Novel anti-atrophic peptide isolated from olive flounder surimi as a nutraceutical additive against TNF-α induced muscle atrophy

Skeletal muscle atrophy has significant negative functional effects, especially on patients with inflammatory diseases. Tumor necrosis factor alpha (TNF-α) plays a crucial role in muscle pathology associated with muscle wasting and impairment of differentiation. The present study evaluated the anti-...
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Gespeichert in:

Autor*in:	Liyanage, N.M. [verfasserIn] Nagahawatta, D.P. [verfasserIn] Jayawardena, Thilina.U. [verfasserIn] Jayawardhana, H.H.A.C.K. [verfasserIn] Jang, Mi-Soon [verfasserIn] Son, Kwang-Tae [verfasserIn] Oh, Jae-Young [verfasserIn] Jeon, You-Jin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Surimi-peptide Myotube TNF-α Functional food TNFR1 receptor Atrophy

Übergeordnetes Werk:	Enthalten in: Journal of functional foods - Amsterdam [u.a.] : Elsevier, 2009, 110
Übergeordnetes Werk:	volume:110

DOI / URN:	10.1016/j.jff.2023.105836

Katalog-ID:	ELV065509404

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520			\|a Skeletal muscle atrophy has significant negative functional effects, especially on patients with inflammatory diseases. Tumor necrosis factor alpha (TNF-α) plays a crucial role in muscle pathology associated with muscle wasting and impairment of differentiation. The present study evaluated the anti-atrophic activity and related mechanism of a novel peptide (Tryptophan-Tyrosine-Lysine) derived from Olive Flounder surimi (OFSP), against TNF-α induced muscle atrophy in C2C12 myotubes. Molecular docking results showed that OFSP binds to TNF-α, inhibiting its binding to TNFR1 receptor. OFSP treatment increased the cell viability and decreased intracellular reactive oxygen species production caused by TNF-α. OFSP markedly downregulated the NF- κB pathway proteins phosphorylation, thereby inhibiting pathway activation. Furthermore, OFSP suppressed IL-6 production and expression of E2 ubiquitin ligases, atrogin-1/MAFbx and MuRF1, while increasing myogenic marker expressions. Current findings indicate that OFSP exhibits excellent anti-atrophic activity against inflammation-induced muscle atrophy, and these characteristics may be valuable in anti-atrophic functional food development.
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allfields	10.1016/j.jff.2023.105836 doi (DE-627)ELV065509404 (ELSEVIER)S1756-4646(23)00436-X DE-627 ger DE-627 rda eng 630 640 610 VZ Liyanage, N.M. verfasserin aut Novel anti-atrophic peptide isolated from olive flounder surimi as a nutraceutical additive against TNF-α induced muscle atrophy 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Skeletal muscle atrophy has significant negative functional effects, especially on patients with inflammatory diseases. Tumor necrosis factor alpha (TNF-α) plays a crucial role in muscle pathology associated with muscle wasting and impairment of differentiation. The present study evaluated the anti-atrophic activity and related mechanism of a novel peptide (Tryptophan-Tyrosine-Lysine) derived from Olive Flounder surimi (OFSP), against TNF-α induced muscle atrophy in C2C12 myotubes. Molecular docking results showed that OFSP binds to TNF-α, inhibiting its binding to TNFR1 receptor. OFSP treatment increased the cell viability and decreased intracellular reactive oxygen species production caused by TNF-α. OFSP markedly downregulated the NF- κB pathway proteins phosphorylation, thereby inhibiting pathway activation. Furthermore, OFSP suppressed IL-6 production and expression of E2 ubiquitin ligases, atrogin-1/MAFbx and MuRF1, while increasing myogenic marker expressions. Current findings indicate that OFSP exhibits excellent anti-atrophic activity against inflammation-induced muscle atrophy, and these characteristics may be valuable in anti-atrophic functional food development. Surimi-peptide Myotube TNF-α Functional food TNFR1 receptor Atrophy Nagahawatta, D.P. verfasserin aut Jayawardena, Thilina.U. verfasserin aut Jayawardhana, H.H.A.C.K. verfasserin aut Jang, Mi-Soon verfasserin aut Son, Kwang-Tae verfasserin aut Oh, Jae-Young verfasserin aut Jeon, You-Jin verfasserin (orcid)0000-0003-3299-7266 aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 110 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:110 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 110
spelling	10.1016/j.jff.2023.105836 doi (DE-627)ELV065509404 (ELSEVIER)S1756-4646(23)00436-X DE-627 ger DE-627 rda eng 630 640 610 VZ Liyanage, N.M. verfasserin aut Novel anti-atrophic peptide isolated from olive flounder surimi as a nutraceutical additive against TNF-α induced muscle atrophy 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Skeletal muscle atrophy has significant negative functional effects, especially on patients with inflammatory diseases. Tumor necrosis factor alpha (TNF-α) plays a crucial role in muscle pathology associated with muscle wasting and impairment of differentiation. The present study evaluated the anti-atrophic activity and related mechanism of a novel peptide (Tryptophan-Tyrosine-Lysine) derived from Olive Flounder surimi (OFSP), against TNF-α induced muscle atrophy in C2C12 myotubes. Molecular docking results showed that OFSP binds to TNF-α, inhibiting its binding to TNFR1 receptor. OFSP treatment increased the cell viability and decreased intracellular reactive oxygen species production caused by TNF-α. OFSP markedly downregulated the NF- κB pathway proteins phosphorylation, thereby inhibiting pathway activation. Furthermore, OFSP suppressed IL-6 production and expression of E2 ubiquitin ligases, atrogin-1/MAFbx and MuRF1, while increasing myogenic marker expressions. Current findings indicate that OFSP exhibits excellent anti-atrophic activity against inflammation-induced muscle atrophy, and these characteristics may be valuable in anti-atrophic functional food development. Surimi-peptide Myotube TNF-α Functional food TNFR1 receptor Atrophy Nagahawatta, D.P. verfasserin aut Jayawardena, Thilina.U. verfasserin aut Jayawardhana, H.H.A.C.K. verfasserin aut Jang, Mi-Soon verfasserin aut Son, Kwang-Tae verfasserin aut Oh, Jae-Young verfasserin aut Jeon, You-Jin verfasserin (orcid)0000-0003-3299-7266 aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 110 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:110 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 110
allfields_unstemmed	10.1016/j.jff.2023.105836 doi (DE-627)ELV065509404 (ELSEVIER)S1756-4646(23)00436-X DE-627 ger DE-627 rda eng 630 640 610 VZ Liyanage, N.M. verfasserin aut Novel anti-atrophic peptide isolated from olive flounder surimi as a nutraceutical additive against TNF-α induced muscle atrophy 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Skeletal muscle atrophy has significant negative functional effects, especially on patients with inflammatory diseases. Tumor necrosis factor alpha (TNF-α) plays a crucial role in muscle pathology associated with muscle wasting and impairment of differentiation. The present study evaluated the anti-atrophic activity and related mechanism of a novel peptide (Tryptophan-Tyrosine-Lysine) derived from Olive Flounder surimi (OFSP), against TNF-α induced muscle atrophy in C2C12 myotubes. Molecular docking results showed that OFSP binds to TNF-α, inhibiting its binding to TNFR1 receptor. OFSP treatment increased the cell viability and decreased intracellular reactive oxygen species production caused by TNF-α. OFSP markedly downregulated the NF- κB pathway proteins phosphorylation, thereby inhibiting pathway activation. Furthermore, OFSP suppressed IL-6 production and expression of E2 ubiquitin ligases, atrogin-1/MAFbx and MuRF1, while increasing myogenic marker expressions. Current findings indicate that OFSP exhibits excellent anti-atrophic activity against inflammation-induced muscle atrophy, and these characteristics may be valuable in anti-atrophic functional food development. Surimi-peptide Myotube TNF-α Functional food TNFR1 receptor Atrophy Nagahawatta, D.P. verfasserin aut Jayawardena, Thilina.U. verfasserin aut Jayawardhana, H.H.A.C.K. verfasserin aut Jang, Mi-Soon verfasserin aut Son, Kwang-Tae verfasserin aut Oh, Jae-Young verfasserin aut Jeon, You-Jin verfasserin (orcid)0000-0003-3299-7266 aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 110 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:110 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 110
allfieldsGer	10.1016/j.jff.2023.105836 doi (DE-627)ELV065509404 (ELSEVIER)S1756-4646(23)00436-X DE-627 ger DE-627 rda eng 630 640 610 VZ Liyanage, N.M. verfasserin aut Novel anti-atrophic peptide isolated from olive flounder surimi as a nutraceutical additive against TNF-α induced muscle atrophy 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Skeletal muscle atrophy has significant negative functional effects, especially on patients with inflammatory diseases. Tumor necrosis factor alpha (TNF-α) plays a crucial role in muscle pathology associated with muscle wasting and impairment of differentiation. The present study evaluated the anti-atrophic activity and related mechanism of a novel peptide (Tryptophan-Tyrosine-Lysine) derived from Olive Flounder surimi (OFSP), against TNF-α induced muscle atrophy in C2C12 myotubes. Molecular docking results showed that OFSP binds to TNF-α, inhibiting its binding to TNFR1 receptor. OFSP treatment increased the cell viability and decreased intracellular reactive oxygen species production caused by TNF-α. OFSP markedly downregulated the NF- κB pathway proteins phosphorylation, thereby inhibiting pathway activation. Furthermore, OFSP suppressed IL-6 production and expression of E2 ubiquitin ligases, atrogin-1/MAFbx and MuRF1, while increasing myogenic marker expressions. Current findings indicate that OFSP exhibits excellent anti-atrophic activity against inflammation-induced muscle atrophy, and these characteristics may be valuable in anti-atrophic functional food development. Surimi-peptide Myotube TNF-α Functional food TNFR1 receptor Atrophy Nagahawatta, D.P. verfasserin aut Jayawardena, Thilina.U. verfasserin aut Jayawardhana, H.H.A.C.K. verfasserin aut Jang, Mi-Soon verfasserin aut Son, Kwang-Tae verfasserin aut Oh, Jae-Young verfasserin aut Jeon, You-Jin verfasserin (orcid)0000-0003-3299-7266 aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 110 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:110 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 110
allfieldsSound	10.1016/j.jff.2023.105836 doi (DE-627)ELV065509404 (ELSEVIER)S1756-4646(23)00436-X DE-627 ger DE-627 rda eng 630 640 610 VZ Liyanage, N.M. verfasserin aut Novel anti-atrophic peptide isolated from olive flounder surimi as a nutraceutical additive against TNF-α induced muscle atrophy 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Skeletal muscle atrophy has significant negative functional effects, especially on patients with inflammatory diseases. Tumor necrosis factor alpha (TNF-α) plays a crucial role in muscle pathology associated with muscle wasting and impairment of differentiation. The present study evaluated the anti-atrophic activity and related mechanism of a novel peptide (Tryptophan-Tyrosine-Lysine) derived from Olive Flounder surimi (OFSP), against TNF-α induced muscle atrophy in C2C12 myotubes. Molecular docking results showed that OFSP binds to TNF-α, inhibiting its binding to TNFR1 receptor. OFSP treatment increased the cell viability and decreased intracellular reactive oxygen species production caused by TNF-α. OFSP markedly downregulated the NF- κB pathway proteins phosphorylation, thereby inhibiting pathway activation. Furthermore, OFSP suppressed IL-6 production and expression of E2 ubiquitin ligases, atrogin-1/MAFbx and MuRF1, while increasing myogenic marker expressions. Current findings indicate that OFSP exhibits excellent anti-atrophic activity against inflammation-induced muscle atrophy, and these characteristics may be valuable in anti-atrophic functional food development. Surimi-peptide Myotube TNF-α Functional food TNFR1 receptor Atrophy Nagahawatta, D.P. verfasserin aut Jayawardena, Thilina.U. verfasserin aut Jayawardhana, H.H.A.C.K. verfasserin aut Jang, Mi-Soon verfasserin aut Son, Kwang-Tae verfasserin aut Oh, Jae-Young verfasserin aut Jeon, You-Jin verfasserin (orcid)0000-0003-3299-7266 aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 110 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:110 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 110
language	English
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sourceStr	Enthalten in Journal of functional foods 110 volume:110
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topic_facet	Surimi-peptide Myotube TNF-α Functional food TNFR1 receptor Atrophy
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container_title	Journal of functional foods
authorswithroles_txt_mv	Liyanage, N.M. @@aut@@ Nagahawatta, D.P. @@aut@@ Jayawardena, Thilina.U. @@aut@@ Jayawardhana, H.H.A.C.K. @@aut@@ Jang, Mi-Soon @@aut@@ Son, Kwang-Tae @@aut@@ Oh, Jae-Young @@aut@@ Jeon, You-Jin @@aut@@
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author	Liyanage, N.M.
spellingShingle	Liyanage, N.M. ddc 630 misc Surimi-peptide misc Myotube misc TNF-α misc Functional food misc TNFR1 receptor misc Atrophy Novel anti-atrophic peptide isolated from olive flounder surimi as a nutraceutical additive against TNF-α induced muscle atrophy
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topic_title	630 640 610 VZ Novel anti-atrophic peptide isolated from olive flounder surimi as a nutraceutical additive against TNF-α induced muscle atrophy Surimi-peptide Myotube TNF-α Functional food TNFR1 receptor Atrophy
topic	ddc 630 misc Surimi-peptide misc Myotube misc TNF-α misc Functional food misc TNFR1 receptor misc Atrophy
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title	Novel anti-atrophic peptide isolated from olive flounder surimi as a nutraceutical additive against TNF-α induced muscle atrophy
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title_full	Novel anti-atrophic peptide isolated from olive flounder surimi as a nutraceutical additive against TNF-α induced muscle atrophy
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author_browse	Liyanage, N.M. Nagahawatta, D.P. Jayawardena, Thilina.U. Jayawardhana, H.H.A.C.K. Jang, Mi-Soon Son, Kwang-Tae Oh, Jae-Young Jeon, You-Jin
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title_sort	novel anti-atrophic peptide isolated from olive flounder surimi as a nutraceutical additive against tnf-α induced muscle atrophy
title_auth	Novel anti-atrophic peptide isolated from olive flounder surimi as a nutraceutical additive against TNF-α induced muscle atrophy
abstract	Skeletal muscle atrophy has significant negative functional effects, especially on patients with inflammatory diseases. Tumor necrosis factor alpha (TNF-α) plays a crucial role in muscle pathology associated with muscle wasting and impairment of differentiation. The present study evaluated the anti-atrophic activity and related mechanism of a novel peptide (Tryptophan-Tyrosine-Lysine) derived from Olive Flounder surimi (OFSP), against TNF-α induced muscle atrophy in C2C12 myotubes. Molecular docking results showed that OFSP binds to TNF-α, inhibiting its binding to TNFR1 receptor. OFSP treatment increased the cell viability and decreased intracellular reactive oxygen species production caused by TNF-α. OFSP markedly downregulated the NF- κB pathway proteins phosphorylation, thereby inhibiting pathway activation. Furthermore, OFSP suppressed IL-6 production and expression of E2 ubiquitin ligases, atrogin-1/MAFbx and MuRF1, while increasing myogenic marker expressions. Current findings indicate that OFSP exhibits excellent anti-atrophic activity against inflammation-induced muscle atrophy, and these characteristics may be valuable in anti-atrophic functional food development.
abstractGer	Skeletal muscle atrophy has significant negative functional effects, especially on patients with inflammatory diseases. Tumor necrosis factor alpha (TNF-α) plays a crucial role in muscle pathology associated with muscle wasting and impairment of differentiation. The present study evaluated the anti-atrophic activity and related mechanism of a novel peptide (Tryptophan-Tyrosine-Lysine) derived from Olive Flounder surimi (OFSP), against TNF-α induced muscle atrophy in C2C12 myotubes. Molecular docking results showed that OFSP binds to TNF-α, inhibiting its binding to TNFR1 receptor. OFSP treatment increased the cell viability and decreased intracellular reactive oxygen species production caused by TNF-α. OFSP markedly downregulated the NF- κB pathway proteins phosphorylation, thereby inhibiting pathway activation. Furthermore, OFSP suppressed IL-6 production and expression of E2 ubiquitin ligases, atrogin-1/MAFbx and MuRF1, while increasing myogenic marker expressions. Current findings indicate that OFSP exhibits excellent anti-atrophic activity against inflammation-induced muscle atrophy, and these characteristics may be valuable in anti-atrophic functional food development.
abstract_unstemmed	Skeletal muscle atrophy has significant negative functional effects, especially on patients with inflammatory diseases. Tumor necrosis factor alpha (TNF-α) plays a crucial role in muscle pathology associated with muscle wasting and impairment of differentiation. The present study evaluated the anti-atrophic activity and related mechanism of a novel peptide (Tryptophan-Tyrosine-Lysine) derived from Olive Flounder surimi (OFSP), against TNF-α induced muscle atrophy in C2C12 myotubes. Molecular docking results showed that OFSP binds to TNF-α, inhibiting its binding to TNFR1 receptor. OFSP treatment increased the cell viability and decreased intracellular reactive oxygen species production caused by TNF-α. OFSP markedly downregulated the NF- κB pathway proteins phosphorylation, thereby inhibiting pathway activation. Furthermore, OFSP suppressed IL-6 production and expression of E2 ubiquitin ligases, atrogin-1/MAFbx and MuRF1, while increasing myogenic marker expressions. Current findings indicate that OFSP exhibits excellent anti-atrophic activity against inflammation-induced muscle atrophy, and these characteristics may be valuable in anti-atrophic functional food development.
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title_short	Novel anti-atrophic peptide isolated from olive flounder surimi as a nutraceutical additive against TNF-α induced muscle atrophy
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author2	Nagahawatta, D.P. Jayawardena, Thilina.U. Jayawardhana, H.H.A.C.K. Jang, Mi-Soon Son, Kwang-Tae Oh, Jae-Young Jeon, You-Jin
author2Str	Nagahawatta, D.P. Jayawardena, Thilina.U. Jayawardhana, H.H.A.C.K. Jang, Mi-Soon Son, Kwang-Tae Oh, Jae-Young Jeon, You-Jin
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doi_str	10.1016/j.jff.2023.105836
up_date	2024-07-06T23:16:43.898Z
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Tumor necrosis factor alpha (TNF-α) plays a crucial role in muscle pathology associated with muscle wasting and impairment of differentiation. The present study evaluated the anti-atrophic activity and related mechanism of a novel peptide (Tryptophan-Tyrosine-Lysine) derived from Olive Flounder surimi (OFSP), against TNF-α induced muscle atrophy in C2C12 myotubes. Molecular docking results showed that OFSP binds to TNF-α, inhibiting its binding to TNFR1 receptor. OFSP treatment increased the cell viability and decreased intracellular reactive oxygen species production caused by TNF-α. OFSP markedly downregulated the NF- κB pathway proteins phosphorylation, thereby inhibiting pathway activation. Furthermore, OFSP suppressed IL-6 production and expression of E2 ubiquitin ligases, atrogin-1/MAFbx and MuRF1, while increasing myogenic marker expressions. 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Novel anti-atrophic peptide isolated from olive flounder surimi as a nutraceutical additive against TNF-α induced muscle atrophy

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