Injectable, stretchable, and conductance-stable fiber for myocardial infarction repair
Injecting electroactive biomaterials into infarcted myocardium to restore blocked electrical signal pathways is an effective way for repairing myocardial infarction. However, re-establishing stable and anisotropic conductive pathways during the constant contraction and relaxation of the heart remain...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Li, Yimeng [verfasserIn] Li, Chaofu [verfasserIn] Shan, Mengqi [verfasserIn] Wei, Leqian [verfasserIn] Lan, Lizhen [verfasserIn] Liu, Xiaoli [verfasserIn] Guo, Lamei [verfasserIn] Wang, Fujun [verfasserIn] Zhang, Ze [verfasserIn] Wang, Lu [verfasserIn] Shen, Li [verfasserIn] Mao, Jifu [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2024 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Composites / B - Amsterdam [u.a.] : Elsevier, 1996, 273 |
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| Übergeordnetes Werk: |
volume:273 |
| DOI / URN: |
10.1016/j.compositesb.2024.111242 |
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| Katalog-ID: |
ELV066989949 |
|---|
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| 245 | 1 | 0 | |a Injectable, stretchable, and conductance-stable fiber for myocardial infarction repair |
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| 520 | |a Injecting electroactive biomaterials into infarcted myocardium to restore blocked electrical signal pathways is an effective way for repairing myocardial infarction. However, re-establishing stable and anisotropic conductive pathways during the constant contraction and relaxation of the heart remains a challenge. Herein, inspired by the myocardial fibers with striated surfaces, a super-elastic and conductance-stable polyurethane fiber with buckled polypyrrole coating (PU150 %PPy) was designed. The bionic composite fiber exhibited excellent stretchability (>450 %), electrical stability under large strains (ΔR/R 0 of only 0.04 at 100 % strain), and long-term durability (>1000000 cycles), enabling stable transmission of electrical signals in a beating heart. Specifically, the composite fibers could be injected into the infarct area in minimally invasive manner and aligned with the myocardial fibers to provide anisotropic conductive pathways. After injecting the PU@PPy fibers into the infarcted heart, the cardiac function was improved (33.19 % increase in fractional shortening and 38.80 % increase in ejection fraction) and the myocardial remodeling was decreased (40.30 % reduction in infarct size and 95.12 % increase in myocardial wall thickness) by re-establishing the electrical communication of the electrically separated cardiomyocytes in the infarct area as well as by providing mechanical support. The injectable, stretchable, and conductance-stable fiber offers a promising strategy for reconstructing infarcted myocardium. | ||
| 650 | 4 | |a Cardiac repair | |
| 650 | 4 | |a Stretchable conductive fiber | |
| 650 | 4 | |a Strain-insensitive conductivity | |
| 650 | 4 | |a Injectable | |
| 650 | 4 | |a Anisotropic | |
| 700 | 1 | |a Li, Chaofu |e verfasserin |4 aut | |
| 700 | 1 | |a Shan, Mengqi |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Leqian |e verfasserin |4 aut | |
| 700 | 1 | |a Lan, Lizhen |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xiaoli |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Lamei |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Fujun |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Ze |e verfasserin |0 (orcid)0000-0003-4331-2058 |4 aut | |
| 700 | 1 | |a Wang, Lu |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Mao, Jifu |e verfasserin |0 (orcid)0000-0001-8707-2135 |4 aut | |
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10.1016/j.compositesb.2024.111242 doi (DE-627)ELV066989949 (ELSEVIER)S1359-8368(24)00053-2 DE-627 ger DE-627 rda eng 660 VZ 51.75 bkl Li, Yimeng verfasserin aut Injectable, stretchable, and conductance-stable fiber for myocardial infarction repair 2024 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Injecting electroactive biomaterials into infarcted myocardium to restore blocked electrical signal pathways is an effective way for repairing myocardial infarction. However, re-establishing stable and anisotropic conductive pathways during the constant contraction and relaxation of the heart remains a challenge. Herein, inspired by the myocardial fibers with striated surfaces, a super-elastic and conductance-stable polyurethane fiber with buckled polypyrrole coating (PU150 %PPy) was designed. The bionic composite fiber exhibited excellent stretchability (>450 %), electrical stability under large strains (ΔR/R 0 of only 0.04 at 100 % strain), and long-term durability (>1000000 cycles), enabling stable transmission of electrical signals in a beating heart. Specifically, the composite fibers could be injected into the infarct area in minimally invasive manner and aligned with the myocardial fibers to provide anisotropic conductive pathways. After injecting the PU@PPy fibers into the infarcted heart, the cardiac function was improved (33.19 % increase in fractional shortening and 38.80 % increase in ejection fraction) and the myocardial remodeling was decreased (40.30 % reduction in infarct size and 95.12 % increase in myocardial wall thickness) by re-establishing the electrical communication of the electrically separated cardiomyocytes in the infarct area as well as by providing mechanical support. The injectable, stretchable, and conductance-stable fiber offers a promising strategy for reconstructing infarcted myocardium. Cardiac repair Stretchable conductive fiber Strain-insensitive conductivity Injectable Anisotropic Li, Chaofu verfasserin aut Shan, Mengqi verfasserin aut Wei, Leqian verfasserin aut Lan, Lizhen verfasserin aut Liu, Xiaoli verfasserin aut Guo, Lamei verfasserin aut Wang, Fujun verfasserin aut Zhang, Ze verfasserin (orcid)0000-0003-4331-2058 aut Wang, Lu verfasserin aut Shen, Li verfasserin aut Mao, Jifu verfasserin (orcid)0000-0001-8707-2135 aut Enthalten in Composites / B Amsterdam [u.a.] : Elsevier, 1996 273 Online-Ressource (DE-627)32050235X (DE-600)2012385-1 (DE-576)094531420 1879-1069 nnns volume:273 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.75 Verbundwerkstoffe Schichtstoffe VZ AR 273 |
| spelling |
10.1016/j.compositesb.2024.111242 doi (DE-627)ELV066989949 (ELSEVIER)S1359-8368(24)00053-2 DE-627 ger DE-627 rda eng 660 VZ 51.75 bkl Li, Yimeng verfasserin aut Injectable, stretchable, and conductance-stable fiber for myocardial infarction repair 2024 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Injecting electroactive biomaterials into infarcted myocardium to restore blocked electrical signal pathways is an effective way for repairing myocardial infarction. However, re-establishing stable and anisotropic conductive pathways during the constant contraction and relaxation of the heart remains a challenge. Herein, inspired by the myocardial fibers with striated surfaces, a super-elastic and conductance-stable polyurethane fiber with buckled polypyrrole coating (PU150 %PPy) was designed. The bionic composite fiber exhibited excellent stretchability (>450 %), electrical stability under large strains (ΔR/R 0 of only 0.04 at 100 % strain), and long-term durability (>1000000 cycles), enabling stable transmission of electrical signals in a beating heart. Specifically, the composite fibers could be injected into the infarct area in minimally invasive manner and aligned with the myocardial fibers to provide anisotropic conductive pathways. After injecting the PU@PPy fibers into the infarcted heart, the cardiac function was improved (33.19 % increase in fractional shortening and 38.80 % increase in ejection fraction) and the myocardial remodeling was decreased (40.30 % reduction in infarct size and 95.12 % increase in myocardial wall thickness) by re-establishing the electrical communication of the electrically separated cardiomyocytes in the infarct area as well as by providing mechanical support. The injectable, stretchable, and conductance-stable fiber offers a promising strategy for reconstructing infarcted myocardium. Cardiac repair Stretchable conductive fiber Strain-insensitive conductivity Injectable Anisotropic Li, Chaofu verfasserin aut Shan, Mengqi verfasserin aut Wei, Leqian verfasserin aut Lan, Lizhen verfasserin aut Liu, Xiaoli verfasserin aut Guo, Lamei verfasserin aut Wang, Fujun verfasserin aut Zhang, Ze verfasserin (orcid)0000-0003-4331-2058 aut Wang, Lu verfasserin aut Shen, Li verfasserin aut Mao, Jifu verfasserin (orcid)0000-0001-8707-2135 aut Enthalten in Composites / B Amsterdam [u.a.] : Elsevier, 1996 273 Online-Ressource (DE-627)32050235X (DE-600)2012385-1 (DE-576)094531420 1879-1069 nnns volume:273 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.75 Verbundwerkstoffe Schichtstoffe VZ AR 273 |
| allfields_unstemmed |
10.1016/j.compositesb.2024.111242 doi (DE-627)ELV066989949 (ELSEVIER)S1359-8368(24)00053-2 DE-627 ger DE-627 rda eng 660 VZ 51.75 bkl Li, Yimeng verfasserin aut Injectable, stretchable, and conductance-stable fiber for myocardial infarction repair 2024 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Injecting electroactive biomaterials into infarcted myocardium to restore blocked electrical signal pathways is an effective way for repairing myocardial infarction. However, re-establishing stable and anisotropic conductive pathways during the constant contraction and relaxation of the heart remains a challenge. Herein, inspired by the myocardial fibers with striated surfaces, a super-elastic and conductance-stable polyurethane fiber with buckled polypyrrole coating (PU150 %PPy) was designed. The bionic composite fiber exhibited excellent stretchability (>450 %), electrical stability under large strains (ΔR/R 0 of only 0.04 at 100 % strain), and long-term durability (>1000000 cycles), enabling stable transmission of electrical signals in a beating heart. Specifically, the composite fibers could be injected into the infarct area in minimally invasive manner and aligned with the myocardial fibers to provide anisotropic conductive pathways. After injecting the PU@PPy fibers into the infarcted heart, the cardiac function was improved (33.19 % increase in fractional shortening and 38.80 % increase in ejection fraction) and the myocardial remodeling was decreased (40.30 % reduction in infarct size and 95.12 % increase in myocardial wall thickness) by re-establishing the electrical communication of the electrically separated cardiomyocytes in the infarct area as well as by providing mechanical support. The injectable, stretchable, and conductance-stable fiber offers a promising strategy for reconstructing infarcted myocardium. Cardiac repair Stretchable conductive fiber Strain-insensitive conductivity Injectable Anisotropic Li, Chaofu verfasserin aut Shan, Mengqi verfasserin aut Wei, Leqian verfasserin aut Lan, Lizhen verfasserin aut Liu, Xiaoli verfasserin aut Guo, Lamei verfasserin aut Wang, Fujun verfasserin aut Zhang, Ze verfasserin (orcid)0000-0003-4331-2058 aut Wang, Lu verfasserin aut Shen, Li verfasserin aut Mao, Jifu verfasserin (orcid)0000-0001-8707-2135 aut Enthalten in Composites / B Amsterdam [u.a.] : Elsevier, 1996 273 Online-Ressource (DE-627)32050235X (DE-600)2012385-1 (DE-576)094531420 1879-1069 nnns volume:273 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.75 Verbundwerkstoffe Schichtstoffe VZ AR 273 |
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10.1016/j.compositesb.2024.111242 doi (DE-627)ELV066989949 (ELSEVIER)S1359-8368(24)00053-2 DE-627 ger DE-627 rda eng 660 VZ 51.75 bkl Li, Yimeng verfasserin aut Injectable, stretchable, and conductance-stable fiber for myocardial infarction repair 2024 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Injecting electroactive biomaterials into infarcted myocardium to restore blocked electrical signal pathways is an effective way for repairing myocardial infarction. However, re-establishing stable and anisotropic conductive pathways during the constant contraction and relaxation of the heart remains a challenge. Herein, inspired by the myocardial fibers with striated surfaces, a super-elastic and conductance-stable polyurethane fiber with buckled polypyrrole coating (PU150 %PPy) was designed. The bionic composite fiber exhibited excellent stretchability (>450 %), electrical stability under large strains (ΔR/R 0 of only 0.04 at 100 % strain), and long-term durability (>1000000 cycles), enabling stable transmission of electrical signals in a beating heart. Specifically, the composite fibers could be injected into the infarct area in minimally invasive manner and aligned with the myocardial fibers to provide anisotropic conductive pathways. After injecting the PU@PPy fibers into the infarcted heart, the cardiac function was improved (33.19 % increase in fractional shortening and 38.80 % increase in ejection fraction) and the myocardial remodeling was decreased (40.30 % reduction in infarct size and 95.12 % increase in myocardial wall thickness) by re-establishing the electrical communication of the electrically separated cardiomyocytes in the infarct area as well as by providing mechanical support. The injectable, stretchable, and conductance-stable fiber offers a promising strategy for reconstructing infarcted myocardium. Cardiac repair Stretchable conductive fiber Strain-insensitive conductivity Injectable Anisotropic Li, Chaofu verfasserin aut Shan, Mengqi verfasserin aut Wei, Leqian verfasserin aut Lan, Lizhen verfasserin aut Liu, Xiaoli verfasserin aut Guo, Lamei verfasserin aut Wang, Fujun verfasserin aut Zhang, Ze verfasserin (orcid)0000-0003-4331-2058 aut Wang, Lu verfasserin aut Shen, Li verfasserin aut Mao, Jifu verfasserin (orcid)0000-0001-8707-2135 aut Enthalten in Composites / B Amsterdam [u.a.] : Elsevier, 1996 273 Online-Ressource (DE-627)32050235X (DE-600)2012385-1 (DE-576)094531420 1879-1069 nnns volume:273 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.75 Verbundwerkstoffe Schichtstoffe VZ AR 273 |
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10.1016/j.compositesb.2024.111242 doi (DE-627)ELV066989949 (ELSEVIER)S1359-8368(24)00053-2 DE-627 ger DE-627 rda eng 660 VZ 51.75 bkl Li, Yimeng verfasserin aut Injectable, stretchable, and conductance-stable fiber for myocardial infarction repair 2024 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Injecting electroactive biomaterials into infarcted myocardium to restore blocked electrical signal pathways is an effective way for repairing myocardial infarction. However, re-establishing stable and anisotropic conductive pathways during the constant contraction and relaxation of the heart remains a challenge. Herein, inspired by the myocardial fibers with striated surfaces, a super-elastic and conductance-stable polyurethane fiber with buckled polypyrrole coating (PU150 %PPy) was designed. The bionic composite fiber exhibited excellent stretchability (>450 %), electrical stability under large strains (ΔR/R 0 of only 0.04 at 100 % strain), and long-term durability (>1000000 cycles), enabling stable transmission of electrical signals in a beating heart. Specifically, the composite fibers could be injected into the infarct area in minimally invasive manner and aligned with the myocardial fibers to provide anisotropic conductive pathways. After injecting the PU@PPy fibers into the infarcted heart, the cardiac function was improved (33.19 % increase in fractional shortening and 38.80 % increase in ejection fraction) and the myocardial remodeling was decreased (40.30 % reduction in infarct size and 95.12 % increase in myocardial wall thickness) by re-establishing the electrical communication of the electrically separated cardiomyocytes in the infarct area as well as by providing mechanical support. The injectable, stretchable, and conductance-stable fiber offers a promising strategy for reconstructing infarcted myocardium. Cardiac repair Stretchable conductive fiber Strain-insensitive conductivity Injectable Anisotropic Li, Chaofu verfasserin aut Shan, Mengqi verfasserin aut Wei, Leqian verfasserin aut Lan, Lizhen verfasserin aut Liu, Xiaoli verfasserin aut Guo, Lamei verfasserin aut Wang, Fujun verfasserin aut Zhang, Ze verfasserin (orcid)0000-0003-4331-2058 aut Wang, Lu verfasserin aut Shen, Li verfasserin aut Mao, Jifu verfasserin (orcid)0000-0001-8707-2135 aut Enthalten in Composites / B Amsterdam [u.a.] : Elsevier, 1996 273 Online-Ressource (DE-627)32050235X (DE-600)2012385-1 (DE-576)094531420 1879-1069 nnns volume:273 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.75 Verbundwerkstoffe Schichtstoffe VZ AR 273 |
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Cardiac repair Stretchable conductive fiber Strain-insensitive conductivity Injectable Anisotropic |
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Li, Yimeng @@aut@@ Li, Chaofu @@aut@@ Shan, Mengqi @@aut@@ Wei, Leqian @@aut@@ Lan, Lizhen @@aut@@ Liu, Xiaoli @@aut@@ Guo, Lamei @@aut@@ Wang, Fujun @@aut@@ Zhang, Ze @@aut@@ Wang, Lu @@aut@@ Shen, Li @@aut@@ Mao, Jifu @@aut@@ |
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2024-01-01T00:00:00Z |
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Li, Yimeng |
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Li, Yimeng ddc 660 bkl 51.75 misc Cardiac repair misc Stretchable conductive fiber misc Strain-insensitive conductivity misc Injectable misc Anisotropic Injectable, stretchable, and conductance-stable fiber for myocardial infarction repair |
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660 VZ 51.75 bkl Injectable, stretchable, and conductance-stable fiber for myocardial infarction repair Cardiac repair Stretchable conductive fiber Strain-insensitive conductivity Injectable Anisotropic |
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ddc 660 bkl 51.75 misc Cardiac repair misc Stretchable conductive fiber misc Strain-insensitive conductivity misc Injectable misc Anisotropic |
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ddc 660 bkl 51.75 misc Cardiac repair misc Stretchable conductive fiber misc Strain-insensitive conductivity misc Injectable misc Anisotropic |
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Li, Yimeng Li, Chaofu Shan, Mengqi Wei, Leqian Lan, Lizhen Liu, Xiaoli Guo, Lamei Wang, Fujun Zhang, Ze Wang, Lu Shen, Li Mao, Jifu |
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injectable, stretchable, and conductance-stable fiber for myocardial infarction repair |
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Injectable, stretchable, and conductance-stable fiber for myocardial infarction repair |
| abstract |
Injecting electroactive biomaterials into infarcted myocardium to restore blocked electrical signal pathways is an effective way for repairing myocardial infarction. However, re-establishing stable and anisotropic conductive pathways during the constant contraction and relaxation of the heart remains a challenge. Herein, inspired by the myocardial fibers with striated surfaces, a super-elastic and conductance-stable polyurethane fiber with buckled polypyrrole coating (PU150 %PPy) was designed. The bionic composite fiber exhibited excellent stretchability (>450 %), electrical stability under large strains (ΔR/R 0 of only 0.04 at 100 % strain), and long-term durability (>1000000 cycles), enabling stable transmission of electrical signals in a beating heart. Specifically, the composite fibers could be injected into the infarct area in minimally invasive manner and aligned with the myocardial fibers to provide anisotropic conductive pathways. After injecting the PU@PPy fibers into the infarcted heart, the cardiac function was improved (33.19 % increase in fractional shortening and 38.80 % increase in ejection fraction) and the myocardial remodeling was decreased (40.30 % reduction in infarct size and 95.12 % increase in myocardial wall thickness) by re-establishing the electrical communication of the electrically separated cardiomyocytes in the infarct area as well as by providing mechanical support. The injectable, stretchable, and conductance-stable fiber offers a promising strategy for reconstructing infarcted myocardium. |
| abstractGer |
Injecting electroactive biomaterials into infarcted myocardium to restore blocked electrical signal pathways is an effective way for repairing myocardial infarction. However, re-establishing stable and anisotropic conductive pathways during the constant contraction and relaxation of the heart remains a challenge. Herein, inspired by the myocardial fibers with striated surfaces, a super-elastic and conductance-stable polyurethane fiber with buckled polypyrrole coating (PU150 %PPy) was designed. The bionic composite fiber exhibited excellent stretchability (>450 %), electrical stability under large strains (ΔR/R 0 of only 0.04 at 100 % strain), and long-term durability (>1000000 cycles), enabling stable transmission of electrical signals in a beating heart. Specifically, the composite fibers could be injected into the infarct area in minimally invasive manner and aligned with the myocardial fibers to provide anisotropic conductive pathways. After injecting the PU@PPy fibers into the infarcted heart, the cardiac function was improved (33.19 % increase in fractional shortening and 38.80 % increase in ejection fraction) and the myocardial remodeling was decreased (40.30 % reduction in infarct size and 95.12 % increase in myocardial wall thickness) by re-establishing the electrical communication of the electrically separated cardiomyocytes in the infarct area as well as by providing mechanical support. The injectable, stretchable, and conductance-stable fiber offers a promising strategy for reconstructing infarcted myocardium. |
| abstract_unstemmed |
Injecting electroactive biomaterials into infarcted myocardium to restore blocked electrical signal pathways is an effective way for repairing myocardial infarction. However, re-establishing stable and anisotropic conductive pathways during the constant contraction and relaxation of the heart remains a challenge. Herein, inspired by the myocardial fibers with striated surfaces, a super-elastic and conductance-stable polyurethane fiber with buckled polypyrrole coating (PU150 %PPy) was designed. The bionic composite fiber exhibited excellent stretchability (>450 %), electrical stability under large strains (ΔR/R 0 of only 0.04 at 100 % strain), and long-term durability (>1000000 cycles), enabling stable transmission of electrical signals in a beating heart. Specifically, the composite fibers could be injected into the infarct area in minimally invasive manner and aligned with the myocardial fibers to provide anisotropic conductive pathways. After injecting the PU@PPy fibers into the infarcted heart, the cardiac function was improved (33.19 % increase in fractional shortening and 38.80 % increase in ejection fraction) and the myocardial remodeling was decreased (40.30 % reduction in infarct size and 95.12 % increase in myocardial wall thickness) by re-establishing the electrical communication of the electrically separated cardiomyocytes in the infarct area as well as by providing mechanical support. The injectable, stretchable, and conductance-stable fiber offers a promising strategy for reconstructing infarcted myocardium. |
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Injectable, stretchable, and conductance-stable fiber for myocardial infarction repair |
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| score |
7.4008837 |