Risk factors for suicidality across psychosis vulnerability spectrum

Background: Suicide is a leading cause of death in individuals with psychotic disorders. Risk factors for suicidality across the psychosis vulnerability spectrum are insufficiently known.Methods: For patients (n = 830), siblings (n = 664) and controls (n = 444), suicidality was assessed by the use o...
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Autor*in:	Stephan, Nils Malte [verfasserIn] van Sprang, Eleonore Dorothée [verfasserIn] Wiebenga, Jasper Xiao Ming [verfasserIn] Dickhoff, Justine [verfasserIn] Schirmbeck, Frederike [verfasserIn] de Haan, Lieuwe [verfasserIn] van Amelsvoort, Therese [verfasserIn] Veling, Wim [verfasserIn] Alizadeh, Behrooz Z. [verfasserIn] Simons, Claudia J.P. [verfasserIn] Heering, Henriëtte Dorothée [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Extended psychosis phenotype Suicidality Proneness-persistence-impairment model High familial risk Suicide attempt Suicidal ideation

Übergeordnetes Werk:	Enthalten in: Schizophrenia research - Amsterdam [u.a.] : Elsevier Science, 1988, 261, Seite 152-160
Übergeordnetes Werk:	volume:261 ; pages:152-160

DOI / URN:	10.1016/j.schres.2023.09.021

Katalog-ID:	ELV06549329X

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245	1	0	\|a Risk factors for suicidality across psychosis vulnerability spectrum
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520			\|a Background: Suicide is a leading cause of death in individuals with psychotic disorders. Risk factors for suicidality across the psychosis vulnerability spectrum are insufficiently known.Methods: For patients (n = 830), siblings (n = 664) and controls (n = 444), suicidality was assessed by the use of a clinical interview. Multilevel modelling was used to investigate risk factors of suicidality. Lastly, risk factor × familial risk interaction effects were examined.Results: Multivariable models revealed a significant relation between suicidality and depressive symptoms across all three groups, and childhood trauma in patients and siblings. The association between suicidality and psychotic-like experiences is more pronounced in siblings compared to controls.Conclusion: Across the psychosis vulnerability spectrum, depressive symptoms and childhood trauma have been associated with suicidality. Clinicians should pay attention to suicidality in individuals at high familial risk for psychosis with psychotic-like experiences.
650		4	\|a Extended psychosis phenotype
650		4	\|a Suicidality
650		4	\|a Proneness-persistence-impairment model
650		4	\|a High familial risk
650		4	\|a Suicide attempt
650		4	\|a Suicidal ideation
700	1		\|a van Sprang, Eleonore Dorothée \|e verfasserin \|4 aut
700	1		\|a Wiebenga, Jasper Xiao Ming \|e verfasserin \|4 aut
700	1		\|a Dickhoff, Justine \|e verfasserin \|4 aut
700	1		\|a Schirmbeck, Frederike \|e verfasserin \|4 aut
700	1		\|a de Haan, Lieuwe \|e verfasserin \|4 aut
700	1		\|a van Amelsvoort, Therese \|e verfasserin \|4 aut
700	1		\|a Veling, Wim \|e verfasserin \|4 aut
700	1		\|a Alizadeh, Behrooz Z. \|e verfasserin \|4 aut
700	1		\|a Simons, Claudia J.P. \|e verfasserin \|4 aut
700	1		\|a Heering, Henriëtte Dorothée \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Schizophrenia research \|d Amsterdam [u.a.] : Elsevier Science, 1988 \|g 261, Seite 152-160 \|h Online-Ressource \|w (DE-627)306710307 \|w (DE-600)1500726-1 \|w (DE-576)082435820 \|x 1573-2509 \|7 nnns
773	1	8	\|g volume:261 \|g pages:152-160
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912			\|a GBV_ILN_602
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912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
936	b	k	\|a 44.91 \|j Psychiatrie \|j Psychopathologie \|q VZ
951			\|a AR
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allfields	10.1016/j.schres.2023.09.021 doi (DE-627)ELV06549329X (ELSEVIER)S0920-9964(23)00332-8 DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Stephan, Nils Malte verfasserin aut Risk factors for suicidality across psychosis vulnerability spectrum 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Suicide is a leading cause of death in individuals with psychotic disorders. Risk factors for suicidality across the psychosis vulnerability spectrum are insufficiently known.Methods: For patients (n = 830), siblings (n = 664) and controls (n = 444), suicidality was assessed by the use of a clinical interview. Multilevel modelling was used to investigate risk factors of suicidality. Lastly, risk factor × familial risk interaction effects were examined.Results: Multivariable models revealed a significant relation between suicidality and depressive symptoms across all three groups, and childhood trauma in patients and siblings. The association between suicidality and psychotic-like experiences is more pronounced in siblings compared to controls.Conclusion: Across the psychosis vulnerability spectrum, depressive symptoms and childhood trauma have been associated with suicidality. Clinicians should pay attention to suicidality in individuals at high familial risk for psychosis with psychotic-like experiences. Extended psychosis phenotype Suicidality Proneness-persistence-impairment model High familial risk Suicide attempt Suicidal ideation van Sprang, Eleonore Dorothée verfasserin aut Wiebenga, Jasper Xiao Ming verfasserin aut Dickhoff, Justine verfasserin aut Schirmbeck, Frederike verfasserin aut de Haan, Lieuwe verfasserin aut van Amelsvoort, Therese verfasserin aut Veling, Wim verfasserin aut Alizadeh, Behrooz Z. verfasserin aut Simons, Claudia J.P. verfasserin aut Heering, Henriëtte Dorothée verfasserin aut Enthalten in Schizophrenia research Amsterdam [u.a.] : Elsevier Science, 1988 261, Seite 152-160 Online-Ressource (DE-627)306710307 (DE-600)1500726-1 (DE-576)082435820 1573-2509 nnns volume:261 pages:152-160 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 261 152-160
spelling	10.1016/j.schres.2023.09.021 doi (DE-627)ELV06549329X (ELSEVIER)S0920-9964(23)00332-8 DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Stephan, Nils Malte verfasserin aut Risk factors for suicidality across psychosis vulnerability spectrum 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Suicide is a leading cause of death in individuals with psychotic disorders. Risk factors for suicidality across the psychosis vulnerability spectrum are insufficiently known.Methods: For patients (n = 830), siblings (n = 664) and controls (n = 444), suicidality was assessed by the use of a clinical interview. Multilevel modelling was used to investigate risk factors of suicidality. Lastly, risk factor × familial risk interaction effects were examined.Results: Multivariable models revealed a significant relation between suicidality and depressive symptoms across all three groups, and childhood trauma in patients and siblings. The association between suicidality and psychotic-like experiences is more pronounced in siblings compared to controls.Conclusion: Across the psychosis vulnerability spectrum, depressive symptoms and childhood trauma have been associated with suicidality. Clinicians should pay attention to suicidality in individuals at high familial risk for psychosis with psychotic-like experiences. Extended psychosis phenotype Suicidality Proneness-persistence-impairment model High familial risk Suicide attempt Suicidal ideation van Sprang, Eleonore Dorothée verfasserin aut Wiebenga, Jasper Xiao Ming verfasserin aut Dickhoff, Justine verfasserin aut Schirmbeck, Frederike verfasserin aut de Haan, Lieuwe verfasserin aut van Amelsvoort, Therese verfasserin aut Veling, Wim verfasserin aut Alizadeh, Behrooz Z. verfasserin aut Simons, Claudia J.P. verfasserin aut Heering, Henriëtte Dorothée verfasserin aut Enthalten in Schizophrenia research Amsterdam [u.a.] : Elsevier Science, 1988 261, Seite 152-160 Online-Ressource (DE-627)306710307 (DE-600)1500726-1 (DE-576)082435820 1573-2509 nnns volume:261 pages:152-160 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 261 152-160
allfields_unstemmed	10.1016/j.schres.2023.09.021 doi (DE-627)ELV06549329X (ELSEVIER)S0920-9964(23)00332-8 DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Stephan, Nils Malte verfasserin aut Risk factors for suicidality across psychosis vulnerability spectrum 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Suicide is a leading cause of death in individuals with psychotic disorders. Risk factors for suicidality across the psychosis vulnerability spectrum are insufficiently known.Methods: For patients (n = 830), siblings (n = 664) and controls (n = 444), suicidality was assessed by the use of a clinical interview. Multilevel modelling was used to investigate risk factors of suicidality. Lastly, risk factor × familial risk interaction effects were examined.Results: Multivariable models revealed a significant relation between suicidality and depressive symptoms across all three groups, and childhood trauma in patients and siblings. The association between suicidality and psychotic-like experiences is more pronounced in siblings compared to controls.Conclusion: Across the psychosis vulnerability spectrum, depressive symptoms and childhood trauma have been associated with suicidality. Clinicians should pay attention to suicidality in individuals at high familial risk for psychosis with psychotic-like experiences. Extended psychosis phenotype Suicidality Proneness-persistence-impairment model High familial risk Suicide attempt Suicidal ideation van Sprang, Eleonore Dorothée verfasserin aut Wiebenga, Jasper Xiao Ming verfasserin aut Dickhoff, Justine verfasserin aut Schirmbeck, Frederike verfasserin aut de Haan, Lieuwe verfasserin aut van Amelsvoort, Therese verfasserin aut Veling, Wim verfasserin aut Alizadeh, Behrooz Z. verfasserin aut Simons, Claudia J.P. verfasserin aut Heering, Henriëtte Dorothée verfasserin aut Enthalten in Schizophrenia research Amsterdam [u.a.] : Elsevier Science, 1988 261, Seite 152-160 Online-Ressource (DE-627)306710307 (DE-600)1500726-1 (DE-576)082435820 1573-2509 nnns volume:261 pages:152-160 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 261 152-160
allfieldsGer	10.1016/j.schres.2023.09.021 doi (DE-627)ELV06549329X (ELSEVIER)S0920-9964(23)00332-8 DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Stephan, Nils Malte verfasserin aut Risk factors for suicidality across psychosis vulnerability spectrum 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Suicide is a leading cause of death in individuals with psychotic disorders. Risk factors for suicidality across the psychosis vulnerability spectrum are insufficiently known.Methods: For patients (n = 830), siblings (n = 664) and controls (n = 444), suicidality was assessed by the use of a clinical interview. Multilevel modelling was used to investigate risk factors of suicidality. Lastly, risk factor × familial risk interaction effects were examined.Results: Multivariable models revealed a significant relation between suicidality and depressive symptoms across all three groups, and childhood trauma in patients and siblings. The association between suicidality and psychotic-like experiences is more pronounced in siblings compared to controls.Conclusion: Across the psychosis vulnerability spectrum, depressive symptoms and childhood trauma have been associated with suicidality. Clinicians should pay attention to suicidality in individuals at high familial risk for psychosis with psychotic-like experiences. Extended psychosis phenotype Suicidality Proneness-persistence-impairment model High familial risk Suicide attempt Suicidal ideation van Sprang, Eleonore Dorothée verfasserin aut Wiebenga, Jasper Xiao Ming verfasserin aut Dickhoff, Justine verfasserin aut Schirmbeck, Frederike verfasserin aut de Haan, Lieuwe verfasserin aut van Amelsvoort, Therese verfasserin aut Veling, Wim verfasserin aut Alizadeh, Behrooz Z. verfasserin aut Simons, Claudia J.P. verfasserin aut Heering, Henriëtte Dorothée verfasserin aut Enthalten in Schizophrenia research Amsterdam [u.a.] : Elsevier Science, 1988 261, Seite 152-160 Online-Ressource (DE-627)306710307 (DE-600)1500726-1 (DE-576)082435820 1573-2509 nnns volume:261 pages:152-160 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 261 152-160
allfieldsSound	10.1016/j.schres.2023.09.021 doi (DE-627)ELV06549329X (ELSEVIER)S0920-9964(23)00332-8 DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Stephan, Nils Malte verfasserin aut Risk factors for suicidality across psychosis vulnerability spectrum 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Suicide is a leading cause of death in individuals with psychotic disorders. Risk factors for suicidality across the psychosis vulnerability spectrum are insufficiently known.Methods: For patients (n = 830), siblings (n = 664) and controls (n = 444), suicidality was assessed by the use of a clinical interview. Multilevel modelling was used to investigate risk factors of suicidality. Lastly, risk factor × familial risk interaction effects were examined.Results: Multivariable models revealed a significant relation between suicidality and depressive symptoms across all three groups, and childhood trauma in patients and siblings. The association between suicidality and psychotic-like experiences is more pronounced in siblings compared to controls.Conclusion: Across the psychosis vulnerability spectrum, depressive symptoms and childhood trauma have been associated with suicidality. Clinicians should pay attention to suicidality in individuals at high familial risk for psychosis with psychotic-like experiences. Extended psychosis phenotype Suicidality Proneness-persistence-impairment model High familial risk Suicide attempt Suicidal ideation van Sprang, Eleonore Dorothée verfasserin aut Wiebenga, Jasper Xiao Ming verfasserin aut Dickhoff, Justine verfasserin aut Schirmbeck, Frederike verfasserin aut de Haan, Lieuwe verfasserin aut van Amelsvoort, Therese verfasserin aut Veling, Wim verfasserin aut Alizadeh, Behrooz Z. verfasserin aut Simons, Claudia J.P. verfasserin aut Heering, Henriëtte Dorothée verfasserin aut Enthalten in Schizophrenia research Amsterdam [u.a.] : Elsevier Science, 1988 261, Seite 152-160 Online-Ressource (DE-627)306710307 (DE-600)1500726-1 (DE-576)082435820 1573-2509 nnns volume:261 pages:152-160 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 261 152-160
language	English
source	Enthalten in Schizophrenia research 261, Seite 152-160 volume:261 pages:152-160
sourceStr	Enthalten in Schizophrenia research 261, Seite 152-160 volume:261 pages:152-160
format_phy_str_mv	Article
bklname	Psychiatrie Psychopathologie
institution	findex.gbv.de
topic_facet	Extended psychosis phenotype Suicidality Proneness-persistence-impairment model High familial risk Suicide attempt Suicidal ideation
dewey-raw	610
isfreeaccess_bool	false
container_title	Schizophrenia research
authorswithroles_txt_mv	Stephan, Nils Malte @@aut@@ van Sprang, Eleonore Dorothée @@aut@@ Wiebenga, Jasper Xiao Ming @@aut@@ Dickhoff, Justine @@aut@@ Schirmbeck, Frederike @@aut@@ de Haan, Lieuwe @@aut@@ van Amelsvoort, Therese @@aut@@ Veling, Wim @@aut@@ Alizadeh, Behrooz Z. @@aut@@ Simons, Claudia J.P. @@aut@@ Heering, Henriëtte Dorothée @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	306710307
dewey-sort	3610
id	ELV06549329X
language_de	englisch
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author	Stephan, Nils Malte
spellingShingle	Stephan, Nils Malte ddc 610 bkl 44.91 misc Extended psychosis phenotype misc Suicidality misc Proneness-persistence-impairment model misc High familial risk misc Suicide attempt misc Suicidal ideation Risk factors for suicidality across psychosis vulnerability spectrum
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topic_title	610 VZ 44.91 bkl Risk factors for suicidality across psychosis vulnerability spectrum Extended psychosis phenotype Suicidality Proneness-persistence-impairment model High familial risk Suicide attempt Suicidal ideation
topic	ddc 610 bkl 44.91 misc Extended psychosis phenotype misc Suicidality misc Proneness-persistence-impairment model misc High familial risk misc Suicide attempt misc Suicidal ideation
topic_unstemmed	ddc 610 bkl 44.91 misc Extended psychosis phenotype misc Suicidality misc Proneness-persistence-impairment model misc High familial risk misc Suicide attempt misc Suicidal ideation
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title	Risk factors for suicidality across psychosis vulnerability spectrum
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title_full	Risk factors for suicidality across psychosis vulnerability spectrum
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author_browse	Stephan, Nils Malte van Sprang, Eleonore Dorothée Wiebenga, Jasper Xiao Ming Dickhoff, Justine Schirmbeck, Frederike de Haan, Lieuwe van Amelsvoort, Therese Veling, Wim Alizadeh, Behrooz Z. Simons, Claudia J.P. Heering, Henriëtte Dorothée
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doi_str_mv	10.1016/j.schres.2023.09.021
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title_sort	risk factors for suicidality across psychosis vulnerability spectrum
title_auth	Risk factors for suicidality across psychosis vulnerability spectrum
abstract	Background: Suicide is a leading cause of death in individuals with psychotic disorders. Risk factors for suicidality across the psychosis vulnerability spectrum are insufficiently known.Methods: For patients (n = 830), siblings (n = 664) and controls (n = 444), suicidality was assessed by the use of a clinical interview. Multilevel modelling was used to investigate risk factors of suicidality. Lastly, risk factor × familial risk interaction effects were examined.Results: Multivariable models revealed a significant relation between suicidality and depressive symptoms across all three groups, and childhood trauma in patients and siblings. The association between suicidality and psychotic-like experiences is more pronounced in siblings compared to controls.Conclusion: Across the psychosis vulnerability spectrum, depressive symptoms and childhood trauma have been associated with suicidality. Clinicians should pay attention to suicidality in individuals at high familial risk for psychosis with psychotic-like experiences.
abstractGer	Background: Suicide is a leading cause of death in individuals with psychotic disorders. Risk factors for suicidality across the psychosis vulnerability spectrum are insufficiently known.Methods: For patients (n = 830), siblings (n = 664) and controls (n = 444), suicidality was assessed by the use of a clinical interview. Multilevel modelling was used to investigate risk factors of suicidality. Lastly, risk factor × familial risk interaction effects were examined.Results: Multivariable models revealed a significant relation between suicidality and depressive symptoms across all three groups, and childhood trauma in patients and siblings. The association between suicidality and psychotic-like experiences is more pronounced in siblings compared to controls.Conclusion: Across the psychosis vulnerability spectrum, depressive symptoms and childhood trauma have been associated with suicidality. Clinicians should pay attention to suicidality in individuals at high familial risk for psychosis with psychotic-like experiences.
abstract_unstemmed	Background: Suicide is a leading cause of death in individuals with psychotic disorders. Risk factors for suicidality across the psychosis vulnerability spectrum are insufficiently known.Methods: For patients (n = 830), siblings (n = 664) and controls (n = 444), suicidality was assessed by the use of a clinical interview. Multilevel modelling was used to investigate risk factors of suicidality. Lastly, risk factor × familial risk interaction effects were examined.Results: Multivariable models revealed a significant relation between suicidality and depressive symptoms across all three groups, and childhood trauma in patients and siblings. The association between suicidality and psychotic-like experiences is more pronounced in siblings compared to controls.Conclusion: Across the psychosis vulnerability spectrum, depressive symptoms and childhood trauma have been associated with suicidality. Clinicians should pay attention to suicidality in individuals at high familial risk for psychosis with psychotic-like experiences.
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title_short	Risk factors for suicidality across psychosis vulnerability spectrum
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author2	van Sprang, Eleonore Dorothée Wiebenga, Jasper Xiao Ming Dickhoff, Justine Schirmbeck, Frederike de Haan, Lieuwe van Amelsvoort, Therese Veling, Wim Alizadeh, Behrooz Z. Simons, Claudia J.P. Heering, Henriëtte Dorothée
author2Str	van Sprang, Eleonore Dorothée Wiebenga, Jasper Xiao Ming Dickhoff, Justine Schirmbeck, Frederike de Haan, Lieuwe van Amelsvoort, Therese Veling, Wim Alizadeh, Behrooz Z. Simons, Claudia J.P. Heering, Henriëtte Dorothée
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up_date	2024-07-06T23:13:25.685Z
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Risk factors for suicidality across psychosis vulnerability spectrum

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