Targeting right orbitofrontal cortex (OFC) with transcranial direct current stimulation (tDCS) can improve cognitive executive function in a major depressive episode, but not depressive mood: A Double-blind Randomized Controlled Pilot Trial

Transcranial direct current stimulation (tDCS) has emerged as a potential treatment for major depressive episodes (MDE). This study aimed to evaluate the efficacy of targeting the right orbitofrontal cortex (rOFC) with tDCS in improving depressed mood and cognitive function in patients with depressi...
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Autor*in:	Huang, Haijing [verfasserIn] Chen, Yiming [verfasserIn] Kong, Shuqi [verfasserIn] Zhang, Mengke [verfasserIn] Wu, Chenglin [verfasserIn] Lyu, Dongbin [verfasserIn] Huang, Qinte [verfasserIn] Yang, Weichieh [verfasserIn] Shi, Shuxiang [verfasserIn] Qian, Nuoshi [verfasserIn] Wang, Fan [verfasserIn] Wei, Zheyi [verfasserIn] Chen, Shentse [verfasserIn] Zhou, Ni [verfasserIn] Zhang, Jianming [verfasserIn] Hong, Wu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Übergeordnetes Werk:	Enthalten in: Journal of psychiatric research - Amsterdam [u.a.] : Elsevier Science, 1961, 168, Seite 108-117
Übergeordnetes Werk:	volume:168 ; pages:108-117

DOI / URN:	10.1016/j.jpsychires.2023.10.016

Katalog-ID:	ELV065714873

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245	1	0	\|a Targeting right orbitofrontal cortex (OFC) with transcranial direct current stimulation (tDCS) can improve cognitive executive function in a major depressive episode, but not depressive mood: A Double-blind Randomized Controlled Pilot Trial
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520			\|a Transcranial direct current stimulation (tDCS) has emerged as a potential treatment for major depressive episodes (MDE). This study aimed to evaluate the efficacy of targeting the right orbitofrontal cortex (rOFC) with tDCS in improving depressed mood and cognitive function in patients with depression. A double-blind, randomized sham-controlled trial was conducted in which 70 patients with depression were randomly assigned to receive rOFC-tDCS (n = 24), left dorsolateral prefrontal cortex (lDLPFC) tDCS (n = 23), or SHAM (n = 23). The treatment course consisted of ten treatments (2 mA, 20 min) delivered over two weeks. Participants were then given once-a-week interventions for the next two weeks. The Hamilton Depression Scale 17 evaluated the severity of depressive symptoms, while the cognitive function was assessed using the Stroop Color-Word Test (SCWT) and the Wisconsin Card Sorting Test (WCST). The primary outcomes were evaluated following ten interventions, with the assessment additionally conducted after maintenance treatment and 4-week follow-up visits. Analyses were performed using linear mixed models. The trial was registered with ChiCTR2000034671. The study did not reveal antidepressant efficacy for rOFC-tDCS or lDLPFC-tDCS over SHAM. Cognitive performance improved for rOFC -tDCS and lDLPFC-tDCS compared to sham for response time on the SWCT and non-perseverative errors in the WCST. However, no statistically significant difference was observed between the two active stimulation groups concerning cognitive performance-enhancing effects. No serious adverse events were noted. In conclusion, while rOFC-tDCS did not present advantages for mood outcomes over lDLPFC-tDCS and SHAM, it may have promising effectiveness in cognitive executive function compared to SHAM.
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700	1		\|a Kong, Shuqi \|e verfasserin \|4 aut
700	1		\|a Zhang, Mengke \|e verfasserin \|4 aut
700	1		\|a Wu, Chenglin \|e verfasserin \|4 aut
700	1		\|a Lyu, Dongbin \|e verfasserin \|4 aut
700	1		\|a Huang, Qinte \|e verfasserin \|4 aut
700	1		\|a Yang, Weichieh \|e verfasserin \|0 (orcid)0000-0002-5521-2794 \|4 aut
700	1		\|a Shi, Shuxiang \|e verfasserin \|4 aut
700	1		\|a Qian, Nuoshi \|e verfasserin \|4 aut
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700	1		\|a Chen, Shentse \|e verfasserin \|4 aut
700	1		\|a Zhou, Ni \|e verfasserin \|4 aut
700	1		\|a Zhang, Jianming \|e verfasserin \|4 aut
700	1		\|a Hong, Wu \|e verfasserin \|4 aut
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allfields	10.1016/j.jpsychires.2023.10.016 doi (DE-627)ELV065714873 (ELSEVIER)S0022-3956(23)00454-5 DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Huang, Haijing verfasserin aut Targeting right orbitofrontal cortex (OFC) with transcranial direct current stimulation (tDCS) can improve cognitive executive function in a major depressive episode, but not depressive mood: A Double-blind Randomized Controlled Pilot Trial 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Transcranial direct current stimulation (tDCS) has emerged as a potential treatment for major depressive episodes (MDE). This study aimed to evaluate the efficacy of targeting the right orbitofrontal cortex (rOFC) with tDCS in improving depressed mood and cognitive function in patients with depression. A double-blind, randomized sham-controlled trial was conducted in which 70 patients with depression were randomly assigned to receive rOFC-tDCS (n = 24), left dorsolateral prefrontal cortex (lDLPFC) tDCS (n = 23), or SHAM (n = 23). The treatment course consisted of ten treatments (2 mA, 20 min) delivered over two weeks. Participants were then given once-a-week interventions for the next two weeks. The Hamilton Depression Scale 17 evaluated the severity of depressive symptoms, while the cognitive function was assessed using the Stroop Color-Word Test (SCWT) and the Wisconsin Card Sorting Test (WCST). The primary outcomes were evaluated following ten interventions, with the assessment additionally conducted after maintenance treatment and 4-week follow-up visits. Analyses were performed using linear mixed models. The trial was registered with ChiCTR2000034671. The study did not reveal antidepressant efficacy for rOFC-tDCS or lDLPFC-tDCS over SHAM. Cognitive performance improved for rOFC -tDCS and lDLPFC-tDCS compared to sham for response time on the SWCT and non-perseverative errors in the WCST. However, no statistically significant difference was observed between the two active stimulation groups concerning cognitive performance-enhancing effects. No serious adverse events were noted. In conclusion, while rOFC-tDCS did not present advantages for mood outcomes over lDLPFC-tDCS and SHAM, it may have promising effectiveness in cognitive executive function compared to SHAM. Chen, Yiming verfasserin aut Kong, Shuqi verfasserin aut Zhang, Mengke verfasserin aut Wu, Chenglin verfasserin aut Lyu, Dongbin verfasserin aut Huang, Qinte verfasserin aut Yang, Weichieh verfasserin (orcid)0000-0002-5521-2794 aut Shi, Shuxiang verfasserin aut Qian, Nuoshi verfasserin aut Wang, Fan verfasserin aut Wei, Zheyi verfasserin aut Chen, Shentse verfasserin aut Zhou, Ni verfasserin aut Zhang, Jianming verfasserin aut Hong, Wu verfasserin aut Enthalten in Journal of psychiatric research Amsterdam [u.a.] : Elsevier Science, 1961 168, Seite 108-117 Online-Ressource (DE-627)30666111X (DE-600)1500641-4 (DE-576)081986718 1879-1379 nnns volume:168 pages:108-117 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 168 108-117
spelling	10.1016/j.jpsychires.2023.10.016 doi (DE-627)ELV065714873 (ELSEVIER)S0022-3956(23)00454-5 DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Huang, Haijing verfasserin aut Targeting right orbitofrontal cortex (OFC) with transcranial direct current stimulation (tDCS) can improve cognitive executive function in a major depressive episode, but not depressive mood: A Double-blind Randomized Controlled Pilot Trial 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Transcranial direct current stimulation (tDCS) has emerged as a potential treatment for major depressive episodes (MDE). This study aimed to evaluate the efficacy of targeting the right orbitofrontal cortex (rOFC) with tDCS in improving depressed mood and cognitive function in patients with depression. A double-blind, randomized sham-controlled trial was conducted in which 70 patients with depression were randomly assigned to receive rOFC-tDCS (n = 24), left dorsolateral prefrontal cortex (lDLPFC) tDCS (n = 23), or SHAM (n = 23). The treatment course consisted of ten treatments (2 mA, 20 min) delivered over two weeks. Participants were then given once-a-week interventions for the next two weeks. The Hamilton Depression Scale 17 evaluated the severity of depressive symptoms, while the cognitive function was assessed using the Stroop Color-Word Test (SCWT) and the Wisconsin Card Sorting Test (WCST). The primary outcomes were evaluated following ten interventions, with the assessment additionally conducted after maintenance treatment and 4-week follow-up visits. Analyses were performed using linear mixed models. The trial was registered with ChiCTR2000034671. The study did not reveal antidepressant efficacy for rOFC-tDCS or lDLPFC-tDCS over SHAM. Cognitive performance improved for rOFC -tDCS and lDLPFC-tDCS compared to sham for response time on the SWCT and non-perseverative errors in the WCST. However, no statistically significant difference was observed between the two active stimulation groups concerning cognitive performance-enhancing effects. No serious adverse events were noted. In conclusion, while rOFC-tDCS did not present advantages for mood outcomes over lDLPFC-tDCS and SHAM, it may have promising effectiveness in cognitive executive function compared to SHAM. Chen, Yiming verfasserin aut Kong, Shuqi verfasserin aut Zhang, Mengke verfasserin aut Wu, Chenglin verfasserin aut Lyu, Dongbin verfasserin aut Huang, Qinte verfasserin aut Yang, Weichieh verfasserin (orcid)0000-0002-5521-2794 aut Shi, Shuxiang verfasserin aut Qian, Nuoshi verfasserin aut Wang, Fan verfasserin aut Wei, Zheyi verfasserin aut Chen, Shentse verfasserin aut Zhou, Ni verfasserin aut Zhang, Jianming verfasserin aut Hong, Wu verfasserin aut Enthalten in Journal of psychiatric research Amsterdam [u.a.] : Elsevier Science, 1961 168, Seite 108-117 Online-Ressource (DE-627)30666111X (DE-600)1500641-4 (DE-576)081986718 1879-1379 nnns volume:168 pages:108-117 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 168 108-117
allfields_unstemmed	10.1016/j.jpsychires.2023.10.016 doi (DE-627)ELV065714873 (ELSEVIER)S0022-3956(23)00454-5 DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Huang, Haijing verfasserin aut Targeting right orbitofrontal cortex (OFC) with transcranial direct current stimulation (tDCS) can improve cognitive executive function in a major depressive episode, but not depressive mood: A Double-blind Randomized Controlled Pilot Trial 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Transcranial direct current stimulation (tDCS) has emerged as a potential treatment for major depressive episodes (MDE). This study aimed to evaluate the efficacy of targeting the right orbitofrontal cortex (rOFC) with tDCS in improving depressed mood and cognitive function in patients with depression. A double-blind, randomized sham-controlled trial was conducted in which 70 patients with depression were randomly assigned to receive rOFC-tDCS (n = 24), left dorsolateral prefrontal cortex (lDLPFC) tDCS (n = 23), or SHAM (n = 23). The treatment course consisted of ten treatments (2 mA, 20 min) delivered over two weeks. Participants were then given once-a-week interventions for the next two weeks. The Hamilton Depression Scale 17 evaluated the severity of depressive symptoms, while the cognitive function was assessed using the Stroop Color-Word Test (SCWT) and the Wisconsin Card Sorting Test (WCST). The primary outcomes were evaluated following ten interventions, with the assessment additionally conducted after maintenance treatment and 4-week follow-up visits. Analyses were performed using linear mixed models. The trial was registered with ChiCTR2000034671. The study did not reveal antidepressant efficacy for rOFC-tDCS or lDLPFC-tDCS over SHAM. Cognitive performance improved for rOFC -tDCS and lDLPFC-tDCS compared to sham for response time on the SWCT and non-perseverative errors in the WCST. However, no statistically significant difference was observed between the two active stimulation groups concerning cognitive performance-enhancing effects. No serious adverse events were noted. In conclusion, while rOFC-tDCS did not present advantages for mood outcomes over lDLPFC-tDCS and SHAM, it may have promising effectiveness in cognitive executive function compared to SHAM. Chen, Yiming verfasserin aut Kong, Shuqi verfasserin aut Zhang, Mengke verfasserin aut Wu, Chenglin verfasserin aut Lyu, Dongbin verfasserin aut Huang, Qinte verfasserin aut Yang, Weichieh verfasserin (orcid)0000-0002-5521-2794 aut Shi, Shuxiang verfasserin aut Qian, Nuoshi verfasserin aut Wang, Fan verfasserin aut Wei, Zheyi verfasserin aut Chen, Shentse verfasserin aut Zhou, Ni verfasserin aut Zhang, Jianming verfasserin aut Hong, Wu verfasserin aut Enthalten in Journal of psychiatric research Amsterdam [u.a.] : Elsevier Science, 1961 168, Seite 108-117 Online-Ressource (DE-627)30666111X (DE-600)1500641-4 (DE-576)081986718 1879-1379 nnns volume:168 pages:108-117 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 168 108-117
allfieldsGer	10.1016/j.jpsychires.2023.10.016 doi (DE-627)ELV065714873 (ELSEVIER)S0022-3956(23)00454-5 DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Huang, Haijing verfasserin aut Targeting right orbitofrontal cortex (OFC) with transcranial direct current stimulation (tDCS) can improve cognitive executive function in a major depressive episode, but not depressive mood: A Double-blind Randomized Controlled Pilot Trial 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Transcranial direct current stimulation (tDCS) has emerged as a potential treatment for major depressive episodes (MDE). This study aimed to evaluate the efficacy of targeting the right orbitofrontal cortex (rOFC) with tDCS in improving depressed mood and cognitive function in patients with depression. A double-blind, randomized sham-controlled trial was conducted in which 70 patients with depression were randomly assigned to receive rOFC-tDCS (n = 24), left dorsolateral prefrontal cortex (lDLPFC) tDCS (n = 23), or SHAM (n = 23). The treatment course consisted of ten treatments (2 mA, 20 min) delivered over two weeks. Participants were then given once-a-week interventions for the next two weeks. The Hamilton Depression Scale 17 evaluated the severity of depressive symptoms, while the cognitive function was assessed using the Stroop Color-Word Test (SCWT) and the Wisconsin Card Sorting Test (WCST). The primary outcomes were evaluated following ten interventions, with the assessment additionally conducted after maintenance treatment and 4-week follow-up visits. Analyses were performed using linear mixed models. The trial was registered with ChiCTR2000034671. The study did not reveal antidepressant efficacy for rOFC-tDCS or lDLPFC-tDCS over SHAM. Cognitive performance improved for rOFC -tDCS and lDLPFC-tDCS compared to sham for response time on the SWCT and non-perseverative errors in the WCST. However, no statistically significant difference was observed between the two active stimulation groups concerning cognitive performance-enhancing effects. No serious adverse events were noted. In conclusion, while rOFC-tDCS did not present advantages for mood outcomes over lDLPFC-tDCS and SHAM, it may have promising effectiveness in cognitive executive function compared to SHAM. Chen, Yiming verfasserin aut Kong, Shuqi verfasserin aut Zhang, Mengke verfasserin aut Wu, Chenglin verfasserin aut Lyu, Dongbin verfasserin aut Huang, Qinte verfasserin aut Yang, Weichieh verfasserin (orcid)0000-0002-5521-2794 aut Shi, Shuxiang verfasserin aut Qian, Nuoshi verfasserin aut Wang, Fan verfasserin aut Wei, Zheyi verfasserin aut Chen, Shentse verfasserin aut Zhou, Ni verfasserin aut Zhang, Jianming verfasserin aut Hong, Wu verfasserin aut Enthalten in Journal of psychiatric research Amsterdam [u.a.] : Elsevier Science, 1961 168, Seite 108-117 Online-Ressource (DE-627)30666111X (DE-600)1500641-4 (DE-576)081986718 1879-1379 nnns volume:168 pages:108-117 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 168 108-117
allfieldsSound	10.1016/j.jpsychires.2023.10.016 doi (DE-627)ELV065714873 (ELSEVIER)S0022-3956(23)00454-5 DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Huang, Haijing verfasserin aut Targeting right orbitofrontal cortex (OFC) with transcranial direct current stimulation (tDCS) can improve cognitive executive function in a major depressive episode, but not depressive mood: A Double-blind Randomized Controlled Pilot Trial 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Transcranial direct current stimulation (tDCS) has emerged as a potential treatment for major depressive episodes (MDE). This study aimed to evaluate the efficacy of targeting the right orbitofrontal cortex (rOFC) with tDCS in improving depressed mood and cognitive function in patients with depression. A double-blind, randomized sham-controlled trial was conducted in which 70 patients with depression were randomly assigned to receive rOFC-tDCS (n = 24), left dorsolateral prefrontal cortex (lDLPFC) tDCS (n = 23), or SHAM (n = 23). The treatment course consisted of ten treatments (2 mA, 20 min) delivered over two weeks. Participants were then given once-a-week interventions for the next two weeks. The Hamilton Depression Scale 17 evaluated the severity of depressive symptoms, while the cognitive function was assessed using the Stroop Color-Word Test (SCWT) and the Wisconsin Card Sorting Test (WCST). The primary outcomes were evaluated following ten interventions, with the assessment additionally conducted after maintenance treatment and 4-week follow-up visits. Analyses were performed using linear mixed models. The trial was registered with ChiCTR2000034671. The study did not reveal antidepressant efficacy for rOFC-tDCS or lDLPFC-tDCS over SHAM. Cognitive performance improved for rOFC -tDCS and lDLPFC-tDCS compared to sham for response time on the SWCT and non-perseverative errors in the WCST. However, no statistically significant difference was observed between the two active stimulation groups concerning cognitive performance-enhancing effects. No serious adverse events were noted. In conclusion, while rOFC-tDCS did not present advantages for mood outcomes over lDLPFC-tDCS and SHAM, it may have promising effectiveness in cognitive executive function compared to SHAM. Chen, Yiming verfasserin aut Kong, Shuqi verfasserin aut Zhang, Mengke verfasserin aut Wu, Chenglin verfasserin aut Lyu, Dongbin verfasserin aut Huang, Qinte verfasserin aut Yang, Weichieh verfasserin (orcid)0000-0002-5521-2794 aut Shi, Shuxiang verfasserin aut Qian, Nuoshi verfasserin aut Wang, Fan verfasserin aut Wei, Zheyi verfasserin aut Chen, Shentse verfasserin aut Zhou, Ni verfasserin aut Zhang, Jianming verfasserin aut Hong, Wu verfasserin aut Enthalten in Journal of psychiatric research Amsterdam [u.a.] : Elsevier Science, 1961 168, Seite 108-117 Online-Ressource (DE-627)30666111X (DE-600)1500641-4 (DE-576)081986718 1879-1379 nnns volume:168 pages:108-117 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 168 108-117
language	English
source	Enthalten in Journal of psychiatric research 168, Seite 108-117 volume:168 pages:108-117
sourceStr	Enthalten in Journal of psychiatric research 168, Seite 108-117 volume:168 pages:108-117
format_phy_str_mv	Article
bklname	Psychiatrie Psychopathologie
institution	findex.gbv.de
dewey-raw	610
isfreeaccess_bool	false
container_title	Journal of psychiatric research
authorswithroles_txt_mv	Huang, Haijing @@aut@@ Chen, Yiming @@aut@@ Kong, Shuqi @@aut@@ Zhang, Mengke @@aut@@ Wu, Chenglin @@aut@@ Lyu, Dongbin @@aut@@ Huang, Qinte @@aut@@ Yang, Weichieh @@aut@@ Shi, Shuxiang @@aut@@ Qian, Nuoshi @@aut@@ Wang, Fan @@aut@@ Wei, Zheyi @@aut@@ Chen, Shentse @@aut@@ Zhou, Ni @@aut@@ Zhang, Jianming @@aut@@ Hong, Wu @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	30666111X
dewey-sort	3610
id	ELV065714873
language_de	englisch
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author	Huang, Haijing
spellingShingle	Huang, Haijing ddc 610 bkl 44.91 Targeting right orbitofrontal cortex (OFC) with transcranial direct current stimulation (tDCS) can improve cognitive executive function in a major depressive episode, but not depressive mood: A Double-blind Randomized Controlled Pilot Trial
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topic_title	610 VZ 44.91 bkl Targeting right orbitofrontal cortex (OFC) with transcranial direct current stimulation (tDCS) can improve cognitive executive function in a major depressive episode, but not depressive mood: A Double-blind Randomized Controlled Pilot Trial
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title	Targeting right orbitofrontal cortex (OFC) with transcranial direct current stimulation (tDCS) can improve cognitive executive function in a major depressive episode, but not depressive mood: A Double-blind Randomized Controlled Pilot Trial
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title_full	Targeting right orbitofrontal cortex (OFC) with transcranial direct current stimulation (tDCS) can improve cognitive executive function in a major depressive episode, but not depressive mood: A Double-blind Randomized Controlled Pilot Trial
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author_browse	Huang, Haijing Chen, Yiming Kong, Shuqi Zhang, Mengke Wu, Chenglin Lyu, Dongbin Huang, Qinte Yang, Weichieh Shi, Shuxiang Qian, Nuoshi Wang, Fan Wei, Zheyi Chen, Shentse Zhou, Ni Zhang, Jianming Hong, Wu
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title_sort	targeting right orbitofrontal cortex (ofc) with transcranial direct current stimulation (tdcs) can improve cognitive executive function in a major depressive episode, but not depressive mood: a double-blind randomized controlled pilot trial
title_auth	Targeting right orbitofrontal cortex (OFC) with transcranial direct current stimulation (tDCS) can improve cognitive executive function in a major depressive episode, but not depressive mood: A Double-blind Randomized Controlled Pilot Trial
abstract	Transcranial direct current stimulation (tDCS) has emerged as a potential treatment for major depressive episodes (MDE). This study aimed to evaluate the efficacy of targeting the right orbitofrontal cortex (rOFC) with tDCS in improving depressed mood and cognitive function in patients with depression. A double-blind, randomized sham-controlled trial was conducted in which 70 patients with depression were randomly assigned to receive rOFC-tDCS (n = 24), left dorsolateral prefrontal cortex (lDLPFC) tDCS (n = 23), or SHAM (n = 23). The treatment course consisted of ten treatments (2 mA, 20 min) delivered over two weeks. Participants were then given once-a-week interventions for the next two weeks. The Hamilton Depression Scale 17 evaluated the severity of depressive symptoms, while the cognitive function was assessed using the Stroop Color-Word Test (SCWT) and the Wisconsin Card Sorting Test (WCST). The primary outcomes were evaluated following ten interventions, with the assessment additionally conducted after maintenance treatment and 4-week follow-up visits. Analyses were performed using linear mixed models. The trial was registered with ChiCTR2000034671. The study did not reveal antidepressant efficacy for rOFC-tDCS or lDLPFC-tDCS over SHAM. Cognitive performance improved for rOFC -tDCS and lDLPFC-tDCS compared to sham for response time on the SWCT and non-perseverative errors in the WCST. However, no statistically significant difference was observed between the two active stimulation groups concerning cognitive performance-enhancing effects. No serious adverse events were noted. In conclusion, while rOFC-tDCS did not present advantages for mood outcomes over lDLPFC-tDCS and SHAM, it may have promising effectiveness in cognitive executive function compared to SHAM.
abstractGer	Transcranial direct current stimulation (tDCS) has emerged as a potential treatment for major depressive episodes (MDE). This study aimed to evaluate the efficacy of targeting the right orbitofrontal cortex (rOFC) with tDCS in improving depressed mood and cognitive function in patients with depression. A double-blind, randomized sham-controlled trial was conducted in which 70 patients with depression were randomly assigned to receive rOFC-tDCS (n = 24), left dorsolateral prefrontal cortex (lDLPFC) tDCS (n = 23), or SHAM (n = 23). The treatment course consisted of ten treatments (2 mA, 20 min) delivered over two weeks. Participants were then given once-a-week interventions for the next two weeks. The Hamilton Depression Scale 17 evaluated the severity of depressive symptoms, while the cognitive function was assessed using the Stroop Color-Word Test (SCWT) and the Wisconsin Card Sorting Test (WCST). The primary outcomes were evaluated following ten interventions, with the assessment additionally conducted after maintenance treatment and 4-week follow-up visits. Analyses were performed using linear mixed models. The trial was registered with ChiCTR2000034671. The study did not reveal antidepressant efficacy for rOFC-tDCS or lDLPFC-tDCS over SHAM. Cognitive performance improved for rOFC -tDCS and lDLPFC-tDCS compared to sham for response time on the SWCT and non-perseverative errors in the WCST. However, no statistically significant difference was observed between the two active stimulation groups concerning cognitive performance-enhancing effects. No serious adverse events were noted. In conclusion, while rOFC-tDCS did not present advantages for mood outcomes over lDLPFC-tDCS and SHAM, it may have promising effectiveness in cognitive executive function compared to SHAM.
abstract_unstemmed	Transcranial direct current stimulation (tDCS) has emerged as a potential treatment for major depressive episodes (MDE). This study aimed to evaluate the efficacy of targeting the right orbitofrontal cortex (rOFC) with tDCS in improving depressed mood and cognitive function in patients with depression. A double-blind, randomized sham-controlled trial was conducted in which 70 patients with depression were randomly assigned to receive rOFC-tDCS (n = 24), left dorsolateral prefrontal cortex (lDLPFC) tDCS (n = 23), or SHAM (n = 23). The treatment course consisted of ten treatments (2 mA, 20 min) delivered over two weeks. Participants were then given once-a-week interventions for the next two weeks. The Hamilton Depression Scale 17 evaluated the severity of depressive symptoms, while the cognitive function was assessed using the Stroop Color-Word Test (SCWT) and the Wisconsin Card Sorting Test (WCST). The primary outcomes were evaluated following ten interventions, with the assessment additionally conducted after maintenance treatment and 4-week follow-up visits. Analyses were performed using linear mixed models. The trial was registered with ChiCTR2000034671. The study did not reveal antidepressant efficacy for rOFC-tDCS or lDLPFC-tDCS over SHAM. Cognitive performance improved for rOFC -tDCS and lDLPFC-tDCS compared to sham for response time on the SWCT and non-perseverative errors in the WCST. However, no statistically significant difference was observed between the two active stimulation groups concerning cognitive performance-enhancing effects. No serious adverse events were noted. In conclusion, while rOFC-tDCS did not present advantages for mood outcomes over lDLPFC-tDCS and SHAM, it may have promising effectiveness in cognitive executive function compared to SHAM.
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title_short	Targeting right orbitofrontal cortex (OFC) with transcranial direct current stimulation (tDCS) can improve cognitive executive function in a major depressive episode, but not depressive mood: A Double-blind Randomized Controlled Pilot Trial
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author2	Chen, Yiming Kong, Shuqi Zhang, Mengke Wu, Chenglin Lyu, Dongbin Huang, Qinte Yang, Weichieh Shi, Shuxiang Qian, Nuoshi Wang, Fan Wei, Zheyi Chen, Shentse Zhou, Ni Zhang, Jianming Hong, Wu
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up_date	2024-07-06T23:59:46.360Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">ELV065714873</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20231121093027.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">231121s2023 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.jpsychires.2023.10.016</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV065714873</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0022-3956(23)00454-5</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.91</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Huang, Haijing</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Targeting right orbitofrontal cortex (OFC) with transcranial direct current stimulation (tDCS) can improve cognitive executive function in a major depressive episode, but not depressive mood: A Double-blind Randomized Controlled Pilot Trial</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Transcranial direct current stimulation (tDCS) has emerged as a potential treatment for major depressive episodes (MDE). This study aimed to evaluate the efficacy of targeting the right orbitofrontal cortex (rOFC) with tDCS in improving depressed mood and cognitive function in patients with depression. A double-blind, randomized sham-controlled trial was conducted in which 70 patients with depression were randomly assigned to receive rOFC-tDCS (n = 24), left dorsolateral prefrontal cortex (lDLPFC) tDCS (n = 23), or SHAM (n = 23). The treatment course consisted of ten treatments (2 mA, 20 min) delivered over two weeks. Participants were then given once-a-week interventions for the next two weeks. The Hamilton Depression Scale 17 evaluated the severity of depressive symptoms, while the cognitive function was assessed using the Stroop Color-Word Test (SCWT) and the Wisconsin Card Sorting Test (WCST). The primary outcomes were evaluated following ten interventions, with the assessment additionally conducted after maintenance treatment and 4-week follow-up visits. Analyses were performed using linear mixed models. The trial was registered with ChiCTR2000034671. The study did not reveal antidepressant efficacy for rOFC-tDCS or lDLPFC-tDCS over SHAM. Cognitive performance improved for rOFC -tDCS and lDLPFC-tDCS compared to sham for response time on the SWCT and non-perseverative errors in the WCST. However, no statistically significant difference was observed between the two active stimulation groups concerning cognitive performance-enhancing effects. No serious adverse events were noted. 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Targeting right orbitofrontal cortex (OFC) with transcranial direct current stimulation (tDCS) can improve cognitive executive function in a major depressive episode, but not depressive mood: A Double-blind Randomized Controlled Pilot Trial

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