity: Preliminary results from a cross-sectional study 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been suggested to play a role in the association between depression and obesity. The study aimed to investigate differences in cortisol levels in individuals with obesity with and without depression and the role of perceived stress on these differences.Methods: Saliva samples were collected at awakening, 15-, 30- and 60-minutes post-awakening from 66 individuals with obesity (30 with major depressive disorder and 36 without major depressive disorder). Salivary cortisol was analysed using ELISA technique. Linear Mixed Models were used for group differences in cortisol awakening response (CAR) with adjustment for socio-demographic confounders and binge eating.Results: Individuals with obesity and depression had lower CAR compared with individuals with obesity without depression (β = −0.44; p = 0.036). When controlling for perceived stress, CAR was no longer influenced by depression (β = −0.09; p = 0.75), but individuals with moderate/high stress had lower CAR compared with those with low stress (β = −0.63; p = 0.036).Conclusions: Our results suggest that differences in CAR between individuals with obesity with and without depression could be due to higher levels of perceived stress in the depressed subjects. Depression Obesity Cortisol levels Perceived stress McLaughlin, Anna verfasserin (orcid)0000-0002-2965-8215 aut Lambert, Ellen verfasserin (orcid)0000-0001-5609-2942 aut Kose, Melisa verfasserin (orcid)0000-0002-3046-3597 aut Nikkheslat, Naghmeh verfasserin aut Patsalos, Olivia verfasserin (orcid)0000-0001-7867-5110 aut Bogdanova, Anna verfasserin aut Chamseddine, Ghassan verfasserin (orcid)0000-0002-3467-9563 aut Panagiotopoulos, Spyros verfasserin aut Chang, Avril verfasserin aut Rubino, Francesco verfasserin aut Mondelli, Valeria verfasserin (orcid)0000-0001-8690-6839 aut Enthalten in Psychoneuroendocrinology Amsterdam [u.a.] : Elsevier Science, 1975 158 Online-Ressource (DE-627)306710102 (DE-600)1500706-6 (DE-576)264423631 1873-3360 nnns volume:158 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie VZ 44.89 Endokrinologie VZ AR 158
allfieldsSound	10.1016/j.psyneuen.2023.106387 doi (DE-627)ELV065483480 (ELSEVIER)S0306-4530(23)00365-7 DE-627 ger DE-627 rda eng 610 VZ 44.90 bkl 44.89 bkl Mariani, Nicole verfasserin (orcid)0000-0001-7918-3492 aut Disentangling the effects of depression and perceived stress on cortisol levels in individuals with obesity: Preliminary results from a cross-sectional study 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been suggested to play a role in the association between depression and obesity. The study aimed to investigate differences in cortisol levels in individuals with obesity with and without depression and the role of perceived stress on these differences.Methods: Saliva samples were collected at awakening, 15-, 30- and 60-minutes post-awakening from 66 individuals with obesity (30 with major depressive disorder and 36 without major depressive disorder). Salivary cortisol was analysed using ELISA technique. Linear Mixed Models were used for group differences in cortisol awakening response (CAR) with adjustment for socio-demographic confounders and binge eating.Results: Individuals with obesity and depression had lower CAR compared with individuals with obesity without depression (β = −0.44; p = 0.036). When controlling for perceived stress, CAR was no longer influenced by depression (β = −0.09; p = 0.75), but individuals with moderate/high stress had lower CAR compared with those with low stress (β = −0.63; p = 0.036).Conclusions: Our results suggest that differences in CAR between individuals with obesity with and without depression could be due to higher levels of perceived stress in the depressed subjects. Depression Obesity Cortisol levels Perceived stress McLaughlin, Anna verfasserin (orcid)0000-0002-2965-8215 aut Lambert, Ellen verfasserin (orcid)0000-0001-5609-2942 aut Kose, Melisa verfasserin (orcid)0000-0002-3046-3597 aut Nikkheslat, Naghmeh verfasserin aut Patsalos, Olivia verfasserin (orcid)0000-0001-7867-5110 aut Bogdanova, Anna verfasserin aut Chamseddine, Ghassan verfasserin (orcid)0000-0002-3467-9563 aut Panagiotopoulos, Spyros verfasserin aut Chang, Avril verfasserin aut Rubino, Francesco verfasserin aut Mondelli, Valeria verfasserin (orcid)0000-0001-8690-6839 aut Enthalten in Psychoneuroendocrinology Amsterdam [u.a.] : Elsevier Science, 1975 158 Online-Ressource (DE-627)306710102 (DE-600)1500706-6 (DE-576)264423631 1873-3360 nnns volume:158 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie VZ 44.89 Endokrinologie VZ AR 158
language	English
source	Enthalten in Psychoneuroendocrinology 158 volume:158
sourceStr	Enthalten in Psychoneuroendocrinology 158 volume:158
format_phy_str_mv	Article
bklname	Neurologie Endokrinologie
institution	findex.gbv.de
topic_facet	Depression Obesity Cortisol levels Perceived stress
dewey-raw	610
isfreeaccess_bool	false
container_title	Psychoneuroendocrinology
authorswithroles_txt_mv	Mariani, Nicole @@aut@@ McLaughlin, Anna @@aut@@ Lambert, Ellen @@aut@@ Kose, Melisa @@aut@@ Nikkheslat, Naghmeh @@aut@@ Patsalos, Olivia @@aut@@ Bogdanova, Anna @@aut@@ Chamseddine, Ghassan @@aut@@ Panagiotopoulos, Spyros @@aut@@ Chang, Avril @@aut@@ Rubino, Francesco @@aut@@ Mondelli, Valeria @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	306710102
dewey-sort	3610
id	ELV065483480
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">ELV065483480</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20231108093201.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">231108s2023 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.psyneuen.2023.106387</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV065483480</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0306-4530(23)00365-7</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.90</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.89</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Mariani, Nicole</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0001-7918-3492</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Disentangling the effects of depression and perceived stress on cortisol levels in individuals with obesity: Preliminary results from a cross-sectional study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been suggested to play a role in the association between depression and obesity. The study aimed to investigate differences in cortisol levels in individuals with obesity with and without depression and the role of perceived stress on these differences.Methods: Saliva samples were collected at awakening, 15-, 30- and 60-minutes post-awakening from 66 individuals with obesity (30 with major depressive disorder and 36 without major depressive disorder). Salivary cortisol was analysed using ELISA technique. Linear Mixed Models were used for group differences in cortisol awakening response (CAR) with adjustment for socio-demographic confounders and binge eating.Results: Individuals with obesity and depression had lower CAR compared with individuals with obesity without depression (β = −0.44; p = 0.036). When controlling for perceived stress, CAR was no longer influenced by depression (β = −0.09; p = 0.75), but individuals with moderate/high stress had lower CAR compared with those with low stress (β = −0.63; p = 0.036).Conclusions: Our results suggest that differences in CAR between individuals with obesity with and without depression could be due to higher levels of perceived stress in the depressed subjects.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Depression</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Obesity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cortisol levels</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Perceived stress</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">McLaughlin, Anna</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0002-2965-8215</subfield><subfield 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author	Mariani, Nicole
spellingShingle	Mariani, Nicole ddc 610 bkl 44.90 bkl 44.89 misc Depression misc Obesity misc Cortisol levels misc Perceived stress Disentangling the effects of depression and perceived stress on cortisol levels in individuals with obesity: Preliminary results from a cross-sectional study
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topic_title	610 VZ 44.90 bkl 44.89 bkl Disentangling the effects of depression and perceived stress on cortisol levels in individuals with obesity: Preliminary results from a cross-sectional study Depression Obesity Cortisol levels Perceived stress
topic	ddc 610 bkl 44.90 bkl 44.89 misc Depression misc Obesity misc Cortisol levels misc Perceived stress
topic_unstemmed	ddc 610 bkl 44.90 bkl 44.89 misc Depression misc Obesity misc Cortisol levels misc Perceived stress
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title	Disentangling the effects of depression and perceived stress on cortisol levels in individuals with obesity: Preliminary results from a cross-sectional study
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title_full	Disentangling the effects of depression and perceived stress on cortisol levels in individuals with obesity: Preliminary results from a cross-sectional study
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author_browse	Mariani, Nicole McLaughlin, Anna Lambert, Ellen Kose, Melisa Nikkheslat, Naghmeh Patsalos, Olivia Bogdanova, Anna Chamseddine, Ghassan Panagiotopoulos, Spyros Chang, Avril Rubino, Francesco Mondelli, Valeria
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title_sort	disentangling the effects of depression and perceived stress on cortisol levels in individuals with obesity: preliminary results from a cross-sectional study
title_auth	Disentangling the effects of depression and perceived stress on cortisol levels in individuals with obesity: Preliminary results from a cross-sectional study
abstract	Background: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been suggested to play a role in the association between depression and obesity. The study aimed to investigate differences in cortisol levels in individuals with obesity with and without depression and the role of perceived stress on these differences.Methods: Saliva samples were collected at awakening, 15-, 30- and 60-minutes post-awakening from 66 individuals with obesity (30 with major depressive disorder and 36 without major depressive disorder). Salivary cortisol was analysed using ELISA technique. Linear Mixed Models were used for group differences in cortisol awakening response (CAR) with adjustment for socio-demographic confounders and binge eating.Results: Individuals with obesity and depression had lower CAR compared with individuals with obesity without depression (β = −0.44; p = 0.036). When controlling for perceived stress, CAR was no longer influenced by depression (β = −0.09; p = 0.75), but individuals with moderate/high stress had lower CAR compared with those with low stress (β = −0.63; p = 0.036).Conclusions: Our results suggest that differences in CAR between individuals with obesity with and without depression could be due to higher levels of perceived stress in the depressed subjects.
abstractGer	Background: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been suggested to play a role in the association between depression and obesity. The study aimed to investigate differences in cortisol levels in individuals with obesity with and without depression and the role of perceived stress on these differences.Methods: Saliva samples were collected at awakening, 15-, 30- and 60-minutes post-awakening from 66 individuals with obesity (30 with major depressive disorder and 36 without major depressive disorder). Salivary cortisol was analysed using ELISA technique. Linear Mixed Models were used for group differences in cortisol awakening response (CAR) with adjustment for socio-demographic confounders and binge eating.Results: Individuals with obesity and depression had lower CAR compared with individuals with obesity without depression (β = −0.44; p = 0.036). When controlling for perceived stress, CAR was no longer influenced by depression (β = −0.09; p = 0.75), but individuals with moderate/high stress had lower CAR compared with those with low stress (β = −0.63; p = 0.036).Conclusions: Our results suggest that differences in CAR between individuals with obesity with and without depression could be due to higher levels of perceived stress in the depressed subjects.
abstract_unstemmed	Background: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been suggested to play a role in the association between depression and obesity. The study aimed to investigate differences in cortisol levels in individuals with obesity with and without depression and the role of perceived stress on these differences.Methods: Saliva samples were collected at awakening, 15-, 30- and 60-minutes post-awakening from 66 individuals with obesity (30 with major depressive disorder and 36 without major depressive disorder). Salivary cortisol was analysed using ELISA technique. Linear Mixed Models were used for group differences in cortisol awakening response (CAR) with adjustment for socio-demographic confounders and binge eating.Results: Individuals with obesity and depression had lower CAR compared with individuals with obesity without depression (β = −0.44; p = 0.036). When controlling for perceived stress, CAR was no longer influenced by depression (β = −0.09; p = 0.75), but individuals with moderate/high stress had lower CAR compared with those with low stress (β = −0.63; p = 0.036).Conclusions: Our results suggest that differences in CAR between individuals with obesity with and without depression could be due to higher levels of perceived stress in the depressed subjects.
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title_short	Disentangling the effects of depression and perceived stress on cortisol levels in individuals with obesity: Preliminary results from a cross-sectional study
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author2	McLaughlin, Anna Lambert, Ellen Kose, Melisa Nikkheslat, Naghmeh Patsalos, Olivia Bogdanova, Anna Chamseddine, Ghassan Panagiotopoulos, Spyros Chang, Avril Rubino, Francesco Mondelli, Valeria
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up_date	2024-07-06T23:11:18.016Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">ELV065483480</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20231108093201.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">231108s2023 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.psyneuen.2023.106387</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV065483480</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0306-4530(23)00365-7</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.90</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.89</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Mariani, Nicole</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0001-7918-3492</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Disentangling the effects of depression and perceived stress on cortisol levels in individuals with obesity: Preliminary results from a cross-sectional study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been suggested to play a role in the association between depression and obesity. The study aimed to investigate differences in cortisol levels in individuals with obesity with and without depression and the role of perceived stress on these differences.Methods: Saliva samples were collected at awakening, 15-, 30- and 60-minutes post-awakening from 66 individuals with obesity (30 with major depressive disorder and 36 without major depressive disorder). Salivary cortisol was analysed using ELISA technique. Linear Mixed Models were used for group differences in cortisol awakening response (CAR) with adjustment for socio-demographic confounders and binge eating.Results: Individuals with obesity and depression had lower CAR compared with individuals with obesity without depression (β = −0.44; p = 0.036). When controlling for perceived stress, CAR was no longer influenced by depression (β = −0.09; p = 0.75), but individuals with moderate/high stress had lower CAR compared with those with low stress (β = −0.63; p = 0.036).Conclusions: Our results suggest that differences in CAR between individuals with obesity with and without depression could be due to higher levels of perceived stress in the depressed subjects.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Depression</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Obesity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cortisol levels</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Perceived stress</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">McLaughlin, Anna</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0002-2965-8215</subfield><subfield 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Disentangling the effects of depression and perceived stress on cortisol levels in individuals with obesity: Preliminary results from a cross-sectional study

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