Sex dimorphism and cancer immunotherapy: May pregnancy solve the puzzle?
In the immunoncology era, growing evidence has shown a clear sex dimorphism in antitumor immune response with a potential impact on outcomes upon immunecheckpoint blockade (ICI) in patients with cancer. Sex dimorphism could affect tumor microenvironment composition and systemic anticancer immunity;...
Ausführliche Beschreibung
Autor*in: |
Venanzi, Francesco Maria [verfasserIn] Bini, Marta [verfasserIn] Nuccio, Antonio [verfasserIn] De Toma, Alessandro [verfasserIn] Lambertini, Matteo [verfasserIn] Ogliari, Francesca Rita [verfasserIn] Oresti, Sara [verfasserIn] Viganò, Maria Grazia [verfasserIn] Brioschi, Elena [verfasserIn] Polignano, Maggie [verfasserIn] Naldini, Matteo Maria [verfasserIn] Riva, Silvia [verfasserIn] Ferrara, Michele [verfasserIn] Fogale, Nicola [verfasserIn] Damiano, Giuseppe [verfasserIn] Russo, Vincenzo [verfasserIn] Reni, Michele [verfasserIn] Veronesi, Giulia [verfasserIn] Foggetti, Giorgia [verfasserIn] Conforti, Fabio [verfasserIn] Bulotta, Alessandra [verfasserIn] Ferrara, Roberto [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2023 |
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Schlagwörter: |
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Übergeordnetes Werk: |
Enthalten in: Cancer treatment reviews - Amsterdam [u.a.] : Elsevier, 1974, 121 |
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Übergeordnetes Werk: |
volume:121 |
DOI / URN: |
10.1016/j.ctrv.2023.102648 |
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Katalog-ID: |
ELV065614240 |
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520 | |a In the immunoncology era, growing evidence has shown a clear sex dimorphism in antitumor immune response with a potential impact on outcomes upon immunecheckpoint blockade (ICI) in patients with cancer. Sex dimorphism could affect tumor microenvironment composition and systemic anticancer immunity; however, the modifications induced by sex are heterogeneous. From a clinical perspective, six metanalyses have explored the role of sex in cancer patients receiving ICI with conflicting results. Environmental and reproductive factors may further jeopardize the sex-related heterogeneity in anticancer immune response. In particular, pregnancy is characterized by orchestrated changes in the immune system, some of which could be long lasting. A persistence of memory T-cells with a potential fetal-antigen specificity has been reported both in human and mice, suggesting that a previous pregnancy may positively impact cancer development or response to ICI, in case of fetal-antigen sharing from tumor cells. On the other hand, a previous pregnancy may also be associated with a regulatory memory characterized by increased tolerance and anergy towards cancer-fetal common antigens. Finally, fetal-maternal microchimerism could represent an additional source of chronic exposure to fetal antigens and may have important immunological implications on cancer development and ICI activity. So far, the role of pregnancy dimorphism (nulliparous vs parous) in women and the impact of pregnancy-related variables remain largely underexplored in cancer patients. In this review, we summarize the evidence regarding sex and pregnancy dimorphism in the context of immune response and anticancer immunotherapy and advocate the importance of analyzing pregnancy variables on ICIs clinical trials. | ||
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700 | 1 | |a Nuccio, Antonio |e verfasserin |4 aut | |
700 | 1 | |a De Toma, Alessandro |e verfasserin |4 aut | |
700 | 1 | |a Lambertini, Matteo |e verfasserin |4 aut | |
700 | 1 | |a Ogliari, Francesca Rita |e verfasserin |4 aut | |
700 | 1 | |a Oresti, Sara |e verfasserin |4 aut | |
700 | 1 | |a Viganò, Maria Grazia |e verfasserin |4 aut | |
700 | 1 | |a Brioschi, Elena |e verfasserin |4 aut | |
700 | 1 | |a Polignano, Maggie |e verfasserin |4 aut | |
700 | 1 | |a Naldini, Matteo Maria |e verfasserin |4 aut | |
700 | 1 | |a Riva, Silvia |e verfasserin |4 aut | |
700 | 1 | |a Ferrara, Michele |e verfasserin |4 aut | |
700 | 1 | |a Fogale, Nicola |e verfasserin |4 aut | |
700 | 1 | |a Damiano, Giuseppe |e verfasserin |4 aut | |
700 | 1 | |a Russo, Vincenzo |e verfasserin |4 aut | |
700 | 1 | |a Reni, Michele |e verfasserin |4 aut | |
700 | 1 | |a Veronesi, Giulia |e verfasserin |4 aut | |
700 | 1 | |a Foggetti, Giorgia |e verfasserin |4 aut | |
700 | 1 | |a Conforti, Fabio |e verfasserin |4 aut | |
700 | 1 | |a Bulotta, Alessandra |e verfasserin |4 aut | |
700 | 1 | |a Ferrara, Roberto |e verfasserin |4 aut | |
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10.1016/j.ctrv.2023.102648 doi (DE-627)ELV065614240 (ELSEVIER)S0305-7372(23)00141-X DE-627 ger DE-627 rda eng 610 VZ 44.81 bkl Venanzi, Francesco Maria verfasserin aut Sex dimorphism and cancer immunotherapy: May pregnancy solve the puzzle? 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the immunoncology era, growing evidence has shown a clear sex dimorphism in antitumor immune response with a potential impact on outcomes upon immunecheckpoint blockade (ICI) in patients with cancer. Sex dimorphism could affect tumor microenvironment composition and systemic anticancer immunity; however, the modifications induced by sex are heterogeneous. From a clinical perspective, six metanalyses have explored the role of sex in cancer patients receiving ICI with conflicting results. Environmental and reproductive factors may further jeopardize the sex-related heterogeneity in anticancer immune response. In particular, pregnancy is characterized by orchestrated changes in the immune system, some of which could be long lasting. A persistence of memory T-cells with a potential fetal-antigen specificity has been reported both in human and mice, suggesting that a previous pregnancy may positively impact cancer development or response to ICI, in case of fetal-antigen sharing from tumor cells. On the other hand, a previous pregnancy may also be associated with a regulatory memory characterized by increased tolerance and anergy towards cancer-fetal common antigens. Finally, fetal-maternal microchimerism could represent an additional source of chronic exposure to fetal antigens and may have important immunological implications on cancer development and ICI activity. So far, the role of pregnancy dimorphism (nulliparous vs parous) in women and the impact of pregnancy-related variables remain largely underexplored in cancer patients. In this review, we summarize the evidence regarding sex and pregnancy dimorphism in the context of immune response and anticancer immunotherapy and advocate the importance of analyzing pregnancy variables on ICIs clinical trials. Sex dimorphism Pregnancy Sex hormones Microchimerism Immunotherapy Bini, Marta verfasserin aut Nuccio, Antonio verfasserin aut De Toma, Alessandro verfasserin aut Lambertini, Matteo verfasserin aut Ogliari, Francesca Rita verfasserin aut Oresti, Sara verfasserin aut Viganò, Maria Grazia verfasserin aut Brioschi, Elena verfasserin aut Polignano, Maggie verfasserin aut Naldini, Matteo Maria verfasserin aut Riva, Silvia verfasserin aut Ferrara, Michele verfasserin aut Fogale, Nicola verfasserin aut Damiano, Giuseppe verfasserin aut Russo, Vincenzo verfasserin aut Reni, Michele verfasserin aut Veronesi, Giulia verfasserin aut Foggetti, Giorgia verfasserin aut Conforti, Fabio verfasserin aut Bulotta, Alessandra verfasserin aut Ferrara, Roberto verfasserin aut Enthalten in Cancer treatment reviews Amsterdam [u.a.] : Elsevier, 1974 121 Online-Ressource (DE-627)320417158 (DE-600)2002084-3 (DE-576)104194154 1532-1967 nnns volume:121 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 Onkologie VZ AR 121 |
spelling |
10.1016/j.ctrv.2023.102648 doi (DE-627)ELV065614240 (ELSEVIER)S0305-7372(23)00141-X DE-627 ger DE-627 rda eng 610 VZ 44.81 bkl Venanzi, Francesco Maria verfasserin aut Sex dimorphism and cancer immunotherapy: May pregnancy solve the puzzle? 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the immunoncology era, growing evidence has shown a clear sex dimorphism in antitumor immune response with a potential impact on outcomes upon immunecheckpoint blockade (ICI) in patients with cancer. Sex dimorphism could affect tumor microenvironment composition and systemic anticancer immunity; however, the modifications induced by sex are heterogeneous. From a clinical perspective, six metanalyses have explored the role of sex in cancer patients receiving ICI with conflicting results. Environmental and reproductive factors may further jeopardize the sex-related heterogeneity in anticancer immune response. In particular, pregnancy is characterized by orchestrated changes in the immune system, some of which could be long lasting. A persistence of memory T-cells with a potential fetal-antigen specificity has been reported both in human and mice, suggesting that a previous pregnancy may positively impact cancer development or response to ICI, in case of fetal-antigen sharing from tumor cells. On the other hand, a previous pregnancy may also be associated with a regulatory memory characterized by increased tolerance and anergy towards cancer-fetal common antigens. Finally, fetal-maternal microchimerism could represent an additional source of chronic exposure to fetal antigens and may have important immunological implications on cancer development and ICI activity. So far, the role of pregnancy dimorphism (nulliparous vs parous) in women and the impact of pregnancy-related variables remain largely underexplored in cancer patients. In this review, we summarize the evidence regarding sex and pregnancy dimorphism in the context of immune response and anticancer immunotherapy and advocate the importance of analyzing pregnancy variables on ICIs clinical trials. Sex dimorphism Pregnancy Sex hormones Microchimerism Immunotherapy Bini, Marta verfasserin aut Nuccio, Antonio verfasserin aut De Toma, Alessandro verfasserin aut Lambertini, Matteo verfasserin aut Ogliari, Francesca Rita verfasserin aut Oresti, Sara verfasserin aut Viganò, Maria Grazia verfasserin aut Brioschi, Elena verfasserin aut Polignano, Maggie verfasserin aut Naldini, Matteo Maria verfasserin aut Riva, Silvia verfasserin aut Ferrara, Michele verfasserin aut Fogale, Nicola verfasserin aut Damiano, Giuseppe verfasserin aut Russo, Vincenzo verfasserin aut Reni, Michele verfasserin aut Veronesi, Giulia verfasserin aut Foggetti, Giorgia verfasserin aut Conforti, Fabio verfasserin aut Bulotta, Alessandra verfasserin aut Ferrara, Roberto verfasserin aut Enthalten in Cancer treatment reviews Amsterdam [u.a.] : Elsevier, 1974 121 Online-Ressource (DE-627)320417158 (DE-600)2002084-3 (DE-576)104194154 1532-1967 nnns volume:121 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 Onkologie VZ AR 121 |
allfields_unstemmed |
10.1016/j.ctrv.2023.102648 doi (DE-627)ELV065614240 (ELSEVIER)S0305-7372(23)00141-X DE-627 ger DE-627 rda eng 610 VZ 44.81 bkl Venanzi, Francesco Maria verfasserin aut Sex dimorphism and cancer immunotherapy: May pregnancy solve the puzzle? 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the immunoncology era, growing evidence has shown a clear sex dimorphism in antitumor immune response with a potential impact on outcomes upon immunecheckpoint blockade (ICI) in patients with cancer. Sex dimorphism could affect tumor microenvironment composition and systemic anticancer immunity; however, the modifications induced by sex are heterogeneous. From a clinical perspective, six metanalyses have explored the role of sex in cancer patients receiving ICI with conflicting results. Environmental and reproductive factors may further jeopardize the sex-related heterogeneity in anticancer immune response. In particular, pregnancy is characterized by orchestrated changes in the immune system, some of which could be long lasting. A persistence of memory T-cells with a potential fetal-antigen specificity has been reported both in human and mice, suggesting that a previous pregnancy may positively impact cancer development or response to ICI, in case of fetal-antigen sharing from tumor cells. On the other hand, a previous pregnancy may also be associated with a regulatory memory characterized by increased tolerance and anergy towards cancer-fetal common antigens. Finally, fetal-maternal microchimerism could represent an additional source of chronic exposure to fetal antigens and may have important immunological implications on cancer development and ICI activity. So far, the role of pregnancy dimorphism (nulliparous vs parous) in women and the impact of pregnancy-related variables remain largely underexplored in cancer patients. In this review, we summarize the evidence regarding sex and pregnancy dimorphism in the context of immune response and anticancer immunotherapy and advocate the importance of analyzing pregnancy variables on ICIs clinical trials. Sex dimorphism Pregnancy Sex hormones Microchimerism Immunotherapy Bini, Marta verfasserin aut Nuccio, Antonio verfasserin aut De Toma, Alessandro verfasserin aut Lambertini, Matteo verfasserin aut Ogliari, Francesca Rita verfasserin aut Oresti, Sara verfasserin aut Viganò, Maria Grazia verfasserin aut Brioschi, Elena verfasserin aut Polignano, Maggie verfasserin aut Naldini, Matteo Maria verfasserin aut Riva, Silvia verfasserin aut Ferrara, Michele verfasserin aut Fogale, Nicola verfasserin aut Damiano, Giuseppe verfasserin aut Russo, Vincenzo verfasserin aut Reni, Michele verfasserin aut Veronesi, Giulia verfasserin aut Foggetti, Giorgia verfasserin aut Conforti, Fabio verfasserin aut Bulotta, Alessandra verfasserin aut Ferrara, Roberto verfasserin aut Enthalten in Cancer treatment reviews Amsterdam [u.a.] : Elsevier, 1974 121 Online-Ressource (DE-627)320417158 (DE-600)2002084-3 (DE-576)104194154 1532-1967 nnns volume:121 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 Onkologie VZ AR 121 |
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10.1016/j.ctrv.2023.102648 doi (DE-627)ELV065614240 (ELSEVIER)S0305-7372(23)00141-X DE-627 ger DE-627 rda eng 610 VZ 44.81 bkl Venanzi, Francesco Maria verfasserin aut Sex dimorphism and cancer immunotherapy: May pregnancy solve the puzzle? 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the immunoncology era, growing evidence has shown a clear sex dimorphism in antitumor immune response with a potential impact on outcomes upon immunecheckpoint blockade (ICI) in patients with cancer. Sex dimorphism could affect tumor microenvironment composition and systemic anticancer immunity; however, the modifications induced by sex are heterogeneous. From a clinical perspective, six metanalyses have explored the role of sex in cancer patients receiving ICI with conflicting results. Environmental and reproductive factors may further jeopardize the sex-related heterogeneity in anticancer immune response. In particular, pregnancy is characterized by orchestrated changes in the immune system, some of which could be long lasting. A persistence of memory T-cells with a potential fetal-antigen specificity has been reported both in human and mice, suggesting that a previous pregnancy may positively impact cancer development or response to ICI, in case of fetal-antigen sharing from tumor cells. On the other hand, a previous pregnancy may also be associated with a regulatory memory characterized by increased tolerance and anergy towards cancer-fetal common antigens. Finally, fetal-maternal microchimerism could represent an additional source of chronic exposure to fetal antigens and may have important immunological implications on cancer development and ICI activity. So far, the role of pregnancy dimorphism (nulliparous vs parous) in women and the impact of pregnancy-related variables remain largely underexplored in cancer patients. In this review, we summarize the evidence regarding sex and pregnancy dimorphism in the context of immune response and anticancer immunotherapy and advocate the importance of analyzing pregnancy variables on ICIs clinical trials. Sex dimorphism Pregnancy Sex hormones Microchimerism Immunotherapy Bini, Marta verfasserin aut Nuccio, Antonio verfasserin aut De Toma, Alessandro verfasserin aut Lambertini, Matteo verfasserin aut Ogliari, Francesca Rita verfasserin aut Oresti, Sara verfasserin aut Viganò, Maria Grazia verfasserin aut Brioschi, Elena verfasserin aut Polignano, Maggie verfasserin aut Naldini, Matteo Maria verfasserin aut Riva, Silvia verfasserin aut Ferrara, Michele verfasserin aut Fogale, Nicola verfasserin aut Damiano, Giuseppe verfasserin aut Russo, Vincenzo verfasserin aut Reni, Michele verfasserin aut Veronesi, Giulia verfasserin aut Foggetti, Giorgia verfasserin aut Conforti, Fabio verfasserin aut Bulotta, Alessandra verfasserin aut Ferrara, Roberto verfasserin aut Enthalten in Cancer treatment reviews Amsterdam [u.a.] : Elsevier, 1974 121 Online-Ressource (DE-627)320417158 (DE-600)2002084-3 (DE-576)104194154 1532-1967 nnns volume:121 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 Onkologie VZ AR 121 |
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10.1016/j.ctrv.2023.102648 doi (DE-627)ELV065614240 (ELSEVIER)S0305-7372(23)00141-X DE-627 ger DE-627 rda eng 610 VZ 44.81 bkl Venanzi, Francesco Maria verfasserin aut Sex dimorphism and cancer immunotherapy: May pregnancy solve the puzzle? 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the immunoncology era, growing evidence has shown a clear sex dimorphism in antitumor immune response with a potential impact on outcomes upon immunecheckpoint blockade (ICI) in patients with cancer. Sex dimorphism could affect tumor microenvironment composition and systemic anticancer immunity; however, the modifications induced by sex are heterogeneous. From a clinical perspective, six metanalyses have explored the role of sex in cancer patients receiving ICI with conflicting results. Environmental and reproductive factors may further jeopardize the sex-related heterogeneity in anticancer immune response. In particular, pregnancy is characterized by orchestrated changes in the immune system, some of which could be long lasting. A persistence of memory T-cells with a potential fetal-antigen specificity has been reported both in human and mice, suggesting that a previous pregnancy may positively impact cancer development or response to ICI, in case of fetal-antigen sharing from tumor cells. On the other hand, a previous pregnancy may also be associated with a regulatory memory characterized by increased tolerance and anergy towards cancer-fetal common antigens. Finally, fetal-maternal microchimerism could represent an additional source of chronic exposure to fetal antigens and may have important immunological implications on cancer development and ICI activity. So far, the role of pregnancy dimorphism (nulliparous vs parous) in women and the impact of pregnancy-related variables remain largely underexplored in cancer patients. In this review, we summarize the evidence regarding sex and pregnancy dimorphism in the context of immune response and anticancer immunotherapy and advocate the importance of analyzing pregnancy variables on ICIs clinical trials. Sex dimorphism Pregnancy Sex hormones Microchimerism Immunotherapy Bini, Marta verfasserin aut Nuccio, Antonio verfasserin aut De Toma, Alessandro verfasserin aut Lambertini, Matteo verfasserin aut Ogliari, Francesca Rita verfasserin aut Oresti, Sara verfasserin aut Viganò, Maria Grazia verfasserin aut Brioschi, Elena verfasserin aut Polignano, Maggie verfasserin aut Naldini, Matteo Maria verfasserin aut Riva, Silvia verfasserin aut Ferrara, Michele verfasserin aut Fogale, Nicola verfasserin aut Damiano, Giuseppe verfasserin aut Russo, Vincenzo verfasserin aut Reni, Michele verfasserin aut Veronesi, Giulia verfasserin aut Foggetti, Giorgia verfasserin aut Conforti, Fabio verfasserin aut Bulotta, Alessandra verfasserin aut Ferrara, Roberto verfasserin aut Enthalten in Cancer treatment reviews Amsterdam [u.a.] : Elsevier, 1974 121 Online-Ressource (DE-627)320417158 (DE-600)2002084-3 (DE-576)104194154 1532-1967 nnns volume:121 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 Onkologie VZ AR 121 |
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Venanzi, Francesco Maria @@aut@@ Bini, Marta @@aut@@ Nuccio, Antonio @@aut@@ De Toma, Alessandro @@aut@@ Lambertini, Matteo @@aut@@ Ogliari, Francesca Rita @@aut@@ Oresti, Sara @@aut@@ Viganò, Maria Grazia @@aut@@ Brioschi, Elena @@aut@@ Polignano, Maggie @@aut@@ Naldini, Matteo Maria @@aut@@ Riva, Silvia @@aut@@ Ferrara, Michele @@aut@@ Fogale, Nicola @@aut@@ Damiano, Giuseppe @@aut@@ Russo, Vincenzo @@aut@@ Reni, Michele @@aut@@ Veronesi, Giulia @@aut@@ Foggetti, Giorgia @@aut@@ Conforti, Fabio @@aut@@ Bulotta, Alessandra @@aut@@ Ferrara, Roberto @@aut@@ |
publishDateDaySort_date |
2023-01-01T00:00:00Z |
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Venanzi, Francesco Maria |
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Sex dimorphism and cancer immunotherapy: May pregnancy solve the puzzle? |
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Venanzi, Francesco Maria Bini, Marta Nuccio, Antonio De Toma, Alessandro Lambertini, Matteo Ogliari, Francesca Rita Oresti, Sara Viganò, Maria Grazia Brioschi, Elena Polignano, Maggie Naldini, Matteo Maria Riva, Silvia Ferrara, Michele Fogale, Nicola Damiano, Giuseppe Russo, Vincenzo Reni, Michele Veronesi, Giulia Foggetti, Giorgia Conforti, Fabio Bulotta, Alessandra Ferrara, Roberto |
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sex dimorphism and cancer immunotherapy: may pregnancy solve the puzzle? |
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Sex dimorphism and cancer immunotherapy: May pregnancy solve the puzzle? |
abstract |
In the immunoncology era, growing evidence has shown a clear sex dimorphism in antitumor immune response with a potential impact on outcomes upon immunecheckpoint blockade (ICI) in patients with cancer. Sex dimorphism could affect tumor microenvironment composition and systemic anticancer immunity; however, the modifications induced by sex are heterogeneous. From a clinical perspective, six metanalyses have explored the role of sex in cancer patients receiving ICI with conflicting results. Environmental and reproductive factors may further jeopardize the sex-related heterogeneity in anticancer immune response. In particular, pregnancy is characterized by orchestrated changes in the immune system, some of which could be long lasting. A persistence of memory T-cells with a potential fetal-antigen specificity has been reported both in human and mice, suggesting that a previous pregnancy may positively impact cancer development or response to ICI, in case of fetal-antigen sharing from tumor cells. On the other hand, a previous pregnancy may also be associated with a regulatory memory characterized by increased tolerance and anergy towards cancer-fetal common antigens. Finally, fetal-maternal microchimerism could represent an additional source of chronic exposure to fetal antigens and may have important immunological implications on cancer development and ICI activity. So far, the role of pregnancy dimorphism (nulliparous vs parous) in women and the impact of pregnancy-related variables remain largely underexplored in cancer patients. In this review, we summarize the evidence regarding sex and pregnancy dimorphism in the context of immune response and anticancer immunotherapy and advocate the importance of analyzing pregnancy variables on ICIs clinical trials. |
abstractGer |
In the immunoncology era, growing evidence has shown a clear sex dimorphism in antitumor immune response with a potential impact on outcomes upon immunecheckpoint blockade (ICI) in patients with cancer. Sex dimorphism could affect tumor microenvironment composition and systemic anticancer immunity; however, the modifications induced by sex are heterogeneous. From a clinical perspective, six metanalyses have explored the role of sex in cancer patients receiving ICI with conflicting results. Environmental and reproductive factors may further jeopardize the sex-related heterogeneity in anticancer immune response. In particular, pregnancy is characterized by orchestrated changes in the immune system, some of which could be long lasting. A persistence of memory T-cells with a potential fetal-antigen specificity has been reported both in human and mice, suggesting that a previous pregnancy may positively impact cancer development or response to ICI, in case of fetal-antigen sharing from tumor cells. On the other hand, a previous pregnancy may also be associated with a regulatory memory characterized by increased tolerance and anergy towards cancer-fetal common antigens. Finally, fetal-maternal microchimerism could represent an additional source of chronic exposure to fetal antigens and may have important immunological implications on cancer development and ICI activity. So far, the role of pregnancy dimorphism (nulliparous vs parous) in women and the impact of pregnancy-related variables remain largely underexplored in cancer patients. In this review, we summarize the evidence regarding sex and pregnancy dimorphism in the context of immune response and anticancer immunotherapy and advocate the importance of analyzing pregnancy variables on ICIs clinical trials. |
abstract_unstemmed |
In the immunoncology era, growing evidence has shown a clear sex dimorphism in antitumor immune response with a potential impact on outcomes upon immunecheckpoint blockade (ICI) in patients with cancer. Sex dimorphism could affect tumor microenvironment composition and systemic anticancer immunity; however, the modifications induced by sex are heterogeneous. From a clinical perspective, six metanalyses have explored the role of sex in cancer patients receiving ICI with conflicting results. Environmental and reproductive factors may further jeopardize the sex-related heterogeneity in anticancer immune response. In particular, pregnancy is characterized by orchestrated changes in the immune system, some of which could be long lasting. A persistence of memory T-cells with a potential fetal-antigen specificity has been reported both in human and mice, suggesting that a previous pregnancy may positively impact cancer development or response to ICI, in case of fetal-antigen sharing from tumor cells. On the other hand, a previous pregnancy may also be associated with a regulatory memory characterized by increased tolerance and anergy towards cancer-fetal common antigens. Finally, fetal-maternal microchimerism could represent an additional source of chronic exposure to fetal antigens and may have important immunological implications on cancer development and ICI activity. So far, the role of pregnancy dimorphism (nulliparous vs parous) in women and the impact of pregnancy-related variables remain largely underexplored in cancer patients. In this review, we summarize the evidence regarding sex and pregnancy dimorphism in the context of immune response and anticancer immunotherapy and advocate the importance of analyzing pregnancy variables on ICIs clinical trials. |
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Bini, Marta Nuccio, Antonio De Toma, Alessandro Lambertini, Matteo Ogliari, Francesca Rita Oresti, Sara Viganò, Maria Grazia Brioschi, Elena Polignano, Maggie Naldini, Matteo Maria Riva, Silvia Ferrara, Michele Fogale, Nicola Damiano, Giuseppe Russo, Vincenzo Reni, Michele Veronesi, Giulia Foggetti, Giorgia Conforti, Fabio Bulotta, Alessandra Ferrara, Roberto |
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Sex dimorphism could affect tumor microenvironment composition and systemic anticancer immunity; however, the modifications induced by sex are heterogeneous. From a clinical perspective, six metanalyses have explored the role of sex in cancer patients receiving ICI with conflicting results. Environmental and reproductive factors may further jeopardize the sex-related heterogeneity in anticancer immune response. In particular, pregnancy is characterized by orchestrated changes in the immune system, some of which could be long lasting. A persistence of memory T-cells with a potential fetal-antigen specificity has been reported both in human and mice, suggesting that a previous pregnancy may positively impact cancer development or response to ICI, in case of fetal-antigen sharing from tumor cells. On the other hand, a previous pregnancy may also be associated with a regulatory memory characterized by increased tolerance and anergy towards cancer-fetal common antigens. Finally, fetal-maternal microchimerism could represent an additional source of chronic exposure to fetal antigens and may have important immunological implications on cancer development and ICI activity. So far, the role of pregnancy dimorphism (nulliparous vs parous) in women and the impact of pregnancy-related variables remain largely underexplored in cancer patients. In this review, we summarize the evidence regarding sex and pregnancy dimorphism in the context of immune response and anticancer immunotherapy and advocate the importance of analyzing pregnancy variables on ICIs clinical trials.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Sex dimorphism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pregnancy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Sex hormones</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Microchimerism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunotherapy</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bini, Marta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nuccio, Antonio</subfield><subfield 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7.3978424 |