Regulation of CncC in insecticide-induced expression of cytochrome P450 CYP9A14 and CYP6AE11 in Helicoverpa armigera
The expression of many detoxification genes can be regulated by CncC pathway and contributes to insecticide tolerance in insects. Our previous study has demonstrated that the transcripts of CncC and cytochrome P450s (CYP9A14, CYP6AE11) were significantly up-regulated after different insecticides tre...
Ausführliche Beschreibung
Autor*in: |
Wu, Peizhuo [verfasserIn] Huang, Yun [verfasserIn] Zheng, Junyue [verfasserIn] Zhang, Yu [verfasserIn] Qiu, Lihong [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2023 |
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Übergeordnetes Werk: |
Enthalten in: Pesticide biochemistry and physiology - Orlando, Fla. : Academic Press, 1971, 197 |
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Übergeordnetes Werk: |
volume:197 |
DOI / URN: |
10.1016/j.pestbp.2023.105707 |
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Katalog-ID: |
ELV066102634 |
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520 | |a The expression of many detoxification genes can be regulated by CncC pathway and contributes to insecticide tolerance in insects. Our previous study has demonstrated that the transcripts of CncC and cytochrome P450s (CYP9A14, CYP6AE11) were significantly up-regulated after different insecticides treatment in Helicoverpa armigera. Further study indicated that H2O2, GSH, and MDA contents and antioxidant enzyme activities of H. armigera were enhanced after chlorantraniliprole, cyantraniliprole, indoxacarb, and spinosad exposure. Silencing CncC by RNA interference significantly down-regulated the expression levels of CYP9A14 and CYP6AE11, and increased the susceptibility of dsRNA-injected larvae to λ-cyhalothrin, chlorantraniliprole, and cyantraniliprole. On the contrary, applying CncC agonist curcumin on H. armigera induced the expression of CYP9A14 and CYP6AE11, and enhanced the tolerance of H. armigera to insecticides. Treatment of ROS scavenger N-acetylcysteine on H. armigera reduced the H2O2 content and antioxidant enzyme activities, suppressed the transcripts of CncC, CYP9A14, and CYP6AE11, and decreased the larval tolerance to insecticides. These results demonstrated that the induced-expression of CYP9A14 and CYP6AE11 related with insecticides tolerance in H. armigera was regulated by CncC, which may be activated by ROS generated by insecticides. This study will help to better understand the underlying regulation mechanisms of CncC pathway in H. armigera tolerance to insecticides. | ||
650 | 4 | |a Insecticide tolerance | |
650 | 4 | |a CncC pathway | |
650 | 4 | |a Cytochrome P450 | |
650 | 4 | |a RNA interference | |
700 | 1 | |a Huang, Yun |e verfasserin |4 aut | |
700 | 1 | |a Zheng, Junyue |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Yu |e verfasserin |4 aut | |
700 | 1 | |a Qiu, Lihong |e verfasserin |4 aut | |
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allfields |
10.1016/j.pestbp.2023.105707 doi (DE-627)ELV066102634 (ELSEVIER)S0048-3575(23)00372-3 DE-627 ger DE-627 rda eng 570 610 VZ 48.54 bkl Wu, Peizhuo verfasserin aut Regulation of CncC in insecticide-induced expression of cytochrome P450 CYP9A14 and CYP6AE11 in Helicoverpa armigera 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The expression of many detoxification genes can be regulated by CncC pathway and contributes to insecticide tolerance in insects. Our previous study has demonstrated that the transcripts of CncC and cytochrome P450s (CYP9A14, CYP6AE11) were significantly up-regulated after different insecticides treatment in Helicoverpa armigera. Further study indicated that H2O2, GSH, and MDA contents and antioxidant enzyme activities of H. armigera were enhanced after chlorantraniliprole, cyantraniliprole, indoxacarb, and spinosad exposure. Silencing CncC by RNA interference significantly down-regulated the expression levels of CYP9A14 and CYP6AE11, and increased the susceptibility of dsRNA-injected larvae to λ-cyhalothrin, chlorantraniliprole, and cyantraniliprole. On the contrary, applying CncC agonist curcumin on H. armigera induced the expression of CYP9A14 and CYP6AE11, and enhanced the tolerance of H. armigera to insecticides. Treatment of ROS scavenger N-acetylcysteine on H. armigera reduced the H2O2 content and antioxidant enzyme activities, suppressed the transcripts of CncC, CYP9A14, and CYP6AE11, and decreased the larval tolerance to insecticides. These results demonstrated that the induced-expression of CYP9A14 and CYP6AE11 related with insecticides tolerance in H. armigera was regulated by CncC, which may be activated by ROS generated by insecticides. This study will help to better understand the underlying regulation mechanisms of CncC pathway in H. armigera tolerance to insecticides. Insecticide tolerance CncC pathway Cytochrome P450 RNA interference Huang, Yun verfasserin aut Zheng, Junyue verfasserin aut Zhang, Yu verfasserin aut Qiu, Lihong verfasserin aut Enthalten in Pesticide biochemistry and physiology Orlando, Fla. : Academic Press, 1971 197 Online-Ressource (DE-627)268125856 (DE-600)1471454-1 (DE-576)255266561 1095-9939 nnns volume:197 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 48.54 Pflanzenpathologie VZ AR 197 |
spelling |
10.1016/j.pestbp.2023.105707 doi (DE-627)ELV066102634 (ELSEVIER)S0048-3575(23)00372-3 DE-627 ger DE-627 rda eng 570 610 VZ 48.54 bkl Wu, Peizhuo verfasserin aut Regulation of CncC in insecticide-induced expression of cytochrome P450 CYP9A14 and CYP6AE11 in Helicoverpa armigera 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The expression of many detoxification genes can be regulated by CncC pathway and contributes to insecticide tolerance in insects. Our previous study has demonstrated that the transcripts of CncC and cytochrome P450s (CYP9A14, CYP6AE11) were significantly up-regulated after different insecticides treatment in Helicoverpa armigera. Further study indicated that H2O2, GSH, and MDA contents and antioxidant enzyme activities of H. armigera were enhanced after chlorantraniliprole, cyantraniliprole, indoxacarb, and spinosad exposure. Silencing CncC by RNA interference significantly down-regulated the expression levels of CYP9A14 and CYP6AE11, and increased the susceptibility of dsRNA-injected larvae to λ-cyhalothrin, chlorantraniliprole, and cyantraniliprole. On the contrary, applying CncC agonist curcumin on H. armigera induced the expression of CYP9A14 and CYP6AE11, and enhanced the tolerance of H. armigera to insecticides. Treatment of ROS scavenger N-acetylcysteine on H. armigera reduced the H2O2 content and antioxidant enzyme activities, suppressed the transcripts of CncC, CYP9A14, and CYP6AE11, and decreased the larval tolerance to insecticides. These results demonstrated that the induced-expression of CYP9A14 and CYP6AE11 related with insecticides tolerance in H. armigera was regulated by CncC, which may be activated by ROS generated by insecticides. This study will help to better understand the underlying regulation mechanisms of CncC pathway in H. armigera tolerance to insecticides. Insecticide tolerance CncC pathway Cytochrome P450 RNA interference Huang, Yun verfasserin aut Zheng, Junyue verfasserin aut Zhang, Yu verfasserin aut Qiu, Lihong verfasserin aut Enthalten in Pesticide biochemistry and physiology Orlando, Fla. : Academic Press, 1971 197 Online-Ressource (DE-627)268125856 (DE-600)1471454-1 (DE-576)255266561 1095-9939 nnns volume:197 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 48.54 Pflanzenpathologie VZ AR 197 |
allfields_unstemmed |
10.1016/j.pestbp.2023.105707 doi (DE-627)ELV066102634 (ELSEVIER)S0048-3575(23)00372-3 DE-627 ger DE-627 rda eng 570 610 VZ 48.54 bkl Wu, Peizhuo verfasserin aut Regulation of CncC in insecticide-induced expression of cytochrome P450 CYP9A14 and CYP6AE11 in Helicoverpa armigera 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The expression of many detoxification genes can be regulated by CncC pathway and contributes to insecticide tolerance in insects. Our previous study has demonstrated that the transcripts of CncC and cytochrome P450s (CYP9A14, CYP6AE11) were significantly up-regulated after different insecticides treatment in Helicoverpa armigera. Further study indicated that H2O2, GSH, and MDA contents and antioxidant enzyme activities of H. armigera were enhanced after chlorantraniliprole, cyantraniliprole, indoxacarb, and spinosad exposure. Silencing CncC by RNA interference significantly down-regulated the expression levels of CYP9A14 and CYP6AE11, and increased the susceptibility of dsRNA-injected larvae to λ-cyhalothrin, chlorantraniliprole, and cyantraniliprole. On the contrary, applying CncC agonist curcumin on H. armigera induced the expression of CYP9A14 and CYP6AE11, and enhanced the tolerance of H. armigera to insecticides. Treatment of ROS scavenger N-acetylcysteine on H. armigera reduced the H2O2 content and antioxidant enzyme activities, suppressed the transcripts of CncC, CYP9A14, and CYP6AE11, and decreased the larval tolerance to insecticides. These results demonstrated that the induced-expression of CYP9A14 and CYP6AE11 related with insecticides tolerance in H. armigera was regulated by CncC, which may be activated by ROS generated by insecticides. This study will help to better understand the underlying regulation mechanisms of CncC pathway in H. armigera tolerance to insecticides. Insecticide tolerance CncC pathway Cytochrome P450 RNA interference Huang, Yun verfasserin aut Zheng, Junyue verfasserin aut Zhang, Yu verfasserin aut Qiu, Lihong verfasserin aut Enthalten in Pesticide biochemistry and physiology Orlando, Fla. : Academic Press, 1971 197 Online-Ressource (DE-627)268125856 (DE-600)1471454-1 (DE-576)255266561 1095-9939 nnns volume:197 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 48.54 Pflanzenpathologie VZ AR 197 |
allfieldsGer |
10.1016/j.pestbp.2023.105707 doi (DE-627)ELV066102634 (ELSEVIER)S0048-3575(23)00372-3 DE-627 ger DE-627 rda eng 570 610 VZ 48.54 bkl Wu, Peizhuo verfasserin aut Regulation of CncC in insecticide-induced expression of cytochrome P450 CYP9A14 and CYP6AE11 in Helicoverpa armigera 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The expression of many detoxification genes can be regulated by CncC pathway and contributes to insecticide tolerance in insects. Our previous study has demonstrated that the transcripts of CncC and cytochrome P450s (CYP9A14, CYP6AE11) were significantly up-regulated after different insecticides treatment in Helicoverpa armigera. Further study indicated that H2O2, GSH, and MDA contents and antioxidant enzyme activities of H. armigera were enhanced after chlorantraniliprole, cyantraniliprole, indoxacarb, and spinosad exposure. Silencing CncC by RNA interference significantly down-regulated the expression levels of CYP9A14 and CYP6AE11, and increased the susceptibility of dsRNA-injected larvae to λ-cyhalothrin, chlorantraniliprole, and cyantraniliprole. On the contrary, applying CncC agonist curcumin on H. armigera induced the expression of CYP9A14 and CYP6AE11, and enhanced the tolerance of H. armigera to insecticides. Treatment of ROS scavenger N-acetylcysteine on H. armigera reduced the H2O2 content and antioxidant enzyme activities, suppressed the transcripts of CncC, CYP9A14, and CYP6AE11, and decreased the larval tolerance to insecticides. These results demonstrated that the induced-expression of CYP9A14 and CYP6AE11 related with insecticides tolerance in H. armigera was regulated by CncC, which may be activated by ROS generated by insecticides. This study will help to better understand the underlying regulation mechanisms of CncC pathway in H. armigera tolerance to insecticides. Insecticide tolerance CncC pathway Cytochrome P450 RNA interference Huang, Yun verfasserin aut Zheng, Junyue verfasserin aut Zhang, Yu verfasserin aut Qiu, Lihong verfasserin aut Enthalten in Pesticide biochemistry and physiology Orlando, Fla. : Academic Press, 1971 197 Online-Ressource (DE-627)268125856 (DE-600)1471454-1 (DE-576)255266561 1095-9939 nnns volume:197 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 48.54 Pflanzenpathologie VZ AR 197 |
allfieldsSound |
10.1016/j.pestbp.2023.105707 doi (DE-627)ELV066102634 (ELSEVIER)S0048-3575(23)00372-3 DE-627 ger DE-627 rda eng 570 610 VZ 48.54 bkl Wu, Peizhuo verfasserin aut Regulation of CncC in insecticide-induced expression of cytochrome P450 CYP9A14 and CYP6AE11 in Helicoverpa armigera 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The expression of many detoxification genes can be regulated by CncC pathway and contributes to insecticide tolerance in insects. Our previous study has demonstrated that the transcripts of CncC and cytochrome P450s (CYP9A14, CYP6AE11) were significantly up-regulated after different insecticides treatment in Helicoverpa armigera. Further study indicated that H2O2, GSH, and MDA contents and antioxidant enzyme activities of H. armigera were enhanced after chlorantraniliprole, cyantraniliprole, indoxacarb, and spinosad exposure. Silencing CncC by RNA interference significantly down-regulated the expression levels of CYP9A14 and CYP6AE11, and increased the susceptibility of dsRNA-injected larvae to λ-cyhalothrin, chlorantraniliprole, and cyantraniliprole. On the contrary, applying CncC agonist curcumin on H. armigera induced the expression of CYP9A14 and CYP6AE11, and enhanced the tolerance of H. armigera to insecticides. Treatment of ROS scavenger N-acetylcysteine on H. armigera reduced the H2O2 content and antioxidant enzyme activities, suppressed the transcripts of CncC, CYP9A14, and CYP6AE11, and decreased the larval tolerance to insecticides. These results demonstrated that the induced-expression of CYP9A14 and CYP6AE11 related with insecticides tolerance in H. armigera was regulated by CncC, which may be activated by ROS generated by insecticides. This study will help to better understand the underlying regulation mechanisms of CncC pathway in H. armigera tolerance to insecticides. Insecticide tolerance CncC pathway Cytochrome P450 RNA interference Huang, Yun verfasserin aut Zheng, Junyue verfasserin aut Zhang, Yu verfasserin aut Qiu, Lihong verfasserin aut Enthalten in Pesticide biochemistry and physiology Orlando, Fla. : Academic Press, 1971 197 Online-Ressource (DE-627)268125856 (DE-600)1471454-1 (DE-576)255266561 1095-9939 nnns volume:197 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 48.54 Pflanzenpathologie VZ AR 197 |
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Enthalten in Pesticide biochemistry and physiology 197 volume:197 |
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Enthalten in Pesticide biochemistry and physiology 197 volume:197 |
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Wu, Peizhuo @@aut@@ Huang, Yun @@aut@@ Zheng, Junyue @@aut@@ Zhang, Yu @@aut@@ Qiu, Lihong @@aut@@ |
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2023-01-01T00:00:00Z |
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Wu, Peizhuo |
spellingShingle |
Wu, Peizhuo ddc 570 bkl 48.54 misc Insecticide tolerance misc CncC pathway misc Cytochrome P450 misc RNA interference Regulation of CncC in insecticide-induced expression of cytochrome P450 CYP9A14 and CYP6AE11 in Helicoverpa armigera |
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570 610 VZ 48.54 bkl Regulation of CncC in insecticide-induced expression of cytochrome P450 CYP9A14 and CYP6AE11 in Helicoverpa armigera Insecticide tolerance CncC pathway Cytochrome P450 RNA interference |
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Regulation of CncC in insecticide-induced expression of cytochrome P450 CYP9A14 and CYP6AE11 in Helicoverpa armigera |
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Regulation of CncC in insecticide-induced expression of cytochrome P450 CYP9A14 and CYP6AE11 in Helicoverpa armigera |
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Wu, Peizhuo |
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Pesticide biochemistry and physiology |
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regulation of cncc in insecticide-induced expression of cytochrome p450 cyp9a14 and cyp6ae11 in helicoverpa armigera |
title_auth |
Regulation of CncC in insecticide-induced expression of cytochrome P450 CYP9A14 and CYP6AE11 in Helicoverpa armigera |
abstract |
The expression of many detoxification genes can be regulated by CncC pathway and contributes to insecticide tolerance in insects. Our previous study has demonstrated that the transcripts of CncC and cytochrome P450s (CYP9A14, CYP6AE11) were significantly up-regulated after different insecticides treatment in Helicoverpa armigera. Further study indicated that H2O2, GSH, and MDA contents and antioxidant enzyme activities of H. armigera were enhanced after chlorantraniliprole, cyantraniliprole, indoxacarb, and spinosad exposure. Silencing CncC by RNA interference significantly down-regulated the expression levels of CYP9A14 and CYP6AE11, and increased the susceptibility of dsRNA-injected larvae to λ-cyhalothrin, chlorantraniliprole, and cyantraniliprole. On the contrary, applying CncC agonist curcumin on H. armigera induced the expression of CYP9A14 and CYP6AE11, and enhanced the tolerance of H. armigera to insecticides. Treatment of ROS scavenger N-acetylcysteine on H. armigera reduced the H2O2 content and antioxidant enzyme activities, suppressed the transcripts of CncC, CYP9A14, and CYP6AE11, and decreased the larval tolerance to insecticides. These results demonstrated that the induced-expression of CYP9A14 and CYP6AE11 related with insecticides tolerance in H. armigera was regulated by CncC, which may be activated by ROS generated by insecticides. This study will help to better understand the underlying regulation mechanisms of CncC pathway in H. armigera tolerance to insecticides. |
abstractGer |
The expression of many detoxification genes can be regulated by CncC pathway and contributes to insecticide tolerance in insects. Our previous study has demonstrated that the transcripts of CncC and cytochrome P450s (CYP9A14, CYP6AE11) were significantly up-regulated after different insecticides treatment in Helicoverpa armigera. Further study indicated that H2O2, GSH, and MDA contents and antioxidant enzyme activities of H. armigera were enhanced after chlorantraniliprole, cyantraniliprole, indoxacarb, and spinosad exposure. Silencing CncC by RNA interference significantly down-regulated the expression levels of CYP9A14 and CYP6AE11, and increased the susceptibility of dsRNA-injected larvae to λ-cyhalothrin, chlorantraniliprole, and cyantraniliprole. On the contrary, applying CncC agonist curcumin on H. armigera induced the expression of CYP9A14 and CYP6AE11, and enhanced the tolerance of H. armigera to insecticides. Treatment of ROS scavenger N-acetylcysteine on H. armigera reduced the H2O2 content and antioxidant enzyme activities, suppressed the transcripts of CncC, CYP9A14, and CYP6AE11, and decreased the larval tolerance to insecticides. These results demonstrated that the induced-expression of CYP9A14 and CYP6AE11 related with insecticides tolerance in H. armigera was regulated by CncC, which may be activated by ROS generated by insecticides. This study will help to better understand the underlying regulation mechanisms of CncC pathway in H. armigera tolerance to insecticides. |
abstract_unstemmed |
The expression of many detoxification genes can be regulated by CncC pathway and contributes to insecticide tolerance in insects. Our previous study has demonstrated that the transcripts of CncC and cytochrome P450s (CYP9A14, CYP6AE11) were significantly up-regulated after different insecticides treatment in Helicoverpa armigera. Further study indicated that H2O2, GSH, and MDA contents and antioxidant enzyme activities of H. armigera were enhanced after chlorantraniliprole, cyantraniliprole, indoxacarb, and spinosad exposure. Silencing CncC by RNA interference significantly down-regulated the expression levels of CYP9A14 and CYP6AE11, and increased the susceptibility of dsRNA-injected larvae to λ-cyhalothrin, chlorantraniliprole, and cyantraniliprole. On the contrary, applying CncC agonist curcumin on H. armigera induced the expression of CYP9A14 and CYP6AE11, and enhanced the tolerance of H. armigera to insecticides. Treatment of ROS scavenger N-acetylcysteine on H. armigera reduced the H2O2 content and antioxidant enzyme activities, suppressed the transcripts of CncC, CYP9A14, and CYP6AE11, and decreased the larval tolerance to insecticides. These results demonstrated that the induced-expression of CYP9A14 and CYP6AE11 related with insecticides tolerance in H. armigera was regulated by CncC, which may be activated by ROS generated by insecticides. This study will help to better understand the underlying regulation mechanisms of CncC pathway in H. armigera tolerance to insecticides. |
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title_short |
Regulation of CncC in insecticide-induced expression of cytochrome P450 CYP9A14 and CYP6AE11 in Helicoverpa armigera |
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|
score |
7.400443 |