Association between autoimmune diseases of the nervous system and schizophrenia: A systematic review and meta-analysis of cohort studies

Introduction: Numerous studies have found an association between autoimmune diseases of the nervous system (ADNS) and schizophrenia (SCZ), but the findings remain controversial. We conducted the first meta-analysis to summarize the current evidence from cohort studies that evaluated the association...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Cao, Yiting [verfasserIn] Ji, Shuang [verfasserIn] Chen, Yujiao [verfasserIn] Zhang, Xiaoshuai [verfasserIn] Ding, Guoyong [verfasserIn] Tang, Fang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	autoimmune diseases of the nervous system schizophrenia autoimmune disease meta-analysis cohort study

Übergeordnetes Werk:	Enthalten in: Comprehensive psychiatry - Amsterdam [u.a.] : Elsevier, 1960, 122
Übergeordnetes Werk:	volume:122

DOI / URN:	10.1016/j.comppsych.2023.152370

Katalog-ID:	ELV066159792

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520			\|a Introduction: Numerous studies have found an association between autoimmune diseases of the nervous system (ADNS) and schizophrenia (SCZ), but the findings remain controversial. We conducted the first meta-analysis to summarize the current evidence from cohort studies that evaluated the association between ADNS and SCZ.Methods: PubMed, Web of Science, and Embase were comprehensively searched until May 30, 2022 for articles on the association between ADNS and SCZ. Every included study was reported effect size with 95% CIs for the association between ADNS and SCZ. Meta-regression and subgroup analysis were used to assess the heterogeneity.Results: A total of 8 cohort studies with 12 cohorts were included in the meta-analysis. We observed a significant association between ADNS and SCZ (RR = 1.42; 95%CI, 1.18–1.72). Subgroup analysis showed that the risk of SCZ was significantly increased when ADNS were used as exposure factors (RR = 1.48; 95%CI, 1.15–1.89), whereas with SCZ did not observe an increased risk of subsequent ADNS (RR = 1.33; 95%CI, 0.92–1.92); multiple sclerosis (MS) was positively associated with SCZ (RR = 1.36; 95%CI, 1.12–1.66), but no significant association was found between Guillain-Barre syndrome (GBS) and SCZ (RR = 1.90; 95%CI, 0.87–4.17). Meanwhile, we found location was the source of heterogeneity.Limitations: High heterogeneity was observed (I 2 = 92.0%), and only English literature was included in the meta-analysis.Conclusions: We found a positive association between ADNS and SCZ, and the association was different across the different types of ADNS. The results of the study are helpful for clinicians to carry out targeted preventive measures for ADNS and SCZ.
650		4	\|a autoimmune diseases of the nervous system
650		4	\|a schizophrenia
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650		4	\|a meta-analysis
650		4	\|a cohort study
700	1		\|a Ji, Shuang \|e verfasserin \|4 aut
700	1		\|a Chen, Yujiao \|e verfasserin \|4 aut
700	1		\|a Zhang, Xiaoshuai \|e verfasserin \|4 aut
700	1		\|a Ding, Guoyong \|e verfasserin \|4 aut
700	1		\|a Tang, Fang \|e verfasserin \|4 aut
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publishDate	2023
allfields	10.1016/j.comppsych.2023.152370 doi (DE-627)ELV066159792 (ELSEVIER)S0010-440X(23)00007-X DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Cao, Yiting verfasserin aut Association between autoimmune diseases of the nervous system and schizophrenia: A systematic review and meta-analysis of cohort studies 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Numerous studies have found an association between autoimmune diseases of the nervous system (ADNS) and schizophrenia (SCZ), but the findings remain controversial. We conducted the first meta-analysis to summarize the current evidence from cohort studies that evaluated the association between ADNS and SCZ.Methods: PubMed, Web of Science, and Embase were comprehensively searched until May 30, 2022 for articles on the association between ADNS and SCZ. Every included study was reported effect size with 95% CIs for the association between ADNS and SCZ. Meta-regression and subgroup analysis were used to assess the heterogeneity.Results: A total of 8 cohort studies with 12 cohorts were included in the meta-analysis. We observed a significant association between ADNS and SCZ (RR = 1.42; 95%CI, 1.18–1.72). Subgroup analysis showed that the risk of SCZ was significantly increased when ADNS were used as exposure factors (RR = 1.48; 95%CI, 1.15–1.89), whereas with SCZ did not observe an increased risk of subsequent ADNS (RR = 1.33; 95%CI, 0.92–1.92); multiple sclerosis (MS) was positively associated with SCZ (RR = 1.36; 95%CI, 1.12–1.66), but no significant association was found between Guillain-Barre syndrome (GBS) and SCZ (RR = 1.90; 95%CI, 0.87–4.17). Meanwhile, we found location was the source of heterogeneity.Limitations: High heterogeneity was observed (I 2 = 92.0%), and only English literature was included in the meta-analysis.Conclusions: We found a positive association between ADNS and SCZ, and the association was different across the different types of ADNS. The results of the study are helpful for clinicians to carry out targeted preventive measures for ADNS and SCZ. autoimmune diseases of the nervous system schizophrenia autoimmune disease meta-analysis cohort study Ji, Shuang verfasserin aut Chen, Yujiao verfasserin aut Zhang, Xiaoshuai verfasserin aut Ding, Guoyong verfasserin aut Tang, Fang verfasserin aut Enthalten in Comprehensive psychiatry Amsterdam [u.a.] : Elsevier, 1960 122 Online-Ressource (DE-627)330080377 (DE-600)2049049-5 (DE-576)105536784 1532-8384 nnns volume:122 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 122
spelling	10.1016/j.comppsych.2023.152370 doi (DE-627)ELV066159792 (ELSEVIER)S0010-440X(23)00007-X DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Cao, Yiting verfasserin aut Association between autoimmune diseases of the nervous system and schizophrenia: A systematic review and meta-analysis of cohort studies 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Numerous studies have found an association between autoimmune diseases of the nervous system (ADNS) and schizophrenia (SCZ), but the findings remain controversial. We conducted the first meta-analysis to summarize the current evidence from cohort studies that evaluated the association between ADNS and SCZ.Methods: PubMed, Web of Science, and Embase were comprehensively searched until May 30, 2022 for articles on the association between ADNS and SCZ. Every included study was reported effect size with 95% CIs for the association between ADNS and SCZ. Meta-regression and subgroup analysis were used to assess the heterogeneity.Results: A total of 8 cohort studies with 12 cohorts were included in the meta-analysis. We observed a significant association between ADNS and SCZ (RR = 1.42; 95%CI, 1.18–1.72). Subgroup analysis showed that the risk of SCZ was significantly increased when ADNS were used as exposure factors (RR = 1.48; 95%CI, 1.15–1.89), whereas with SCZ did not observe an increased risk of subsequent ADNS (RR = 1.33; 95%CI, 0.92–1.92); multiple sclerosis (MS) was positively associated with SCZ (RR = 1.36; 95%CI, 1.12–1.66), but no significant association was found between Guillain-Barre syndrome (GBS) and SCZ (RR = 1.90; 95%CI, 0.87–4.17). Meanwhile, we found location was the source of heterogeneity.Limitations: High heterogeneity was observed (I 2 = 92.0%), and only English literature was included in the meta-analysis.Conclusions: We found a positive association between ADNS and SCZ, and the association was different across the different types of ADNS. The results of the study are helpful for clinicians to carry out targeted preventive measures for ADNS and SCZ. autoimmune diseases of the nervous system schizophrenia autoimmune disease meta-analysis cohort study Ji, Shuang verfasserin aut Chen, Yujiao verfasserin aut Zhang, Xiaoshuai verfasserin aut Ding, Guoyong verfasserin aut Tang, Fang verfasserin aut Enthalten in Comprehensive psychiatry Amsterdam [u.a.] : Elsevier, 1960 122 Online-Ressource (DE-627)330080377 (DE-600)2049049-5 (DE-576)105536784 1532-8384 nnns volume:122 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 122
allfields_unstemmed	10.1016/j.comppsych.2023.152370 doi (DE-627)ELV066159792 (ELSEVIER)S0010-440X(23)00007-X DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Cao, Yiting verfasserin aut Association between autoimmune diseases of the nervous system and schizophrenia: A systematic review and meta-analysis of cohort studies 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Numerous studies have found an association between autoimmune diseases of the nervous system (ADNS) and schizophrenia (SCZ), but the findings remain controversial. We conducted the first meta-analysis to summarize the current evidence from cohort studies that evaluated the association between ADNS and SCZ.Methods: PubMed, Web of Science, and Embase were comprehensively searched until May 30, 2022 for articles on the association between ADNS and SCZ. Every included study was reported effect size with 95% CIs for the association between ADNS and SCZ. Meta-regression and subgroup analysis were used to assess the heterogeneity.Results: A total of 8 cohort studies with 12 cohorts were included in the meta-analysis. We observed a significant association between ADNS and SCZ (RR = 1.42; 95%CI, 1.18–1.72). Subgroup analysis showed that the risk of SCZ was significantly increased when ADNS were used as exposure factors (RR = 1.48; 95%CI, 1.15–1.89), whereas with SCZ did not observe an increased risk of subsequent ADNS (RR = 1.33; 95%CI, 0.92–1.92); multiple sclerosis (MS) was positively associated with SCZ (RR = 1.36; 95%CI, 1.12–1.66), but no significant association was found between Guillain-Barre syndrome (GBS) and SCZ (RR = 1.90; 95%CI, 0.87–4.17). Meanwhile, we found location was the source of heterogeneity.Limitations: High heterogeneity was observed (I 2 = 92.0%), and only English literature was included in the meta-analysis.Conclusions: We found a positive association between ADNS and SCZ, and the association was different across the different types of ADNS. The results of the study are helpful for clinicians to carry out targeted preventive measures for ADNS and SCZ. autoimmune diseases of the nervous system schizophrenia autoimmune disease meta-analysis cohort study Ji, Shuang verfasserin aut Chen, Yujiao verfasserin aut Zhang, Xiaoshuai verfasserin aut Ding, Guoyong verfasserin aut Tang, Fang verfasserin aut Enthalten in Comprehensive psychiatry Amsterdam [u.a.] : Elsevier, 1960 122 Online-Ressource (DE-627)330080377 (DE-600)2049049-5 (DE-576)105536784 1532-8384 nnns volume:122 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 122
allfieldsGer	10.1016/j.comppsych.2023.152370 doi (DE-627)ELV066159792 (ELSEVIER)S0010-440X(23)00007-X DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Cao, Yiting verfasserin aut Association between autoimmune diseases of the nervous system and schizophrenia: A systematic review and meta-analysis of cohort studies 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Numerous studies have found an association between autoimmune diseases of the nervous system (ADNS) and schizophrenia (SCZ), but the findings remain controversial. We conducted the first meta-analysis to summarize the current evidence from cohort studies that evaluated the association between ADNS and SCZ.Methods: PubMed, Web of Science, and Embase were comprehensively searched until May 30, 2022 for articles on the association between ADNS and SCZ. Every included study was reported effect size with 95% CIs for the association between ADNS and SCZ. Meta-regression and subgroup analysis were used to assess the heterogeneity.Results: A total of 8 cohort studies with 12 cohorts were included in the meta-analysis. We observed a significant association between ADNS and SCZ (RR = 1.42; 95%CI, 1.18–1.72). Subgroup analysis showed that the risk of SCZ was significantly increased when ADNS were used as exposure factors (RR = 1.48; 95%CI, 1.15–1.89), whereas with SCZ did not observe an increased risk of subsequent ADNS (RR = 1.33; 95%CI, 0.92–1.92); multiple sclerosis (MS) was positively associated with SCZ (RR = 1.36; 95%CI, 1.12–1.66), but no significant association was found between Guillain-Barre syndrome (GBS) and SCZ (RR = 1.90; 95%CI, 0.87–4.17). Meanwhile, we found location was the source of heterogeneity.Limitations: High heterogeneity was observed (I 2 = 92.0%), and only English literature was included in the meta-analysis.Conclusions: We found a positive association between ADNS and SCZ, and the association was different across the different types of ADNS. The results of the study are helpful for clinicians to carry out targeted preventive measures for ADNS and SCZ. autoimmune diseases of the nervous system schizophrenia autoimmune disease meta-analysis cohort study Ji, Shuang verfasserin aut Chen, Yujiao verfasserin aut Zhang, Xiaoshuai verfasserin aut Ding, Guoyong verfasserin aut Tang, Fang verfasserin aut Enthalten in Comprehensive psychiatry Amsterdam [u.a.] : Elsevier, 1960 122 Online-Ressource (DE-627)330080377 (DE-600)2049049-5 (DE-576)105536784 1532-8384 nnns volume:122 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 122
allfieldsSound	10.1016/j.comppsych.2023.152370 doi (DE-627)ELV066159792 (ELSEVIER)S0010-440X(23)00007-X DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Cao, Yiting verfasserin aut Association between autoimmune diseases of the nervous system and schizophrenia: A systematic review and meta-analysis of cohort studies 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Numerous studies have found an association between autoimmune diseases of the nervous system (ADNS) and schizophrenia (SCZ), but the findings remain controversial. We conducted the first meta-analysis to summarize the current evidence from cohort studies that evaluated the association between ADNS and SCZ.Methods: PubMed, Web of Science, and Embase were comprehensively searched until May 30, 2022 for articles on the association between ADNS and SCZ. Every included study was reported effect size with 95% CIs for the association between ADNS and SCZ. Meta-regression and subgroup analysis were used to assess the heterogeneity.Results: A total of 8 cohort studies with 12 cohorts were included in the meta-analysis. We observed a significant association between ADNS and SCZ (RR = 1.42; 95%CI, 1.18–1.72). Subgroup analysis showed that the risk of SCZ was significantly increased when ADNS were used as exposure factors (RR = 1.48; 95%CI, 1.15–1.89), whereas with SCZ did not observe an increased risk of subsequent ADNS (RR = 1.33; 95%CI, 0.92–1.92); multiple sclerosis (MS) was positively associated with SCZ (RR = 1.36; 95%CI, 1.12–1.66), but no significant association was found between Guillain-Barre syndrome (GBS) and SCZ (RR = 1.90; 95%CI, 0.87–4.17). Meanwhile, we found location was the source of heterogeneity.Limitations: High heterogeneity was observed (I 2 = 92.0%), and only English literature was included in the meta-analysis.Conclusions: We found a positive association between ADNS and SCZ, and the association was different across the different types of ADNS. The results of the study are helpful for clinicians to carry out targeted preventive measures for ADNS and SCZ. autoimmune diseases of the nervous system schizophrenia autoimmune disease meta-analysis cohort study Ji, Shuang verfasserin aut Chen, Yujiao verfasserin aut Zhang, Xiaoshuai verfasserin aut Ding, Guoyong verfasserin aut Tang, Fang verfasserin aut Enthalten in Comprehensive psychiatry Amsterdam [u.a.] : Elsevier, 1960 122 Online-Ressource (DE-627)330080377 (DE-600)2049049-5 (DE-576)105536784 1532-8384 nnns volume:122 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 122
language	English
source	Enthalten in Comprehensive psychiatry 122 volume:122
sourceStr	Enthalten in Comprehensive psychiatry 122 volume:122
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topic_facet	autoimmune diseases of the nervous system schizophrenia autoimmune disease meta-analysis cohort study
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container_title	Comprehensive psychiatry
authorswithroles_txt_mv	Cao, Yiting @@aut@@ Ji, Shuang @@aut@@ Chen, Yujiao @@aut@@ Zhang, Xiaoshuai @@aut@@ Ding, Guoyong @@aut@@ Tang, Fang @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
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author	Cao, Yiting
spellingShingle	Cao, Yiting ddc 610 bkl 44.91 misc autoimmune diseases of the nervous system misc schizophrenia misc autoimmune disease misc meta-analysis misc cohort study Association between autoimmune diseases of the nervous system and schizophrenia: A systematic review and meta-analysis of cohort studies
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topic_title	610 VZ 44.91 bkl Association between autoimmune diseases of the nervous system and schizophrenia: A systematic review and meta-analysis of cohort studies autoimmune diseases of the nervous system schizophrenia autoimmune disease meta-analysis cohort study
topic	ddc 610 bkl 44.91 misc autoimmune diseases of the nervous system misc schizophrenia misc autoimmune disease misc meta-analysis misc cohort study
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title	Association between autoimmune diseases of the nervous system and schizophrenia: A systematic review and meta-analysis of cohort studies
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title_full	Association between autoimmune diseases of the nervous system and schizophrenia: A systematic review and meta-analysis of cohort studies
author_sort	Cao, Yiting
journal	Comprehensive psychiatry
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author_browse	Cao, Yiting Ji, Shuang Chen, Yujiao Zhang, Xiaoshuai Ding, Guoyong Tang, Fang
container_volume	122
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author-letter	Cao, Yiting
doi_str_mv	10.1016/j.comppsych.2023.152370
dewey-full	610
author2-role	verfasserin
title_sort	association between autoimmune diseases of the nervous system and schizophrenia: a systematic review and meta-analysis of cohort studies
title_auth	Association between autoimmune diseases of the nervous system and schizophrenia: A systematic review and meta-analysis of cohort studies
abstract	Introduction: Numerous studies have found an association between autoimmune diseases of the nervous system (ADNS) and schizophrenia (SCZ), but the findings remain controversial. We conducted the first meta-analysis to summarize the current evidence from cohort studies that evaluated the association between ADNS and SCZ.Methods: PubMed, Web of Science, and Embase were comprehensively searched until May 30, 2022 for articles on the association between ADNS and SCZ. Every included study was reported effect size with 95% CIs for the association between ADNS and SCZ. Meta-regression and subgroup analysis were used to assess the heterogeneity.Results: A total of 8 cohort studies with 12 cohorts were included in the meta-analysis. We observed a significant association between ADNS and SCZ (RR = 1.42; 95%CI, 1.18–1.72). Subgroup analysis showed that the risk of SCZ was significantly increased when ADNS were used as exposure factors (RR = 1.48; 95%CI, 1.15–1.89), whereas with SCZ did not observe an increased risk of subsequent ADNS (RR = 1.33; 95%CI, 0.92–1.92); multiple sclerosis (MS) was positively associated with SCZ (RR = 1.36; 95%CI, 1.12–1.66), but no significant association was found between Guillain-Barre syndrome (GBS) and SCZ (RR = 1.90; 95%CI, 0.87–4.17). Meanwhile, we found location was the source of heterogeneity.Limitations: High heterogeneity was observed (I 2 = 92.0%), and only English literature was included in the meta-analysis.Conclusions: We found a positive association between ADNS and SCZ, and the association was different across the different types of ADNS. The results of the study are helpful for clinicians to carry out targeted preventive measures for ADNS and SCZ.
abstractGer	Introduction: Numerous studies have found an association between autoimmune diseases of the nervous system (ADNS) and schizophrenia (SCZ), but the findings remain controversial. We conducted the first meta-analysis to summarize the current evidence from cohort studies that evaluated the association between ADNS and SCZ.Methods: PubMed, Web of Science, and Embase were comprehensively searched until May 30, 2022 for articles on the association between ADNS and SCZ. Every included study was reported effect size with 95% CIs for the association between ADNS and SCZ. Meta-regression and subgroup analysis were used to assess the heterogeneity.Results: A total of 8 cohort studies with 12 cohorts were included in the meta-analysis. We observed a significant association between ADNS and SCZ (RR = 1.42; 95%CI, 1.18–1.72). Subgroup analysis showed that the risk of SCZ was significantly increased when ADNS were used as exposure factors (RR = 1.48; 95%CI, 1.15–1.89), whereas with SCZ did not observe an increased risk of subsequent ADNS (RR = 1.33; 95%CI, 0.92–1.92); multiple sclerosis (MS) was positively associated with SCZ (RR = 1.36; 95%CI, 1.12–1.66), but no significant association was found between Guillain-Barre syndrome (GBS) and SCZ (RR = 1.90; 95%CI, 0.87–4.17). Meanwhile, we found location was the source of heterogeneity.Limitations: High heterogeneity was observed (I 2 = 92.0%), and only English literature was included in the meta-analysis.Conclusions: We found a positive association between ADNS and SCZ, and the association was different across the different types of ADNS. The results of the study are helpful for clinicians to carry out targeted preventive measures for ADNS and SCZ.
abstract_unstemmed	Introduction: Numerous studies have found an association between autoimmune diseases of the nervous system (ADNS) and schizophrenia (SCZ), but the findings remain controversial. We conducted the first meta-analysis to summarize the current evidence from cohort studies that evaluated the association between ADNS and SCZ.Methods: PubMed, Web of Science, and Embase were comprehensively searched until May 30, 2022 for articles on the association between ADNS and SCZ. Every included study was reported effect size with 95% CIs for the association between ADNS and SCZ. Meta-regression and subgroup analysis were used to assess the heterogeneity.Results: A total of 8 cohort studies with 12 cohorts were included in the meta-analysis. We observed a significant association between ADNS and SCZ (RR = 1.42; 95%CI, 1.18–1.72). Subgroup analysis showed that the risk of SCZ was significantly increased when ADNS were used as exposure factors (RR = 1.48; 95%CI, 1.15–1.89), whereas with SCZ did not observe an increased risk of subsequent ADNS (RR = 1.33; 95%CI, 0.92–1.92); multiple sclerosis (MS) was positively associated with SCZ (RR = 1.36; 95%CI, 1.12–1.66), but no significant association was found between Guillain-Barre syndrome (GBS) and SCZ (RR = 1.90; 95%CI, 0.87–4.17). Meanwhile, we found location was the source of heterogeneity.Limitations: High heterogeneity was observed (I 2 = 92.0%), and only English literature was included in the meta-analysis.Conclusions: We found a positive association between ADNS and SCZ, and the association was different across the different types of ADNS. The results of the study are helpful for clinicians to carry out targeted preventive measures for ADNS and SCZ.
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title_short	Association between autoimmune diseases of the nervous system and schizophrenia: A systematic review and meta-analysis of cohort studies
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author2	Ji, Shuang Chen, Yujiao Zhang, Xiaoshuai Ding, Guoyong Tang, Fang
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doi_str	10.1016/j.comppsych.2023.152370
up_date	2024-07-06T16:47:19.571Z
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