Advances in the effect of gut-joint axis dysfunction on rheumatoid arthritis and the intervention of natural products
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory malady that predominantly affects the joints. Emerging evidence highlights the perturbation of intestinal microflora and its resultant metabolites as potential instigators of disruptions within the “gut-joint axis”. These disruptions sub...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
GUO, Wentao [verfasserIn] LV, Guangfu [verfasserIn] YANG, Di [verfasserIn] ZHANG, Wenjing [verfasserIn] LI, Nian [verfasserIn] HU, Jiannan [verfasserIn] WU, Yongxi [verfasserIn] PI, Zifeng [verfasserIn] LIN, Zhe [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2024 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Chinese journal of analytical chemistry - Changchun : Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 2006, 52 |
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| Übergeordnetes Werk: |
volume:52 |
| DOI / URN: |
10.1016/j.cjac.2023.100354 |
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| Katalog-ID: |
ELV066740843 |
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| 520 | |a Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory malady that predominantly affects the joints. Emerging evidence highlights the perturbation of intestinal microflora and its resultant metabolites as potential instigators of disruptions within the “gut-joint axis”. These disruptions subsequently trigger localized or systemic immune responses, culminating in joint inflammation and consequent impairment. While the efficacy of natural compounds in managing RA has been increasingly recognized, the precise mechanisms underlying their actions within the“gut-joint axis” remain incompletely elucidated. The primary objective of this comprehensive investigation is to assess the effects of the intestinal barrier, gut microbiota, and metabolites on the pathogenesis of RA. Moreover, it aims to delineate the mechanisms through which natural products exert their therapeutic effects on the treatment of RA, all within the framework of the “gut-joint axis”. | ||
| 650 | 4 | |a Rheumatoid arthritis | |
| 650 | 4 | |a Mechanism | |
| 650 | 4 | |a Gut-joint axis | |
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10.1016/j.cjac.2023.100354 doi (DE-627)ELV066740843 (ELSEVIER)S1872-2040(23)00128-7 DE-627 ger DE-627 rda eng 540 VZ GUO, Wentao verfasserin aut Advances in the effect of gut-joint axis dysfunction on rheumatoid arthritis and the intervention of natural products 2024 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory malady that predominantly affects the joints. Emerging evidence highlights the perturbation of intestinal microflora and its resultant metabolites as potential instigators of disruptions within the “gut-joint axis”. These disruptions subsequently trigger localized or systemic immune responses, culminating in joint inflammation and consequent impairment. While the efficacy of natural compounds in managing RA has been increasingly recognized, the precise mechanisms underlying their actions within the“gut-joint axis” remain incompletely elucidated. The primary objective of this comprehensive investigation is to assess the effects of the intestinal barrier, gut microbiota, and metabolites on the pathogenesis of RA. Moreover, it aims to delineate the mechanisms through which natural products exert their therapeutic effects on the treatment of RA, all within the framework of the “gut-joint axis”. Rheumatoid arthritis Mechanism Gut-joint axis Natural products Barriers of the gut LV, Guangfu verfasserin aut YANG, Di verfasserin aut ZHANG, Wenjing verfasserin aut LI, Nian verfasserin aut HU, Jiannan verfasserin aut WU, Yongxi verfasserin aut PI, Zifeng verfasserin (orcid)0000-0001-7075-5319 aut LIN, Zhe verfasserin aut Enthalten in Chinese journal of analytical chemistry Changchun : Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 2006 52 Online-Ressource (DE-627)552254266 (DE-600)2399980-9 (DE-576)284927163 1872-2040 nnns volume:52 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 52 |
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10.1016/j.cjac.2023.100354 doi (DE-627)ELV066740843 (ELSEVIER)S1872-2040(23)00128-7 DE-627 ger DE-627 rda eng 540 VZ GUO, Wentao verfasserin aut Advances in the effect of gut-joint axis dysfunction on rheumatoid arthritis and the intervention of natural products 2024 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory malady that predominantly affects the joints. Emerging evidence highlights the perturbation of intestinal microflora and its resultant metabolites as potential instigators of disruptions within the “gut-joint axis”. These disruptions subsequently trigger localized or systemic immune responses, culminating in joint inflammation and consequent impairment. While the efficacy of natural compounds in managing RA has been increasingly recognized, the precise mechanisms underlying their actions within the“gut-joint axis” remain incompletely elucidated. The primary objective of this comprehensive investigation is to assess the effects of the intestinal barrier, gut microbiota, and metabolites on the pathogenesis of RA. Moreover, it aims to delineate the mechanisms through which natural products exert their therapeutic effects on the treatment of RA, all within the framework of the “gut-joint axis”. Rheumatoid arthritis Mechanism Gut-joint axis Natural products Barriers of the gut LV, Guangfu verfasserin aut YANG, Di verfasserin aut ZHANG, Wenjing verfasserin aut LI, Nian verfasserin aut HU, Jiannan verfasserin aut WU, Yongxi verfasserin aut PI, Zifeng verfasserin (orcid)0000-0001-7075-5319 aut LIN, Zhe verfasserin aut Enthalten in Chinese journal of analytical chemistry Changchun : Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 2006 52 Online-Ressource (DE-627)552254266 (DE-600)2399980-9 (DE-576)284927163 1872-2040 nnns volume:52 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 52 |
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10.1016/j.cjac.2023.100354 doi (DE-627)ELV066740843 (ELSEVIER)S1872-2040(23)00128-7 DE-627 ger DE-627 rda eng 540 VZ GUO, Wentao verfasserin aut Advances in the effect of gut-joint axis dysfunction on rheumatoid arthritis and the intervention of natural products 2024 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory malady that predominantly affects the joints. Emerging evidence highlights the perturbation of intestinal microflora and its resultant metabolites as potential instigators of disruptions within the “gut-joint axis”. These disruptions subsequently trigger localized or systemic immune responses, culminating in joint inflammation and consequent impairment. While the efficacy of natural compounds in managing RA has been increasingly recognized, the precise mechanisms underlying their actions within the“gut-joint axis” remain incompletely elucidated. The primary objective of this comprehensive investigation is to assess the effects of the intestinal barrier, gut microbiota, and metabolites on the pathogenesis of RA. Moreover, it aims to delineate the mechanisms through which natural products exert their therapeutic effects on the treatment of RA, all within the framework of the “gut-joint axis”. Rheumatoid arthritis Mechanism Gut-joint axis Natural products Barriers of the gut LV, Guangfu verfasserin aut YANG, Di verfasserin aut ZHANG, Wenjing verfasserin aut LI, Nian verfasserin aut HU, Jiannan verfasserin aut WU, Yongxi verfasserin aut PI, Zifeng verfasserin (orcid)0000-0001-7075-5319 aut LIN, Zhe verfasserin aut Enthalten in Chinese journal of analytical chemistry Changchun : Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 2006 52 Online-Ressource (DE-627)552254266 (DE-600)2399980-9 (DE-576)284927163 1872-2040 nnns volume:52 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 52 |
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10.1016/j.cjac.2023.100354 doi (DE-627)ELV066740843 (ELSEVIER)S1872-2040(23)00128-7 DE-627 ger DE-627 rda eng 540 VZ GUO, Wentao verfasserin aut Advances in the effect of gut-joint axis dysfunction on rheumatoid arthritis and the intervention of natural products 2024 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory malady that predominantly affects the joints. Emerging evidence highlights the perturbation of intestinal microflora and its resultant metabolites as potential instigators of disruptions within the “gut-joint axis”. These disruptions subsequently trigger localized or systemic immune responses, culminating in joint inflammation and consequent impairment. While the efficacy of natural compounds in managing RA has been increasingly recognized, the precise mechanisms underlying their actions within the“gut-joint axis” remain incompletely elucidated. The primary objective of this comprehensive investigation is to assess the effects of the intestinal barrier, gut microbiota, and metabolites on the pathogenesis of RA. Moreover, it aims to delineate the mechanisms through which natural products exert their therapeutic effects on the treatment of RA, all within the framework of the “gut-joint axis”. Rheumatoid arthritis Mechanism Gut-joint axis Natural products Barriers of the gut LV, Guangfu verfasserin aut YANG, Di verfasserin aut ZHANG, Wenjing verfasserin aut LI, Nian verfasserin aut HU, Jiannan verfasserin aut WU, Yongxi verfasserin aut PI, Zifeng verfasserin (orcid)0000-0001-7075-5319 aut LIN, Zhe verfasserin aut Enthalten in Chinese journal of analytical chemistry Changchun : Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 2006 52 Online-Ressource (DE-627)552254266 (DE-600)2399980-9 (DE-576)284927163 1872-2040 nnns volume:52 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 52 |
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10.1016/j.cjac.2023.100354 doi (DE-627)ELV066740843 (ELSEVIER)S1872-2040(23)00128-7 DE-627 ger DE-627 rda eng 540 VZ GUO, Wentao verfasserin aut Advances in the effect of gut-joint axis dysfunction on rheumatoid arthritis and the intervention of natural products 2024 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory malady that predominantly affects the joints. Emerging evidence highlights the perturbation of intestinal microflora and its resultant metabolites as potential instigators of disruptions within the “gut-joint axis”. These disruptions subsequently trigger localized or systemic immune responses, culminating in joint inflammation and consequent impairment. While the efficacy of natural compounds in managing RA has been increasingly recognized, the precise mechanisms underlying their actions within the“gut-joint axis” remain incompletely elucidated. The primary objective of this comprehensive investigation is to assess the effects of the intestinal barrier, gut microbiota, and metabolites on the pathogenesis of RA. Moreover, it aims to delineate the mechanisms through which natural products exert their therapeutic effects on the treatment of RA, all within the framework of the “gut-joint axis”. Rheumatoid arthritis Mechanism Gut-joint axis Natural products Barriers of the gut LV, Guangfu verfasserin aut YANG, Di verfasserin aut ZHANG, Wenjing verfasserin aut LI, Nian verfasserin aut HU, Jiannan verfasserin aut WU, Yongxi verfasserin aut PI, Zifeng verfasserin (orcid)0000-0001-7075-5319 aut LIN, Zhe verfasserin aut Enthalten in Chinese journal of analytical chemistry Changchun : Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 2006 52 Online-Ressource (DE-627)552254266 (DE-600)2399980-9 (DE-576)284927163 1872-2040 nnns volume:52 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 52 |
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advances in the effect of gut-joint axis dysfunction on rheumatoid arthritis and the intervention of natural products |
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Advances in the effect of gut-joint axis dysfunction on rheumatoid arthritis and the intervention of natural products |
| abstract |
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory malady that predominantly affects the joints. Emerging evidence highlights the perturbation of intestinal microflora and its resultant metabolites as potential instigators of disruptions within the “gut-joint axis”. These disruptions subsequently trigger localized or systemic immune responses, culminating in joint inflammation and consequent impairment. While the efficacy of natural compounds in managing RA has been increasingly recognized, the precise mechanisms underlying their actions within the“gut-joint axis” remain incompletely elucidated. The primary objective of this comprehensive investigation is to assess the effects of the intestinal barrier, gut microbiota, and metabolites on the pathogenesis of RA. Moreover, it aims to delineate the mechanisms through which natural products exert their therapeutic effects on the treatment of RA, all within the framework of the “gut-joint axis”. |
| abstractGer |
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory malady that predominantly affects the joints. Emerging evidence highlights the perturbation of intestinal microflora and its resultant metabolites as potential instigators of disruptions within the “gut-joint axis”. These disruptions subsequently trigger localized or systemic immune responses, culminating in joint inflammation and consequent impairment. While the efficacy of natural compounds in managing RA has been increasingly recognized, the precise mechanisms underlying their actions within the“gut-joint axis” remain incompletely elucidated. The primary objective of this comprehensive investigation is to assess the effects of the intestinal barrier, gut microbiota, and metabolites on the pathogenesis of RA. Moreover, it aims to delineate the mechanisms through which natural products exert their therapeutic effects on the treatment of RA, all within the framework of the “gut-joint axis”. |
| abstract_unstemmed |
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory malady that predominantly affects the joints. Emerging evidence highlights the perturbation of intestinal microflora and its resultant metabolites as potential instigators of disruptions within the “gut-joint axis”. These disruptions subsequently trigger localized or systemic immune responses, culminating in joint inflammation and consequent impairment. While the efficacy of natural compounds in managing RA has been increasingly recognized, the precise mechanisms underlying their actions within the“gut-joint axis” remain incompletely elucidated. The primary objective of this comprehensive investigation is to assess the effects of the intestinal barrier, gut microbiota, and metabolites on the pathogenesis of RA. Moreover, it aims to delineate the mechanisms through which natural products exert their therapeutic effects on the treatment of RA, all within the framework of the “gut-joint axis”. |
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7.400199 |