Radiation therapy, tissue radiosensitization, and potential synergism in the era of novel antibody-drug conjugates

Antibody-drug conjugates (ADCs) represent a therapeutic class of agents designed to selectively deliver cytotoxic payloads to cancer cells. With the increasingly positioning of ADCs in the clinical practice, combinations with other treatment modalities, including radiation therapy (RT), will open ne...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Natangelo, Stefano [verfasserIn] Trapani, Dario [verfasserIn] Koukoutzeli, Chrysanthi [verfasserIn] Boscolo Bielo, Luca [verfasserIn] Marvaso, Giulia [verfasserIn] Jereczek-Fossa, Barbara Alicja [verfasserIn] Curigliano, Giuseppe [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Radiosensitization Radiation therapy Antibody-drug conjugates HER-2 directed ADCs Photoimmunotherapy Toxicity Radionecrosis Breast cancer

Übergeordnetes Werk:	Enthalten in: Critical reviews in oncology, hematology - Amsterdam [u.a.] : Elsevier Science, 2011, 195
Übergeordnetes Werk:	volume:195

DOI / URN:	10.1016/j.critrevonc.2024.104270

Katalog-ID:	ELV067168108

Internformat


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520			\|a Antibody-drug conjugates (ADCs) represent a therapeutic class of agents designed to selectively deliver cytotoxic payloads to cancer cells. With the increasingly positioning of ADCs in the clinical practice, combinations with other treatment modalities, including radiation therapy (RT), will open new opportunities but also challenges. This review evaluates ADC-RT interactions, examining therapeutic synergies and potential caveats. ADC payloads can be radiosensitizing, enhancing cytotoxicity when used in combination with RT. Antigens targeted by ADCs can have various tissue expressions, resulting in possible off-target toxicities by tissue radiosensitization. Notably, the HER-2-directed ADC trastuzumab emtansine has appeared to increase the risk of radionecrosis when used concomitantly with brain RT, as glial cells can express HER2, too. Other possible organ-specific effects are discussed, such as pulmonary and cardiac toxicities. The lack of robust clinical data on the ADC-RT combination raises concerns regarding specific side effects and the ultimate trade-off of toxicity and safety of some combined approaches. Clinical studies are needed to assess ADC-RT combination safety and efficacy.
650		4	\|a Radiosensitization
650		4	\|a Radiation therapy
650		4	\|a Antibody-drug conjugates
650		4	\|a HER-2 directed ADCs
650		4	\|a Photoimmunotherapy
650		4	\|a Toxicity
650		4	\|a Radionecrosis
650		4	\|a Breast cancer
700	1		\|a Trapani, Dario \|e verfasserin \|0 (orcid)0000-0003-1672-9560 \|4 aut
700	1		\|a Koukoutzeli, Chrysanthi \|e verfasserin \|4 aut
700	1		\|a Boscolo Bielo, Luca \|e verfasserin \|4 aut
700	1		\|a Marvaso, Giulia \|e verfasserin \|4 aut
700	1		\|a Jereczek-Fossa, Barbara Alicja \|e verfasserin \|4 aut
700	1		\|a Curigliano, Giuseppe \|e verfasserin \|4 aut
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912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
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912			\|a GBV_ILN_2021
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912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
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912			\|a GBV_ILN_2088
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912			\|a GBV_ILN_2112
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912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 195

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publishDate	2024
allfields	10.1016/j.critrevonc.2024.104270 doi (DE-627)ELV067168108 (ELSEVIER)S1040-8428(24)00013-1 DE-627 ger DE-627 rda eng 610 VZ Natangelo, Stefano verfasserin aut Radiation therapy, tissue radiosensitization, and potential synergism in the era of novel antibody-drug conjugates 2024 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Antibody-drug conjugates (ADCs) represent a therapeutic class of agents designed to selectively deliver cytotoxic payloads to cancer cells. With the increasingly positioning of ADCs in the clinical practice, combinations with other treatment modalities, including radiation therapy (RT), will open new opportunities but also challenges. This review evaluates ADC-RT interactions, examining therapeutic synergies and potential caveats. ADC payloads can be radiosensitizing, enhancing cytotoxicity when used in combination with RT. Antigens targeted by ADCs can have various tissue expressions, resulting in possible off-target toxicities by tissue radiosensitization. Notably, the HER-2-directed ADC trastuzumab emtansine has appeared to increase the risk of radionecrosis when used concomitantly with brain RT, as glial cells can express HER2, too. Other possible organ-specific effects are discussed, such as pulmonary and cardiac toxicities. The lack of robust clinical data on the ADC-RT combination raises concerns regarding specific side effects and the ultimate trade-off of toxicity and safety of some combined approaches. Clinical studies are needed to assess ADC-RT combination safety and efficacy. Radiosensitization Radiation therapy Antibody-drug conjugates HER-2 directed ADCs Photoimmunotherapy Toxicity Radionecrosis Breast cancer Trapani, Dario verfasserin (orcid)0000-0003-1672-9560 aut Koukoutzeli, Chrysanthi verfasserin aut Boscolo Bielo, Luca verfasserin aut Marvaso, Giulia verfasserin aut Jereczek-Fossa, Barbara Alicja verfasserin aut Curigliano, Giuseppe verfasserin aut Enthalten in Critical reviews in oncology, hematology Amsterdam [u.a.] : Elsevier Science, 2011 195 (DE-627)320649024 (DE-600)2025731-4 187-90461 nnns volume:195 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 195
spelling	10.1016/j.critrevonc.2024.104270 doi (DE-627)ELV067168108 (ELSEVIER)S1040-8428(24)00013-1 DE-627 ger DE-627 rda eng 610 VZ Natangelo, Stefano verfasserin aut Radiation therapy, tissue radiosensitization, and potential synergism in the era of novel antibody-drug conjugates 2024 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Antibody-drug conjugates (ADCs) represent a therapeutic class of agents designed to selectively deliver cytotoxic payloads to cancer cells. With the increasingly positioning of ADCs in the clinical practice, combinations with other treatment modalities, including radiation therapy (RT), will open new opportunities but also challenges. This review evaluates ADC-RT interactions, examining therapeutic synergies and potential caveats. ADC payloads can be radiosensitizing, enhancing cytotoxicity when used in combination with RT. Antigens targeted by ADCs can have various tissue expressions, resulting in possible off-target toxicities by tissue radiosensitization. Notably, the HER-2-directed ADC trastuzumab emtansine has appeared to increase the risk of radionecrosis when used concomitantly with brain RT, as glial cells can express HER2, too. Other possible organ-specific effects are discussed, such as pulmonary and cardiac toxicities. The lack of robust clinical data on the ADC-RT combination raises concerns regarding specific side effects and the ultimate trade-off of toxicity and safety of some combined approaches. Clinical studies are needed to assess ADC-RT combination safety and efficacy. Radiosensitization Radiation therapy Antibody-drug conjugates HER-2 directed ADCs Photoimmunotherapy Toxicity Radionecrosis Breast cancer Trapani, Dario verfasserin (orcid)0000-0003-1672-9560 aut Koukoutzeli, Chrysanthi verfasserin aut Boscolo Bielo, Luca verfasserin aut Marvaso, Giulia verfasserin aut Jereczek-Fossa, Barbara Alicja verfasserin aut Curigliano, Giuseppe verfasserin aut Enthalten in Critical reviews in oncology, hematology Amsterdam [u.a.] : Elsevier Science, 2011 195 (DE-627)320649024 (DE-600)2025731-4 187-90461 nnns volume:195 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 195
allfields_unstemmed	10.1016/j.critrevonc.2024.104270 doi (DE-627)ELV067168108 (ELSEVIER)S1040-8428(24)00013-1 DE-627 ger DE-627 rda eng 610 VZ Natangelo, Stefano verfasserin aut Radiation therapy, tissue radiosensitization, and potential synergism in the era of novel antibody-drug conjugates 2024 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Antibody-drug conjugates (ADCs) represent a therapeutic class of agents designed to selectively deliver cytotoxic payloads to cancer cells. With the increasingly positioning of ADCs in the clinical practice, combinations with other treatment modalities, including radiation therapy (RT), will open new opportunities but also challenges. This review evaluates ADC-RT interactions, examining therapeutic synergies and potential caveats. ADC payloads can be radiosensitizing, enhancing cytotoxicity when used in combination with RT. Antigens targeted by ADCs can have various tissue expressions, resulting in possible off-target toxicities by tissue radiosensitization. Notably, the HER-2-directed ADC trastuzumab emtansine has appeared to increase the risk of radionecrosis when used concomitantly with brain RT, as glial cells can express HER2, too. Other possible organ-specific effects are discussed, such as pulmonary and cardiac toxicities. The lack of robust clinical data on the ADC-RT combination raises concerns regarding specific side effects and the ultimate trade-off of toxicity and safety of some combined approaches. Clinical studies are needed to assess ADC-RT combination safety and efficacy. Radiosensitization Radiation therapy Antibody-drug conjugates HER-2 directed ADCs Photoimmunotherapy Toxicity Radionecrosis Breast cancer Trapani, Dario verfasserin (orcid)0000-0003-1672-9560 aut Koukoutzeli, Chrysanthi verfasserin aut Boscolo Bielo, Luca verfasserin aut Marvaso, Giulia verfasserin aut Jereczek-Fossa, Barbara Alicja verfasserin aut Curigliano, Giuseppe verfasserin aut Enthalten in Critical reviews in oncology, hematology Amsterdam [u.a.] : Elsevier Science, 2011 195 (DE-627)320649024 (DE-600)2025731-4 187-90461 nnns volume:195 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 195
allfieldsGer	10.1016/j.critrevonc.2024.104270 doi (DE-627)ELV067168108 (ELSEVIER)S1040-8428(24)00013-1 DE-627 ger DE-627 rda eng 610 VZ Natangelo, Stefano verfasserin aut Radiation therapy, tissue radiosensitization, and potential synergism in the era of novel antibody-drug conjugates 2024 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Antibody-drug conjugates (ADCs) represent a therapeutic class of agents designed to selectively deliver cytotoxic payloads to cancer cells. With the increasingly positioning of ADCs in the clinical practice, combinations with other treatment modalities, including radiation therapy (RT), will open new opportunities but also challenges. This review evaluates ADC-RT interactions, examining therapeutic synergies and potential caveats. ADC payloads can be radiosensitizing, enhancing cytotoxicity when used in combination with RT. Antigens targeted by ADCs can have various tissue expressions, resulting in possible off-target toxicities by tissue radiosensitization. Notably, the HER-2-directed ADC trastuzumab emtansine has appeared to increase the risk of radionecrosis when used concomitantly with brain RT, as glial cells can express HER2, too. Other possible organ-specific effects are discussed, such as pulmonary and cardiac toxicities. The lack of robust clinical data on the ADC-RT combination raises concerns regarding specific side effects and the ultimate trade-off of toxicity and safety of some combined approaches. Clinical studies are needed to assess ADC-RT combination safety and efficacy. Radiosensitization Radiation therapy Antibody-drug conjugates HER-2 directed ADCs Photoimmunotherapy Toxicity Radionecrosis Breast cancer Trapani, Dario verfasserin (orcid)0000-0003-1672-9560 aut Koukoutzeli, Chrysanthi verfasserin aut Boscolo Bielo, Luca verfasserin aut Marvaso, Giulia verfasserin aut Jereczek-Fossa, Barbara Alicja verfasserin aut Curigliano, Giuseppe verfasserin aut Enthalten in Critical reviews in oncology, hematology Amsterdam [u.a.] : Elsevier Science, 2011 195 (DE-627)320649024 (DE-600)2025731-4 187-90461 nnns volume:195 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 195
allfieldsSound	10.1016/j.critrevonc.2024.104270 doi (DE-627)ELV067168108 (ELSEVIER)S1040-8428(24)00013-1 DE-627 ger DE-627 rda eng 610 VZ Natangelo, Stefano verfasserin aut Radiation therapy, tissue radiosensitization, and potential synergism in the era of novel antibody-drug conjugates 2024 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Antibody-drug conjugates (ADCs) represent a therapeutic class of agents designed to selectively deliver cytotoxic payloads to cancer cells. With the increasingly positioning of ADCs in the clinical practice, combinations with other treatment modalities, including radiation therapy (RT), will open new opportunities but also challenges. This review evaluates ADC-RT interactions, examining therapeutic synergies and potential caveats. ADC payloads can be radiosensitizing, enhancing cytotoxicity when used in combination with RT. Antigens targeted by ADCs can have various tissue expressions, resulting in possible off-target toxicities by tissue radiosensitization. Notably, the HER-2-directed ADC trastuzumab emtansine has appeared to increase the risk of radionecrosis when used concomitantly with brain RT, as glial cells can express HER2, too. Other possible organ-specific effects are discussed, such as pulmonary and cardiac toxicities. The lack of robust clinical data on the ADC-RT combination raises concerns regarding specific side effects and the ultimate trade-off of toxicity and safety of some combined approaches. Clinical studies are needed to assess ADC-RT combination safety and efficacy. Radiosensitization Radiation therapy Antibody-drug conjugates HER-2 directed ADCs Photoimmunotherapy Toxicity Radionecrosis Breast cancer Trapani, Dario verfasserin (orcid)0000-0003-1672-9560 aut Koukoutzeli, Chrysanthi verfasserin aut Boscolo Bielo, Luca verfasserin aut Marvaso, Giulia verfasserin aut Jereczek-Fossa, Barbara Alicja verfasserin aut Curigliano, Giuseppe verfasserin aut Enthalten in Critical reviews in oncology, hematology Amsterdam [u.a.] : Elsevier Science, 2011 195 (DE-627)320649024 (DE-600)2025731-4 187-90461 nnns volume:195 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 195
language	English
source	Enthalten in Critical reviews in oncology, hematology 195 volume:195
sourceStr	Enthalten in Critical reviews in oncology, hematology 195 volume:195
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Radiosensitization Radiation therapy Antibody-drug conjugates HER-2 directed ADCs Photoimmunotherapy Toxicity Radionecrosis Breast cancer
dewey-raw	610
isfreeaccess_bool	false
container_title	Critical reviews in oncology, hematology
authorswithroles_txt_mv	Natangelo, Stefano @@aut@@ Trapani, Dario @@aut@@ Koukoutzeli, Chrysanthi @@aut@@ Boscolo Bielo, Luca @@aut@@ Marvaso, Giulia @@aut@@ Jereczek-Fossa, Barbara Alicja @@aut@@ Curigliano, Giuseppe @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
hierarchy_top_id	320649024
dewey-sort	3610
id	ELV067168108
language_de	englisch
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author	Natangelo, Stefano
spellingShingle	Natangelo, Stefano ddc 610 misc Radiosensitization misc Radiation therapy misc Antibody-drug conjugates misc HER-2 directed ADCs misc Photoimmunotherapy misc Toxicity misc Radionecrosis misc Breast cancer Radiation therapy, tissue radiosensitization, and potential synergism in the era of novel antibody-drug conjugates
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topic_title	610 VZ Radiation therapy, tissue radiosensitization, and potential synergism in the era of novel antibody-drug conjugates Radiosensitization Radiation therapy Antibody-drug conjugates HER-2 directed ADCs Photoimmunotherapy Toxicity Radionecrosis Breast cancer
topic	ddc 610 misc Radiosensitization misc Radiation therapy misc Antibody-drug conjugates misc HER-2 directed ADCs misc Photoimmunotherapy misc Toxicity misc Radionecrosis misc Breast cancer
topic_unstemmed	ddc 610 misc Radiosensitization misc Radiation therapy misc Antibody-drug conjugates misc HER-2 directed ADCs misc Photoimmunotherapy misc Toxicity misc Radionecrosis misc Breast cancer
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title	Radiation therapy, tissue radiosensitization, and potential synergism in the era of novel antibody-drug conjugates
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title_full	Radiation therapy, tissue radiosensitization, and potential synergism in the era of novel antibody-drug conjugates
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title_sort	radiation therapy, tissue radiosensitization, and potential synergism in the era of novel antibody-drug conjugates
title_auth	Radiation therapy, tissue radiosensitization, and potential synergism in the era of novel antibody-drug conjugates
abstract	Antibody-drug conjugates (ADCs) represent a therapeutic class of agents designed to selectively deliver cytotoxic payloads to cancer cells. With the increasingly positioning of ADCs in the clinical practice, combinations with other treatment modalities, including radiation therapy (RT), will open new opportunities but also challenges. This review evaluates ADC-RT interactions, examining therapeutic synergies and potential caveats. ADC payloads can be radiosensitizing, enhancing cytotoxicity when used in combination with RT. Antigens targeted by ADCs can have various tissue expressions, resulting in possible off-target toxicities by tissue radiosensitization. Notably, the HER-2-directed ADC trastuzumab emtansine has appeared to increase the risk of radionecrosis when used concomitantly with brain RT, as glial cells can express HER2, too. Other possible organ-specific effects are discussed, such as pulmonary and cardiac toxicities. The lack of robust clinical data on the ADC-RT combination raises concerns regarding specific side effects and the ultimate trade-off of toxicity and safety of some combined approaches. Clinical studies are needed to assess ADC-RT combination safety and efficacy.
abstractGer	Antibody-drug conjugates (ADCs) represent a therapeutic class of agents designed to selectively deliver cytotoxic payloads to cancer cells. With the increasingly positioning of ADCs in the clinical practice, combinations with other treatment modalities, including radiation therapy (RT), will open new opportunities but also challenges. This review evaluates ADC-RT interactions, examining therapeutic synergies and potential caveats. ADC payloads can be radiosensitizing, enhancing cytotoxicity when used in combination with RT. Antigens targeted by ADCs can have various tissue expressions, resulting in possible off-target toxicities by tissue radiosensitization. Notably, the HER-2-directed ADC trastuzumab emtansine has appeared to increase the risk of radionecrosis when used concomitantly with brain RT, as glial cells can express HER2, too. Other possible organ-specific effects are discussed, such as pulmonary and cardiac toxicities. The lack of robust clinical data on the ADC-RT combination raises concerns regarding specific side effects and the ultimate trade-off of toxicity and safety of some combined approaches. Clinical studies are needed to assess ADC-RT combination safety and efficacy.
abstract_unstemmed	Antibody-drug conjugates (ADCs) represent a therapeutic class of agents designed to selectively deliver cytotoxic payloads to cancer cells. With the increasingly positioning of ADCs in the clinical practice, combinations with other treatment modalities, including radiation therapy (RT), will open new opportunities but also challenges. This review evaluates ADC-RT interactions, examining therapeutic synergies and potential caveats. ADC payloads can be radiosensitizing, enhancing cytotoxicity when used in combination with RT. Antigens targeted by ADCs can have various tissue expressions, resulting in possible off-target toxicities by tissue radiosensitization. Notably, the HER-2-directed ADC trastuzumab emtansine has appeared to increase the risk of radionecrosis when used concomitantly with brain RT, as glial cells can express HER2, too. Other possible organ-specific effects are discussed, such as pulmonary and cardiac toxicities. The lack of robust clinical data on the ADC-RT combination raises concerns regarding specific side effects and the ultimate trade-off of toxicity and safety of some combined approaches. Clinical studies are needed to assess ADC-RT combination safety and efficacy.
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title_short	Radiation therapy, tissue radiosensitization, and potential synergism in the era of novel antibody-drug conjugates
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author2	Trapani, Dario Koukoutzeli, Chrysanthi Boscolo Bielo, Luca Marvaso, Giulia Jereczek-Fossa, Barbara Alicja Curigliano, Giuseppe
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up_date	2024-07-06T20:20:16.667Z
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