Design and synthesis of a novel dipeptide mimetic of the 4
A novel neurotrophin-3 loop 4 dipeptide mimetic, bis(N-γ-hydroxybutyryl-L-glutamyl-L-asparagine) hexamethylenedi-amide (GTS-302), was designed and synthesized. Compound GTS-302 activated the tyrosine kinase receptors TrkC and TrkB, exhibited cytoprotective activity (10-8–10-5 M) in oxidative stress...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Tarasiuk, Alexey V. [verfasserIn] Sazonova, Nellya M. [verfasserIn] Melnikova, Marina V. [verfasserIn] Pomogaybo, Sergey V. [verfasserIn] Logvinov, Ilya O. [verfasserIn] Nikolaev, Sergey V. [verfasserIn] Nikiforov, Dmitry M. [verfasserIn] Antipova, Tatiana A. [verfasserIn] Povarnina, Polina Yu. [verfasserIn] Vakhitova, Yulia V. [verfasserIn] Gudasheva, Tatiana A. [verfasserIn] Seredenin, Sergey B. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Mendeleev communications - London : Turpion, 1991, 33, Seite 786-789 |
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| Übergeordnetes Werk: |
volume:33 ; pages:786-789 |
| DOI / URN: |
10.1016/j.mencom.2023.10.016 |
|---|
| Katalog-ID: |
ELV065898443 |
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| 520 | |a A novel neurotrophin-3 loop 4 dipeptide mimetic, bis(N-γ-hydroxybutyryl-L-glutamyl-L-asparagine) hexamethylenedi-amide (GTS-302), was designed and synthesized. Compound GTS-302 activated the tyrosine kinase receptors TrkC and TrkB, exhibited cytoprotective activity (10-8–10-5 M) in oxidative stress model in HT-22 cells and in 6-hydroxy-dopamine-induced SH-SY5Y cell damage. It also demon- strated an antidepressant-like activity in the forced swim test in mice (0.5–10.0 mg kg–1, intraperitoneally). | ||
| 650 | 4 | |a dipeptide mimetic | |
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| 650 | 4 | |a design | |
| 650 | 4 | |a neurotrophin-3 | |
| 650 | 4 | |a cytoprotective activity | |
| 650 | 4 | |a antidepressant-like activity | |
| 700 | 1 | |a Sazonova, Nellya M. |e verfasserin |4 aut | |
| 700 | 1 | |a Melnikova, Marina V. |e verfasserin |4 aut | |
| 700 | 1 | |a Pomogaybo, Sergey V. |e verfasserin |4 aut | |
| 700 | 1 | |a Logvinov, Ilya O. |e verfasserin |4 aut | |
| 700 | 1 | |a Nikolaev, Sergey V. |e verfasserin |4 aut | |
| 700 | 1 | |a Nikiforov, Dmitry M. |e verfasserin |4 aut | |
| 700 | 1 | |a Antipova, Tatiana A. |e verfasserin |4 aut | |
| 700 | 1 | |a Povarnina, Polina Yu. |e verfasserin |4 aut | |
| 700 | 1 | |a Vakhitova, Yulia V. |e verfasserin |4 aut | |
| 700 | 1 | |a Gudasheva, Tatiana A. |e verfasserin |4 aut | |
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10.1016/j.mencom.2023.10.016 doi (DE-627)ELV065898443 (ELSEVIER)S0959-9436(23)00305-X DE-627 ger DE-627 rda eng 540 VZ 35.00 bkl Tarasiuk, Alexey V. verfasserin aut Design and synthesis of a novel dipeptide mimetic of the 4 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A novel neurotrophin-3 loop 4 dipeptide mimetic, bis(N-γ-hydroxybutyryl-L-glutamyl-L-asparagine) hexamethylenedi-amide (GTS-302), was designed and synthesized. Compound GTS-302 activated the tyrosine kinase receptors TrkC and TrkB, exhibited cytoprotective activity (10-8–10-5 M) in oxidative stress model in HT-22 cells and in 6-hydroxy-dopamine-induced SH-SY5Y cell damage. It also demon- strated an antidepressant-like activity in the forced swim test in mice (0.5–10.0 mg kg–1, intraperitoneally). dipeptide mimetic low-molecular mimetic design neurotrophin-3 cytoprotective activity antidepressant-like activity Sazonova, Nellya M. verfasserin aut Melnikova, Marina V. verfasserin aut Pomogaybo, Sergey V. verfasserin aut Logvinov, Ilya O. verfasserin aut Nikolaev, Sergey V. verfasserin aut Nikiforov, Dmitry M. verfasserin aut Antipova, Tatiana A. verfasserin aut Povarnina, Polina Yu. verfasserin aut Vakhitova, Yulia V. verfasserin aut Gudasheva, Tatiana A. verfasserin aut Seredenin, Sergey B. verfasserin aut Enthalten in Mendeleev communications London : Turpion, 1991 33, Seite 786-789 Online-Ressource (DE-627)271179341 (DE-600)1479351-9 (DE-576)096806346 1364-551X nnns volume:33 pages:786-789 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_31 GBV_ILN_95 GBV_ILN_150 GBV_ILN_2004 GBV_ILN_2111 GBV_ILN_2336 GBV_ILN_4251 35.00 Chemie: Allgemeines VZ AR 33 786-789 |
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10.1016/j.mencom.2023.10.016 doi (DE-627)ELV065898443 (ELSEVIER)S0959-9436(23)00305-X DE-627 ger DE-627 rda eng 540 VZ 35.00 bkl Tarasiuk, Alexey V. verfasserin aut Design and synthesis of a novel dipeptide mimetic of the 4 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A novel neurotrophin-3 loop 4 dipeptide mimetic, bis(N-γ-hydroxybutyryl-L-glutamyl-L-asparagine) hexamethylenedi-amide (GTS-302), was designed and synthesized. Compound GTS-302 activated the tyrosine kinase receptors TrkC and TrkB, exhibited cytoprotective activity (10-8–10-5 M) in oxidative stress model in HT-22 cells and in 6-hydroxy-dopamine-induced SH-SY5Y cell damage. It also demon- strated an antidepressant-like activity in the forced swim test in mice (0.5–10.0 mg kg–1, intraperitoneally). dipeptide mimetic low-molecular mimetic design neurotrophin-3 cytoprotective activity antidepressant-like activity Sazonova, Nellya M. verfasserin aut Melnikova, Marina V. verfasserin aut Pomogaybo, Sergey V. verfasserin aut Logvinov, Ilya O. verfasserin aut Nikolaev, Sergey V. verfasserin aut Nikiforov, Dmitry M. verfasserin aut Antipova, Tatiana A. verfasserin aut Povarnina, Polina Yu. verfasserin aut Vakhitova, Yulia V. verfasserin aut Gudasheva, Tatiana A. verfasserin aut Seredenin, Sergey B. verfasserin aut Enthalten in Mendeleev communications London : Turpion, 1991 33, Seite 786-789 Online-Ressource (DE-627)271179341 (DE-600)1479351-9 (DE-576)096806346 1364-551X nnns volume:33 pages:786-789 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_31 GBV_ILN_95 GBV_ILN_150 GBV_ILN_2004 GBV_ILN_2111 GBV_ILN_2336 GBV_ILN_4251 35.00 Chemie: Allgemeines VZ AR 33 786-789 |
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10.1016/j.mencom.2023.10.016 doi (DE-627)ELV065898443 (ELSEVIER)S0959-9436(23)00305-X DE-627 ger DE-627 rda eng 540 VZ 35.00 bkl Tarasiuk, Alexey V. verfasserin aut Design and synthesis of a novel dipeptide mimetic of the 4 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A novel neurotrophin-3 loop 4 dipeptide mimetic, bis(N-γ-hydroxybutyryl-L-glutamyl-L-asparagine) hexamethylenedi-amide (GTS-302), was designed and synthesized. Compound GTS-302 activated the tyrosine kinase receptors TrkC and TrkB, exhibited cytoprotective activity (10-8–10-5 M) in oxidative stress model in HT-22 cells and in 6-hydroxy-dopamine-induced SH-SY5Y cell damage. It also demon- strated an antidepressant-like activity in the forced swim test in mice (0.5–10.0 mg kg–1, intraperitoneally). dipeptide mimetic low-molecular mimetic design neurotrophin-3 cytoprotective activity antidepressant-like activity Sazonova, Nellya M. verfasserin aut Melnikova, Marina V. verfasserin aut Pomogaybo, Sergey V. verfasserin aut Logvinov, Ilya O. verfasserin aut Nikolaev, Sergey V. verfasserin aut Nikiforov, Dmitry M. verfasserin aut Antipova, Tatiana A. verfasserin aut Povarnina, Polina Yu. verfasserin aut Vakhitova, Yulia V. verfasserin aut Gudasheva, Tatiana A. verfasserin aut Seredenin, Sergey B. verfasserin aut Enthalten in Mendeleev communications London : Turpion, 1991 33, Seite 786-789 Online-Ressource (DE-627)271179341 (DE-600)1479351-9 (DE-576)096806346 1364-551X nnns volume:33 pages:786-789 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_31 GBV_ILN_95 GBV_ILN_150 GBV_ILN_2004 GBV_ILN_2111 GBV_ILN_2336 GBV_ILN_4251 35.00 Chemie: Allgemeines VZ AR 33 786-789 |
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10.1016/j.mencom.2023.10.016 doi (DE-627)ELV065898443 (ELSEVIER)S0959-9436(23)00305-X DE-627 ger DE-627 rda eng 540 VZ 35.00 bkl Tarasiuk, Alexey V. verfasserin aut Design and synthesis of a novel dipeptide mimetic of the 4 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A novel neurotrophin-3 loop 4 dipeptide mimetic, bis(N-γ-hydroxybutyryl-L-glutamyl-L-asparagine) hexamethylenedi-amide (GTS-302), was designed and synthesized. Compound GTS-302 activated the tyrosine kinase receptors TrkC and TrkB, exhibited cytoprotective activity (10-8–10-5 M) in oxidative stress model in HT-22 cells and in 6-hydroxy-dopamine-induced SH-SY5Y cell damage. It also demon- strated an antidepressant-like activity in the forced swim test in mice (0.5–10.0 mg kg–1, intraperitoneally). dipeptide mimetic low-molecular mimetic design neurotrophin-3 cytoprotective activity antidepressant-like activity Sazonova, Nellya M. verfasserin aut Melnikova, Marina V. verfasserin aut Pomogaybo, Sergey V. verfasserin aut Logvinov, Ilya O. verfasserin aut Nikolaev, Sergey V. verfasserin aut Nikiforov, Dmitry M. verfasserin aut Antipova, Tatiana A. verfasserin aut Povarnina, Polina Yu. verfasserin aut Vakhitova, Yulia V. verfasserin aut Gudasheva, Tatiana A. verfasserin aut Seredenin, Sergey B. verfasserin aut Enthalten in Mendeleev communications London : Turpion, 1991 33, Seite 786-789 Online-Ressource (DE-627)271179341 (DE-600)1479351-9 (DE-576)096806346 1364-551X nnns volume:33 pages:786-789 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_31 GBV_ILN_95 GBV_ILN_150 GBV_ILN_2004 GBV_ILN_2111 GBV_ILN_2336 GBV_ILN_4251 35.00 Chemie: Allgemeines VZ AR 33 786-789 |
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10.1016/j.mencom.2023.10.016 doi (DE-627)ELV065898443 (ELSEVIER)S0959-9436(23)00305-X DE-627 ger DE-627 rda eng 540 VZ 35.00 bkl Tarasiuk, Alexey V. verfasserin aut Design and synthesis of a novel dipeptide mimetic of the 4 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A novel neurotrophin-3 loop 4 dipeptide mimetic, bis(N-γ-hydroxybutyryl-L-glutamyl-L-asparagine) hexamethylenedi-amide (GTS-302), was designed and synthesized. Compound GTS-302 activated the tyrosine kinase receptors TrkC and TrkB, exhibited cytoprotective activity (10-8–10-5 M) in oxidative stress model in HT-22 cells and in 6-hydroxy-dopamine-induced SH-SY5Y cell damage. It also demon- strated an antidepressant-like activity in the forced swim test in mice (0.5–10.0 mg kg–1, intraperitoneally). dipeptide mimetic low-molecular mimetic design neurotrophin-3 cytoprotective activity antidepressant-like activity Sazonova, Nellya M. verfasserin aut Melnikova, Marina V. verfasserin aut Pomogaybo, Sergey V. verfasserin aut Logvinov, Ilya O. verfasserin aut Nikolaev, Sergey V. verfasserin aut Nikiforov, Dmitry M. verfasserin aut Antipova, Tatiana A. verfasserin aut Povarnina, Polina Yu. verfasserin aut Vakhitova, Yulia V. verfasserin aut Gudasheva, Tatiana A. verfasserin aut Seredenin, Sergey B. verfasserin aut Enthalten in Mendeleev communications London : Turpion, 1991 33, Seite 786-789 Online-Ressource (DE-627)271179341 (DE-600)1479351-9 (DE-576)096806346 1364-551X nnns volume:33 pages:786-789 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_31 GBV_ILN_95 GBV_ILN_150 GBV_ILN_2004 GBV_ILN_2111 GBV_ILN_2336 GBV_ILN_4251 35.00 Chemie: Allgemeines VZ AR 33 786-789 |
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Tarasiuk, Alexey V. @@aut@@ Sazonova, Nellya M. @@aut@@ Melnikova, Marina V. @@aut@@ Pomogaybo, Sergey V. @@aut@@ Logvinov, Ilya O. @@aut@@ Nikolaev, Sergey V. @@aut@@ Nikiforov, Dmitry M. @@aut@@ Antipova, Tatiana A. @@aut@@ Povarnina, Polina Yu. @@aut@@ Vakhitova, Yulia V. @@aut@@ Gudasheva, Tatiana A. @@aut@@ Seredenin, Sergey B. @@aut@@ |
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Tarasiuk, Alexey V. |
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Tarasiuk, Alexey V. ddc 540 bkl 35.00 misc dipeptide mimetic misc low-molecular mimetic misc design misc neurotrophin-3 misc cytoprotective activity misc antidepressant-like activity Design and synthesis of a novel dipeptide mimetic of the 4 |
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540 VZ 35.00 bkl Design and synthesis of a novel dipeptide mimetic of the 4 dipeptide mimetic low-molecular mimetic design neurotrophin-3 cytoprotective activity antidepressant-like activity |
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ddc 540 bkl 35.00 misc dipeptide mimetic misc low-molecular mimetic misc design misc neurotrophin-3 misc cytoprotective activity misc antidepressant-like activity |
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ddc 540 bkl 35.00 misc dipeptide mimetic misc low-molecular mimetic misc design misc neurotrophin-3 misc cytoprotective activity misc antidepressant-like activity |
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ddc 540 bkl 35.00 misc dipeptide mimetic misc low-molecular mimetic misc design misc neurotrophin-3 misc cytoprotective activity misc antidepressant-like activity |
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Design and synthesis of a novel dipeptide mimetic of the 4 |
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Design and synthesis of a novel dipeptide mimetic of the 4 |
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Tarasiuk, Alexey V. |
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Mendeleev communications |
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Tarasiuk, Alexey V. Sazonova, Nellya M. Melnikova, Marina V. Pomogaybo, Sergey V. Logvinov, Ilya O. Nikolaev, Sergey V. Nikiforov, Dmitry M. Antipova, Tatiana A. Povarnina, Polina Yu. Vakhitova, Yulia V. Gudasheva, Tatiana A. Seredenin, Sergey B. |
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Tarasiuk, Alexey V. |
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10.1016/j.mencom.2023.10.016 |
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design and synthesis of a novel dipeptide mimetic of the 4 |
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Design and synthesis of a novel dipeptide mimetic of the 4 |
| abstract |
A novel neurotrophin-3 loop 4 dipeptide mimetic, bis(N-γ-hydroxybutyryl-L-glutamyl-L-asparagine) hexamethylenedi-amide (GTS-302), was designed and synthesized. Compound GTS-302 activated the tyrosine kinase receptors TrkC and TrkB, exhibited cytoprotective activity (10-8–10-5 M) in oxidative stress model in HT-22 cells and in 6-hydroxy-dopamine-induced SH-SY5Y cell damage. It also demon- strated an antidepressant-like activity in the forced swim test in mice (0.5–10.0 mg kg–1, intraperitoneally). |
| abstractGer |
A novel neurotrophin-3 loop 4 dipeptide mimetic, bis(N-γ-hydroxybutyryl-L-glutamyl-L-asparagine) hexamethylenedi-amide (GTS-302), was designed and synthesized. Compound GTS-302 activated the tyrosine kinase receptors TrkC and TrkB, exhibited cytoprotective activity (10-8–10-5 M) in oxidative stress model in HT-22 cells and in 6-hydroxy-dopamine-induced SH-SY5Y cell damage. It also demon- strated an antidepressant-like activity in the forced swim test in mice (0.5–10.0 mg kg–1, intraperitoneally). |
| abstract_unstemmed |
A novel neurotrophin-3 loop 4 dipeptide mimetic, bis(N-γ-hydroxybutyryl-L-glutamyl-L-asparagine) hexamethylenedi-amide (GTS-302), was designed and synthesized. Compound GTS-302 activated the tyrosine kinase receptors TrkC and TrkB, exhibited cytoprotective activity (10-8–10-5 M) in oxidative stress model in HT-22 cells and in 6-hydroxy-dopamine-induced SH-SY5Y cell damage. It also demon- strated an antidepressant-like activity in the forced swim test in mice (0.5–10.0 mg kg–1, intraperitoneally). |
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Design and synthesis of a novel dipeptide mimetic of the 4 |
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Sazonova, Nellya M. Melnikova, Marina V. Pomogaybo, Sergey V. Logvinov, Ilya O. Nikolaev, Sergey V. Nikiforov, Dmitry M. Antipova, Tatiana A. Povarnina, Polina Yu Vakhitova, Yulia V. Gudasheva, Tatiana A. Seredenin, Sergey B. |
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