Downregulation of PGC-1α during cisplatin-induced muscle atrophy in murine skeletal muscle
This study aimed to investigate the effects of cisplatin on adenosine triphosphate (ATP) levels, expressions of genes related to mitochondrial oxidative phosphorylation (OXPHOS), and the factors related to mitochondrial biosynthesis in skeletal muscle. Systemic cisplatin administration decreased ske...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sato, Ken [verfasserIn] Satoshi, Yoshida [verfasserIn] Miyauchi, Yu [verfasserIn] Sato, Fumiaki [verfasserIn] Kon, Risako [verfasserIn] Ikarashi, Nobutomo [verfasserIn] Chiba, Yoshihiko [verfasserIn] Hosoe, Tomoo [verfasserIn] Sakai, Hiroyasu [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Biochimica et biophysica acta / Molecular basis of disease - Amsterdam : Elsevier, 1990, 1870 |
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| Übergeordnetes Werk: |
volume:1870 |
| DOI / URN: |
10.1016/j.bbadis.2023.166877 |
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| Katalog-ID: |
ELV065532023 |
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| 245 | 1 | 0 | |a Downregulation of PGC-1α during cisplatin-induced muscle atrophy in murine skeletal muscle |
| 264 | 1 | |c 2023 | |
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| 520 | |a This study aimed to investigate the effects of cisplatin on adenosine triphosphate (ATP) levels, expressions of genes related to mitochondrial oxidative phosphorylation (OXPHOS), and the factors related to mitochondrial biosynthesis in skeletal muscle. Systemic cisplatin administration decreased skeletal muscle mass, skeletal muscle strength, and endurance. The mitochondrial DNA /nuclear DNA ratio was also reduced after treatment with cisplatin. Moreover, among the factors related to mitochondrial biogenesis and function, peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) was significantly downregulated in the cisplatin-treated group. Downregulation of PGC-1α in the skeletal muscle may contribute to muscle weakness during cisplatin-induced muscle atrophy. | ||
| 650 | 4 | |a Cisplatin | |
| 650 | 4 | |a Muscle atrophy | |
| 650 | 4 | |a PGC-1α | |
| 650 | 4 | |a ATP | |
| 650 | 4 | |a Mitochondria | |
| 700 | 1 | |a Satoshi, Yoshida |e verfasserin |4 aut | |
| 700 | 1 | |a Miyauchi, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Sato, Fumiaki |e verfasserin |4 aut | |
| 700 | 1 | |a Kon, Risako |e verfasserin |4 aut | |
| 700 | 1 | |a Ikarashi, Nobutomo |e verfasserin |4 aut | |
| 700 | 1 | |a Chiba, Yoshihiko |e verfasserin |4 aut | |
| 700 | 1 | |a Hosoe, Tomoo |e verfasserin |4 aut | |
| 700 | 1 | |a Sakai, Hiroyasu |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biochimica et biophysica acta / Molecular basis of disease |d Amsterdam : Elsevier, 1990 |g 1870 |h Online-Ressource |w (DE-627)502924330 |w (DE-600)2209528-7 |w (DE-576)251822699 |x 1879-260X |7 nnns |
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10.1016/j.bbadis.2023.166877 doi (DE-627)ELV065532023 (ELSEVIER)S0925-4439(23)00243-0 DE-627 ger DE-627 rda eng 570 610 VZ BIODIV DE-30 fid 35.70 bkl 42.12 bkl 42.13 bkl Sato, Ken verfasserin aut Downregulation of PGC-1α during cisplatin-induced muscle atrophy in murine skeletal muscle 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study aimed to investigate the effects of cisplatin on adenosine triphosphate (ATP) levels, expressions of genes related to mitochondrial oxidative phosphorylation (OXPHOS), and the factors related to mitochondrial biosynthesis in skeletal muscle. Systemic cisplatin administration decreased skeletal muscle mass, skeletal muscle strength, and endurance. The mitochondrial DNA /nuclear DNA ratio was also reduced after treatment with cisplatin. Moreover, among the factors related to mitochondrial biogenesis and function, peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) was significantly downregulated in the cisplatin-treated group. Downregulation of PGC-1α in the skeletal muscle may contribute to muscle weakness during cisplatin-induced muscle atrophy. Cisplatin Muscle atrophy PGC-1α ATP Mitochondria Satoshi, Yoshida verfasserin aut Miyauchi, Yu verfasserin aut Sato, Fumiaki verfasserin aut Kon, Risako verfasserin aut Ikarashi, Nobutomo verfasserin aut Chiba, Yoshihiko verfasserin aut Hosoe, Tomoo verfasserin aut Sakai, Hiroyasu verfasserin aut Enthalten in Biochimica et biophysica acta / Molecular basis of disease Amsterdam : Elsevier, 1990 1870 Online-Ressource (DE-627)502924330 (DE-600)2209528-7 (DE-576)251822699 1879-260X nnns volume:1870 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2056 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 35.70 Biochemie: Allgemeines VZ 42.12 Biophysik VZ 42.13 Molekularbiologie VZ AR 1870 |
| spelling |
10.1016/j.bbadis.2023.166877 doi (DE-627)ELV065532023 (ELSEVIER)S0925-4439(23)00243-0 DE-627 ger DE-627 rda eng 570 610 VZ BIODIV DE-30 fid 35.70 bkl 42.12 bkl 42.13 bkl Sato, Ken verfasserin aut Downregulation of PGC-1α during cisplatin-induced muscle atrophy in murine skeletal muscle 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study aimed to investigate the effects of cisplatin on adenosine triphosphate (ATP) levels, expressions of genes related to mitochondrial oxidative phosphorylation (OXPHOS), and the factors related to mitochondrial biosynthesis in skeletal muscle. Systemic cisplatin administration decreased skeletal muscle mass, skeletal muscle strength, and endurance. The mitochondrial DNA /nuclear DNA ratio was also reduced after treatment with cisplatin. Moreover, among the factors related to mitochondrial biogenesis and function, peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) was significantly downregulated in the cisplatin-treated group. Downregulation of PGC-1α in the skeletal muscle may contribute to muscle weakness during cisplatin-induced muscle atrophy. Cisplatin Muscle atrophy PGC-1α ATP Mitochondria Satoshi, Yoshida verfasserin aut Miyauchi, Yu verfasserin aut Sato, Fumiaki verfasserin aut Kon, Risako verfasserin aut Ikarashi, Nobutomo verfasserin aut Chiba, Yoshihiko verfasserin aut Hosoe, Tomoo verfasserin aut Sakai, Hiroyasu verfasserin aut Enthalten in Biochimica et biophysica acta / Molecular basis of disease Amsterdam : Elsevier, 1990 1870 Online-Ressource (DE-627)502924330 (DE-600)2209528-7 (DE-576)251822699 1879-260X nnns volume:1870 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2056 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 35.70 Biochemie: Allgemeines VZ 42.12 Biophysik VZ 42.13 Molekularbiologie VZ AR 1870 |
| allfields_unstemmed |
10.1016/j.bbadis.2023.166877 doi (DE-627)ELV065532023 (ELSEVIER)S0925-4439(23)00243-0 DE-627 ger DE-627 rda eng 570 610 VZ BIODIV DE-30 fid 35.70 bkl 42.12 bkl 42.13 bkl Sato, Ken verfasserin aut Downregulation of PGC-1α during cisplatin-induced muscle atrophy in murine skeletal muscle 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study aimed to investigate the effects of cisplatin on adenosine triphosphate (ATP) levels, expressions of genes related to mitochondrial oxidative phosphorylation (OXPHOS), and the factors related to mitochondrial biosynthesis in skeletal muscle. Systemic cisplatin administration decreased skeletal muscle mass, skeletal muscle strength, and endurance. The mitochondrial DNA /nuclear DNA ratio was also reduced after treatment with cisplatin. Moreover, among the factors related to mitochondrial biogenesis and function, peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) was significantly downregulated in the cisplatin-treated group. Downregulation of PGC-1α in the skeletal muscle may contribute to muscle weakness during cisplatin-induced muscle atrophy. Cisplatin Muscle atrophy PGC-1α ATP Mitochondria Satoshi, Yoshida verfasserin aut Miyauchi, Yu verfasserin aut Sato, Fumiaki verfasserin aut Kon, Risako verfasserin aut Ikarashi, Nobutomo verfasserin aut Chiba, Yoshihiko verfasserin aut Hosoe, Tomoo verfasserin aut Sakai, Hiroyasu verfasserin aut Enthalten in Biochimica et biophysica acta / Molecular basis of disease Amsterdam : Elsevier, 1990 1870 Online-Ressource (DE-627)502924330 (DE-600)2209528-7 (DE-576)251822699 1879-260X nnns volume:1870 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2056 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 35.70 Biochemie: Allgemeines VZ 42.12 Biophysik VZ 42.13 Molekularbiologie VZ AR 1870 |
| allfieldsGer |
10.1016/j.bbadis.2023.166877 doi (DE-627)ELV065532023 (ELSEVIER)S0925-4439(23)00243-0 DE-627 ger DE-627 rda eng 570 610 VZ BIODIV DE-30 fid 35.70 bkl 42.12 bkl 42.13 bkl Sato, Ken verfasserin aut Downregulation of PGC-1α during cisplatin-induced muscle atrophy in murine skeletal muscle 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study aimed to investigate the effects of cisplatin on adenosine triphosphate (ATP) levels, expressions of genes related to mitochondrial oxidative phosphorylation (OXPHOS), and the factors related to mitochondrial biosynthesis in skeletal muscle. Systemic cisplatin administration decreased skeletal muscle mass, skeletal muscle strength, and endurance. The mitochondrial DNA /nuclear DNA ratio was also reduced after treatment with cisplatin. Moreover, among the factors related to mitochondrial biogenesis and function, peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) was significantly downregulated in the cisplatin-treated group. Downregulation of PGC-1α in the skeletal muscle may contribute to muscle weakness during cisplatin-induced muscle atrophy. Cisplatin Muscle atrophy PGC-1α ATP Mitochondria Satoshi, Yoshida verfasserin aut Miyauchi, Yu verfasserin aut Sato, Fumiaki verfasserin aut Kon, Risako verfasserin aut Ikarashi, Nobutomo verfasserin aut Chiba, Yoshihiko verfasserin aut Hosoe, Tomoo verfasserin aut Sakai, Hiroyasu verfasserin aut Enthalten in Biochimica et biophysica acta / Molecular basis of disease Amsterdam : Elsevier, 1990 1870 Online-Ressource (DE-627)502924330 (DE-600)2209528-7 (DE-576)251822699 1879-260X nnns volume:1870 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2056 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 35.70 Biochemie: Allgemeines VZ 42.12 Biophysik VZ 42.13 Molekularbiologie VZ AR 1870 |
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10.1016/j.bbadis.2023.166877 doi (DE-627)ELV065532023 (ELSEVIER)S0925-4439(23)00243-0 DE-627 ger DE-627 rda eng 570 610 VZ BIODIV DE-30 fid 35.70 bkl 42.12 bkl 42.13 bkl Sato, Ken verfasserin aut Downregulation of PGC-1α during cisplatin-induced muscle atrophy in murine skeletal muscle 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study aimed to investigate the effects of cisplatin on adenosine triphosphate (ATP) levels, expressions of genes related to mitochondrial oxidative phosphorylation (OXPHOS), and the factors related to mitochondrial biosynthesis in skeletal muscle. Systemic cisplatin administration decreased skeletal muscle mass, skeletal muscle strength, and endurance. The mitochondrial DNA /nuclear DNA ratio was also reduced after treatment with cisplatin. Moreover, among the factors related to mitochondrial biogenesis and function, peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) was significantly downregulated in the cisplatin-treated group. Downregulation of PGC-1α in the skeletal muscle may contribute to muscle weakness during cisplatin-induced muscle atrophy. Cisplatin Muscle atrophy PGC-1α ATP Mitochondria Satoshi, Yoshida verfasserin aut Miyauchi, Yu verfasserin aut Sato, Fumiaki verfasserin aut Kon, Risako verfasserin aut Ikarashi, Nobutomo verfasserin aut Chiba, Yoshihiko verfasserin aut Hosoe, Tomoo verfasserin aut Sakai, Hiroyasu verfasserin aut Enthalten in Biochimica et biophysica acta / Molecular basis of disease Amsterdam : Elsevier, 1990 1870 Online-Ressource (DE-627)502924330 (DE-600)2209528-7 (DE-576)251822699 1879-260X nnns volume:1870 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2056 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 35.70 Biochemie: Allgemeines VZ 42.12 Biophysik VZ 42.13 Molekularbiologie VZ AR 1870 |
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Downregulation of PGC-1α during cisplatin-induced muscle atrophy in murine skeletal muscle |
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Downregulation of PGC-1α during cisplatin-induced muscle atrophy in murine skeletal muscle |
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Sato, Ken |
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Biochimica et biophysica acta / Molecular basis of disease |
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Biochimica et biophysica acta / Molecular basis of disease |
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Sato, Ken Satoshi, Yoshida Miyauchi, Yu Sato, Fumiaki Kon, Risako Ikarashi, Nobutomo Chiba, Yoshihiko Hosoe, Tomoo Sakai, Hiroyasu |
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Sato, Ken |
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10.1016/j.bbadis.2023.166877 |
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downregulation of pgc-1α during cisplatin-induced muscle atrophy in murine skeletal muscle |
| title_auth |
Downregulation of PGC-1α during cisplatin-induced muscle atrophy in murine skeletal muscle |
| abstract |
This study aimed to investigate the effects of cisplatin on adenosine triphosphate (ATP) levels, expressions of genes related to mitochondrial oxidative phosphorylation (OXPHOS), and the factors related to mitochondrial biosynthesis in skeletal muscle. Systemic cisplatin administration decreased skeletal muscle mass, skeletal muscle strength, and endurance. The mitochondrial DNA /nuclear DNA ratio was also reduced after treatment with cisplatin. Moreover, among the factors related to mitochondrial biogenesis and function, peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) was significantly downregulated in the cisplatin-treated group. Downregulation of PGC-1α in the skeletal muscle may contribute to muscle weakness during cisplatin-induced muscle atrophy. |
| abstractGer |
This study aimed to investigate the effects of cisplatin on adenosine triphosphate (ATP) levels, expressions of genes related to mitochondrial oxidative phosphorylation (OXPHOS), and the factors related to mitochondrial biosynthesis in skeletal muscle. Systemic cisplatin administration decreased skeletal muscle mass, skeletal muscle strength, and endurance. The mitochondrial DNA /nuclear DNA ratio was also reduced after treatment with cisplatin. Moreover, among the factors related to mitochondrial biogenesis and function, peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) was significantly downregulated in the cisplatin-treated group. Downregulation of PGC-1α in the skeletal muscle may contribute to muscle weakness during cisplatin-induced muscle atrophy. |
| abstract_unstemmed |
This study aimed to investigate the effects of cisplatin on adenosine triphosphate (ATP) levels, expressions of genes related to mitochondrial oxidative phosphorylation (OXPHOS), and the factors related to mitochondrial biosynthesis in skeletal muscle. Systemic cisplatin administration decreased skeletal muscle mass, skeletal muscle strength, and endurance. The mitochondrial DNA /nuclear DNA ratio was also reduced after treatment with cisplatin. Moreover, among the factors related to mitochondrial biogenesis and function, peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) was significantly downregulated in the cisplatin-treated group. Downregulation of PGC-1α in the skeletal muscle may contribute to muscle weakness during cisplatin-induced muscle atrophy. |
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| title_short |
Downregulation of PGC-1α during cisplatin-induced muscle atrophy in murine skeletal muscle |
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Satoshi, Yoshida Miyauchi, Yu Sato, Fumiaki Kon, Risako Ikarashi, Nobutomo Chiba, Yoshihiko Hosoe, Tomoo Sakai, Hiroyasu |
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