Clot waveform analysis for perioperative hemostatic monitoring in a hemophilia A patient on emicizumab undergoing liver transplantation

How to optimize perioperative factor VIII (FVIII) replacement through hemostatic monitoring is critically important to manage hemophilia A patients. The bispecific antibody emicizumab binds activated FIX (FIXa) and FX to functionally mimic FVIIIa. While being used for hemostatic control in hemophili...
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Autor*in:	Awane, Mai [verfasserIn] Wakui, Masatoshi [verfasserIn] Ozaki, Yuko [verfasserIn] Kondo, Yoshino [verfasserIn] Oka, Shusaku [verfasserIn] Fujimori, Yuta [verfasserIn] Yatabe, Yoko [verfasserIn] Arai, Tomoko [verfasserIn] Yamada, Yohei [verfasserIn] Hori, Shutaro [verfasserIn] Obara, Hideaki [verfasserIn] Hasegawa, Yasushi [verfasserIn] Matsushita, Hiromichi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Clot waveform analysis Hemophilia A Emicizumab Liver transplantation Perioperative hemostasis

Übergeordnetes Werk:	Enthalten in: Clinica chimica acta - Amsterdam [u.a.] : Elsevier Science, 1956, 544
Übergeordnetes Werk:	volume:544

DOI / URN:	10.1016/j.cca.2023.117339

Katalog-ID:	ELV06617631X

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245	1	0	\|a Clot waveform analysis for perioperative hemostatic monitoring in a hemophilia A patient on emicizumab undergoing liver transplantation
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520			\|a How to optimize perioperative factor VIII (FVIII) replacement through hemostatic monitoring is critically important to manage hemophilia A patients. The bispecific antibody emicizumab binds activated FIX (FIXa) and FX to functionally mimic FVIIIa. While being used for hemostatic control in hemophilia A, this therapeutic antibody inconveniently interferes with coagulation tests using human FIXa and FX, such as activated partial thromboplastin time (APTT) and FVIII activity measurement based on one-stage clotting assays. Clot waveform analysis (CWA) extends the interpretation of measurement curves for coagulation time to provide global information. We performed APTT-CWA to monitor perioperative hemostasis in a hemophilia A patient on emicizumab undergoing liver transplantation. Plasma samples were treated with anti-idiotype monoclonal antibodies against emicizumab to enable accurate coagulation assays. Kinetics of maximum coagulation velocity and acceleration mimicked that of FVIII activity. These CWA parameters better correlated with FVIII activity than APTT. The plateaus of them were observed at FVIII activity of 100% or more, supporting the protocol for perioperative FVIII replacement. Thus, CWA may measure coagulation potential in hemophilia A patients undergoing liver transplantation, aiding in optimizing perioperative hemostasis.
650		4	\|a Clot waveform analysis
650		4	\|a Hemophilia A
650		4	\|a Emicizumab
650		4	\|a Liver transplantation
650		4	\|a Perioperative hemostasis
700	1		\|a Wakui, Masatoshi \|e verfasserin \|0 (orcid)0000-0002-3953-0872 \|4 aut
700	1		\|a Ozaki, Yuko \|e verfasserin \|4 aut
700	1		\|a Kondo, Yoshino \|e verfasserin \|4 aut
700	1		\|a Oka, Shusaku \|e verfasserin \|4 aut
700	1		\|a Fujimori, Yuta \|e verfasserin \|4 aut
700	1		\|a Yatabe, Yoko \|e verfasserin \|4 aut
700	1		\|a Arai, Tomoko \|e verfasserin \|4 aut
700	1		\|a Yamada, Yohei \|e verfasserin \|4 aut
700	1		\|a Hori, Shutaro \|e verfasserin \|4 aut
700	1		\|a Obara, Hideaki \|e verfasserin \|4 aut
700	1		\|a Hasegawa, Yasushi \|e verfasserin \|4 aut
700	1		\|a Matsushita, Hiromichi \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Clinica chimica acta \|d Amsterdam [u.a.] : Elsevier Science, 1956 \|g 544 \|h Online-Ressource \|w (DE-627)306654423 \|w (DE-600)1499920-1 \|w (DE-576)094531242 \|x 1873-3492 \|7 nnns
773	1	8	\|g volume:544
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912			\|a GBV_ILN_4242
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912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
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publishDate	2023
allfields	10.1016/j.cca.2023.117339 doi (DE-627)ELV06617631X (ELSEVIER)S0009-8981(23)00141-9 DE-627 ger DE-627 rda eng 540 610 VZ 35.00 bkl 44.46 bkl Awane, Mai verfasserin aut Clot waveform analysis for perioperative hemostatic monitoring in a hemophilia A patient on emicizumab undergoing liver transplantation 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier How to optimize perioperative factor VIII (FVIII) replacement through hemostatic monitoring is critically important to manage hemophilia A patients. The bispecific antibody emicizumab binds activated FIX (FIXa) and FX to functionally mimic FVIIIa. While being used for hemostatic control in hemophilia A, this therapeutic antibody inconveniently interferes with coagulation tests using human FIXa and FX, such as activated partial thromboplastin time (APTT) and FVIII activity measurement based on one-stage clotting assays. Clot waveform analysis (CWA) extends the interpretation of measurement curves for coagulation time to provide global information. We performed APTT-CWA to monitor perioperative hemostasis in a hemophilia A patient on emicizumab undergoing liver transplantation. Plasma samples were treated with anti-idiotype monoclonal antibodies against emicizumab to enable accurate coagulation assays. Kinetics of maximum coagulation velocity and acceleration mimicked that of FVIII activity. These CWA parameters better correlated with FVIII activity than APTT. The plateaus of them were observed at FVIII activity of 100% or more, supporting the protocol for perioperative FVIII replacement. Thus, CWA may measure coagulation potential in hemophilia A patients undergoing liver transplantation, aiding in optimizing perioperative hemostasis. Clot waveform analysis Hemophilia A Emicizumab Liver transplantation Perioperative hemostasis Wakui, Masatoshi verfasserin (orcid)0000-0002-3953-0872 aut Ozaki, Yuko verfasserin aut Kondo, Yoshino verfasserin aut Oka, Shusaku verfasserin aut Fujimori, Yuta verfasserin aut Yatabe, Yoko verfasserin aut Arai, Tomoko verfasserin aut Yamada, Yohei verfasserin aut Hori, Shutaro verfasserin aut Obara, Hideaki verfasserin aut Hasegawa, Yasushi verfasserin aut Matsushita, Hiromichi verfasserin aut Enthalten in Clinica chimica acta Amsterdam [u.a.] : Elsevier Science, 1956 544 Online-Ressource (DE-627)306654423 (DE-600)1499920-1 (DE-576)094531242 1873-3492 nnns volume:544 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.00 Chemie: Allgemeines VZ 44.46 Klinische Pathologie VZ AR 544
spelling	10.1016/j.cca.2023.117339 doi (DE-627)ELV06617631X (ELSEVIER)S0009-8981(23)00141-9 DE-627 ger DE-627 rda eng 540 610 VZ 35.00 bkl 44.46 bkl Awane, Mai verfasserin aut Clot waveform analysis for perioperative hemostatic monitoring in a hemophilia A patient on emicizumab undergoing liver transplantation 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier How to optimize perioperative factor VIII (FVIII) replacement through hemostatic monitoring is critically important to manage hemophilia A patients. The bispecific antibody emicizumab binds activated FIX (FIXa) and FX to functionally mimic FVIIIa. While being used for hemostatic control in hemophilia A, this therapeutic antibody inconveniently interferes with coagulation tests using human FIXa and FX, such as activated partial thromboplastin time (APTT) and FVIII activity measurement based on one-stage clotting assays. Clot waveform analysis (CWA) extends the interpretation of measurement curves for coagulation time to provide global information. We performed APTT-CWA to monitor perioperative hemostasis in a hemophilia A patient on emicizumab undergoing liver transplantation. Plasma samples were treated with anti-idiotype monoclonal antibodies against emicizumab to enable accurate coagulation assays. Kinetics of maximum coagulation velocity and acceleration mimicked that of FVIII activity. These CWA parameters better correlated with FVIII activity than APTT. The plateaus of them were observed at FVIII activity of 100% or more, supporting the protocol for perioperative FVIII replacement. Thus, CWA may measure coagulation potential in hemophilia A patients undergoing liver transplantation, aiding in optimizing perioperative hemostasis. Clot waveform analysis Hemophilia A Emicizumab Liver transplantation Perioperative hemostasis Wakui, Masatoshi verfasserin (orcid)0000-0002-3953-0872 aut Ozaki, Yuko verfasserin aut Kondo, Yoshino verfasserin aut Oka, Shusaku verfasserin aut Fujimori, Yuta verfasserin aut Yatabe, Yoko verfasserin aut Arai, Tomoko verfasserin aut Yamada, Yohei verfasserin aut Hori, Shutaro verfasserin aut Obara, Hideaki verfasserin aut Hasegawa, Yasushi verfasserin aut Matsushita, Hiromichi verfasserin aut Enthalten in Clinica chimica acta Amsterdam [u.a.] : Elsevier Science, 1956 544 Online-Ressource (DE-627)306654423 (DE-600)1499920-1 (DE-576)094531242 1873-3492 nnns volume:544 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.00 Chemie: Allgemeines VZ 44.46 Klinische Pathologie VZ AR 544
allfields_unstemmed	10.1016/j.cca.2023.117339 doi (DE-627)ELV06617631X (ELSEVIER)S0009-8981(23)00141-9 DE-627 ger DE-627 rda eng 540 610 VZ 35.00 bkl 44.46 bkl Awane, Mai verfasserin aut Clot waveform analysis for perioperative hemostatic monitoring in a hemophilia A patient on emicizumab undergoing liver transplantation 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier How to optimize perioperative factor VIII (FVIII) replacement through hemostatic monitoring is critically important to manage hemophilia A patients. The bispecific antibody emicizumab binds activated FIX (FIXa) and FX to functionally mimic FVIIIa. While being used for hemostatic control in hemophilia A, this therapeutic antibody inconveniently interferes with coagulation tests using human FIXa and FX, such as activated partial thromboplastin time (APTT) and FVIII activity measurement based on one-stage clotting assays. Clot waveform analysis (CWA) extends the interpretation of measurement curves for coagulation time to provide global information. We performed APTT-CWA to monitor perioperative hemostasis in a hemophilia A patient on emicizumab undergoing liver transplantation. Plasma samples were treated with anti-idiotype monoclonal antibodies against emicizumab to enable accurate coagulation assays. Kinetics of maximum coagulation velocity and acceleration mimicked that of FVIII activity. These CWA parameters better correlated with FVIII activity than APTT. The plateaus of them were observed at FVIII activity of 100% or more, supporting the protocol for perioperative FVIII replacement. Thus, CWA may measure coagulation potential in hemophilia A patients undergoing liver transplantation, aiding in optimizing perioperative hemostasis. Clot waveform analysis Hemophilia A Emicizumab Liver transplantation Perioperative hemostasis Wakui, Masatoshi verfasserin (orcid)0000-0002-3953-0872 aut Ozaki, Yuko verfasserin aut Kondo, Yoshino verfasserin aut Oka, Shusaku verfasserin aut Fujimori, Yuta verfasserin aut Yatabe, Yoko verfasserin aut Arai, Tomoko verfasserin aut Yamada, Yohei verfasserin aut Hori, Shutaro verfasserin aut Obara, Hideaki verfasserin aut Hasegawa, Yasushi verfasserin aut Matsushita, Hiromichi verfasserin aut Enthalten in Clinica chimica acta Amsterdam [u.a.] : Elsevier Science, 1956 544 Online-Ressource (DE-627)306654423 (DE-600)1499920-1 (DE-576)094531242 1873-3492 nnns volume:544 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.00 Chemie: Allgemeines VZ 44.46 Klinische Pathologie VZ AR 544
allfieldsGer	10.1016/j.cca.2023.117339 doi (DE-627)ELV06617631X (ELSEVIER)S0009-8981(23)00141-9 DE-627 ger DE-627 rda eng 540 610 VZ 35.00 bkl 44.46 bkl Awane, Mai verfasserin aut Clot waveform analysis for perioperative hemostatic monitoring in a hemophilia A patient on emicizumab undergoing liver transplantation 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier How to optimize perioperative factor VIII (FVIII) replacement through hemostatic monitoring is critically important to manage hemophilia A patients. The bispecific antibody emicizumab binds activated FIX (FIXa) and FX to functionally mimic FVIIIa. While being used for hemostatic control in hemophilia A, this therapeutic antibody inconveniently interferes with coagulation tests using human FIXa and FX, such as activated partial thromboplastin time (APTT) and FVIII activity measurement based on one-stage clotting assays. Clot waveform analysis (CWA) extends the interpretation of measurement curves for coagulation time to provide global information. We performed APTT-CWA to monitor perioperative hemostasis in a hemophilia A patient on emicizumab undergoing liver transplantation. Plasma samples were treated with anti-idiotype monoclonal antibodies against emicizumab to enable accurate coagulation assays. Kinetics of maximum coagulation velocity and acceleration mimicked that of FVIII activity. These CWA parameters better correlated with FVIII activity than APTT. The plateaus of them were observed at FVIII activity of 100% or more, supporting the protocol for perioperative FVIII replacement. Thus, CWA may measure coagulation potential in hemophilia A patients undergoing liver transplantation, aiding in optimizing perioperative hemostasis. Clot waveform analysis Hemophilia A Emicizumab Liver transplantation Perioperative hemostasis Wakui, Masatoshi verfasserin (orcid)0000-0002-3953-0872 aut Ozaki, Yuko verfasserin aut Kondo, Yoshino verfasserin aut Oka, Shusaku verfasserin aut Fujimori, Yuta verfasserin aut Yatabe, Yoko verfasserin aut Arai, Tomoko verfasserin aut Yamada, Yohei verfasserin aut Hori, Shutaro verfasserin aut Obara, Hideaki verfasserin aut Hasegawa, Yasushi verfasserin aut Matsushita, Hiromichi verfasserin aut Enthalten in Clinica chimica acta Amsterdam [u.a.] : Elsevier Science, 1956 544 Online-Ressource (DE-627)306654423 (DE-600)1499920-1 (DE-576)094531242 1873-3492 nnns volume:544 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.00 Chemie: Allgemeines VZ 44.46 Klinische Pathologie VZ AR 544
allfieldsSound	10.1016/j.cca.2023.117339 doi (DE-627)ELV06617631X (ELSEVIER)S0009-8981(23)00141-9 DE-627 ger DE-627 rda eng 540 610 VZ 35.00 bkl 44.46 bkl Awane, Mai verfasserin aut Clot waveform analysis for perioperative hemostatic monitoring in a hemophilia A patient on emicizumab undergoing liver transplantation 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier How to optimize perioperative factor VIII (FVIII) replacement through hemostatic monitoring is critically important to manage hemophilia A patients. The bispecific antibody emicizumab binds activated FIX (FIXa) and FX to functionally mimic FVIIIa. While being used for hemostatic control in hemophilia A, this therapeutic antibody inconveniently interferes with coagulation tests using human FIXa and FX, such as activated partial thromboplastin time (APTT) and FVIII activity measurement based on one-stage clotting assays. Clot waveform analysis (CWA) extends the interpretation of measurement curves for coagulation time to provide global information. We performed APTT-CWA to monitor perioperative hemostasis in a hemophilia A patient on emicizumab undergoing liver transplantation. Plasma samples were treated with anti-idiotype monoclonal antibodies against emicizumab to enable accurate coagulation assays. Kinetics of maximum coagulation velocity and acceleration mimicked that of FVIII activity. These CWA parameters better correlated with FVIII activity than APTT. The plateaus of them were observed at FVIII activity of 100% or more, supporting the protocol for perioperative FVIII replacement. Thus, CWA may measure coagulation potential in hemophilia A patients undergoing liver transplantation, aiding in optimizing perioperative hemostasis. Clot waveform analysis Hemophilia A Emicizumab Liver transplantation Perioperative hemostasis Wakui, Masatoshi verfasserin (orcid)0000-0002-3953-0872 aut Ozaki, Yuko verfasserin aut Kondo, Yoshino verfasserin aut Oka, Shusaku verfasserin aut Fujimori, Yuta verfasserin aut Yatabe, Yoko verfasserin aut Arai, Tomoko verfasserin aut Yamada, Yohei verfasserin aut Hori, Shutaro verfasserin aut Obara, Hideaki verfasserin aut Hasegawa, Yasushi verfasserin aut Matsushita, Hiromichi verfasserin aut Enthalten in Clinica chimica acta Amsterdam [u.a.] : Elsevier Science, 1956 544 Online-Ressource (DE-627)306654423 (DE-600)1499920-1 (DE-576)094531242 1873-3492 nnns volume:544 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.00 Chemie: Allgemeines VZ 44.46 Klinische Pathologie VZ AR 544
language	English
source	Enthalten in Clinica chimica acta 544 volume:544
sourceStr	Enthalten in Clinica chimica acta 544 volume:544
format_phy_str_mv	Article
bklname	Chemie: Allgemeines Klinische Pathologie
institution	findex.gbv.de
topic_facet	Clot waveform analysis Hemophilia A Emicizumab Liver transplantation Perioperative hemostasis
dewey-raw	540
isfreeaccess_bool	false
container_title	Clinica chimica acta
authorswithroles_txt_mv	Awane, Mai @@aut@@ Wakui, Masatoshi @@aut@@ Ozaki, Yuko @@aut@@ Kondo, Yoshino @@aut@@ Oka, Shusaku @@aut@@ Fujimori, Yuta @@aut@@ Yatabe, Yoko @@aut@@ Arai, Tomoko @@aut@@ Yamada, Yohei @@aut@@ Hori, Shutaro @@aut@@ Obara, Hideaki @@aut@@ Hasegawa, Yasushi @@aut@@ Matsushita, Hiromichi @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	306654423
dewey-sort	3540
id	ELV06617631X
language_de	englisch
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author	Awane, Mai
spellingShingle	Awane, Mai ddc 540 bkl 35.00 bkl 44.46 misc Clot waveform analysis misc Hemophilia A misc Emicizumab misc Liver transplantation misc Perioperative hemostasis Clot waveform analysis for perioperative hemostatic monitoring in a hemophilia A patient on emicizumab undergoing liver transplantation
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topic_title	540 610 VZ 35.00 bkl 44.46 bkl Clot waveform analysis for perioperative hemostatic monitoring in a hemophilia A patient on emicizumab undergoing liver transplantation Clot waveform analysis Hemophilia A Emicizumab Liver transplantation Perioperative hemostasis
topic	ddc 540 bkl 35.00 bkl 44.46 misc Clot waveform analysis misc Hemophilia A misc Emicizumab misc Liver transplantation misc Perioperative hemostasis
topic_unstemmed	ddc 540 bkl 35.00 bkl 44.46 misc Clot waveform analysis misc Hemophilia A misc Emicizumab misc Liver transplantation misc Perioperative hemostasis
topic_browse	ddc 540 bkl 35.00 bkl 44.46 misc Clot waveform analysis misc Hemophilia A misc Emicizumab misc Liver transplantation misc Perioperative hemostasis
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title	Clot waveform analysis for perioperative hemostatic monitoring in a hemophilia A patient on emicizumab undergoing liver transplantation
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title_full	Clot waveform analysis for perioperative hemostatic monitoring in a hemophilia A patient on emicizumab undergoing liver transplantation
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author_browse	Awane, Mai Wakui, Masatoshi Ozaki, Yuko Kondo, Yoshino Oka, Shusaku Fujimori, Yuta Yatabe, Yoko Arai, Tomoko Yamada, Yohei Hori, Shutaro Obara, Hideaki Hasegawa, Yasushi Matsushita, Hiromichi
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title_sort	clot waveform analysis for perioperative hemostatic monitoring in a hemophilia a patient on emicizumab undergoing liver transplantation
title_auth	Clot waveform analysis for perioperative hemostatic monitoring in a hemophilia A patient on emicizumab undergoing liver transplantation
abstract	How to optimize perioperative factor VIII (FVIII) replacement through hemostatic monitoring is critically important to manage hemophilia A patients. The bispecific antibody emicizumab binds activated FIX (FIXa) and FX to functionally mimic FVIIIa. While being used for hemostatic control in hemophilia A, this therapeutic antibody inconveniently interferes with coagulation tests using human FIXa and FX, such as activated partial thromboplastin time (APTT) and FVIII activity measurement based on one-stage clotting assays. Clot waveform analysis (CWA) extends the interpretation of measurement curves for coagulation time to provide global information. We performed APTT-CWA to monitor perioperative hemostasis in a hemophilia A patient on emicizumab undergoing liver transplantation. Plasma samples were treated with anti-idiotype monoclonal antibodies against emicizumab to enable accurate coagulation assays. Kinetics of maximum coagulation velocity and acceleration mimicked that of FVIII activity. These CWA parameters better correlated with FVIII activity than APTT. The plateaus of them were observed at FVIII activity of 100% or more, supporting the protocol for perioperative FVIII replacement. Thus, CWA may measure coagulation potential in hemophilia A patients undergoing liver transplantation, aiding in optimizing perioperative hemostasis.
abstractGer	How to optimize perioperative factor VIII (FVIII) replacement through hemostatic monitoring is critically important to manage hemophilia A patients. The bispecific antibody emicizumab binds activated FIX (FIXa) and FX to functionally mimic FVIIIa. While being used for hemostatic control in hemophilia A, this therapeutic antibody inconveniently interferes with coagulation tests using human FIXa and FX, such as activated partial thromboplastin time (APTT) and FVIII activity measurement based on one-stage clotting assays. Clot waveform analysis (CWA) extends the interpretation of measurement curves for coagulation time to provide global information. We performed APTT-CWA to monitor perioperative hemostasis in a hemophilia A patient on emicizumab undergoing liver transplantation. Plasma samples were treated with anti-idiotype monoclonal antibodies against emicizumab to enable accurate coagulation assays. Kinetics of maximum coagulation velocity and acceleration mimicked that of FVIII activity. These CWA parameters better correlated with FVIII activity than APTT. The plateaus of them were observed at FVIII activity of 100% or more, supporting the protocol for perioperative FVIII replacement. Thus, CWA may measure coagulation potential in hemophilia A patients undergoing liver transplantation, aiding in optimizing perioperative hemostasis.
abstract_unstemmed	How to optimize perioperative factor VIII (FVIII) replacement through hemostatic monitoring is critically important to manage hemophilia A patients. The bispecific antibody emicizumab binds activated FIX (FIXa) and FX to functionally mimic FVIIIa. While being used for hemostatic control in hemophilia A, this therapeutic antibody inconveniently interferes with coagulation tests using human FIXa and FX, such as activated partial thromboplastin time (APTT) and FVIII activity measurement based on one-stage clotting assays. Clot waveform analysis (CWA) extends the interpretation of measurement curves for coagulation time to provide global information. We performed APTT-CWA to monitor perioperative hemostasis in a hemophilia A patient on emicizumab undergoing liver transplantation. Plasma samples were treated with anti-idiotype monoclonal antibodies against emicizumab to enable accurate coagulation assays. Kinetics of maximum coagulation velocity and acceleration mimicked that of FVIII activity. These CWA parameters better correlated with FVIII activity than APTT. The plateaus of them were observed at FVIII activity of 100% or more, supporting the protocol for perioperative FVIII replacement. Thus, CWA may measure coagulation potential in hemophilia A patients undergoing liver transplantation, aiding in optimizing perioperative hemostasis.
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title_short	Clot waveform analysis for perioperative hemostatic monitoring in a hemophilia A patient on emicizumab undergoing liver transplantation
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author2	Wakui, Masatoshi Ozaki, Yuko Kondo, Yoshino Oka, Shusaku Fujimori, Yuta Yatabe, Yoko Arai, Tomoko Yamada, Yohei Hori, Shutaro Obara, Hideaki Hasegawa, Yasushi Matsushita, Hiromichi
author2Str	Wakui, Masatoshi Ozaki, Yuko Kondo, Yoshino Oka, Shusaku Fujimori, Yuta Yatabe, Yoko Arai, Tomoko Yamada, Yohei Hori, Shutaro Obara, Hideaki Hasegawa, Yasushi Matsushita, Hiromichi
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doi_str	10.1016/j.cca.2023.117339
up_date	2024-07-06T16:50:46.485Z
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The bispecific antibody emicizumab binds activated FIX (FIXa) and FX to functionally mimic FVIIIa. While being used for hemostatic control in hemophilia A, this therapeutic antibody inconveniently interferes with coagulation tests using human FIXa and FX, such as activated partial thromboplastin time (APTT) and FVIII activity measurement based on one-stage clotting assays. Clot waveform analysis (CWA) extends the interpretation of measurement curves for coagulation time to provide global information. We performed APTT-CWA to monitor perioperative hemostasis in a hemophilia A patient on emicizumab undergoing liver transplantation. Plasma samples were treated with anti-idiotype monoclonal antibodies against emicizumab to enable accurate coagulation assays. Kinetics of maximum coagulation velocity and acceleration mimicked that of FVIII activity. These CWA parameters better correlated with FVIII activity than APTT. The plateaus of them were observed at FVIII activity of 100% or more, supporting the protocol for perioperative FVIII replacement. 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Clot waveform analysis for perioperative hemostatic monitoring in a hemophilia A patient on emicizumab undergoing liver transplantation

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