Metabolomics integrated with transcriptomics provides insights into the regulatory networks of phenylpropanoids and flavonoids accumulation in Chinese chestnut kernels

Chinese chestnut is a globally important tree nut crop. The kernels of chestnut form a rich source of phenylpropanoids and flavonoids (PFs), which are important bioactive phytochemicals with potential health and nutritional benefits. To explore the metabolic basis of PFs accumulation in Chinese ches...
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Gespeichert in:

Autor*in:	Wang, Wu [verfasserIn] Zhang, Shijie [verfasserIn] Chen, Yu [verfasserIn] Zhao, Yuqiang [verfasserIn] Khalil-Ur-Rehman, Muhammad [verfasserIn] Zhu, Cancan [verfasserIn] Nieuwenhuizen, Niels J. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Chestnut Phenylpropanoids and flavonoids Untargeted metabolomic Transcriptomic Developmental stages

Übergeordnetes Werk:	Enthalten in: Scientia horticulturae - Amsterdam [u.a.] : Elsevier Science, 1973, 325
Übergeordnetes Werk:	volume:325

DOI / URN:	10.1016/j.scienta.2023.112716

Katalog-ID:	ELV06596392X

Internformat


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520			\|a Chinese chestnut is a globally important tree nut crop. The kernels of chestnut form a rich source of phenylpropanoids and flavonoids (PFs), which are important bioactive phytochemicals with potential health and nutritional benefits. To explore the metabolic basis of PFs accumulation in Chinese chestnut kernels, untargeted metabolomic and transcriptomic analysis of four kernel developmental stages (HLS1-HLS4) were performed. In total, 455 (in positive ion mode) and 521 (in negative ion mode) differentially accumulated metabolites (DAMs) were identified. Most components were classified into the categories “organic acids and derivatives”, “lipids and lipid-like molecules” and “phenylpropanoids and polyketides”, with twenty-five and nineteen DAMs annotated as phenylpropanoids and flavonoids respectively. Furthermore, transcriptomics analysis of the kernels was used to assess transcript expression levels. The phenylpropanoid biosynthesis pathway (ko00940) was significantly enriched in the comparison of HLS1-vs-HLS4, HLS2-vs-HLS3, HLS2-vs-HLS4, HLS3-vs-HLS4. Weighted gene co-expression correlation network analysis (WGCNA) was performed by integrating metabolomics and transcriptomics data to investigate the association between PFs and their structural genes, which revealed key enzyme genes (PAL, C4H, 4CL, CHS, CHI, F3H, F3′H, DFR and LAR) linked to the synthesis of PFs. In addition, key members of transcription factors families (e.g., ERFs) that potentially participate in the regulation of PFs biosynthesis by acting on structural gene promoters were screened with a correlative analysis method according to their specific expression patterns in chestnut kernels. This comprehensive data set lays a foundation for further research into the biosynthesis and metabolism of PFs, which will be valuable for genetically improving and future breeding of high-PFs Chinese chestnut varieties.
650		4	\|a Chestnut
650		4	\|a Phenylpropanoids and flavonoids
650		4	\|a Untargeted metabolomic
650		4	\|a Transcriptomic
650		4	\|a Developmental stages
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700	1		\|a Khalil-Ur-Rehman, Muhammad \|e verfasserin \|4 aut
700	1		\|a Zhu, Cancan \|e verfasserin \|4 aut
700	1		\|a Nieuwenhuizen, Niels J. \|e verfasserin \|4 aut
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allfields	10.1016/j.scienta.2023.112716 doi (DE-627)ELV06596392X (ELSEVIER)S0304-4238(23)00884-1 DE-627 ger DE-627 rda eng 630 640 VZ 48.50 bkl Wang, Wu verfasserin aut Metabolomics integrated with transcriptomics provides insights into the regulatory networks of phenylpropanoids and flavonoids accumulation in Chinese chestnut kernels 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chinese chestnut is a globally important tree nut crop. The kernels of chestnut form a rich source of phenylpropanoids and flavonoids (PFs), which are important bioactive phytochemicals with potential health and nutritional benefits. To explore the metabolic basis of PFs accumulation in Chinese chestnut kernels, untargeted metabolomic and transcriptomic analysis of four kernel developmental stages (HLS1-HLS4) were performed. In total, 455 (in positive ion mode) and 521 (in negative ion mode) differentially accumulated metabolites (DAMs) were identified. Most components were classified into the categories “organic acids and derivatives”, “lipids and lipid-like molecules” and “phenylpropanoids and polyketides”, with twenty-five and nineteen DAMs annotated as phenylpropanoids and flavonoids respectively. Furthermore, transcriptomics analysis of the kernels was used to assess transcript expression levels. The phenylpropanoid biosynthesis pathway (ko00940) was significantly enriched in the comparison of HLS1-vs-HLS4, HLS2-vs-HLS3, HLS2-vs-HLS4, HLS3-vs-HLS4. Weighted gene co-expression correlation network analysis (WGCNA) was performed by integrating metabolomics and transcriptomics data to investigate the association between PFs and their structural genes, which revealed key enzyme genes (PAL, C4H, 4CL, CHS, CHI, F3H, F3′H, DFR and LAR) linked to the synthesis of PFs. In addition, key members of transcription factors families (e.g., ERFs) that potentially participate in the regulation of PFs biosynthesis by acting on structural gene promoters were screened with a correlative analysis method according to their specific expression patterns in chestnut kernels. This comprehensive data set lays a foundation for further research into the biosynthesis and metabolism of PFs, which will be valuable for genetically improving and future breeding of high-PFs Chinese chestnut varieties. Chestnut Phenylpropanoids and flavonoids Untargeted metabolomic Transcriptomic Developmental stages Zhang, Shijie verfasserin aut Chen, Yu verfasserin aut Zhao, Yuqiang verfasserin aut Khalil-Ur-Rehman, Muhammad verfasserin aut Zhu, Cancan verfasserin aut Nieuwenhuizen, Niels J. verfasserin aut Enthalten in Scientia horticulturae Amsterdam [u.a.] : Elsevier Science, 1973 325 Online-Ressource (DE-627)320569748 (DE-600)2016351-4 (DE-576)105430587 1879-1018 nnns volume:325 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 48.50 Pflanzenproduktion: Allgemeines VZ AR 325
spelling	10.1016/j.scienta.2023.112716 doi (DE-627)ELV06596392X (ELSEVIER)S0304-4238(23)00884-1 DE-627 ger DE-627 rda eng 630 640 VZ 48.50 bkl Wang, Wu verfasserin aut Metabolomics integrated with transcriptomics provides insights into the regulatory networks of phenylpropanoids and flavonoids accumulation in Chinese chestnut kernels 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chinese chestnut is a globally important tree nut crop. The kernels of chestnut form a rich source of phenylpropanoids and flavonoids (PFs), which are important bioactive phytochemicals with potential health and nutritional benefits. To explore the metabolic basis of PFs accumulation in Chinese chestnut kernels, untargeted metabolomic and transcriptomic analysis of four kernel developmental stages (HLS1-HLS4) were performed. In total, 455 (in positive ion mode) and 521 (in negative ion mode) differentially accumulated metabolites (DAMs) were identified. Most components were classified into the categories “organic acids and derivatives”, “lipids and lipid-like molecules” and “phenylpropanoids and polyketides”, with twenty-five and nineteen DAMs annotated as phenylpropanoids and flavonoids respectively. Furthermore, transcriptomics analysis of the kernels was used to assess transcript expression levels. The phenylpropanoid biosynthesis pathway (ko00940) was significantly enriched in the comparison of HLS1-vs-HLS4, HLS2-vs-HLS3, HLS2-vs-HLS4, HLS3-vs-HLS4. Weighted gene co-expression correlation network analysis (WGCNA) was performed by integrating metabolomics and transcriptomics data to investigate the association between PFs and their structural genes, which revealed key enzyme genes (PAL, C4H, 4CL, CHS, CHI, F3H, F3′H, DFR and LAR) linked to the synthesis of PFs. In addition, key members of transcription factors families (e.g., ERFs) that potentially participate in the regulation of PFs biosynthesis by acting on structural gene promoters were screened with a correlative analysis method according to their specific expression patterns in chestnut kernels. This comprehensive data set lays a foundation for further research into the biosynthesis and metabolism of PFs, which will be valuable for genetically improving and future breeding of high-PFs Chinese chestnut varieties. Chestnut Phenylpropanoids and flavonoids Untargeted metabolomic Transcriptomic Developmental stages Zhang, Shijie verfasserin aut Chen, Yu verfasserin aut Zhao, Yuqiang verfasserin aut Khalil-Ur-Rehman, Muhammad verfasserin aut Zhu, Cancan verfasserin aut Nieuwenhuizen, Niels J. verfasserin aut Enthalten in Scientia horticulturae Amsterdam [u.a.] : Elsevier Science, 1973 325 Online-Ressource (DE-627)320569748 (DE-600)2016351-4 (DE-576)105430587 1879-1018 nnns volume:325 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 48.50 Pflanzenproduktion: Allgemeines VZ AR 325
allfields_unstemmed	10.1016/j.scienta.2023.112716 doi (DE-627)ELV06596392X (ELSEVIER)S0304-4238(23)00884-1 DE-627 ger DE-627 rda eng 630 640 VZ 48.50 bkl Wang, Wu verfasserin aut Metabolomics integrated with transcriptomics provides insights into the regulatory networks of phenylpropanoids and flavonoids accumulation in Chinese chestnut kernels 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chinese chestnut is a globally important tree nut crop. The kernels of chestnut form a rich source of phenylpropanoids and flavonoids (PFs), which are important bioactive phytochemicals with potential health and nutritional benefits. To explore the metabolic basis of PFs accumulation in Chinese chestnut kernels, untargeted metabolomic and transcriptomic analysis of four kernel developmental stages (HLS1-HLS4) were performed. In total, 455 (in positive ion mode) and 521 (in negative ion mode) differentially accumulated metabolites (DAMs) were identified. Most components were classified into the categories “organic acids and derivatives”, “lipids and lipid-like molecules” and “phenylpropanoids and polyketides”, with twenty-five and nineteen DAMs annotated as phenylpropanoids and flavonoids respectively. Furthermore, transcriptomics analysis of the kernels was used to assess transcript expression levels. The phenylpropanoid biosynthesis pathway (ko00940) was significantly enriched in the comparison of HLS1-vs-HLS4, HLS2-vs-HLS3, HLS2-vs-HLS4, HLS3-vs-HLS4. Weighted gene co-expression correlation network analysis (WGCNA) was performed by integrating metabolomics and transcriptomics data to investigate the association between PFs and their structural genes, which revealed key enzyme genes (PAL, C4H, 4CL, CHS, CHI, F3H, F3′H, DFR and LAR) linked to the synthesis of PFs. In addition, key members of transcription factors families (e.g., ERFs) that potentially participate in the regulation of PFs biosynthesis by acting on structural gene promoters were screened with a correlative analysis method according to their specific expression patterns in chestnut kernels. This comprehensive data set lays a foundation for further research into the biosynthesis and metabolism of PFs, which will be valuable for genetically improving and future breeding of high-PFs Chinese chestnut varieties. Chestnut Phenylpropanoids and flavonoids Untargeted metabolomic Transcriptomic Developmental stages Zhang, Shijie verfasserin aut Chen, Yu verfasserin aut Zhao, Yuqiang verfasserin aut Khalil-Ur-Rehman, Muhammad verfasserin aut Zhu, Cancan verfasserin aut Nieuwenhuizen, Niels J. verfasserin aut Enthalten in Scientia horticulturae Amsterdam [u.a.] : Elsevier Science, 1973 325 Online-Ressource (DE-627)320569748 (DE-600)2016351-4 (DE-576)105430587 1879-1018 nnns volume:325 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 48.50 Pflanzenproduktion: Allgemeines VZ AR 325
allfieldsGer	10.1016/j.scienta.2023.112716 doi (DE-627)ELV06596392X (ELSEVIER)S0304-4238(23)00884-1 DE-627 ger DE-627 rda eng 630 640 VZ 48.50 bkl Wang, Wu verfasserin aut Metabolomics integrated with transcriptomics provides insights into the regulatory networks of phenylpropanoids and flavonoids accumulation in Chinese chestnut kernels 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chinese chestnut is a globally important tree nut crop. The kernels of chestnut form a rich source of phenylpropanoids and flavonoids (PFs), which are important bioactive phytochemicals with potential health and nutritional benefits. To explore the metabolic basis of PFs accumulation in Chinese chestnut kernels, untargeted metabolomic and transcriptomic analysis of four kernel developmental stages (HLS1-HLS4) were performed. In total, 455 (in positive ion mode) and 521 (in negative ion mode) differentially accumulated metabolites (DAMs) were identified. Most components were classified into the categories “organic acids and derivatives”, “lipids and lipid-like molecules” and “phenylpropanoids and polyketides”, with twenty-five and nineteen DAMs annotated as phenylpropanoids and flavonoids respectively. Furthermore, transcriptomics analysis of the kernels was used to assess transcript expression levels. The phenylpropanoid biosynthesis pathway (ko00940) was significantly enriched in the comparison of HLS1-vs-HLS4, HLS2-vs-HLS3, HLS2-vs-HLS4, HLS3-vs-HLS4. Weighted gene co-expression correlation network analysis (WGCNA) was performed by integrating metabolomics and transcriptomics data to investigate the association between PFs and their structural genes, which revealed key enzyme genes (PAL, C4H, 4CL, CHS, CHI, F3H, F3′H, DFR and LAR) linked to the synthesis of PFs. In addition, key members of transcription factors families (e.g., ERFs) that potentially participate in the regulation of PFs biosynthesis by acting on structural gene promoters were screened with a correlative analysis method according to their specific expression patterns in chestnut kernels. This comprehensive data set lays a foundation for further research into the biosynthesis and metabolism of PFs, which will be valuable for genetically improving and future breeding of high-PFs Chinese chestnut varieties. Chestnut Phenylpropanoids and flavonoids Untargeted metabolomic Transcriptomic Developmental stages Zhang, Shijie verfasserin aut Chen, Yu verfasserin aut Zhao, Yuqiang verfasserin aut Khalil-Ur-Rehman, Muhammad verfasserin aut Zhu, Cancan verfasserin aut Nieuwenhuizen, Niels J. verfasserin aut Enthalten in Scientia horticulturae Amsterdam [u.a.] : Elsevier Science, 1973 325 Online-Ressource (DE-627)320569748 (DE-600)2016351-4 (DE-576)105430587 1879-1018 nnns volume:325 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 48.50 Pflanzenproduktion: Allgemeines VZ AR 325
allfieldsSound	10.1016/j.scienta.2023.112716 doi (DE-627)ELV06596392X (ELSEVIER)S0304-4238(23)00884-1 DE-627 ger DE-627 rda eng 630 640 VZ 48.50 bkl Wang, Wu verfasserin aut Metabolomics integrated with transcriptomics provides insights into the regulatory networks of phenylpropanoids and flavonoids accumulation in Chinese chestnut kernels 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chinese chestnut is a globally important tree nut crop. The kernels of chestnut form a rich source of phenylpropanoids and flavonoids (PFs), which are important bioactive phytochemicals with potential health and nutritional benefits. To explore the metabolic basis of PFs accumulation in Chinese chestnut kernels, untargeted metabolomic and transcriptomic analysis of four kernel developmental stages (HLS1-HLS4) were performed. In total, 455 (in positive ion mode) and 521 (in negative ion mode) differentially accumulated metabolites (DAMs) were identified. Most components were classified into the categories “organic acids and derivatives”, “lipids and lipid-like molecules” and “phenylpropanoids and polyketides”, with twenty-five and nineteen DAMs annotated as phenylpropanoids and flavonoids respectively. Furthermore, transcriptomics analysis of the kernels was used to assess transcript expression levels. The phenylpropanoid biosynthesis pathway (ko00940) was significantly enriched in the comparison of HLS1-vs-HLS4, HLS2-vs-HLS3, HLS2-vs-HLS4, HLS3-vs-HLS4. Weighted gene co-expression correlation network analysis (WGCNA) was performed by integrating metabolomics and transcriptomics data to investigate the association between PFs and their structural genes, which revealed key enzyme genes (PAL, C4H, 4CL, CHS, CHI, F3H, F3′H, DFR and LAR) linked to the synthesis of PFs. In addition, key members of transcription factors families (e.g., ERFs) that potentially participate in the regulation of PFs biosynthesis by acting on structural gene promoters were screened with a correlative analysis method according to their specific expression patterns in chestnut kernels. This comprehensive data set lays a foundation for further research into the biosynthesis and metabolism of PFs, which will be valuable for genetically improving and future breeding of high-PFs Chinese chestnut varieties. Chestnut Phenylpropanoids and flavonoids Untargeted metabolomic Transcriptomic Developmental stages Zhang, Shijie verfasserin aut Chen, Yu verfasserin aut Zhao, Yuqiang verfasserin aut Khalil-Ur-Rehman, Muhammad verfasserin aut Zhu, Cancan verfasserin aut Nieuwenhuizen, Niels J. verfasserin aut Enthalten in Scientia horticulturae Amsterdam [u.a.] : Elsevier Science, 1973 325 Online-Ressource (DE-627)320569748 (DE-600)2016351-4 (DE-576)105430587 1879-1018 nnns volume:325 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 48.50 Pflanzenproduktion: Allgemeines VZ AR 325
language	English
source	Enthalten in Scientia horticulturae 325 volume:325
sourceStr	Enthalten in Scientia horticulturae 325 volume:325
format_phy_str_mv	Article
bklname	Pflanzenproduktion: Allgemeines
institution	findex.gbv.de
topic_facet	Chestnut Phenylpropanoids and flavonoids Untargeted metabolomic Transcriptomic Developmental stages
dewey-raw	630
isfreeaccess_bool	false
container_title	Scientia horticulturae
authorswithroles_txt_mv	Wang, Wu @@aut@@ Zhang, Shijie @@aut@@ Chen, Yu @@aut@@ Zhao, Yuqiang @@aut@@ Khalil-Ur-Rehman, Muhammad @@aut@@ Zhu, Cancan @@aut@@ Nieuwenhuizen, Niels J. @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	320569748
dewey-sort	3630
id	ELV06596392X
language_de	englisch
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The kernels of chestnut form a rich source of phenylpropanoids and flavonoids (PFs), which are important bioactive phytochemicals with potential health and nutritional benefits. To explore the metabolic basis of PFs accumulation in Chinese chestnut kernels, untargeted metabolomic and transcriptomic analysis of four kernel developmental stages (HLS1-HLS4) were performed. In total, 455 (in positive ion mode) and 521 (in negative ion mode) differentially accumulated metabolites (DAMs) were identified. Most components were classified into the categories “organic acids and derivatives”, “lipids and lipid-like molecules” and “phenylpropanoids and polyketides”, with twenty-five and nineteen DAMs annotated as phenylpropanoids and flavonoids respectively. Furthermore, transcriptomics analysis of the kernels was used to assess transcript expression levels. The phenylpropanoid biosynthesis pathway (ko00940) was significantly enriched in the comparison of HLS1-vs-HLS4, HLS2-vs-HLS3, HLS2-vs-HLS4, HLS3-vs-HLS4. Weighted gene co-expression correlation network analysis (WGCNA) was performed by integrating metabolomics and transcriptomics data to investigate the association between PFs and their structural genes, which revealed key enzyme genes (PAL, C4H, 4CL, CHS, CHI, F3H, F3′H, DFR and LAR) linked to the synthesis of PFs. In addition, key members of transcription factors families (e.g., ERFs) that potentially participate in the regulation of PFs biosynthesis by acting on structural gene promoters were screened with a correlative analysis method according to their specific expression patterns in chestnut kernels. 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spellingShingle	Wang, Wu ddc 630 bkl 48.50 misc Chestnut misc Phenylpropanoids and flavonoids misc Untargeted metabolomic misc Transcriptomic misc Developmental stages Metabolomics integrated with transcriptomics provides insights into the regulatory networks of phenylpropanoids and flavonoids accumulation in Chinese chestnut kernels
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topic_title	630 640 VZ 48.50 bkl Metabolomics integrated with transcriptomics provides insights into the regulatory networks of phenylpropanoids and flavonoids accumulation in Chinese chestnut kernels Chestnut Phenylpropanoids and flavonoids Untargeted metabolomic Transcriptomic Developmental stages
topic	ddc 630 bkl 48.50 misc Chestnut misc Phenylpropanoids and flavonoids misc Untargeted metabolomic misc Transcriptomic misc Developmental stages
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title	Metabolomics integrated with transcriptomics provides insights into the regulatory networks of phenylpropanoids and flavonoids accumulation in Chinese chestnut kernels
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title_full	Metabolomics integrated with transcriptomics provides insights into the regulatory networks of phenylpropanoids and flavonoids accumulation in Chinese chestnut kernels
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title_sort	metabolomics integrated with transcriptomics provides insights into the regulatory networks of phenylpropanoids and flavonoids accumulation in chinese chestnut kernels
title_auth	Metabolomics integrated with transcriptomics provides insights into the regulatory networks of phenylpropanoids and flavonoids accumulation in Chinese chestnut kernels
abstract	Chinese chestnut is a globally important tree nut crop. The kernels of chestnut form a rich source of phenylpropanoids and flavonoids (PFs), which are important bioactive phytochemicals with potential health and nutritional benefits. To explore the metabolic basis of PFs accumulation in Chinese chestnut kernels, untargeted metabolomic and transcriptomic analysis of four kernel developmental stages (HLS1-HLS4) were performed. In total, 455 (in positive ion mode) and 521 (in negative ion mode) differentially accumulated metabolites (DAMs) were identified. Most components were classified into the categories “organic acids and derivatives”, “lipids and lipid-like molecules” and “phenylpropanoids and polyketides”, with twenty-five and nineteen DAMs annotated as phenylpropanoids and flavonoids respectively. Furthermore, transcriptomics analysis of the kernels was used to assess transcript expression levels. The phenylpropanoid biosynthesis pathway (ko00940) was significantly enriched in the comparison of HLS1-vs-HLS4, HLS2-vs-HLS3, HLS2-vs-HLS4, HLS3-vs-HLS4. Weighted gene co-expression correlation network analysis (WGCNA) was performed by integrating metabolomics and transcriptomics data to investigate the association between PFs and their structural genes, which revealed key enzyme genes (PAL, C4H, 4CL, CHS, CHI, F3H, F3′H, DFR and LAR) linked to the synthesis of PFs. In addition, key members of transcription factors families (e.g., ERFs) that potentially participate in the regulation of PFs biosynthesis by acting on structural gene promoters were screened with a correlative analysis method according to their specific expression patterns in chestnut kernels. This comprehensive data set lays a foundation for further research into the biosynthesis and metabolism of PFs, which will be valuable for genetically improving and future breeding of high-PFs Chinese chestnut varieties.
abstractGer	Chinese chestnut is a globally important tree nut crop. The kernels of chestnut form a rich source of phenylpropanoids and flavonoids (PFs), which are important bioactive phytochemicals with potential health and nutritional benefits. To explore the metabolic basis of PFs accumulation in Chinese chestnut kernels, untargeted metabolomic and transcriptomic analysis of four kernel developmental stages (HLS1-HLS4) were performed. In total, 455 (in positive ion mode) and 521 (in negative ion mode) differentially accumulated metabolites (DAMs) were identified. Most components were classified into the categories “organic acids and derivatives”, “lipids and lipid-like molecules” and “phenylpropanoids and polyketides”, with twenty-five and nineteen DAMs annotated as phenylpropanoids and flavonoids respectively. Furthermore, transcriptomics analysis of the kernels was used to assess transcript expression levels. The phenylpropanoid biosynthesis pathway (ko00940) was significantly enriched in the comparison of HLS1-vs-HLS4, HLS2-vs-HLS3, HLS2-vs-HLS4, HLS3-vs-HLS4. Weighted gene co-expression correlation network analysis (WGCNA) was performed by integrating metabolomics and transcriptomics data to investigate the association between PFs and their structural genes, which revealed key enzyme genes (PAL, C4H, 4CL, CHS, CHI, F3H, F3′H, DFR and LAR) linked to the synthesis of PFs. In addition, key members of transcription factors families (e.g., ERFs) that potentially participate in the regulation of PFs biosynthesis by acting on structural gene promoters were screened with a correlative analysis method according to their specific expression patterns in chestnut kernels. This comprehensive data set lays a foundation for further research into the biosynthesis and metabolism of PFs, which will be valuable for genetically improving and future breeding of high-PFs Chinese chestnut varieties.
abstract_unstemmed	Chinese chestnut is a globally important tree nut crop. The kernels of chestnut form a rich source of phenylpropanoids and flavonoids (PFs), which are important bioactive phytochemicals with potential health and nutritional benefits. To explore the metabolic basis of PFs accumulation in Chinese chestnut kernels, untargeted metabolomic and transcriptomic analysis of four kernel developmental stages (HLS1-HLS4) were performed. In total, 455 (in positive ion mode) and 521 (in negative ion mode) differentially accumulated metabolites (DAMs) were identified. Most components were classified into the categories “organic acids and derivatives”, “lipids and lipid-like molecules” and “phenylpropanoids and polyketides”, with twenty-five and nineteen DAMs annotated as phenylpropanoids and flavonoids respectively. Furthermore, transcriptomics analysis of the kernels was used to assess transcript expression levels. The phenylpropanoid biosynthesis pathway (ko00940) was significantly enriched in the comparison of HLS1-vs-HLS4, HLS2-vs-HLS3, HLS2-vs-HLS4, HLS3-vs-HLS4. Weighted gene co-expression correlation network analysis (WGCNA) was performed by integrating metabolomics and transcriptomics data to investigate the association between PFs and their structural genes, which revealed key enzyme genes (PAL, C4H, 4CL, CHS, CHI, F3H, F3′H, DFR and LAR) linked to the synthesis of PFs. In addition, key members of transcription factors families (e.g., ERFs) that potentially participate in the regulation of PFs biosynthesis by acting on structural gene promoters were screened with a correlative analysis method according to their specific expression patterns in chestnut kernels. This comprehensive data set lays a foundation for further research into the biosynthesis and metabolism of PFs, which will be valuable for genetically improving and future breeding of high-PFs Chinese chestnut varieties.
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title_short	Metabolomics integrated with transcriptomics provides insights into the regulatory networks of phenylpropanoids and flavonoids accumulation in Chinese chestnut kernels
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author2	Zhang, Shijie Chen, Yu Zhao, Yuqiang Khalil-Ur-Rehman, Muhammad Zhu, Cancan Nieuwenhuizen, Niels J.
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up_date	2024-07-07T00:51:31.250Z
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The kernels of chestnut form a rich source of phenylpropanoids and flavonoids (PFs), which are important bioactive phytochemicals with potential health and nutritional benefits. To explore the metabolic basis of PFs accumulation in Chinese chestnut kernels, untargeted metabolomic and transcriptomic analysis of four kernel developmental stages (HLS1-HLS4) were performed. In total, 455 (in positive ion mode) and 521 (in negative ion mode) differentially accumulated metabolites (DAMs) were identified. Most components were classified into the categories “organic acids and derivatives”, “lipids and lipid-like molecules” and “phenylpropanoids and polyketides”, with twenty-five and nineteen DAMs annotated as phenylpropanoids and flavonoids respectively. Furthermore, transcriptomics analysis of the kernels was used to assess transcript expression levels. The phenylpropanoid biosynthesis pathway (ko00940) was significantly enriched in the comparison of HLS1-vs-HLS4, HLS2-vs-HLS3, HLS2-vs-HLS4, HLS3-vs-HLS4. Weighted gene co-expression correlation network analysis (WGCNA) was performed by integrating metabolomics and transcriptomics data to investigate the association between PFs and their structural genes, which revealed key enzyme genes (PAL, C4H, 4CL, CHS, CHI, F3H, F3′H, DFR and LAR) linked to the synthesis of PFs. In addition, key members of transcription factors families (e.g., ERFs) that potentially participate in the regulation of PFs biosynthesis by acting on structural gene promoters were screened with a correlative analysis method according to their specific expression patterns in chestnut kernels. This comprehensive data set lays a foundation for further research into the biosynthesis and metabolism of PFs, which will be valuable for genetically improving and future breeding of high-PFs Chinese chestnut varieties.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chestnut</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Phenylpropanoids and flavonoids</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Untargeted metabolomic</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Transcriptomic</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Developmental stages</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhang, Shijie</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chen, Yu</subfield><subfield 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Metabolomics integrated with transcriptomics provides insights into the regulatory networks of phenylpropanoids and flavonoids accumulation in Chinese chestnut kernels

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