Identification of 3-hydroxy-3-ethylglutaric acid in urine of patients with propionic acidaemia
By gas chromatographic mass spectrometric analysis, 3-hydroxy-3-ethylglutaric acid was identified in the urine of patients with propionyl CoA carboxylase deficiency. Simultaneously, large amounts of 3-hydroxyvaleric acid and 3-oxovaleric acid, as well as a number of metabolites previously well known...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1983 |
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| Umfang: |
2 Ill. ; 1 Tab. 4 |
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| Reproduktion: |
Wiley InterScience Backfile Collection 1832-2000 |
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| Übergeordnetes Werk: |
in: Biological Mass Spectrometry - Chichester : Wiley Subscription Services, Inc., A Wiley Company, 10(1983) vom: Dez., Seite 629-632 |
| Übergeordnetes Werk: |
volume:10 ; year:1983 ; month:12 ; pages:629-632 ; extent:4 |
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| 520 | |a By gas chromatographic mass spectrometric analysis, 3-hydroxy-3-ethylglutaric acid was identified in the urine of patients with propionyl CoA carboxylase deficiency. Simultaneously, large amounts of 3-hydroxyvaleric acid and 3-oxovaleric acid, as well as a number of metabolites previously well known in this disorder, were also found in the urine of the patients. It is suggested that formation of 3-oxovaleric acid and 3-hydroxyvaleric acid proceeds via 3-hydroxy-3-ethylglutaryl CoA as an intermediate by a mechanism similar to that of ketone body formation. | ||
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| 700 | 1 | |a Matsumoto, Isamuu |4 oth | |
| 700 | 1 | |a Matsuo, Masafumi |4 oth | |
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(DE-627)NLEJ159148073 DE-627 ger DE-627 rakwb eng Identification of 3-hydroxy-3-ethylglutaric acid in urine of patients with propionic acidaemia 1983 2 Ill. 1 Tab. 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier By gas chromatographic mass spectrometric analysis, 3-hydroxy-3-ethylglutaric acid was identified in the urine of patients with propionyl CoA carboxylase deficiency. Simultaneously, large amounts of 3-hydroxyvaleric acid and 3-oxovaleric acid, as well as a number of metabolites previously well known in this disorder, were also found in the urine of the patients. It is suggested that formation of 3-oxovaleric acid and 3-hydroxyvaleric acid proceeds via 3-hydroxy-3-ethylglutaryl CoA as an intermediate by a mechanism similar to that of ketone body formation. Wiley InterScience Backfile Collection 1832-2000 Kuhara, Tomiko oth Inoue, Yoshito oth Shinka, Toshihiro oth Matsumoto, Isamuu oth Matsuo, Masafumi oth in Biological Mass Spectrometry Chichester : Wiley Subscription Services, Inc., A Wiley Company 10(1983) vom: Dez., Seite 629-632 (DE-627)NLEJ159070465 (DE-600)2197367-2 0306-042X nnns volume:10 year:1983 month:12 pages:629-632 extent:4 http://dx.doi.org/10.1002/bms.1200101202 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 10 1983 12 629-632 4 |
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(DE-627)NLEJ159148073 DE-627 ger DE-627 rakwb eng Identification of 3-hydroxy-3-ethylglutaric acid in urine of patients with propionic acidaemia 1983 2 Ill. 1 Tab. 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier By gas chromatographic mass spectrometric analysis, 3-hydroxy-3-ethylglutaric acid was identified in the urine of patients with propionyl CoA carboxylase deficiency. Simultaneously, large amounts of 3-hydroxyvaleric acid and 3-oxovaleric acid, as well as a number of metabolites previously well known in this disorder, were also found in the urine of the patients. It is suggested that formation of 3-oxovaleric acid and 3-hydroxyvaleric acid proceeds via 3-hydroxy-3-ethylglutaryl CoA as an intermediate by a mechanism similar to that of ketone body formation. Wiley InterScience Backfile Collection 1832-2000 Kuhara, Tomiko oth Inoue, Yoshito oth Shinka, Toshihiro oth Matsumoto, Isamuu oth Matsuo, Masafumi oth in Biological Mass Spectrometry Chichester : Wiley Subscription Services, Inc., A Wiley Company 10(1983) vom: Dez., Seite 629-632 (DE-627)NLEJ159070465 (DE-600)2197367-2 0306-042X nnns volume:10 year:1983 month:12 pages:629-632 extent:4 http://dx.doi.org/10.1002/bms.1200101202 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 10 1983 12 629-632 4 |
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(DE-627)NLEJ159148073 DE-627 ger DE-627 rakwb eng Identification of 3-hydroxy-3-ethylglutaric acid in urine of patients with propionic acidaemia 1983 2 Ill. 1 Tab. 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier By gas chromatographic mass spectrometric analysis, 3-hydroxy-3-ethylglutaric acid was identified in the urine of patients with propionyl CoA carboxylase deficiency. Simultaneously, large amounts of 3-hydroxyvaleric acid and 3-oxovaleric acid, as well as a number of metabolites previously well known in this disorder, were also found in the urine of the patients. It is suggested that formation of 3-oxovaleric acid and 3-hydroxyvaleric acid proceeds via 3-hydroxy-3-ethylglutaryl CoA as an intermediate by a mechanism similar to that of ketone body formation. Wiley InterScience Backfile Collection 1832-2000 Kuhara, Tomiko oth Inoue, Yoshito oth Shinka, Toshihiro oth Matsumoto, Isamuu oth Matsuo, Masafumi oth in Biological Mass Spectrometry Chichester : Wiley Subscription Services, Inc., A Wiley Company 10(1983) vom: Dez., Seite 629-632 (DE-627)NLEJ159070465 (DE-600)2197367-2 0306-042X nnns volume:10 year:1983 month:12 pages:629-632 extent:4 http://dx.doi.org/10.1002/bms.1200101202 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 10 1983 12 629-632 4 |
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(DE-627)NLEJ159148073 DE-627 ger DE-627 rakwb eng Identification of 3-hydroxy-3-ethylglutaric acid in urine of patients with propionic acidaemia 1983 2 Ill. 1 Tab. 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier By gas chromatographic mass spectrometric analysis, 3-hydroxy-3-ethylglutaric acid was identified in the urine of patients with propionyl CoA carboxylase deficiency. Simultaneously, large amounts of 3-hydroxyvaleric acid and 3-oxovaleric acid, as well as a number of metabolites previously well known in this disorder, were also found in the urine of the patients. It is suggested that formation of 3-oxovaleric acid and 3-hydroxyvaleric acid proceeds via 3-hydroxy-3-ethylglutaryl CoA as an intermediate by a mechanism similar to that of ketone body formation. Wiley InterScience Backfile Collection 1832-2000 Kuhara, Tomiko oth Inoue, Yoshito oth Shinka, Toshihiro oth Matsumoto, Isamuu oth Matsuo, Masafumi oth in Biological Mass Spectrometry Chichester : Wiley Subscription Services, Inc., A Wiley Company 10(1983) vom: Dez., Seite 629-632 (DE-627)NLEJ159070465 (DE-600)2197367-2 0306-042X nnns volume:10 year:1983 month:12 pages:629-632 extent:4 http://dx.doi.org/10.1002/bms.1200101202 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 10 1983 12 629-632 4 |
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(DE-627)NLEJ159148073 DE-627 ger DE-627 rakwb eng Identification of 3-hydroxy-3-ethylglutaric acid in urine of patients with propionic acidaemia 1983 2 Ill. 1 Tab. 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier By gas chromatographic mass spectrometric analysis, 3-hydroxy-3-ethylglutaric acid was identified in the urine of patients with propionyl CoA carboxylase deficiency. Simultaneously, large amounts of 3-hydroxyvaleric acid and 3-oxovaleric acid, as well as a number of metabolites previously well known in this disorder, were also found in the urine of the patients. It is suggested that formation of 3-oxovaleric acid and 3-hydroxyvaleric acid proceeds via 3-hydroxy-3-ethylglutaryl CoA as an intermediate by a mechanism similar to that of ketone body formation. Wiley InterScience Backfile Collection 1832-2000 Kuhara, Tomiko oth Inoue, Yoshito oth Shinka, Toshihiro oth Matsumoto, Isamuu oth Matsuo, Masafumi oth in Biological Mass Spectrometry Chichester : Wiley Subscription Services, Inc., A Wiley Company 10(1983) vom: Dez., Seite 629-632 (DE-627)NLEJ159070465 (DE-600)2197367-2 0306-042X nnns volume:10 year:1983 month:12 pages:629-632 extent:4 http://dx.doi.org/10.1002/bms.1200101202 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 10 1983 12 629-632 4 |
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identification of 3-hydroxy-3-ethylglutaric acid in urine of patients with propionic acidaemia |
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Identification of 3-hydroxy-3-ethylglutaric acid in urine of patients with propionic acidaemia |
| abstract |
By gas chromatographic mass spectrometric analysis, 3-hydroxy-3-ethylglutaric acid was identified in the urine of patients with propionyl CoA carboxylase deficiency. Simultaneously, large amounts of 3-hydroxyvaleric acid and 3-oxovaleric acid, as well as a number of metabolites previously well known in this disorder, were also found in the urine of the patients. It is suggested that formation of 3-oxovaleric acid and 3-hydroxyvaleric acid proceeds via 3-hydroxy-3-ethylglutaryl CoA as an intermediate by a mechanism similar to that of ketone body formation. |
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By gas chromatographic mass spectrometric analysis, 3-hydroxy-3-ethylglutaric acid was identified in the urine of patients with propionyl CoA carboxylase deficiency. Simultaneously, large amounts of 3-hydroxyvaleric acid and 3-oxovaleric acid, as well as a number of metabolites previously well known in this disorder, were also found in the urine of the patients. It is suggested that formation of 3-oxovaleric acid and 3-hydroxyvaleric acid proceeds via 3-hydroxy-3-ethylglutaryl CoA as an intermediate by a mechanism similar to that of ketone body formation. |
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By gas chromatographic mass spectrometric analysis, 3-hydroxy-3-ethylglutaric acid was identified in the urine of patients with propionyl CoA carboxylase deficiency. Simultaneously, large amounts of 3-hydroxyvaleric acid and 3-oxovaleric acid, as well as a number of metabolites previously well known in this disorder, were also found in the urine of the patients. It is suggested that formation of 3-oxovaleric acid and 3-hydroxyvaleric acid proceeds via 3-hydroxy-3-ethylglutaryl CoA as an intermediate by a mechanism similar to that of ketone body formation. |
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Identification of 3-hydroxy-3-ethylglutaric acid in urine of patients with propionic acidaemia |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ159148073</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707000941.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070201s1983 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ159148073</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Identification of 3-hydroxy-3-ethylglutaric acid in urine of patients with propionic acidaemia</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1983</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="b">2 Ill.</subfield><subfield code="b">1 Tab.</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">4</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">By gas chromatographic mass spectrometric analysis, 3-hydroxy-3-ethylglutaric acid was identified in the urine of patients with propionyl CoA carboxylase deficiency. Simultaneously, large amounts of 3-hydroxyvaleric acid and 3-oxovaleric acid, as well as a number of metabolites previously well known in this disorder, were also found in the urine of the patients. It is suggested that formation of 3-oxovaleric acid and 3-hydroxyvaleric acid proceeds via 3-hydroxy-3-ethylglutaryl CoA as an intermediate by a mechanism similar to that of ketone body formation.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Wiley InterScience Backfile Collection 1832-2000</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kuhara, Tomiko</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Inoue, Yoshito</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Shinka, Toshihiro</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Matsumoto, Isamuu</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Matsuo, Masafumi</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Biological Mass Spectrometry</subfield><subfield code="d">Chichester : Wiley Subscription Services, Inc., A Wiley Company</subfield><subfield code="g">10(1983) vom: Dez., Seite 629-632</subfield><subfield code="w">(DE-627)NLEJ159070465</subfield><subfield code="w">(DE-600)2197367-2</subfield><subfield code="x">0306-042X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:10</subfield><subfield code="g">year:1983</subfield><subfield code="g">month:12</subfield><subfield code="g">pages:629-632</subfield><subfield code="g">extent:4</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1002/bms.1200101202</subfield><subfield code="q">text/html</subfield><subfield code="z">Deutschlandweit zugänglich</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-WIS</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">10</subfield><subfield code="j">1983</subfield><subfield code="c">12</subfield><subfield code="h">629-632</subfield><subfield code="g">4</subfield></datafield></record></collection>
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