NEO1/NEO-EXT studies: Long-term muscle quantitative magnetic resonance imaging and functional efficacy in adults with late-onset Pompe disease (LOPD) on avalglucosidase alfa treatment

Gespeichert in:

Autor*in:	Byrne, Barry [verfasserIn] Carlier, Pierre G. [verfasserIn] Vissing, John [verfasserIn] Dimachkie, Mazen M. [verfasserIn] Barohn, Richard [verfasserIn] Kishnani, Priya S. [verfasserIn] Ladha, Shafeeq [verfasserIn] Mengel, Eugen [verfasserIn] Sacconi, Sabrina [verfasserIn] Trivedi, Jaya [verfasserIn] Young, Peter [verfasserIn] Haack, Kristina An [verfasserIn] Armstrong, Nicole [verfasserIn] Miossec, Patrick [verfasserIn] Thibault, Nathan [verfasserIn] Sparks, Susan [verfasserIn] Schoser, Benedikt [verfasserIn] Diaz-Manera, Jordi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Übergeordnetes Werk:	Enthalten in: Molecular genetics and metabolism - Orlando, Fla. : Academic Press, 1998, 141
Übergeordnetes Werk:	volume:141

DOI / URN:	10.1016/j.ymgme.2023.107783

Katalog-ID:	ELV066818818

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bklnumber	42.13 44.33
publishDate	2023
allfields	10.1016/j.ymgme.2023.107783 doi (DE-627)ELV066818818 (ELSEVIER)S1096-7192(23)00413-4 DE-627 ger DE-627 rda eng 610 VZ 42.13 bkl 44.33 bkl Byrne, Barry verfasserin aut NEO1/NEO-EXT studies: Long-term muscle quantitative magnetic resonance imaging and functional efficacy in adults with late-onset Pompe disease (LOPD) on avalglucosidase alfa treatment 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Carlier, Pierre G. verfasserin aut Vissing, John verfasserin aut Dimachkie, Mazen M. verfasserin aut Barohn, Richard verfasserin aut Kishnani, Priya S. verfasserin aut Ladha, Shafeeq verfasserin aut Mengel, Eugen verfasserin aut Sacconi, Sabrina verfasserin aut Trivedi, Jaya verfasserin aut Young, Peter verfasserin aut Haack, Kristina An verfasserin aut Armstrong, Nicole verfasserin aut Miossec, Patrick verfasserin aut Thibault, Nathan verfasserin aut Sparks, Susan verfasserin aut Schoser, Benedikt verfasserin aut Diaz-Manera, Jordi verfasserin aut Enthalten in Molecular genetics and metabolism Orlando, Fla. : Academic Press, 1998 141 Online-Ressource (DE-627)268125260 (DE-600)1471393-7 (DE-576)106869493 1096-7206 nnns volume:141 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.13 Molekularbiologie VZ 44.33 Physiologische Chemie VZ AR 141
spelling	10.1016/j.ymgme.2023.107783 doi (DE-627)ELV066818818 (ELSEVIER)S1096-7192(23)00413-4 DE-627 ger DE-627 rda eng 610 VZ 42.13 bkl 44.33 bkl Byrne, Barry verfasserin aut NEO1/NEO-EXT studies: Long-term muscle quantitative magnetic resonance imaging and functional efficacy in adults with late-onset Pompe disease (LOPD) on avalglucosidase alfa treatment 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Carlier, Pierre G. verfasserin aut Vissing, John verfasserin aut Dimachkie, Mazen M. verfasserin aut Barohn, Richard verfasserin aut Kishnani, Priya S. verfasserin aut Ladha, Shafeeq verfasserin aut Mengel, Eugen verfasserin aut Sacconi, Sabrina verfasserin aut Trivedi, Jaya verfasserin aut Young, Peter verfasserin aut Haack, Kristina An verfasserin aut Armstrong, Nicole verfasserin aut Miossec, Patrick verfasserin aut Thibault, Nathan verfasserin aut Sparks, Susan verfasserin aut Schoser, Benedikt verfasserin aut Diaz-Manera, Jordi verfasserin aut Enthalten in Molecular genetics and metabolism Orlando, Fla. : Academic Press, 1998 141 Online-Ressource (DE-627)268125260 (DE-600)1471393-7 (DE-576)106869493 1096-7206 nnns volume:141 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.13 Molekularbiologie VZ 44.33 Physiologische Chemie VZ AR 141
allfields_unstemmed	10.1016/j.ymgme.2023.107783 doi (DE-627)ELV066818818 (ELSEVIER)S1096-7192(23)00413-4 DE-627 ger DE-627 rda eng 610 VZ 42.13 bkl 44.33 bkl Byrne, Barry verfasserin aut NEO1/NEO-EXT studies: Long-term muscle quantitative magnetic resonance imaging and functional efficacy in adults with late-onset Pompe disease (LOPD) on avalglucosidase alfa treatment 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Carlier, Pierre G. verfasserin aut Vissing, John verfasserin aut Dimachkie, Mazen M. verfasserin aut Barohn, Richard verfasserin aut Kishnani, Priya S. verfasserin aut Ladha, Shafeeq verfasserin aut Mengel, Eugen verfasserin aut Sacconi, Sabrina verfasserin aut Trivedi, Jaya verfasserin aut Young, Peter verfasserin aut Haack, Kristina An verfasserin aut Armstrong, Nicole verfasserin aut Miossec, Patrick verfasserin aut Thibault, Nathan verfasserin aut Sparks, Susan verfasserin aut Schoser, Benedikt verfasserin aut Diaz-Manera, Jordi verfasserin aut Enthalten in Molecular genetics and metabolism Orlando, Fla. : Academic Press, 1998 141 Online-Ressource (DE-627)268125260 (DE-600)1471393-7 (DE-576)106869493 1096-7206 nnns volume:141 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.13 Molekularbiologie VZ 44.33 Physiologische Chemie VZ AR 141
allfieldsGer	10.1016/j.ymgme.2023.107783 doi (DE-627)ELV066818818 (ELSEVIER)S1096-7192(23)00413-4 DE-627 ger DE-627 rda eng 610 VZ 42.13 bkl 44.33 bkl Byrne, Barry verfasserin aut NEO1/NEO-EXT studies: Long-term muscle quantitative magnetic resonance imaging and functional efficacy in adults with late-onset Pompe disease (LOPD) on avalglucosidase alfa treatment 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Carlier, Pierre G. verfasserin aut Vissing, John verfasserin aut Dimachkie, Mazen M. verfasserin aut Barohn, Richard verfasserin aut Kishnani, Priya S. verfasserin aut Ladha, Shafeeq verfasserin aut Mengel, Eugen verfasserin aut Sacconi, Sabrina verfasserin aut Trivedi, Jaya verfasserin aut Young, Peter verfasserin aut Haack, Kristina An verfasserin aut Armstrong, Nicole verfasserin aut Miossec, Patrick verfasserin aut Thibault, Nathan verfasserin aut Sparks, Susan verfasserin aut Schoser, Benedikt verfasserin aut Diaz-Manera, Jordi verfasserin aut Enthalten in Molecular genetics and metabolism Orlando, Fla. : Academic Press, 1998 141 Online-Ressource (DE-627)268125260 (DE-600)1471393-7 (DE-576)106869493 1096-7206 nnns volume:141 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.13 Molekularbiologie VZ 44.33 Physiologische Chemie VZ AR 141
allfieldsSound	10.1016/j.ymgme.2023.107783 doi (DE-627)ELV066818818 (ELSEVIER)S1096-7192(23)00413-4 DE-627 ger DE-627 rda eng 610 VZ 42.13 bkl 44.33 bkl Byrne, Barry verfasserin aut NEO1/NEO-EXT studies: Long-term muscle quantitative magnetic resonance imaging and functional efficacy in adults with late-onset Pompe disease (LOPD) on avalglucosidase alfa treatment 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Carlier, Pierre G. verfasserin aut Vissing, John verfasserin aut Dimachkie, Mazen M. verfasserin aut Barohn, Richard verfasserin aut Kishnani, Priya S. verfasserin aut Ladha, Shafeeq verfasserin aut Mengel, Eugen verfasserin aut Sacconi, Sabrina verfasserin aut Trivedi, Jaya verfasserin aut Young, Peter verfasserin aut Haack, Kristina An verfasserin aut Armstrong, Nicole verfasserin aut Miossec, Patrick verfasserin aut Thibault, Nathan verfasserin aut Sparks, Susan verfasserin aut Schoser, Benedikt verfasserin aut Diaz-Manera, Jordi verfasserin aut Enthalten in Molecular genetics and metabolism Orlando, Fla. : Academic Press, 1998 141 Online-Ressource (DE-627)268125260 (DE-600)1471393-7 (DE-576)106869493 1096-7206 nnns volume:141 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.13 Molekularbiologie VZ 44.33 Physiologische Chemie VZ AR 141
language	English
source	Enthalten in Molecular genetics and metabolism 141 volume:141
sourceStr	Enthalten in Molecular genetics and metabolism 141 volume:141
format_phy_str_mv	Article
bklname	Molekularbiologie Physiologische Chemie
institution	findex.gbv.de
dewey-raw	610
isfreeaccess_bool	false
container_title	Molecular genetics and metabolism
authorswithroles_txt_mv	Byrne, Barry @@aut@@ Carlier, Pierre G. @@aut@@ Vissing, John @@aut@@ Dimachkie, Mazen M. @@aut@@ Barohn, Richard @@aut@@ Kishnani, Priya S. @@aut@@ Ladha, Shafeeq @@aut@@ Mengel, Eugen @@aut@@ Sacconi, Sabrina @@aut@@ Trivedi, Jaya @@aut@@ Young, Peter @@aut@@ Haack, Kristina An @@aut@@ Armstrong, Nicole @@aut@@ Miossec, Patrick @@aut@@ Thibault, Nathan @@aut@@ Sparks, Susan @@aut@@ Schoser, Benedikt @@aut@@ Diaz-Manera, Jordi @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	268125260
dewey-sort	3610
id	ELV066818818
language_de	englisch
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spellingShingle	Byrne, Barry ddc 610 bkl 42.13 bkl 44.33 NEO1/NEO-EXT studies: Long-term muscle quantitative magnetic resonance imaging and functional efficacy in adults with late-onset Pompe disease (LOPD) on avalglucosidase alfa treatment
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topic_title	610 VZ 42.13 bkl 44.33 bkl NEO1/NEO-EXT studies: Long-term muscle quantitative magnetic resonance imaging and functional efficacy in adults with late-onset Pompe disease (LOPD) on avalglucosidase alfa treatment
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title	NEO1/NEO-EXT studies: Long-term muscle quantitative magnetic resonance imaging and functional efficacy in adults with late-onset Pompe disease (LOPD) on avalglucosidase alfa treatment
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title_full	NEO1/NEO-EXT studies: Long-term muscle quantitative magnetic resonance imaging and functional efficacy in adults with late-onset Pompe disease (LOPD) on avalglucosidase alfa treatment
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doi_str_mv	10.1016/j.ymgme.2023.107783
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title_sort	neo1/neo-ext studies: long-term muscle quantitative magnetic resonance imaging and functional efficacy in adults with late-onset pompe disease (lopd) on avalglucosidase alfa treatment
title_auth	NEO1/NEO-EXT studies: Long-term muscle quantitative magnetic resonance imaging and functional efficacy in adults with late-onset Pompe disease (LOPD) on avalglucosidase alfa treatment
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title_short	NEO1/NEO-EXT studies: Long-term muscle quantitative magnetic resonance imaging and functional efficacy in adults with late-onset Pompe disease (LOPD) on avalglucosidase alfa treatment
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author2	Carlier, Pierre G. Vissing, John Dimachkie, Mazen M. Barohn, Richard Kishnani, Priya S. Ladha, Shafeeq Mengel, Eugen Sacconi, Sabrina Trivedi, Jaya Young, Peter Haack, Kristina An Armstrong, Nicole Miossec, Patrick Thibault, Nathan Sparks, Susan Schoser, Benedikt Diaz-Manera, Jordi
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up_date	2024-07-06T19:06:36.973Z
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NEO1/NEO-EXT studies: Long-term muscle quantitative magnetic resonance imaging and functional efficacy in adults with late-onset Pompe disease (LOPD) on avalglucosidase alfa treatment

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