The depth of neuromuscular blockade is not related to chest wall elastance and respiratory mechanics in moderate to severe acute respiratory distress syndrome patients. A prospective cohort study
Background: Data concerning the depth of neuromuscular blockade (NMB) required for effective relaxation of the respiratory muscles in ARDS are scarce. We hypothesised that complete versus partial NMB can modify respiratory mechanics.Method: Prospective study to compare the respiratory mechanics of A...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Barbarot, Nicolas [verfasserIn] Tinelli, Arthur [verfasserIn] Fillatre, Pierre [verfasserIn] Debarre, Matthieu [verfasserIn] Magalhaes, Eric [verfasserIn] Massart, Nicolas [verfasserIn] Wallois, Julien [verfasserIn] Legay, François [verfasserIn] Mari, Arnaud [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of critical care - [Amsterdam] : Elsevier, 1986, 80 |
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| Übergeordnetes Werk: |
volume:80 |
| DOI / URN: |
10.1016/j.jcrc.2023.154505 |
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| Katalog-ID: |
ELV066650682 |
|---|
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| 024 | 7 | |a 10.1016/j.jcrc.2023.154505 |2 doi | |
| 035 | |a (DE-627)ELV066650682 | ||
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| 084 | |a 44.69 |2 bkl | ||
| 100 | 1 | |a Barbarot, Nicolas |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a The depth of neuromuscular blockade is not related to chest wall elastance and respiratory mechanics in moderate to severe acute respiratory distress syndrome patients. A prospective cohort study |
| 264 | 1 | |c 2023 | |
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Background: Data concerning the depth of neuromuscular blockade (NMB) required for effective relaxation of the respiratory muscles in ARDS are scarce. We hypothesised that complete versus partial NMB can modify respiratory mechanics.Method: Prospective study to compare the respiratory mechanics of ARDS patients according to the NMB depth. Each patient was analysed at two times: deep NMB (facial train of four count (TOFC) = 0) and intermediate NMB (TOFC >0). The primary endpoint was the comparison of chest wall elastance (ELCW) according to the NMB level.Results: 33 ARDS patients were analysed. There was no statistical difference between the ELCW at TOFC = 0 compared to TOFC >0: 7 cmH2O/l [5.7–9.5] versus 7 cmH2O/l [5.3–10.8] (p = 0.36). The depth of NMB did not modify the expiratory nor inspiratory oesophageal pressure (Pesexp = 8 cmH2O [5–9.5] at TOFC = 0 versus 7 cmH2O [5–10] at TOFC >0; (p = 0.16) and Pesinsp = 10 cmH2O [8.2–13] at TOFC = 0 versus 10 cmH2O [8–13] at TOFC >0; (p = 0.12)).Conclusion: In ARDS, the relaxation of the respiratory muscles seems to be independent of the NMB level. | ||
| 650 | 4 | |a ARDS | |
| 650 | 4 | |a Transpulmonary pressure | |
| 650 | 4 | |a Respiratory mechanics | |
| 650 | 4 | |a VILI | |
| 650 | 4 | |a Neuromuscular blockade | |
| 650 | 4 | |a Train of four | |
| 700 | 1 | |a Tinelli, Arthur |e verfasserin |4 aut | |
| 700 | 1 | |a Fillatre, Pierre |e verfasserin |4 aut | |
| 700 | 1 | |a Debarre, Matthieu |e verfasserin |4 aut | |
| 700 | 1 | |a Magalhaes, Eric |e verfasserin |4 aut | |
| 700 | 1 | |a Massart, Nicolas |e verfasserin |4 aut | |
| 700 | 1 | |a Wallois, Julien |e verfasserin |4 aut | |
| 700 | 1 | |a Legay, François |e verfasserin |4 aut | |
| 700 | 1 | |a Mari, Arnaud |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of critical care |d [Amsterdam] : Elsevier, 1986 |g 80 |h Online-Ressource |w (DE-627)326646167 |w (DE-600)2041640-4 |w (DE-576)096188820 |x 1557-8615 |7 nnns |
| 773 | 1 | 8 | |g volume:80 |
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| 912 | |a SSG-OLC-PHA | ||
| 912 | |a GBV_ILN_20 | ||
| 912 | |a GBV_ILN_22 | ||
| 912 | |a GBV_ILN_23 | ||
| 912 | |a GBV_ILN_24 | ||
| 912 | |a GBV_ILN_31 | ||
| 912 | |a GBV_ILN_32 | ||
| 912 | |a GBV_ILN_40 | ||
| 912 | |a GBV_ILN_60 | ||
| 912 | |a GBV_ILN_62 | ||
| 912 | |a GBV_ILN_65 | ||
| 912 | |a GBV_ILN_69 | ||
| 912 | |a GBV_ILN_70 | ||
| 912 | |a GBV_ILN_73 | ||
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| 912 | |a GBV_ILN_187 | ||
| 912 | |a GBV_ILN_213 | ||
| 912 | |a GBV_ILN_224 | ||
| 912 | |a GBV_ILN_230 | ||
| 912 | |a GBV_ILN_370 | ||
| 912 | |a GBV_ILN_602 | ||
| 912 | |a GBV_ILN_702 | ||
| 912 | |a GBV_ILN_2001 | ||
| 912 | |a GBV_ILN_2003 | ||
| 912 | |a GBV_ILN_2004 | ||
| 912 | |a GBV_ILN_2005 | ||
| 912 | |a GBV_ILN_2007 | ||
| 912 | |a GBV_ILN_2008 | ||
| 912 | |a GBV_ILN_2009 | ||
| 912 | |a GBV_ILN_2010 | ||
| 912 | |a GBV_ILN_2011 | ||
| 912 | |a GBV_ILN_2014 | ||
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| 912 | |a GBV_ILN_2026 | ||
| 912 | |a GBV_ILN_2027 | ||
| 912 | |a GBV_ILN_2034 | ||
| 912 | |a GBV_ILN_2044 | ||
| 912 | |a GBV_ILN_2048 | ||
| 912 | |a GBV_ILN_2049 | ||
| 912 | |a GBV_ILN_2050 | ||
| 912 | |a GBV_ILN_2055 | ||
| 912 | |a GBV_ILN_2056 | ||
| 912 | |a GBV_ILN_2059 | ||
| 912 | |a GBV_ILN_2061 | ||
| 912 | |a GBV_ILN_2064 | ||
| 912 | |a GBV_ILN_2088 | ||
| 912 | |a GBV_ILN_2106 | ||
| 912 | |a GBV_ILN_2110 | ||
| 912 | |a GBV_ILN_2111 | ||
| 912 | |a GBV_ILN_2112 | ||
| 912 | |a GBV_ILN_2122 | ||
| 912 | |a GBV_ILN_2129 | ||
| 912 | |a GBV_ILN_2143 | ||
| 912 | |a GBV_ILN_2152 | ||
| 912 | |a GBV_ILN_2153 | ||
| 912 | |a GBV_ILN_2190 | ||
| 912 | |a GBV_ILN_2232 | ||
| 912 | |a GBV_ILN_2336 | ||
| 912 | |a GBV_ILN_2470 | ||
| 912 | |a GBV_ILN_2507 | ||
| 912 | |a GBV_ILN_4035 | ||
| 912 | |a GBV_ILN_4037 | ||
| 912 | |a GBV_ILN_4112 | ||
| 912 | |a GBV_ILN_4125 | ||
| 912 | |a GBV_ILN_4242 | ||
| 912 | |a GBV_ILN_4249 | ||
| 912 | |a GBV_ILN_4251 | ||
| 912 | |a GBV_ILN_4305 | ||
| 912 | |a GBV_ILN_4306 | ||
| 912 | |a GBV_ILN_4307 | ||
| 912 | |a GBV_ILN_4313 | ||
| 912 | |a GBV_ILN_4322 | ||
| 912 | |a GBV_ILN_4323 | ||
| 912 | |a GBV_ILN_4324 | ||
| 912 | |a GBV_ILN_4325 | ||
| 912 | |a GBV_ILN_4326 | ||
| 912 | |a GBV_ILN_4333 | ||
| 912 | |a GBV_ILN_4334 | ||
| 912 | |a GBV_ILN_4338 | ||
| 912 | |a GBV_ILN_4393 | ||
| 912 | |a GBV_ILN_4700 | ||
| 936 | b | k | |a 44.69 |j Intensivmedizin |q VZ |
| 951 | |a AR | ||
| 952 | |d 80 | ||
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2023 |
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44.69 |
| publishDate |
2023 |
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10.1016/j.jcrc.2023.154505 doi (DE-627)ELV066650682 (ELSEVIER)S0883-9441(23)00254-X DE-627 ger DE-627 rda eng 610 VZ 44.69 bkl Barbarot, Nicolas verfasserin aut The depth of neuromuscular blockade is not related to chest wall elastance and respiratory mechanics in moderate to severe acute respiratory distress syndrome patients. A prospective cohort study 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Data concerning the depth of neuromuscular blockade (NMB) required for effective relaxation of the respiratory muscles in ARDS are scarce. We hypothesised that complete versus partial NMB can modify respiratory mechanics.Method: Prospective study to compare the respiratory mechanics of ARDS patients according to the NMB depth. Each patient was analysed at two times: deep NMB (facial train of four count (TOFC) = 0) and intermediate NMB (TOFC >0). The primary endpoint was the comparison of chest wall elastance (ELCW) according to the NMB level.Results: 33 ARDS patients were analysed. There was no statistical difference between the ELCW at TOFC = 0 compared to TOFC >0: 7 cmH2O/l [5.7–9.5] versus 7 cmH2O/l [5.3–10.8] (p = 0.36). The depth of NMB did not modify the expiratory nor inspiratory oesophageal pressure (Pesexp = 8 cmH2O [5–9.5] at TOFC = 0 versus 7 cmH2O [5–10] at TOFC >0; (p = 0.16) and Pesinsp = 10 cmH2O [8.2–13] at TOFC = 0 versus 10 cmH2O [8–13] at TOFC >0; (p = 0.12)).Conclusion: In ARDS, the relaxation of the respiratory muscles seems to be independent of the NMB level. ARDS Transpulmonary pressure Respiratory mechanics VILI Neuromuscular blockade Train of four Tinelli, Arthur verfasserin aut Fillatre, Pierre verfasserin aut Debarre, Matthieu verfasserin aut Magalhaes, Eric verfasserin aut Massart, Nicolas verfasserin aut Wallois, Julien verfasserin aut Legay, François verfasserin aut Mari, Arnaud verfasserin aut Enthalten in Journal of critical care [Amsterdam] : Elsevier, 1986 80 Online-Ressource (DE-627)326646167 (DE-600)2041640-4 (DE-576)096188820 1557-8615 nnns volume:80 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.69 Intensivmedizin VZ AR 80 |
| spelling |
10.1016/j.jcrc.2023.154505 doi (DE-627)ELV066650682 (ELSEVIER)S0883-9441(23)00254-X DE-627 ger DE-627 rda eng 610 VZ 44.69 bkl Barbarot, Nicolas verfasserin aut The depth of neuromuscular blockade is not related to chest wall elastance and respiratory mechanics in moderate to severe acute respiratory distress syndrome patients. A prospective cohort study 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Data concerning the depth of neuromuscular blockade (NMB) required for effective relaxation of the respiratory muscles in ARDS are scarce. We hypothesised that complete versus partial NMB can modify respiratory mechanics.Method: Prospective study to compare the respiratory mechanics of ARDS patients according to the NMB depth. Each patient was analysed at two times: deep NMB (facial train of four count (TOFC) = 0) and intermediate NMB (TOFC >0). The primary endpoint was the comparison of chest wall elastance (ELCW) according to the NMB level.Results: 33 ARDS patients were analysed. There was no statistical difference between the ELCW at TOFC = 0 compared to TOFC >0: 7 cmH2O/l [5.7–9.5] versus 7 cmH2O/l [5.3–10.8] (p = 0.36). The depth of NMB did not modify the expiratory nor inspiratory oesophageal pressure (Pesexp = 8 cmH2O [5–9.5] at TOFC = 0 versus 7 cmH2O [5–10] at TOFC >0; (p = 0.16) and Pesinsp = 10 cmH2O [8.2–13] at TOFC = 0 versus 10 cmH2O [8–13] at TOFC >0; (p = 0.12)).Conclusion: In ARDS, the relaxation of the respiratory muscles seems to be independent of the NMB level. ARDS Transpulmonary pressure Respiratory mechanics VILI Neuromuscular blockade Train of four Tinelli, Arthur verfasserin aut Fillatre, Pierre verfasserin aut Debarre, Matthieu verfasserin aut Magalhaes, Eric verfasserin aut Massart, Nicolas verfasserin aut Wallois, Julien verfasserin aut Legay, François verfasserin aut Mari, Arnaud verfasserin aut Enthalten in Journal of critical care [Amsterdam] : Elsevier, 1986 80 Online-Ressource (DE-627)326646167 (DE-600)2041640-4 (DE-576)096188820 1557-8615 nnns volume:80 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.69 Intensivmedizin VZ AR 80 |
| allfields_unstemmed |
10.1016/j.jcrc.2023.154505 doi (DE-627)ELV066650682 (ELSEVIER)S0883-9441(23)00254-X DE-627 ger DE-627 rda eng 610 VZ 44.69 bkl Barbarot, Nicolas verfasserin aut The depth of neuromuscular blockade is not related to chest wall elastance and respiratory mechanics in moderate to severe acute respiratory distress syndrome patients. A prospective cohort study 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Data concerning the depth of neuromuscular blockade (NMB) required for effective relaxation of the respiratory muscles in ARDS are scarce. We hypothesised that complete versus partial NMB can modify respiratory mechanics.Method: Prospective study to compare the respiratory mechanics of ARDS patients according to the NMB depth. Each patient was analysed at two times: deep NMB (facial train of four count (TOFC) = 0) and intermediate NMB (TOFC >0). The primary endpoint was the comparison of chest wall elastance (ELCW) according to the NMB level.Results: 33 ARDS patients were analysed. There was no statistical difference between the ELCW at TOFC = 0 compared to TOFC >0: 7 cmH2O/l [5.7–9.5] versus 7 cmH2O/l [5.3–10.8] (p = 0.36). The depth of NMB did not modify the expiratory nor inspiratory oesophageal pressure (Pesexp = 8 cmH2O [5–9.5] at TOFC = 0 versus 7 cmH2O [5–10] at TOFC >0; (p = 0.16) and Pesinsp = 10 cmH2O [8.2–13] at TOFC = 0 versus 10 cmH2O [8–13] at TOFC >0; (p = 0.12)).Conclusion: In ARDS, the relaxation of the respiratory muscles seems to be independent of the NMB level. ARDS Transpulmonary pressure Respiratory mechanics VILI Neuromuscular blockade Train of four Tinelli, Arthur verfasserin aut Fillatre, Pierre verfasserin aut Debarre, Matthieu verfasserin aut Magalhaes, Eric verfasserin aut Massart, Nicolas verfasserin aut Wallois, Julien verfasserin aut Legay, François verfasserin aut Mari, Arnaud verfasserin aut Enthalten in Journal of critical care [Amsterdam] : Elsevier, 1986 80 Online-Ressource (DE-627)326646167 (DE-600)2041640-4 (DE-576)096188820 1557-8615 nnns volume:80 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.69 Intensivmedizin VZ AR 80 |
| allfieldsGer |
10.1016/j.jcrc.2023.154505 doi (DE-627)ELV066650682 (ELSEVIER)S0883-9441(23)00254-X DE-627 ger DE-627 rda eng 610 VZ 44.69 bkl Barbarot, Nicolas verfasserin aut The depth of neuromuscular blockade is not related to chest wall elastance and respiratory mechanics in moderate to severe acute respiratory distress syndrome patients. A prospective cohort study 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Data concerning the depth of neuromuscular blockade (NMB) required for effective relaxation of the respiratory muscles in ARDS are scarce. We hypothesised that complete versus partial NMB can modify respiratory mechanics.Method: Prospective study to compare the respiratory mechanics of ARDS patients according to the NMB depth. Each patient was analysed at two times: deep NMB (facial train of four count (TOFC) = 0) and intermediate NMB (TOFC >0). The primary endpoint was the comparison of chest wall elastance (ELCW) according to the NMB level.Results: 33 ARDS patients were analysed. There was no statistical difference between the ELCW at TOFC = 0 compared to TOFC >0: 7 cmH2O/l [5.7–9.5] versus 7 cmH2O/l [5.3–10.8] (p = 0.36). The depth of NMB did not modify the expiratory nor inspiratory oesophageal pressure (Pesexp = 8 cmH2O [5–9.5] at TOFC = 0 versus 7 cmH2O [5–10] at TOFC >0; (p = 0.16) and Pesinsp = 10 cmH2O [8.2–13] at TOFC = 0 versus 10 cmH2O [8–13] at TOFC >0; (p = 0.12)).Conclusion: In ARDS, the relaxation of the respiratory muscles seems to be independent of the NMB level. ARDS Transpulmonary pressure Respiratory mechanics VILI Neuromuscular blockade Train of four Tinelli, Arthur verfasserin aut Fillatre, Pierre verfasserin aut Debarre, Matthieu verfasserin aut Magalhaes, Eric verfasserin aut Massart, Nicolas verfasserin aut Wallois, Julien verfasserin aut Legay, François verfasserin aut Mari, Arnaud verfasserin aut Enthalten in Journal of critical care [Amsterdam] : Elsevier, 1986 80 Online-Ressource (DE-627)326646167 (DE-600)2041640-4 (DE-576)096188820 1557-8615 nnns volume:80 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.69 Intensivmedizin VZ AR 80 |
| allfieldsSound |
10.1016/j.jcrc.2023.154505 doi (DE-627)ELV066650682 (ELSEVIER)S0883-9441(23)00254-X DE-627 ger DE-627 rda eng 610 VZ 44.69 bkl Barbarot, Nicolas verfasserin aut The depth of neuromuscular blockade is not related to chest wall elastance and respiratory mechanics in moderate to severe acute respiratory distress syndrome patients. A prospective cohort study 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Data concerning the depth of neuromuscular blockade (NMB) required for effective relaxation of the respiratory muscles in ARDS are scarce. We hypothesised that complete versus partial NMB can modify respiratory mechanics.Method: Prospective study to compare the respiratory mechanics of ARDS patients according to the NMB depth. Each patient was analysed at two times: deep NMB (facial train of four count (TOFC) = 0) and intermediate NMB (TOFC >0). The primary endpoint was the comparison of chest wall elastance (ELCW) according to the NMB level.Results: 33 ARDS patients were analysed. There was no statistical difference between the ELCW at TOFC = 0 compared to TOFC >0: 7 cmH2O/l [5.7–9.5] versus 7 cmH2O/l [5.3–10.8] (p = 0.36). The depth of NMB did not modify the expiratory nor inspiratory oesophageal pressure (Pesexp = 8 cmH2O [5–9.5] at TOFC = 0 versus 7 cmH2O [5–10] at TOFC >0; (p = 0.16) and Pesinsp = 10 cmH2O [8.2–13] at TOFC = 0 versus 10 cmH2O [8–13] at TOFC >0; (p = 0.12)).Conclusion: In ARDS, the relaxation of the respiratory muscles seems to be independent of the NMB level. ARDS Transpulmonary pressure Respiratory mechanics VILI Neuromuscular blockade Train of four Tinelli, Arthur verfasserin aut Fillatre, Pierre verfasserin aut Debarre, Matthieu verfasserin aut Magalhaes, Eric verfasserin aut Massart, Nicolas verfasserin aut Wallois, Julien verfasserin aut Legay, François verfasserin aut Mari, Arnaud verfasserin aut Enthalten in Journal of critical care [Amsterdam] : Elsevier, 1986 80 Online-Ressource (DE-627)326646167 (DE-600)2041640-4 (DE-576)096188820 1557-8615 nnns volume:80 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.69 Intensivmedizin VZ AR 80 |
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Enthalten in Journal of critical care 80 volume:80 |
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ARDS Transpulmonary pressure Respiratory mechanics VILI Neuromuscular blockade Train of four |
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Barbarot, Nicolas @@aut@@ Tinelli, Arthur @@aut@@ Fillatre, Pierre @@aut@@ Debarre, Matthieu @@aut@@ Magalhaes, Eric @@aut@@ Massart, Nicolas @@aut@@ Wallois, Julien @@aut@@ Legay, François @@aut@@ Mari, Arnaud @@aut@@ |
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2023-01-01T00:00:00Z |
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Barbarot, Nicolas |
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Barbarot, Nicolas ddc 610 bkl 44.69 misc ARDS misc Transpulmonary pressure misc Respiratory mechanics misc VILI misc Neuromuscular blockade misc Train of four The depth of neuromuscular blockade is not related to chest wall elastance and respiratory mechanics in moderate to severe acute respiratory distress syndrome patients. A prospective cohort study |
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610 VZ 44.69 bkl The depth of neuromuscular blockade is not related to chest wall elastance and respiratory mechanics in moderate to severe acute respiratory distress syndrome patients. A prospective cohort study ARDS Transpulmonary pressure Respiratory mechanics VILI Neuromuscular blockade Train of four |
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ddc 610 bkl 44.69 misc ARDS misc Transpulmonary pressure misc Respiratory mechanics misc VILI misc Neuromuscular blockade misc Train of four |
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ddc 610 bkl 44.69 misc ARDS misc Transpulmonary pressure misc Respiratory mechanics misc VILI misc Neuromuscular blockade misc Train of four |
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ddc 610 bkl 44.69 misc ARDS misc Transpulmonary pressure misc Respiratory mechanics misc VILI misc Neuromuscular blockade misc Train of four |
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The depth of neuromuscular blockade is not related to chest wall elastance and respiratory mechanics in moderate to severe acute respiratory distress syndrome patients. A prospective cohort study |
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The depth of neuromuscular blockade is not related to chest wall elastance and respiratory mechanics in moderate to severe acute respiratory distress syndrome patients. A prospective cohort study |
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Barbarot, Nicolas |
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Journal of critical care |
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2023 |
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Barbarot, Nicolas Tinelli, Arthur Fillatre, Pierre Debarre, Matthieu Magalhaes, Eric Massart, Nicolas Wallois, Julien Legay, François Mari, Arnaud |
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Barbarot, Nicolas |
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10.1016/j.jcrc.2023.154505 |
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610 |
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verfasserin |
| title_sort |
the depth of neuromuscular blockade is not related to chest wall elastance and respiratory mechanics in moderate to severe acute respiratory distress syndrome patients. a prospective cohort study |
| title_auth |
The depth of neuromuscular blockade is not related to chest wall elastance and respiratory mechanics in moderate to severe acute respiratory distress syndrome patients. A prospective cohort study |
| abstract |
Background: Data concerning the depth of neuromuscular blockade (NMB) required for effective relaxation of the respiratory muscles in ARDS are scarce. We hypothesised that complete versus partial NMB can modify respiratory mechanics.Method: Prospective study to compare the respiratory mechanics of ARDS patients according to the NMB depth. Each patient was analysed at two times: deep NMB (facial train of four count (TOFC) = 0) and intermediate NMB (TOFC >0). The primary endpoint was the comparison of chest wall elastance (ELCW) according to the NMB level.Results: 33 ARDS patients were analysed. There was no statistical difference between the ELCW at TOFC = 0 compared to TOFC >0: 7 cmH2O/l [5.7–9.5] versus 7 cmH2O/l [5.3–10.8] (p = 0.36). The depth of NMB did not modify the expiratory nor inspiratory oesophageal pressure (Pesexp = 8 cmH2O [5–9.5] at TOFC = 0 versus 7 cmH2O [5–10] at TOFC >0; (p = 0.16) and Pesinsp = 10 cmH2O [8.2–13] at TOFC = 0 versus 10 cmH2O [8–13] at TOFC >0; (p = 0.12)).Conclusion: In ARDS, the relaxation of the respiratory muscles seems to be independent of the NMB level. |
| abstractGer |
Background: Data concerning the depth of neuromuscular blockade (NMB) required for effective relaxation of the respiratory muscles in ARDS are scarce. We hypothesised that complete versus partial NMB can modify respiratory mechanics.Method: Prospective study to compare the respiratory mechanics of ARDS patients according to the NMB depth. Each patient was analysed at two times: deep NMB (facial train of four count (TOFC) = 0) and intermediate NMB (TOFC >0). The primary endpoint was the comparison of chest wall elastance (ELCW) according to the NMB level.Results: 33 ARDS patients were analysed. There was no statistical difference between the ELCW at TOFC = 0 compared to TOFC >0: 7 cmH2O/l [5.7–9.5] versus 7 cmH2O/l [5.3–10.8] (p = 0.36). The depth of NMB did not modify the expiratory nor inspiratory oesophageal pressure (Pesexp = 8 cmH2O [5–9.5] at TOFC = 0 versus 7 cmH2O [5–10] at TOFC >0; (p = 0.16) and Pesinsp = 10 cmH2O [8.2–13] at TOFC = 0 versus 10 cmH2O [8–13] at TOFC >0; (p = 0.12)).Conclusion: In ARDS, the relaxation of the respiratory muscles seems to be independent of the NMB level. |
| abstract_unstemmed |
Background: Data concerning the depth of neuromuscular blockade (NMB) required for effective relaxation of the respiratory muscles in ARDS are scarce. We hypothesised that complete versus partial NMB can modify respiratory mechanics.Method: Prospective study to compare the respiratory mechanics of ARDS patients according to the NMB depth. Each patient was analysed at two times: deep NMB (facial train of four count (TOFC) = 0) and intermediate NMB (TOFC >0). The primary endpoint was the comparison of chest wall elastance (ELCW) according to the NMB level.Results: 33 ARDS patients were analysed. There was no statistical difference between the ELCW at TOFC = 0 compared to TOFC >0: 7 cmH2O/l [5.7–9.5] versus 7 cmH2O/l [5.3–10.8] (p = 0.36). The depth of NMB did not modify the expiratory nor inspiratory oesophageal pressure (Pesexp = 8 cmH2O [5–9.5] at TOFC = 0 versus 7 cmH2O [5–10] at TOFC >0; (p = 0.16) and Pesinsp = 10 cmH2O [8.2–13] at TOFC = 0 versus 10 cmH2O [8–13] at TOFC >0; (p = 0.12)).Conclusion: In ARDS, the relaxation of the respiratory muscles seems to be independent of the NMB level. |
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The depth of neuromuscular blockade is not related to chest wall elastance and respiratory mechanics in moderate to severe acute respiratory distress syndrome patients. A prospective cohort study |
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| score |
7.400176 |