Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention
The prevention of pre-eclampsia is difficult due to the syndromic nature and multiple underlying mechanisms of this severe complication of pregnancy. The current clinical distinction between early- and late-onset disease, although clinically useful, does not reflect the true nature and complexity of...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Than, Nándor Gábor [verfasserIn] Romero, Roberto [verfasserIn] Posta, Máté [verfasserIn] Györffy, Dániel [verfasserIn] Szalai, Gábor [verfasserIn] Rossi, Simona W. [verfasserIn] Szilágyi, András [verfasserIn] Hupuczi, Petronella [verfasserIn] Nagy, Sándor [verfasserIn] Török, Olga [verfasserIn] Tarca, Adi L. [verfasserIn] Erez, Offer [verfasserIn] Ács, Nándor [verfasserIn] Papp, Zoltán [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
Extracellular matrix-related pre-eclampsia |
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| Übergeordnetes Werk: |
Enthalten in: Journal of reproductive immunology - Oxford : Oxford University Press, 1979, 161 |
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| Übergeordnetes Werk: |
volume:161 |
| DOI / URN: |
10.1016/j.jri.2023.104172 |
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| Katalog-ID: |
ELV066620309 |
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| 520 | |a The prevention of pre-eclampsia is difficult due to the syndromic nature and multiple underlying mechanisms of this severe complication of pregnancy. The current clinical distinction between early- and late-onset disease, although clinically useful, does not reflect the true nature and complexity of the pathologic processes leading to pre-eclampsia. The current gaps in knowledge on the heterogeneous molecular pathways of this syndrome and the lack of adequate, specific diagnostic methods are major obstacles to early screening and tailored preventive strategies. The development of novel diagnostic tools for detecting the activation of the identified disease pathways would enable early, accurate screening and personalized preventive therapies. We implemented a holistic approach that includes the utilization of different proteomic profiling methods of maternal plasma samples collected from various ethnic populations and the application of systems biology analysis to plasma proteomic, maternal demographic, clinical characteristic, and placental histopathologic data. This approach enabled the identification of four molecular subclasses of pre-eclampsia in which distinct and shared disease mechanisms are activated. The current review summarizes the results and conclusions from these studies and the research and clinical implications of our findings. | ||
| 650 | 4 | |a Extracellular matrix-related pre-eclampsia | |
| 650 | 4 | |a Liquid biopsy | |
| 650 | 4 | |a Maternal anti-fetal rejection-type pre-eclampsia | |
| 650 | 4 | |a Metabolic pre-eclampsia | |
| 650 | 4 | |a Personalized medicine | |
| 650 | 4 | |a Placental pre-eclampsia | |
| 650 | 4 | |a Prenatal diagnosis | |
| 650 | 4 | |a Proteomics | |
| 650 | 4 | |a Screening | |
| 700 | 1 | |a Romero, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Posta, Máté |e verfasserin |4 aut | |
| 700 | 1 | |a Györffy, Dániel |e verfasserin |4 aut | |
| 700 | 1 | |a Szalai, Gábor |e verfasserin |4 aut | |
| 700 | 1 | |a Rossi, Simona W. |e verfasserin |4 aut | |
| 700 | 1 | |a Szilágyi, András |e verfasserin |4 aut | |
| 700 | 1 | |a Hupuczi, Petronella |e verfasserin |4 aut | |
| 700 | 1 | |a Nagy, Sándor |e verfasserin |4 aut | |
| 700 | 1 | |a Török, Olga |e verfasserin |4 aut | |
| 700 | 1 | |a Tarca, Adi L. |e verfasserin |4 aut | |
| 700 | 1 | |a Erez, Offer |e verfasserin |4 aut | |
| 700 | 1 | |a Ács, Nándor |e verfasserin |4 aut | |
| 700 | 1 | |a Papp, Zoltán |e verfasserin |4 aut | |
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10.1016/j.jri.2023.104172 doi (DE-627)ELV066620309 (ELSEVIER)S0165-0378(23)00378-9 DE-627 ger DE-627 rda eng 610 VZ 44.45 bkl Than, Nándor Gábor verfasserin aut Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The prevention of pre-eclampsia is difficult due to the syndromic nature and multiple underlying mechanisms of this severe complication of pregnancy. The current clinical distinction between early- and late-onset disease, although clinically useful, does not reflect the true nature and complexity of the pathologic processes leading to pre-eclampsia. The current gaps in knowledge on the heterogeneous molecular pathways of this syndrome and the lack of adequate, specific diagnostic methods are major obstacles to early screening and tailored preventive strategies. The development of novel diagnostic tools for detecting the activation of the identified disease pathways would enable early, accurate screening and personalized preventive therapies. We implemented a holistic approach that includes the utilization of different proteomic profiling methods of maternal plasma samples collected from various ethnic populations and the application of systems biology analysis to plasma proteomic, maternal demographic, clinical characteristic, and placental histopathologic data. This approach enabled the identification of four molecular subclasses of pre-eclampsia in which distinct and shared disease mechanisms are activated. The current review summarizes the results and conclusions from these studies and the research and clinical implications of our findings. Extracellular matrix-related pre-eclampsia Liquid biopsy Maternal anti-fetal rejection-type pre-eclampsia Metabolic pre-eclampsia Personalized medicine Placental pre-eclampsia Prenatal diagnosis Proteomics Screening Romero, Roberto verfasserin aut Posta, Máté verfasserin aut Györffy, Dániel verfasserin aut Szalai, Gábor verfasserin aut Rossi, Simona W. verfasserin aut Szilágyi, András verfasserin aut Hupuczi, Petronella verfasserin aut Nagy, Sándor verfasserin aut Török, Olga verfasserin aut Tarca, Adi L. verfasserin aut Erez, Offer verfasserin aut Ács, Nándor verfasserin aut Papp, Zoltán verfasserin aut Enthalten in Journal of reproductive immunology Oxford : Oxford University Press, 1979 161 Online-Ressource (DE-627)320464458 (DE-600)2007694-0 (DE-576)095660186 1872-7603 nnns volume:161 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.45 Immunologie VZ AR 161 |
| spelling |
10.1016/j.jri.2023.104172 doi (DE-627)ELV066620309 (ELSEVIER)S0165-0378(23)00378-9 DE-627 ger DE-627 rda eng 610 VZ 44.45 bkl Than, Nándor Gábor verfasserin aut Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The prevention of pre-eclampsia is difficult due to the syndromic nature and multiple underlying mechanisms of this severe complication of pregnancy. The current clinical distinction between early- and late-onset disease, although clinically useful, does not reflect the true nature and complexity of the pathologic processes leading to pre-eclampsia. The current gaps in knowledge on the heterogeneous molecular pathways of this syndrome and the lack of adequate, specific diagnostic methods are major obstacles to early screening and tailored preventive strategies. The development of novel diagnostic tools for detecting the activation of the identified disease pathways would enable early, accurate screening and personalized preventive therapies. We implemented a holistic approach that includes the utilization of different proteomic profiling methods of maternal plasma samples collected from various ethnic populations and the application of systems biology analysis to plasma proteomic, maternal demographic, clinical characteristic, and placental histopathologic data. This approach enabled the identification of four molecular subclasses of pre-eclampsia in which distinct and shared disease mechanisms are activated. The current review summarizes the results and conclusions from these studies and the research and clinical implications of our findings. Extracellular matrix-related pre-eclampsia Liquid biopsy Maternal anti-fetal rejection-type pre-eclampsia Metabolic pre-eclampsia Personalized medicine Placental pre-eclampsia Prenatal diagnosis Proteomics Screening Romero, Roberto verfasserin aut Posta, Máté verfasserin aut Györffy, Dániel verfasserin aut Szalai, Gábor verfasserin aut Rossi, Simona W. verfasserin aut Szilágyi, András verfasserin aut Hupuczi, Petronella verfasserin aut Nagy, Sándor verfasserin aut Török, Olga verfasserin aut Tarca, Adi L. verfasserin aut Erez, Offer verfasserin aut Ács, Nándor verfasserin aut Papp, Zoltán verfasserin aut Enthalten in Journal of reproductive immunology Oxford : Oxford University Press, 1979 161 Online-Ressource (DE-627)320464458 (DE-600)2007694-0 (DE-576)095660186 1872-7603 nnns volume:161 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.45 Immunologie VZ AR 161 |
| allfields_unstemmed |
10.1016/j.jri.2023.104172 doi (DE-627)ELV066620309 (ELSEVIER)S0165-0378(23)00378-9 DE-627 ger DE-627 rda eng 610 VZ 44.45 bkl Than, Nándor Gábor verfasserin aut Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The prevention of pre-eclampsia is difficult due to the syndromic nature and multiple underlying mechanisms of this severe complication of pregnancy. The current clinical distinction between early- and late-onset disease, although clinically useful, does not reflect the true nature and complexity of the pathologic processes leading to pre-eclampsia. The current gaps in knowledge on the heterogeneous molecular pathways of this syndrome and the lack of adequate, specific diagnostic methods are major obstacles to early screening and tailored preventive strategies. The development of novel diagnostic tools for detecting the activation of the identified disease pathways would enable early, accurate screening and personalized preventive therapies. We implemented a holistic approach that includes the utilization of different proteomic profiling methods of maternal plasma samples collected from various ethnic populations and the application of systems biology analysis to plasma proteomic, maternal demographic, clinical characteristic, and placental histopathologic data. This approach enabled the identification of four molecular subclasses of pre-eclampsia in which distinct and shared disease mechanisms are activated. The current review summarizes the results and conclusions from these studies and the research and clinical implications of our findings. Extracellular matrix-related pre-eclampsia Liquid biopsy Maternal anti-fetal rejection-type pre-eclampsia Metabolic pre-eclampsia Personalized medicine Placental pre-eclampsia Prenatal diagnosis Proteomics Screening Romero, Roberto verfasserin aut Posta, Máté verfasserin aut Györffy, Dániel verfasserin aut Szalai, Gábor verfasserin aut Rossi, Simona W. verfasserin aut Szilágyi, András verfasserin aut Hupuczi, Petronella verfasserin aut Nagy, Sándor verfasserin aut Török, Olga verfasserin aut Tarca, Adi L. verfasserin aut Erez, Offer verfasserin aut Ács, Nándor verfasserin aut Papp, Zoltán verfasserin aut Enthalten in Journal of reproductive immunology Oxford : Oxford University Press, 1979 161 Online-Ressource (DE-627)320464458 (DE-600)2007694-0 (DE-576)095660186 1872-7603 nnns volume:161 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.45 Immunologie VZ AR 161 |
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10.1016/j.jri.2023.104172 doi (DE-627)ELV066620309 (ELSEVIER)S0165-0378(23)00378-9 DE-627 ger DE-627 rda eng 610 VZ 44.45 bkl Than, Nándor Gábor verfasserin aut Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The prevention of pre-eclampsia is difficult due to the syndromic nature and multiple underlying mechanisms of this severe complication of pregnancy. The current clinical distinction between early- and late-onset disease, although clinically useful, does not reflect the true nature and complexity of the pathologic processes leading to pre-eclampsia. The current gaps in knowledge on the heterogeneous molecular pathways of this syndrome and the lack of adequate, specific diagnostic methods are major obstacles to early screening and tailored preventive strategies. The development of novel diagnostic tools for detecting the activation of the identified disease pathways would enable early, accurate screening and personalized preventive therapies. We implemented a holistic approach that includes the utilization of different proteomic profiling methods of maternal plasma samples collected from various ethnic populations and the application of systems biology analysis to plasma proteomic, maternal demographic, clinical characteristic, and placental histopathologic data. This approach enabled the identification of four molecular subclasses of pre-eclampsia in which distinct and shared disease mechanisms are activated. The current review summarizes the results and conclusions from these studies and the research and clinical implications of our findings. Extracellular matrix-related pre-eclampsia Liquid biopsy Maternal anti-fetal rejection-type pre-eclampsia Metabolic pre-eclampsia Personalized medicine Placental pre-eclampsia Prenatal diagnosis Proteomics Screening Romero, Roberto verfasserin aut Posta, Máté verfasserin aut Györffy, Dániel verfasserin aut Szalai, Gábor verfasserin aut Rossi, Simona W. verfasserin aut Szilágyi, András verfasserin aut Hupuczi, Petronella verfasserin aut Nagy, Sándor verfasserin aut Török, Olga verfasserin aut Tarca, Adi L. verfasserin aut Erez, Offer verfasserin aut Ács, Nándor verfasserin aut Papp, Zoltán verfasserin aut Enthalten in Journal of reproductive immunology Oxford : Oxford University Press, 1979 161 Online-Ressource (DE-627)320464458 (DE-600)2007694-0 (DE-576)095660186 1872-7603 nnns volume:161 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.45 Immunologie VZ AR 161 |
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10.1016/j.jri.2023.104172 doi (DE-627)ELV066620309 (ELSEVIER)S0165-0378(23)00378-9 DE-627 ger DE-627 rda eng 610 VZ 44.45 bkl Than, Nándor Gábor verfasserin aut Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The prevention of pre-eclampsia is difficult due to the syndromic nature and multiple underlying mechanisms of this severe complication of pregnancy. The current clinical distinction between early- and late-onset disease, although clinically useful, does not reflect the true nature and complexity of the pathologic processes leading to pre-eclampsia. The current gaps in knowledge on the heterogeneous molecular pathways of this syndrome and the lack of adequate, specific diagnostic methods are major obstacles to early screening and tailored preventive strategies. The development of novel diagnostic tools for detecting the activation of the identified disease pathways would enable early, accurate screening and personalized preventive therapies. We implemented a holistic approach that includes the utilization of different proteomic profiling methods of maternal plasma samples collected from various ethnic populations and the application of systems biology analysis to plasma proteomic, maternal demographic, clinical characteristic, and placental histopathologic data. This approach enabled the identification of four molecular subclasses of pre-eclampsia in which distinct and shared disease mechanisms are activated. The current review summarizes the results and conclusions from these studies and the research and clinical implications of our findings. Extracellular matrix-related pre-eclampsia Liquid biopsy Maternal anti-fetal rejection-type pre-eclampsia Metabolic pre-eclampsia Personalized medicine Placental pre-eclampsia Prenatal diagnosis Proteomics Screening Romero, Roberto verfasserin aut Posta, Máté verfasserin aut Györffy, Dániel verfasserin aut Szalai, Gábor verfasserin aut Rossi, Simona W. verfasserin aut Szilágyi, András verfasserin aut Hupuczi, Petronella verfasserin aut Nagy, Sándor verfasserin aut Török, Olga verfasserin aut Tarca, Adi L. verfasserin aut Erez, Offer verfasserin aut Ács, Nándor verfasserin aut Papp, Zoltán verfasserin aut Enthalten in Journal of reproductive immunology Oxford : Oxford University Press, 1979 161 Online-Ressource (DE-627)320464458 (DE-600)2007694-0 (DE-576)095660186 1872-7603 nnns volume:161 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.45 Immunologie VZ AR 161 |
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Than, Nándor Gábor @@aut@@ Romero, Roberto @@aut@@ Posta, Máté @@aut@@ Györffy, Dániel @@aut@@ Szalai, Gábor @@aut@@ Rossi, Simona W. @@aut@@ Szilágyi, András @@aut@@ Hupuczi, Petronella @@aut@@ Nagy, Sándor @@aut@@ Török, Olga @@aut@@ Tarca, Adi L. @@aut@@ Erez, Offer @@aut@@ Ács, Nándor @@aut@@ Papp, Zoltán @@aut@@ |
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Than, Nándor Gábor |
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Than, Nándor Gábor ddc 610 bkl 44.45 misc Extracellular matrix-related pre-eclampsia misc Liquid biopsy misc Maternal anti-fetal rejection-type pre-eclampsia misc Metabolic pre-eclampsia misc Personalized medicine misc Placental pre-eclampsia misc Prenatal diagnosis misc Proteomics misc Screening Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention |
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610 VZ 44.45 bkl Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention Extracellular matrix-related pre-eclampsia Liquid biopsy Maternal anti-fetal rejection-type pre-eclampsia Metabolic pre-eclampsia Personalized medicine Placental pre-eclampsia Prenatal diagnosis Proteomics Screening |
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ddc 610 bkl 44.45 misc Extracellular matrix-related pre-eclampsia misc Liquid biopsy misc Maternal anti-fetal rejection-type pre-eclampsia misc Metabolic pre-eclampsia misc Personalized medicine misc Placental pre-eclampsia misc Prenatal diagnosis misc Proteomics misc Screening |
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ddc 610 bkl 44.45 misc Extracellular matrix-related pre-eclampsia misc Liquid biopsy misc Maternal anti-fetal rejection-type pre-eclampsia misc Metabolic pre-eclampsia misc Personalized medicine misc Placental pre-eclampsia misc Prenatal diagnosis misc Proteomics misc Screening |
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Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention |
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Than, Nándor Gábor Romero, Roberto Posta, Máté Györffy, Dániel Szalai, Gábor Rossi, Simona W. Szilágyi, András Hupuczi, Petronella Nagy, Sándor Török, Olga Tarca, Adi L. Erez, Offer Ács, Nándor Papp, Zoltán |
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classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention |
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Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention |
| abstract |
The prevention of pre-eclampsia is difficult due to the syndromic nature and multiple underlying mechanisms of this severe complication of pregnancy. The current clinical distinction between early- and late-onset disease, although clinically useful, does not reflect the true nature and complexity of the pathologic processes leading to pre-eclampsia. The current gaps in knowledge on the heterogeneous molecular pathways of this syndrome and the lack of adequate, specific diagnostic methods are major obstacles to early screening and tailored preventive strategies. The development of novel diagnostic tools for detecting the activation of the identified disease pathways would enable early, accurate screening and personalized preventive therapies. We implemented a holistic approach that includes the utilization of different proteomic profiling methods of maternal plasma samples collected from various ethnic populations and the application of systems biology analysis to plasma proteomic, maternal demographic, clinical characteristic, and placental histopathologic data. This approach enabled the identification of four molecular subclasses of pre-eclampsia in which distinct and shared disease mechanisms are activated. The current review summarizes the results and conclusions from these studies and the research and clinical implications of our findings. |
| abstractGer |
The prevention of pre-eclampsia is difficult due to the syndromic nature and multiple underlying mechanisms of this severe complication of pregnancy. The current clinical distinction between early- and late-onset disease, although clinically useful, does not reflect the true nature and complexity of the pathologic processes leading to pre-eclampsia. The current gaps in knowledge on the heterogeneous molecular pathways of this syndrome and the lack of adequate, specific diagnostic methods are major obstacles to early screening and tailored preventive strategies. The development of novel diagnostic tools for detecting the activation of the identified disease pathways would enable early, accurate screening and personalized preventive therapies. We implemented a holistic approach that includes the utilization of different proteomic profiling methods of maternal plasma samples collected from various ethnic populations and the application of systems biology analysis to plasma proteomic, maternal demographic, clinical characteristic, and placental histopathologic data. This approach enabled the identification of four molecular subclasses of pre-eclampsia in which distinct and shared disease mechanisms are activated. The current review summarizes the results and conclusions from these studies and the research and clinical implications of our findings. |
| abstract_unstemmed |
The prevention of pre-eclampsia is difficult due to the syndromic nature and multiple underlying mechanisms of this severe complication of pregnancy. The current clinical distinction between early- and late-onset disease, although clinically useful, does not reflect the true nature and complexity of the pathologic processes leading to pre-eclampsia. The current gaps in knowledge on the heterogeneous molecular pathways of this syndrome and the lack of adequate, specific diagnostic methods are major obstacles to early screening and tailored preventive strategies. The development of novel diagnostic tools for detecting the activation of the identified disease pathways would enable early, accurate screening and personalized preventive therapies. We implemented a holistic approach that includes the utilization of different proteomic profiling methods of maternal plasma samples collected from various ethnic populations and the application of systems biology analysis to plasma proteomic, maternal demographic, clinical characteristic, and placental histopathologic data. This approach enabled the identification of four molecular subclasses of pre-eclampsia in which distinct and shared disease mechanisms are activated. The current review summarizes the results and conclusions from these studies and the research and clinical implications of our findings. |
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Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention |
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Romero, Roberto Posta, Máté Györffy, Dániel Szalai, Gábor Rossi, Simona W. Szilágyi, András Hupuczi, Petronella Nagy, Sándor Török, Olga Tarca, Adi L. Erez, Offer Ács, Nándor Papp, Zoltán |
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| score |
7.399646 |