Concept of lipid droplet biogenesis

Lipid droplets (LD) are functionally conserved fat storage organelles found in all cell types. LDs have a unique structure comprising of a hydrophobic core of neutral lipids (fat), triacylglycerol (TAG) and cholesterol esters (CE) surrounded by a phospholipid monolayer. LD surface is decorated by a...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Kumari, R.Mankamna [verfasserIn] Khatri, Amit [verfasserIn] Chaudhary, Ritika [verfasserIn] Choudhary, Vineet [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Lipid droplet Organelle biogenesis Endoplasmic reticulum Membrane trafficking Fat storage Seipin TAG Lipodystrophy Lipid storage disorders Metabolic syndrome

Übergeordnetes Werk:	Enthalten in: European journal of cell biology - München : Elsevier, 1998, 102
Übergeordnetes Werk:	volume:102

DOI / URN:	10.1016/j.ejcb.2023.151362

Katalog-ID:	ELV065756894

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520			\|a Lipid droplets (LD) are functionally conserved fat storage organelles found in all cell types. LDs have a unique structure comprising of a hydrophobic core of neutral lipids (fat), triacylglycerol (TAG) and cholesterol esters (CE) surrounded by a phospholipid monolayer. LD surface is decorated by a multitude of proteins and enzymes rendering this compartment functional. Accumulating evidence suggests that LDs originate from discrete ER-subdomains, demarcated by the lipodystrophy protein seipin, however, the mechanisms of which are not well understood. LD biogenesis factors together with biophysical properties of the ER membrane orchestrate spatiotemporal regulation of LD nucleation and growth at specific ER subdomains in response to metabolic cues. Defects in LD formation manifests in several human pathologies, including obesity, lipodystrophy, ectopic fat accumulation, and insulin resistance. Here, we review recent advances in understanding the molecular events during initial stages of eukaryotic LD assembly and discuss the critical role of factors that ensure fidelity of this process.
650		4	\|a Lipid droplet
650		4	\|a Organelle biogenesis
650		4	\|a Endoplasmic reticulum
650		4	\|a Membrane trafficking
650		4	\|a Fat storage
650		4	\|a Seipin
650		4	\|a TAG
650		4	\|a Lipodystrophy
650		4	\|a Lipid storage disorders
650		4	\|a Metabolic syndrome
700	1		\|a Khatri, Amit \|e verfasserin \|4 aut
700	1		\|a Chaudhary, Ritika \|e verfasserin \|4 aut
700	1		\|a Choudhary, Vineet \|e verfasserin \|4 aut
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allfields	10.1016/j.ejcb.2023.151362 doi (DE-627)ELV065756894 (ELSEVIER)S0171-9335(23)00077-8 DE-627 ger DE-627 rda eng 570 610 VZ 12 ssgn 42.15 bkl 42.00 bkl Kumari, R.Mankamna verfasserin aut Concept of lipid droplet biogenesis 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Lipid droplets (LD) are functionally conserved fat storage organelles found in all cell types. LDs have a unique structure comprising of a hydrophobic core of neutral lipids (fat), triacylglycerol (TAG) and cholesterol esters (CE) surrounded by a phospholipid monolayer. LD surface is decorated by a multitude of proteins and enzymes rendering this compartment functional. Accumulating evidence suggests that LDs originate from discrete ER-subdomains, demarcated by the lipodystrophy protein seipin, however, the mechanisms of which are not well understood. LD biogenesis factors together with biophysical properties of the ER membrane orchestrate spatiotemporal regulation of LD nucleation and growth at specific ER subdomains in response to metabolic cues. Defects in LD formation manifests in several human pathologies, including obesity, lipodystrophy, ectopic fat accumulation, and insulin resistance. Here, we review recent advances in understanding the molecular events during initial stages of eukaryotic LD assembly and discuss the critical role of factors that ensure fidelity of this process. Lipid droplet Organelle biogenesis Endoplasmic reticulum Membrane trafficking Fat storage Seipin TAG Lipodystrophy Lipid storage disorders Metabolic syndrome Khatri, Amit verfasserin aut Chaudhary, Ritika verfasserin aut Choudhary, Vineet verfasserin aut Enthalten in European journal of cell biology München : Elsevier, 1998 102 Online-Ressource (DE-627)334288150 (DE-600)2056855-1 (DE-576)094661901 1618-1298 nnns volume:102 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 42.15 Zellbiologie VZ 42.00 Biologie: Allgemeines VZ AR 102
spelling	10.1016/j.ejcb.2023.151362 doi (DE-627)ELV065756894 (ELSEVIER)S0171-9335(23)00077-8 DE-627 ger DE-627 rda eng 570 610 VZ 12 ssgn 42.15 bkl 42.00 bkl Kumari, R.Mankamna verfasserin aut Concept of lipid droplet biogenesis 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Lipid droplets (LD) are functionally conserved fat storage organelles found in all cell types. LDs have a unique structure comprising of a hydrophobic core of neutral lipids (fat), triacylglycerol (TAG) and cholesterol esters (CE) surrounded by a phospholipid monolayer. LD surface is decorated by a multitude of proteins and enzymes rendering this compartment functional. Accumulating evidence suggests that LDs originate from discrete ER-subdomains, demarcated by the lipodystrophy protein seipin, however, the mechanisms of which are not well understood. LD biogenesis factors together with biophysical properties of the ER membrane orchestrate spatiotemporal regulation of LD nucleation and growth at specific ER subdomains in response to metabolic cues. Defects in LD formation manifests in several human pathologies, including obesity, lipodystrophy, ectopic fat accumulation, and insulin resistance. Here, we review recent advances in understanding the molecular events during initial stages of eukaryotic LD assembly and discuss the critical role of factors that ensure fidelity of this process. Lipid droplet Organelle biogenesis Endoplasmic reticulum Membrane trafficking Fat storage Seipin TAG Lipodystrophy Lipid storage disorders Metabolic syndrome Khatri, Amit verfasserin aut Chaudhary, Ritika verfasserin aut Choudhary, Vineet verfasserin aut Enthalten in European journal of cell biology München : Elsevier, 1998 102 Online-Ressource (DE-627)334288150 (DE-600)2056855-1 (DE-576)094661901 1618-1298 nnns volume:102 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 42.15 Zellbiologie VZ 42.00 Biologie: Allgemeines VZ AR 102
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allfieldsSound	10.1016/j.ejcb.2023.151362 doi (DE-627)ELV065756894 (ELSEVIER)S0171-9335(23)00077-8 DE-627 ger DE-627 rda eng 570 610 VZ 12 ssgn 42.15 bkl 42.00 bkl Kumari, R.Mankamna verfasserin aut Concept of lipid droplet biogenesis 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Lipid droplets (LD) are functionally conserved fat storage organelles found in all cell types. LDs have a unique structure comprising of a hydrophobic core of neutral lipids (fat), triacylglycerol (TAG) and cholesterol esters (CE) surrounded by a phospholipid monolayer. LD surface is decorated by a multitude of proteins and enzymes rendering this compartment functional. Accumulating evidence suggests that LDs originate from discrete ER-subdomains, demarcated by the lipodystrophy protein seipin, however, the mechanisms of which are not well understood. LD biogenesis factors together with biophysical properties of the ER membrane orchestrate spatiotemporal regulation of LD nucleation and growth at specific ER subdomains in response to metabolic cues. Defects in LD formation manifests in several human pathologies, including obesity, lipodystrophy, ectopic fat accumulation, and insulin resistance. Here, we review recent advances in understanding the molecular events during initial stages of eukaryotic LD assembly and discuss the critical role of factors that ensure fidelity of this process. Lipid droplet Organelle biogenesis Endoplasmic reticulum Membrane trafficking Fat storage Seipin TAG Lipodystrophy Lipid storage disorders Metabolic syndrome Khatri, Amit verfasserin aut Chaudhary, Ritika verfasserin aut Choudhary, Vineet verfasserin aut Enthalten in European journal of cell biology München : Elsevier, 1998 102 Online-Ressource (DE-627)334288150 (DE-600)2056855-1 (DE-576)094661901 1618-1298 nnns volume:102 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 42.15 Zellbiologie VZ 42.00 Biologie: Allgemeines VZ AR 102
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topic_facet	Lipid droplet Organelle biogenesis Endoplasmic reticulum Membrane trafficking Fat storage Seipin TAG Lipodystrophy Lipid storage disorders Metabolic syndrome
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container_title	European journal of cell biology
authorswithroles_txt_mv	Kumari, R.Mankamna @@aut@@ Khatri, Amit @@aut@@ Chaudhary, Ritika @@aut@@ Choudhary, Vineet @@aut@@
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author	Kumari, R.Mankamna
spellingShingle	Kumari, R.Mankamna ddc 570 ssgn 12 bkl 42.15 bkl 42.00 misc Lipid droplet misc Organelle biogenesis misc Endoplasmic reticulum misc Membrane trafficking misc Fat storage misc Seipin misc TAG misc Lipodystrophy misc Lipid storage disorders misc Metabolic syndrome Concept of lipid droplet biogenesis
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topic_title	570 610 VZ 12 ssgn 42.15 bkl 42.00 bkl Concept of lipid droplet biogenesis Lipid droplet Organelle biogenesis Endoplasmic reticulum Membrane trafficking Fat storage Seipin TAG Lipodystrophy Lipid storage disorders Metabolic syndrome
topic	ddc 570 ssgn 12 bkl 42.15 bkl 42.00 misc Lipid droplet misc Organelle biogenesis misc Endoplasmic reticulum misc Membrane trafficking misc Fat storage misc Seipin misc TAG misc Lipodystrophy misc Lipid storage disorders misc Metabolic syndrome
topic_unstemmed	ddc 570 ssgn 12 bkl 42.15 bkl 42.00 misc Lipid droplet misc Organelle biogenesis misc Endoplasmic reticulum misc Membrane trafficking misc Fat storage misc Seipin misc TAG misc Lipodystrophy misc Lipid storage disorders misc Metabolic syndrome
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title	Concept of lipid droplet biogenesis
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title_full	Concept of lipid droplet biogenesis
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title_sort	concept of lipid droplet biogenesis
title_auth	Concept of lipid droplet biogenesis
abstract	Lipid droplets (LD) are functionally conserved fat storage organelles found in all cell types. LDs have a unique structure comprising of a hydrophobic core of neutral lipids (fat), triacylglycerol (TAG) and cholesterol esters (CE) surrounded by a phospholipid monolayer. LD surface is decorated by a multitude of proteins and enzymes rendering this compartment functional. Accumulating evidence suggests that LDs originate from discrete ER-subdomains, demarcated by the lipodystrophy protein seipin, however, the mechanisms of which are not well understood. LD biogenesis factors together with biophysical properties of the ER membrane orchestrate spatiotemporal regulation of LD nucleation and growth at specific ER subdomains in response to metabolic cues. Defects in LD formation manifests in several human pathologies, including obesity, lipodystrophy, ectopic fat accumulation, and insulin resistance. Here, we review recent advances in understanding the molecular events during initial stages of eukaryotic LD assembly and discuss the critical role of factors that ensure fidelity of this process.
abstractGer	Lipid droplets (LD) are functionally conserved fat storage organelles found in all cell types. LDs have a unique structure comprising of a hydrophobic core of neutral lipids (fat), triacylglycerol (TAG) and cholesterol esters (CE) surrounded by a phospholipid monolayer. LD surface is decorated by a multitude of proteins and enzymes rendering this compartment functional. Accumulating evidence suggests that LDs originate from discrete ER-subdomains, demarcated by the lipodystrophy protein seipin, however, the mechanisms of which are not well understood. LD biogenesis factors together with biophysical properties of the ER membrane orchestrate spatiotemporal regulation of LD nucleation and growth at specific ER subdomains in response to metabolic cues. Defects in LD formation manifests in several human pathologies, including obesity, lipodystrophy, ectopic fat accumulation, and insulin resistance. Here, we review recent advances in understanding the molecular events during initial stages of eukaryotic LD assembly and discuss the critical role of factors that ensure fidelity of this process.
abstract_unstemmed	Lipid droplets (LD) are functionally conserved fat storage organelles found in all cell types. LDs have a unique structure comprising of a hydrophobic core of neutral lipids (fat), triacylglycerol (TAG) and cholesterol esters (CE) surrounded by a phospholipid monolayer. LD surface is decorated by a multitude of proteins and enzymes rendering this compartment functional. Accumulating evidence suggests that LDs originate from discrete ER-subdomains, demarcated by the lipodystrophy protein seipin, however, the mechanisms of which are not well understood. LD biogenesis factors together with biophysical properties of the ER membrane orchestrate spatiotemporal regulation of LD nucleation and growth at specific ER subdomains in response to metabolic cues. Defects in LD formation manifests in several human pathologies, including obesity, lipodystrophy, ectopic fat accumulation, and insulin resistance. Here, we review recent advances in understanding the molecular events during initial stages of eukaryotic LD assembly and discuss the critical role of factors that ensure fidelity of this process.
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title_short	Concept of lipid droplet biogenesis
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author2	Khatri, Amit Chaudhary, Ritika Choudhary, Vineet
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up_date	2024-07-07T00:08:42.822Z
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LDs have a unique structure comprising of a hydrophobic core of neutral lipids (fat), triacylglycerol (TAG) and cholesterol esters (CE) surrounded by a phospholipid monolayer. LD surface is decorated by a multitude of proteins and enzymes rendering this compartment functional. Accumulating evidence suggests that LDs originate from discrete ER-subdomains, demarcated by the lipodystrophy protein seipin, however, the mechanisms of which are not well understood. LD biogenesis factors together with biophysical properties of the ER membrane orchestrate spatiotemporal regulation of LD nucleation and growth at specific ER subdomains in response to metabolic cues. Defects in LD formation manifests in several human pathologies, including obesity, lipodystrophy, ectopic fat accumulation, and insulin resistance. 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Concept of lipid droplet biogenesis

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