Efficacy and safety of a novel dietary pyrroloquinoline quinone disodium salt on muscle strength and physical function in healthy volunteers: A randomized, double-blind, placebo-controlled study

A randomized, double-blind, placebo-controlled study was conducted in 64 healthy Japanese male and female adults over a period of 12 weeks to demonstrate the safety and efficacy of pyrroloquinoline quinone (PQQ) disodium salt (mnemoPQQ®; 21.5 mg/day as PQQ disodium salt) for improving muscle strengt...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Shiojima, Yoshiaki [verfasserIn] Takahashi, Megumi [verfasserIn] Takahashi, Ryohei [verfasserIn] Moriyama, Hiroyoshi [verfasserIn] Bagchi, Manashi [verfasserIn] Kanbayashi, Isao [verfasserIn] Sasaki, Takuro [verfasserIn] Goda, Taketoshi [verfasserIn] Bagchi, Debasis [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Pyrroloquinoline quinone disodium salt Muscle strength Leg extension muscle strength Grip strength Physical function Motor function Walking ability

Übergeordnetes Werk:	Enthalten in: Journal of functional foods - Amsterdam [u.a.] : Elsevier, 2009, 113
Übergeordnetes Werk:	volume:113

DOI / URN:	10.1016/j.jff.2024.106012

Katalog-ID:	ELV067024556

Internformat


LEADER	01000caa a22002652 4500
001	ELV067024556
003	DE-627
005	20240217093030.0
007	cr uuu---uuuuu
008	240214s2024 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.1016/j.jff.2024.106012 \|2 doi
035			\|a (DE-627)ELV067024556
035			\|a (ELSEVIER)S1756-4646(24)00014-8
040			\|a DE-627 \|b ger \|c DE-627 \|e rda
041			\|a eng
082	0	4	\|a 630 \|a 640 \|a 610 \|q VZ
100	1		\|a Shiojima, Yoshiaki \|e verfasserin \|4 aut
245	1	0	\|a Efficacy and safety of a novel dietary pyrroloquinoline quinone disodium salt on muscle strength and physical function in healthy volunteers: A randomized, double-blind, placebo-controlled study
264		1	\|c 2024
336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a A randomized, double-blind, placebo-controlled study was conducted in 64 healthy Japanese male and female adults over a period of 12 weeks to demonstrate the safety and efficacy of pyrroloquinoline quinone (PQQ) disodium salt (mnemoPQQ®; 21.5 mg/day as PQQ disodium salt) for improving muscle strength and physical function. The subjects were randomly assigned to receive either mnemoPQQ® or placebo. The efficacy on muscle strength and physical function was investigated using lower limb extension muscle strength as the primary outcome (primary endpoint) and grip strength, 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests as secondary outcomes (secondary endpoints). A total of 62 subjects [placebo = 31 (age = 54.2 ± 1.2 Y); mnemoPQQ® = 31 (age = 54.5 ± 1.0 Y)] completed the study. Significant improvements were observed in lower limb extension muscle strength and grip strength in the mnemoPQQ® group (p < 0.01). The physical function results of the 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests were also significantly improved in the mnemoPQQ® group (p < 0.01). No adverse events were observed. Overall, the present study demonstrates that mnemoPQQ® supplementation improves muscle strength and physical function (motor function) in healthy Japanese male and female volunteers.
650		4	\|a Pyrroloquinoline quinone disodium salt
650		4	\|a Muscle strength
650		4	\|a Leg extension muscle strength
650		4	\|a Grip strength
650		4	\|a Physical function
650		4	\|a Motor function
650		4	\|a Walking ability
700	1		\|a Takahashi, Megumi \|e verfasserin \|0 (orcid)0000-0002-2563-3176 \|4 aut
700	1		\|a Takahashi, Ryohei \|e verfasserin \|0 (orcid)0000-0002-2684-8953 \|4 aut
700	1		\|a Moriyama, Hiroyoshi \|e verfasserin \|4 aut
700	1		\|a Bagchi, Manashi \|e verfasserin \|4 aut
700	1		\|a Kanbayashi, Isao \|e verfasserin \|4 aut
700	1		\|a Sasaki, Takuro \|e verfasserin \|4 aut
700	1		\|a Goda, Taketoshi \|e verfasserin \|4 aut
700	1		\|a Bagchi, Debasis \|e verfasserin \|0 (orcid)0000-0001-9478-6427 \|4 aut
773	0	8	\|i Enthalten in \|t Journal of functional foods \|d Amsterdam [u.a.] : Elsevier, 2009 \|g 113 \|h Online-Ressource \|w (DE-627)587138432 \|w (DE-600)2467241-5 \|w (DE-576)302178430 \|x 1756-4646 \|7 nnns
773	1	8	\|g volume:113
912			\|a GBV_USEFLAG_U
912			\|a GBV_ELV
912			\|a SYSFLAG_U
912			\|a SSG-OLC-PHA
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_165
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 113

Indexfelder

author_variant	y s ys m t mt r t rt h m hm m b mb i k ik t s ts t g tg d b db
matchkey_str	article:17564646:2024----::fiaynsftoaoedeayyrlqioieunndsduslomslsrntadhsclucinnelhvlnera
hierarchy_sort_str	2024
publishDate	2024
allfields	10.1016/j.jff.2024.106012 doi (DE-627)ELV067024556 (ELSEVIER)S1756-4646(24)00014-8 DE-627 ger DE-627 rda eng 630 640 610 VZ Shiojima, Yoshiaki verfasserin aut Efficacy and safety of a novel dietary pyrroloquinoline quinone disodium salt on muscle strength and physical function in healthy volunteers: A randomized, double-blind, placebo-controlled study 2024 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A randomized, double-blind, placebo-controlled study was conducted in 64 healthy Japanese male and female adults over a period of 12 weeks to demonstrate the safety and efficacy of pyrroloquinoline quinone (PQQ) disodium salt (mnemoPQQ®; 21.5 mg/day as PQQ disodium salt) for improving muscle strength and physical function. The subjects were randomly assigned to receive either mnemoPQQ® or placebo. The efficacy on muscle strength and physical function was investigated using lower limb extension muscle strength as the primary outcome (primary endpoint) and grip strength, 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests as secondary outcomes (secondary endpoints). A total of 62 subjects [placebo = 31 (age = 54.2 ± 1.2 Y); mnemoPQQ® = 31 (age = 54.5 ± 1.0 Y)] completed the study. Significant improvements were observed in lower limb extension muscle strength and grip strength in the mnemoPQQ® group (p < 0.01). The physical function results of the 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests were also significantly improved in the mnemoPQQ® group (p < 0.01). No adverse events were observed. Overall, the present study demonstrates that mnemoPQQ® supplementation improves muscle strength and physical function (motor function) in healthy Japanese male and female volunteers. Pyrroloquinoline quinone disodium salt Muscle strength Leg extension muscle strength Grip strength Physical function Motor function Walking ability Takahashi, Megumi verfasserin (orcid)0000-0002-2563-3176 aut Takahashi, Ryohei verfasserin (orcid)0000-0002-2684-8953 aut Moriyama, Hiroyoshi verfasserin aut Bagchi, Manashi verfasserin aut Kanbayashi, Isao verfasserin aut Sasaki, Takuro verfasserin aut Goda, Taketoshi verfasserin aut Bagchi, Debasis verfasserin (orcid)0000-0001-9478-6427 aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 113 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:113 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 113
spelling	10.1016/j.jff.2024.106012 doi (DE-627)ELV067024556 (ELSEVIER)S1756-4646(24)00014-8 DE-627 ger DE-627 rda eng 630 640 610 VZ Shiojima, Yoshiaki verfasserin aut Efficacy and safety of a novel dietary pyrroloquinoline quinone disodium salt on muscle strength and physical function in healthy volunteers: A randomized, double-blind, placebo-controlled study 2024 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A randomized, double-blind, placebo-controlled study was conducted in 64 healthy Japanese male and female adults over a period of 12 weeks to demonstrate the safety and efficacy of pyrroloquinoline quinone (PQQ) disodium salt (mnemoPQQ®; 21.5 mg/day as PQQ disodium salt) for improving muscle strength and physical function. The subjects were randomly assigned to receive either mnemoPQQ® or placebo. The efficacy on muscle strength and physical function was investigated using lower limb extension muscle strength as the primary outcome (primary endpoint) and grip strength, 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests as secondary outcomes (secondary endpoints). A total of 62 subjects [placebo = 31 (age = 54.2 ± 1.2 Y); mnemoPQQ® = 31 (age = 54.5 ± 1.0 Y)] completed the study. Significant improvements were observed in lower limb extension muscle strength and grip strength in the mnemoPQQ® group (p < 0.01). The physical function results of the 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests were also significantly improved in the mnemoPQQ® group (p < 0.01). No adverse events were observed. Overall, the present study demonstrates that mnemoPQQ® supplementation improves muscle strength and physical function (motor function) in healthy Japanese male and female volunteers. Pyrroloquinoline quinone disodium salt Muscle strength Leg extension muscle strength Grip strength Physical function Motor function Walking ability Takahashi, Megumi verfasserin (orcid)0000-0002-2563-3176 aut Takahashi, Ryohei verfasserin (orcid)0000-0002-2684-8953 aut Moriyama, Hiroyoshi verfasserin aut Bagchi, Manashi verfasserin aut Kanbayashi, Isao verfasserin aut Sasaki, Takuro verfasserin aut Goda, Taketoshi verfasserin aut Bagchi, Debasis verfasserin (orcid)0000-0001-9478-6427 aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 113 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:113 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 113
allfields_unstemmed	10.1016/j.jff.2024.106012 doi (DE-627)ELV067024556 (ELSEVIER)S1756-4646(24)00014-8 DE-627 ger DE-627 rda eng 630 640 610 VZ Shiojima, Yoshiaki verfasserin aut Efficacy and safety of a novel dietary pyrroloquinoline quinone disodium salt on muscle strength and physical function in healthy volunteers: A randomized, double-blind, placebo-controlled study 2024 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A randomized, double-blind, placebo-controlled study was conducted in 64 healthy Japanese male and female adults over a period of 12 weeks to demonstrate the safety and efficacy of pyrroloquinoline quinone (PQQ) disodium salt (mnemoPQQ®; 21.5 mg/day as PQQ disodium salt) for improving muscle strength and physical function. The subjects were randomly assigned to receive either mnemoPQQ® or placebo. The efficacy on muscle strength and physical function was investigated using lower limb extension muscle strength as the primary outcome (primary endpoint) and grip strength, 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests as secondary outcomes (secondary endpoints). A total of 62 subjects [placebo = 31 (age = 54.2 ± 1.2 Y); mnemoPQQ® = 31 (age = 54.5 ± 1.0 Y)] completed the study. Significant improvements were observed in lower limb extension muscle strength and grip strength in the mnemoPQQ® group (p < 0.01). The physical function results of the 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests were also significantly improved in the mnemoPQQ® group (p < 0.01). No adverse events were observed. Overall, the present study demonstrates that mnemoPQQ® supplementation improves muscle strength and physical function (motor function) in healthy Japanese male and female volunteers. Pyrroloquinoline quinone disodium salt Muscle strength Leg extension muscle strength Grip strength Physical function Motor function Walking ability Takahashi, Megumi verfasserin (orcid)0000-0002-2563-3176 aut Takahashi, Ryohei verfasserin (orcid)0000-0002-2684-8953 aut Moriyama, Hiroyoshi verfasserin aut Bagchi, Manashi verfasserin aut Kanbayashi, Isao verfasserin aut Sasaki, Takuro verfasserin aut Goda, Taketoshi verfasserin aut Bagchi, Debasis verfasserin (orcid)0000-0001-9478-6427 aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 113 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:113 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 113
allfieldsGer	10.1016/j.jff.2024.106012 doi (DE-627)ELV067024556 (ELSEVIER)S1756-4646(24)00014-8 DE-627 ger DE-627 rda eng 630 640 610 VZ Shiojima, Yoshiaki verfasserin aut Efficacy and safety of a novel dietary pyrroloquinoline quinone disodium salt on muscle strength and physical function in healthy volunteers: A randomized, double-blind, placebo-controlled study 2024 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A randomized, double-blind, placebo-controlled study was conducted in 64 healthy Japanese male and female adults over a period of 12 weeks to demonstrate the safety and efficacy of pyrroloquinoline quinone (PQQ) disodium salt (mnemoPQQ®; 21.5 mg/day as PQQ disodium salt) for improving muscle strength and physical function. The subjects were randomly assigned to receive either mnemoPQQ® or placebo. The efficacy on muscle strength and physical function was investigated using lower limb extension muscle strength as the primary outcome (primary endpoint) and grip strength, 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests as secondary outcomes (secondary endpoints). A total of 62 subjects [placebo = 31 (age = 54.2 ± 1.2 Y); mnemoPQQ® = 31 (age = 54.5 ± 1.0 Y)] completed the study. Significant improvements were observed in lower limb extension muscle strength and grip strength in the mnemoPQQ® group (p < 0.01). The physical function results of the 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests were also significantly improved in the mnemoPQQ® group (p < 0.01). No adverse events were observed. Overall, the present study demonstrates that mnemoPQQ® supplementation improves muscle strength and physical function (motor function) in healthy Japanese male and female volunteers. Pyrroloquinoline quinone disodium salt Muscle strength Leg extension muscle strength Grip strength Physical function Motor function Walking ability Takahashi, Megumi verfasserin (orcid)0000-0002-2563-3176 aut Takahashi, Ryohei verfasserin (orcid)0000-0002-2684-8953 aut Moriyama, Hiroyoshi verfasserin aut Bagchi, Manashi verfasserin aut Kanbayashi, Isao verfasserin aut Sasaki, Takuro verfasserin aut Goda, Taketoshi verfasserin aut Bagchi, Debasis verfasserin (orcid)0000-0001-9478-6427 aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 113 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:113 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 113
allfieldsSound	10.1016/j.jff.2024.106012 doi (DE-627)ELV067024556 (ELSEVIER)S1756-4646(24)00014-8 DE-627 ger DE-627 rda eng 630 640 610 VZ Shiojima, Yoshiaki verfasserin aut Efficacy and safety of a novel dietary pyrroloquinoline quinone disodium salt on muscle strength and physical function in healthy volunteers: A randomized, double-blind, placebo-controlled study 2024 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A randomized, double-blind, placebo-controlled study was conducted in 64 healthy Japanese male and female adults over a period of 12 weeks to demonstrate the safety and efficacy of pyrroloquinoline quinone (PQQ) disodium salt (mnemoPQQ®; 21.5 mg/day as PQQ disodium salt) for improving muscle strength and physical function. The subjects were randomly assigned to receive either mnemoPQQ® or placebo. The efficacy on muscle strength and physical function was investigated using lower limb extension muscle strength as the primary outcome (primary endpoint) and grip strength, 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests as secondary outcomes (secondary endpoints). A total of 62 subjects [placebo = 31 (age = 54.2 ± 1.2 Y); mnemoPQQ® = 31 (age = 54.5 ± 1.0 Y)] completed the study. Significant improvements were observed in lower limb extension muscle strength and grip strength in the mnemoPQQ® group (p < 0.01). The physical function results of the 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests were also significantly improved in the mnemoPQQ® group (p < 0.01). No adverse events were observed. Overall, the present study demonstrates that mnemoPQQ® supplementation improves muscle strength and physical function (motor function) in healthy Japanese male and female volunteers. Pyrroloquinoline quinone disodium salt Muscle strength Leg extension muscle strength Grip strength Physical function Motor function Walking ability Takahashi, Megumi verfasserin (orcid)0000-0002-2563-3176 aut Takahashi, Ryohei verfasserin (orcid)0000-0002-2684-8953 aut Moriyama, Hiroyoshi verfasserin aut Bagchi, Manashi verfasserin aut Kanbayashi, Isao verfasserin aut Sasaki, Takuro verfasserin aut Goda, Taketoshi verfasserin aut Bagchi, Debasis verfasserin (orcid)0000-0001-9478-6427 aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 113 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:113 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 113
language	English
source	Enthalten in Journal of functional foods 113 volume:113
sourceStr	Enthalten in Journal of functional foods 113 volume:113
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Pyrroloquinoline quinone disodium salt Muscle strength Leg extension muscle strength Grip strength Physical function Motor function Walking ability
dewey-raw	630
isfreeaccess_bool	false
container_title	Journal of functional foods
authorswithroles_txt_mv	Shiojima, Yoshiaki @@aut@@ Takahashi, Megumi @@aut@@ Takahashi, Ryohei @@aut@@ Moriyama, Hiroyoshi @@aut@@ Bagchi, Manashi @@aut@@ Kanbayashi, Isao @@aut@@ Sasaki, Takuro @@aut@@ Goda, Taketoshi @@aut@@ Bagchi, Debasis @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
hierarchy_top_id	587138432
dewey-sort	3630
id	ELV067024556
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV067024556</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240217093030.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240214s2024 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.jff.2024.106012</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV067024556</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1756-4646(24)00014-8</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">630</subfield><subfield code="a">640</subfield><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Shiojima, Yoshiaki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Efficacy and safety of a novel dietary pyrroloquinoline quinone disodium salt on muscle strength and physical function in healthy volunteers: A randomized, double-blind, placebo-controlled study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2024</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">A randomized, double-blind, placebo-controlled study was conducted in 64 healthy Japanese male and female adults over a period of 12 weeks to demonstrate the safety and efficacy of pyrroloquinoline quinone (PQQ) disodium salt (mnemoPQQ®; 21.5 mg/day as PQQ disodium salt) for improving muscle strength and physical function. The subjects were randomly assigned to receive either mnemoPQQ® or placebo. The efficacy on muscle strength and physical function was investigated using lower limb extension muscle strength as the primary outcome (primary endpoint) and grip strength, 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests as secondary outcomes (secondary endpoints). A total of 62 subjects [placebo = 31 (age = 54.2 ± 1.2 Y); mnemoPQQ® = 31 (age = 54.5 ± 1.0 Y)] completed the study. Significant improvements were observed in lower limb extension muscle strength and grip strength in the mnemoPQQ® group (p < 0.01). The physical function results of the 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests were also significantly improved in the mnemoPQQ® group (p < 0.01). No adverse events were observed. Overall, the present study demonstrates that mnemoPQQ® supplementation improves muscle strength and physical function (motor function) in healthy Japanese male and female volunteers.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pyrroloquinoline quinone disodium salt</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Muscle strength</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Leg extension muscle strength</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Grip strength</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Physical function</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Motor function</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Walking ability</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Takahashi, Megumi</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0002-2563-3176</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Takahashi, Ryohei</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0002-2684-8953</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Moriyama, Hiroyoshi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bagchi, Manashi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kanbayashi, Isao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sasaki, Takuro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Goda, Taketoshi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bagchi, Debasis</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0001-9478-6427</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Journal of functional foods</subfield><subfield code="d">Amsterdam [u.a.] : Elsevier, 2009</subfield><subfield code="g">113</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)587138432</subfield><subfield code="w">(DE-600)2467241-5</subfield><subfield code="w">(DE-576)302178430</subfield><subfield code="x">1756-4646</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:113</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_165</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2004</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2008</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2034</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2044</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2048</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2064</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2106</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2122</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2143</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2153</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2232</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">113</subfield></datafield></record></collection>
author	Shiojima, Yoshiaki
spellingShingle	Shiojima, Yoshiaki ddc 630 misc Pyrroloquinoline quinone disodium salt misc Muscle strength misc Leg extension muscle strength misc Grip strength misc Physical function misc Motor function misc Walking ability Efficacy and safety of a novel dietary pyrroloquinoline quinone disodium salt on muscle strength and physical function in healthy volunteers: A randomized, double-blind, placebo-controlled study
authorStr	Shiojima, Yoshiaki
ppnlink_with_tag_str_mv	@@773@@(DE-627)587138432
format	electronic Article
dewey-ones	630 - Agriculture & related technologies 640 - Home & family management 610 - Medicine & health
delete_txt_mv	keep
author_role	aut aut aut aut aut aut aut aut aut
collection	elsevier
remote_str	true
illustrated	Not Illustrated
issn	1756-4646
topic_title	630 640 610 VZ Efficacy and safety of a novel dietary pyrroloquinoline quinone disodium salt on muscle strength and physical function in healthy volunteers: A randomized, double-blind, placebo-controlled study Pyrroloquinoline quinone disodium salt Muscle strength Leg extension muscle strength Grip strength Physical function Motor function Walking ability
topic	ddc 630 misc Pyrroloquinoline quinone disodium salt misc Muscle strength misc Leg extension muscle strength misc Grip strength misc Physical function misc Motor function misc Walking ability
topic_unstemmed	ddc 630 misc Pyrroloquinoline quinone disodium salt misc Muscle strength misc Leg extension muscle strength misc Grip strength misc Physical function misc Motor function misc Walking ability
topic_browse	ddc 630 misc Pyrroloquinoline quinone disodium salt misc Muscle strength misc Leg extension muscle strength misc Grip strength misc Physical function misc Motor function misc Walking ability
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	Journal of functional foods
hierarchy_parent_id	587138432
dewey-tens	630 - Agriculture 640 - Home & family management 610 - Medicine & health
hierarchy_top_title	Journal of functional foods
isfreeaccess_txt	false
familylinks_str_mv	(DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430
title	Efficacy and safety of a novel dietary pyrroloquinoline quinone disodium salt on muscle strength and physical function in healthy volunteers: A randomized, double-blind, placebo-controlled study
ctrlnum	(DE-627)ELV067024556 (ELSEVIER)S1756-4646(24)00014-8
title_full	Efficacy and safety of a novel dietary pyrroloquinoline quinone disodium salt on muscle strength and physical function in healthy volunteers: A randomized, double-blind, placebo-controlled study
author_sort	Shiojima, Yoshiaki
journal	Journal of functional foods
journalStr	Journal of functional foods
lang_code	eng
isOA_bool	false
dewey-hundreds	600 - Technology
recordtype	marc
publishDateSort	2024
contenttype_str_mv	zzz
author_browse	Shiojima, Yoshiaki Takahashi, Megumi Takahashi, Ryohei Moriyama, Hiroyoshi Bagchi, Manashi Kanbayashi, Isao Sasaki, Takuro Goda, Taketoshi Bagchi, Debasis
container_volume	113
class	630 640 610 VZ
format_se	Elektronische Aufsätze
author-letter	Shiojima, Yoshiaki
doi_str_mv	10.1016/j.jff.2024.106012
normlink	(ORCID)0000-0002-2563-3176 (ORCID)0000-0002-2684-8953 (ORCID)0000-0001-9478-6427
normlink_prefix_str_mv	(orcid)0000-0002-2563-3176 (orcid)0000-0002-2684-8953 (orcid)0000-0001-9478-6427
dewey-full	630 640 610
author2-role	verfasserin
title_sort	efficacy and safety of a novel dietary pyrroloquinoline quinone disodium salt on muscle strength and physical function in healthy volunteers: a randomized, double-blind, placebo-controlled study
title_auth	Efficacy and safety of a novel dietary pyrroloquinoline quinone disodium salt on muscle strength and physical function in healthy volunteers: A randomized, double-blind, placebo-controlled study
abstract	A randomized, double-blind, placebo-controlled study was conducted in 64 healthy Japanese male and female adults over a period of 12 weeks to demonstrate the safety and efficacy of pyrroloquinoline quinone (PQQ) disodium salt (mnemoPQQ®; 21.5 mg/day as PQQ disodium salt) for improving muscle strength and physical function. The subjects were randomly assigned to receive either mnemoPQQ® or placebo. The efficacy on muscle strength and physical function was investigated using lower limb extension muscle strength as the primary outcome (primary endpoint) and grip strength, 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests as secondary outcomes (secondary endpoints). A total of 62 subjects [placebo = 31 (age = 54.2 ± 1.2 Y); mnemoPQQ® = 31 (age = 54.5 ± 1.0 Y)] completed the study. Significant improvements were observed in lower limb extension muscle strength and grip strength in the mnemoPQQ® group (p < 0.01). The physical function results of the 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests were also significantly improved in the mnemoPQQ® group (p < 0.01). No adverse events were observed. Overall, the present study demonstrates that mnemoPQQ® supplementation improves muscle strength and physical function (motor function) in healthy Japanese male and female volunteers.
abstractGer	A randomized, double-blind, placebo-controlled study was conducted in 64 healthy Japanese male and female adults over a period of 12 weeks to demonstrate the safety and efficacy of pyrroloquinoline quinone (PQQ) disodium salt (mnemoPQQ®; 21.5 mg/day as PQQ disodium salt) for improving muscle strength and physical function. The subjects were randomly assigned to receive either mnemoPQQ® or placebo. The efficacy on muscle strength and physical function was investigated using lower limb extension muscle strength as the primary outcome (primary endpoint) and grip strength, 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests as secondary outcomes (secondary endpoints). A total of 62 subjects [placebo = 31 (age = 54.2 ± 1.2 Y); mnemoPQQ® = 31 (age = 54.5 ± 1.0 Y)] completed the study. Significant improvements were observed in lower limb extension muscle strength and grip strength in the mnemoPQQ® group (p < 0.01). The physical function results of the 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests were also significantly improved in the mnemoPQQ® group (p < 0.01). No adverse events were observed. Overall, the present study demonstrates that mnemoPQQ® supplementation improves muscle strength and physical function (motor function) in healthy Japanese male and female volunteers.
abstract_unstemmed	A randomized, double-blind, placebo-controlled study was conducted in 64 healthy Japanese male and female adults over a period of 12 weeks to demonstrate the safety and efficacy of pyrroloquinoline quinone (PQQ) disodium salt (mnemoPQQ®; 21.5 mg/day as PQQ disodium salt) for improving muscle strength and physical function. The subjects were randomly assigned to receive either mnemoPQQ® or placebo. The efficacy on muscle strength and physical function was investigated using lower limb extension muscle strength as the primary outcome (primary endpoint) and grip strength, 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests as secondary outcomes (secondary endpoints). A total of 62 subjects [placebo = 31 (age = 54.2 ± 1.2 Y); mnemoPQQ® = 31 (age = 54.5 ± 1.0 Y)] completed the study. Significant improvements were observed in lower limb extension muscle strength and grip strength in the mnemoPQQ® group (p < 0.01). The physical function results of the 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests were also significantly improved in the mnemoPQQ® group (p < 0.01). No adverse events were observed. Overall, the present study demonstrates that mnemoPQQ® supplementation improves muscle strength and physical function (motor function) in healthy Japanese male and female volunteers.
collection_details	GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
title_short	Efficacy and safety of a novel dietary pyrroloquinoline quinone disodium salt on muscle strength and physical function in healthy volunteers: A randomized, double-blind, placebo-controlled study
remote_bool	true
author2	Takahashi, Megumi Takahashi, Ryohei Moriyama, Hiroyoshi Bagchi, Manashi Kanbayashi, Isao Sasaki, Takuro Goda, Taketoshi Bagchi, Debasis
author2Str	Takahashi, Megumi Takahashi, Ryohei Moriyama, Hiroyoshi Bagchi, Manashi Kanbayashi, Isao Sasaki, Takuro Goda, Taketoshi Bagchi, Debasis
ppnlink	587138432
mediatype_str_mv	c
isOA_txt	false
hochschulschrift_bool	false
doi_str	10.1016/j.jff.2024.106012
up_date	2024-07-06T19:49:11.291Z
_version_	1803860418277408768
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV067024556</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240217093030.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240214s2024 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.jff.2024.106012</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV067024556</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1756-4646(24)00014-8</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">630</subfield><subfield code="a">640</subfield><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Shiojima, Yoshiaki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Efficacy and safety of a novel dietary pyrroloquinoline quinone disodium salt on muscle strength and physical function in healthy volunteers: A randomized, double-blind, placebo-controlled study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2024</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">A randomized, double-blind, placebo-controlled study was conducted in 64 healthy Japanese male and female adults over a period of 12 weeks to demonstrate the safety and efficacy of pyrroloquinoline quinone (PQQ) disodium salt (mnemoPQQ®; 21.5 mg/day as PQQ disodium salt) for improving muscle strength and physical function. The subjects were randomly assigned to receive either mnemoPQQ® or placebo. The efficacy on muscle strength and physical function was investigated using lower limb extension muscle strength as the primary outcome (primary endpoint) and grip strength, 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests as secondary outcomes (secondary endpoints). A total of 62 subjects [placebo = 31 (age = 54.2 ± 1.2 Y); mnemoPQQ® = 31 (age = 54.5 ± 1.0 Y)] completed the study. Significant improvements were observed in lower limb extension muscle strength and grip strength in the mnemoPQQ® group (p < 0.01). The physical function results of the 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests were also significantly improved in the mnemoPQQ® group (p < 0.01). No adverse events were observed. Overall, the present study demonstrates that mnemoPQQ® supplementation improves muscle strength and physical function (motor function) in healthy Japanese male and female volunteers.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pyrroloquinoline quinone disodium salt</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Muscle strength</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Leg extension muscle strength</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Grip strength</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Physical function</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Motor function</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Walking ability</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Takahashi, Megumi</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0002-2563-3176</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Takahashi, Ryohei</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0002-2684-8953</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Moriyama, Hiroyoshi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bagchi, Manashi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kanbayashi, Isao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sasaki, Takuro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Goda, Taketoshi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bagchi, Debasis</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0001-9478-6427</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Journal of functional foods</subfield><subfield code="d">Amsterdam [u.a.] : Elsevier, 2009</subfield><subfield code="g">113</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)587138432</subfield><subfield code="w">(DE-600)2467241-5</subfield><subfield code="w">(DE-576)302178430</subfield><subfield code="x">1756-4646</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:113</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_165</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2004</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2008</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2034</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2044</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2048</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2064</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2106</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2122</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2143</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2153</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2232</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">113</subfield></datafield></record></collection>
score	7.3996716

Nicht das Richtige dabei?

Schreiben Sie uns!

Efficacy and safety of a novel dietary pyrroloquinoline quinone disodium salt on muscle strength and physical function in healthy volunteers: A randomized, double-blind, placebo-controlled study

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?