The immunosuppressive mini-domain of human lactoferrin
It has been found that the disulphide-bridged 231-245 pentadecapeptide loop of the lactoferrin (LF) N-lobe contains a region of immunosuppressive activity. The activity resides within a thymopentin-like sequence (Arg-Lys-Pro-Val-Asp) of the loop. Peptides related to the 575-589 loop of the LF C-lobe...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1995 |
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| Umfang: |
1 Ill. ; 4 Tab. 8 |
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| Reproduktion: |
Wiley InterScience Backfile Collection 1832-2000 |
|---|---|
| Übergeordnetes Werk: |
in: Journal of Peptide Science - New York, NY [u.a.] : Wiley, 1(1995) vom: Mai, Seite 295-302 |
| Übergeordnetes Werk: |
volume:1 ; year:1995 ; month:05 ; pages:295-302 ; extent:8 |
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| 520 | |a It has been found that the disulphide-bridged 231-245 pentadecapeptide loop of the lactoferrin (LF) N-lobe contains a region of immunosuppressive activity. The activity resides within a thymopentin-like sequence (Arg-Lys-Pro-Val-Asp) of the loop. Peptides related to the 575-589 loop of the LF C-lobe differ in their immunomodulatory activity from those related to the 231-245 loop. We ascribe this difference to the replacement of the Asp residue in the 231-245 loop by Thr in the 575-589 loop. Two other fragments of LF which were studied, 27-34 and 309-315, do not manifest any activy in the DTH test (cellular immune response), but, on testing in vivo, stimulate the humoral immune response. The 27-34 fragment is related to the bactericidal and immunostimulative region of LF identified by Bellamy et al. [1]. Our results show that the LF molecule contains, not only the known immunostimulating mini-domain, but also a region endowed with immunosuppressive activity. | ||
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(DE-627)NLEJ159432820 DE-627 ger DE-627 rakwb eng The immunosuppressive mini-domain of human lactoferrin 1995 1 Ill. 4 Tab. 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier It has been found that the disulphide-bridged 231-245 pentadecapeptide loop of the lactoferrin (LF) N-lobe contains a region of immunosuppressive activity. The activity resides within a thymopentin-like sequence (Arg-Lys-Pro-Val-Asp) of the loop. Peptides related to the 575-589 loop of the LF C-lobe differ in their immunomodulatory activity from those related to the 231-245 loop. We ascribe this difference to the replacement of the Asp residue in the 231-245 loop by Thr in the 575-589 loop. Two other fragments of LF which were studied, 27-34 and 309-315, do not manifest any activy in the DTH test (cellular immune response), but, on testing in vivo, stimulate the humoral immune response. The 27-34 fragment is related to the bactericidal and immunostimulative region of LF identified by Bellamy et al. [1]. Our results show that the LF molecule contains, not only the known immunostimulating mini-domain, but also a region endowed with immunosuppressive activity. Wiley InterScience Backfile Collection 1832-2000 Siemion, Ignacy Z. oth Sloń, Jacek oth Wieczorek, Zbigniew oth in Journal of Peptide Science New York, NY [u.a.] : Wiley 1(1995) vom: Mai, Seite 295-302 (DE-627)NLEJ159070635 (DE-600)1491819-5 1075-2617 nnns volume:1 year:1995 month:05 pages:295-302 extent:8 http://dx.doi.org/10.1002/psc.310010504 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 1 1995 5 295-302 8 |
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(DE-627)NLEJ159432820 DE-627 ger DE-627 rakwb eng The immunosuppressive mini-domain of human lactoferrin 1995 1 Ill. 4 Tab. 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier It has been found that the disulphide-bridged 231-245 pentadecapeptide loop of the lactoferrin (LF) N-lobe contains a region of immunosuppressive activity. The activity resides within a thymopentin-like sequence (Arg-Lys-Pro-Val-Asp) of the loop. Peptides related to the 575-589 loop of the LF C-lobe differ in their immunomodulatory activity from those related to the 231-245 loop. We ascribe this difference to the replacement of the Asp residue in the 231-245 loop by Thr in the 575-589 loop. Two other fragments of LF which were studied, 27-34 and 309-315, do not manifest any activy in the DTH test (cellular immune response), but, on testing in vivo, stimulate the humoral immune response. The 27-34 fragment is related to the bactericidal and immunostimulative region of LF identified by Bellamy et al. [1]. Our results show that the LF molecule contains, not only the known immunostimulating mini-domain, but also a region endowed with immunosuppressive activity. Wiley InterScience Backfile Collection 1832-2000 Siemion, Ignacy Z. oth Sloń, Jacek oth Wieczorek, Zbigniew oth in Journal of Peptide Science New York, NY [u.a.] : Wiley 1(1995) vom: Mai, Seite 295-302 (DE-627)NLEJ159070635 (DE-600)1491819-5 1075-2617 nnns volume:1 year:1995 month:05 pages:295-302 extent:8 http://dx.doi.org/10.1002/psc.310010504 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 1 1995 5 295-302 8 |
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(DE-627)NLEJ159432820 DE-627 ger DE-627 rakwb eng The immunosuppressive mini-domain of human lactoferrin 1995 1 Ill. 4 Tab. 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier It has been found that the disulphide-bridged 231-245 pentadecapeptide loop of the lactoferrin (LF) N-lobe contains a region of immunosuppressive activity. The activity resides within a thymopentin-like sequence (Arg-Lys-Pro-Val-Asp) of the loop. Peptides related to the 575-589 loop of the LF C-lobe differ in their immunomodulatory activity from those related to the 231-245 loop. We ascribe this difference to the replacement of the Asp residue in the 231-245 loop by Thr in the 575-589 loop. Two other fragments of LF which were studied, 27-34 and 309-315, do not manifest any activy in the DTH test (cellular immune response), but, on testing in vivo, stimulate the humoral immune response. The 27-34 fragment is related to the bactericidal and immunostimulative region of LF identified by Bellamy et al. [1]. Our results show that the LF molecule contains, not only the known immunostimulating mini-domain, but also a region endowed with immunosuppressive activity. Wiley InterScience Backfile Collection 1832-2000 Siemion, Ignacy Z. oth Sloń, Jacek oth Wieczorek, Zbigniew oth in Journal of Peptide Science New York, NY [u.a.] : Wiley 1(1995) vom: Mai, Seite 295-302 (DE-627)NLEJ159070635 (DE-600)1491819-5 1075-2617 nnns volume:1 year:1995 month:05 pages:295-302 extent:8 http://dx.doi.org/10.1002/psc.310010504 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 1 1995 5 295-302 8 |
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(DE-627)NLEJ159432820 DE-627 ger DE-627 rakwb eng The immunosuppressive mini-domain of human lactoferrin 1995 1 Ill. 4 Tab. 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier It has been found that the disulphide-bridged 231-245 pentadecapeptide loop of the lactoferrin (LF) N-lobe contains a region of immunosuppressive activity. The activity resides within a thymopentin-like sequence (Arg-Lys-Pro-Val-Asp) of the loop. Peptides related to the 575-589 loop of the LF C-lobe differ in their immunomodulatory activity from those related to the 231-245 loop. We ascribe this difference to the replacement of the Asp residue in the 231-245 loop by Thr in the 575-589 loop. Two other fragments of LF which were studied, 27-34 and 309-315, do not manifest any activy in the DTH test (cellular immune response), but, on testing in vivo, stimulate the humoral immune response. The 27-34 fragment is related to the bactericidal and immunostimulative region of LF identified by Bellamy et al. [1]. Our results show that the LF molecule contains, not only the known immunostimulating mini-domain, but also a region endowed with immunosuppressive activity. Wiley InterScience Backfile Collection 1832-2000 Siemion, Ignacy Z. oth Sloń, Jacek oth Wieczorek, Zbigniew oth in Journal of Peptide Science New York, NY [u.a.] : Wiley 1(1995) vom: Mai, Seite 295-302 (DE-627)NLEJ159070635 (DE-600)1491819-5 1075-2617 nnns volume:1 year:1995 month:05 pages:295-302 extent:8 http://dx.doi.org/10.1002/psc.310010504 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 1 1995 5 295-302 8 |
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(DE-627)NLEJ159432820 DE-627 ger DE-627 rakwb eng The immunosuppressive mini-domain of human lactoferrin 1995 1 Ill. 4 Tab. 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier It has been found that the disulphide-bridged 231-245 pentadecapeptide loop of the lactoferrin (LF) N-lobe contains a region of immunosuppressive activity. The activity resides within a thymopentin-like sequence (Arg-Lys-Pro-Val-Asp) of the loop. Peptides related to the 575-589 loop of the LF C-lobe differ in their immunomodulatory activity from those related to the 231-245 loop. We ascribe this difference to the replacement of the Asp residue in the 231-245 loop by Thr in the 575-589 loop. Two other fragments of LF which were studied, 27-34 and 309-315, do not manifest any activy in the DTH test (cellular immune response), but, on testing in vivo, stimulate the humoral immune response. The 27-34 fragment is related to the bactericidal and immunostimulative region of LF identified by Bellamy et al. [1]. Our results show that the LF molecule contains, not only the known immunostimulating mini-domain, but also a region endowed with immunosuppressive activity. Wiley InterScience Backfile Collection 1832-2000 Siemion, Ignacy Z. oth Sloń, Jacek oth Wieczorek, Zbigniew oth in Journal of Peptide Science New York, NY [u.a.] : Wiley 1(1995) vom: Mai, Seite 295-302 (DE-627)NLEJ159070635 (DE-600)1491819-5 1075-2617 nnns volume:1 year:1995 month:05 pages:295-302 extent:8 http://dx.doi.org/10.1002/psc.310010504 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 1 1995 5 295-302 8 |
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The immunosuppressive mini-domain of human lactoferrin |
| abstract |
It has been found that the disulphide-bridged 231-245 pentadecapeptide loop of the lactoferrin (LF) N-lobe contains a region of immunosuppressive activity. The activity resides within a thymopentin-like sequence (Arg-Lys-Pro-Val-Asp) of the loop. Peptides related to the 575-589 loop of the LF C-lobe differ in their immunomodulatory activity from those related to the 231-245 loop. We ascribe this difference to the replacement of the Asp residue in the 231-245 loop by Thr in the 575-589 loop. Two other fragments of LF which were studied, 27-34 and 309-315, do not manifest any activy in the DTH test (cellular immune response), but, on testing in vivo, stimulate the humoral immune response. The 27-34 fragment is related to the bactericidal and immunostimulative region of LF identified by Bellamy et al. [1]. Our results show that the LF molecule contains, not only the known immunostimulating mini-domain, but also a region endowed with immunosuppressive activity. |
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It has been found that the disulphide-bridged 231-245 pentadecapeptide loop of the lactoferrin (LF) N-lobe contains a region of immunosuppressive activity. The activity resides within a thymopentin-like sequence (Arg-Lys-Pro-Val-Asp) of the loop. Peptides related to the 575-589 loop of the LF C-lobe differ in their immunomodulatory activity from those related to the 231-245 loop. We ascribe this difference to the replacement of the Asp residue in the 231-245 loop by Thr in the 575-589 loop. Two other fragments of LF which were studied, 27-34 and 309-315, do not manifest any activy in the DTH test (cellular immune response), but, on testing in vivo, stimulate the humoral immune response. The 27-34 fragment is related to the bactericidal and immunostimulative region of LF identified by Bellamy et al. [1]. Our results show that the LF molecule contains, not only the known immunostimulating mini-domain, but also a region endowed with immunosuppressive activity. |
| abstract_unstemmed |
It has been found that the disulphide-bridged 231-245 pentadecapeptide loop of the lactoferrin (LF) N-lobe contains a region of immunosuppressive activity. The activity resides within a thymopentin-like sequence (Arg-Lys-Pro-Val-Asp) of the loop. Peptides related to the 575-589 loop of the LF C-lobe differ in their immunomodulatory activity from those related to the 231-245 loop. We ascribe this difference to the replacement of the Asp residue in the 231-245 loop by Thr in the 575-589 loop. Two other fragments of LF which were studied, 27-34 and 309-315, do not manifest any activy in the DTH test (cellular immune response), but, on testing in vivo, stimulate the humoral immune response. The 27-34 fragment is related to the bactericidal and immunostimulative region of LF identified by Bellamy et al. [1]. Our results show that the LF molecule contains, not only the known immunostimulating mini-domain, but also a region endowed with immunosuppressive activity. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ159432820</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707005941.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070201s1995 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ159432820</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">The immunosuppressive mini-domain of human lactoferrin</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1995</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="b">1 Ill.</subfield><subfield code="b">4 Tab.</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">8</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">It has been found that the disulphide-bridged 231-245 pentadecapeptide loop of the lactoferrin (LF) N-lobe contains a region of immunosuppressive activity. The activity resides within a thymopentin-like sequence (Arg-Lys-Pro-Val-Asp) of the loop. Peptides related to the 575-589 loop of the LF C-lobe differ in their immunomodulatory activity from those related to the 231-245 loop. We ascribe this difference to the replacement of the Asp residue in the 231-245 loop by Thr in the 575-589 loop. Two other fragments of LF which were studied, 27-34 and 309-315, do not manifest any activy in the DTH test (cellular immune response), but, on testing in vivo, stimulate the humoral immune response. The 27-34 fragment is related to the bactericidal and immunostimulative region of LF identified by Bellamy et al. [1]. Our results show that the LF molecule contains, not only the known immunostimulating mini-domain, but also a region endowed with immunosuppressive activity.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Wiley InterScience Backfile Collection 1832-2000</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Siemion, Ignacy Z.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sloń, Jacek</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wieczorek, Zbigniew</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Journal of Peptide Science</subfield><subfield code="d">New York, NY [u.a.] : Wiley</subfield><subfield code="g">1(1995) vom: Mai, Seite 295-302</subfield><subfield code="w">(DE-627)NLEJ159070635</subfield><subfield code="w">(DE-600)1491819-5</subfield><subfield code="x">1075-2617</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:1</subfield><subfield code="g">year:1995</subfield><subfield code="g">month:05</subfield><subfield code="g">pages:295-302</subfield><subfield code="g">extent:8</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1002/psc.310010504</subfield><subfield code="q">text/html</subfield><subfield code="z">Deutschlandweit zugänglich</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-WIS</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">1</subfield><subfield code="j">1995</subfield><subfield code="c">5</subfield><subfield code="h">295-302</subfield><subfield code="g">8</subfield></datafield></record></collection>
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