Oncogene amplification correlates with dense lymphocyte infiltration in human breast cancers: A role for hematopoietic growth factor release by tumor cells?
One hundred six primary breast cancer samples were analysed for c-erbB2, int-2, and c-myc gene amplification. Surgically confirmed nodal involvement was observed in 42%. Level of gene amplification was studied by Southern and/or slot blottechniques. Amplified c-erbB2 gene sequences were present in 2...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1990 |
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| Umfang: |
3 Ill. ; 5 Tab. 10 |
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| Reproduktion: |
Wiley InterScience Backfile Collection 1832-2000 |
|---|---|
| Übergeordnetes Werk: |
in: Journal of Cellular Biochemistry - New York, N.Y. : Alan R. Liss, Inc, 44(1990) vom: März, Seite 189-198 |
| Übergeordnetes Werk: |
volume:44 ; year:1990 ; month:03 ; pages:189-198 ; extent:10 |
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NLEJ159853028 |
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| 520 | |a One hundred six primary breast cancer samples were analysed for c-erbB2, int-2, and c-myc gene amplification. Surgically confirmed nodal involvement was observed in 42%. Level of gene amplification was studied by Southern and/or slot blottechniques. Amplified c-erbB2 gene sequences were present in 21.5% of all samples. Int-2 was amplified in 13.1% and c-myc was amplified in 10.3%. In a non-parametric test (Kruskal-Wallis) a strong negative association was found between high levels of c-erbB2 amplification and absence of estrogen receptor (ER) (P = .0009) or progesterone receptor (PR) (P = .011) expression. No correlations were found between all or high levels of amplification of each oncogene separately or combined with T, N, grade, multifocality of tumor, or associated carcinoma in situ. There was a trend approaching statistical significance for patients with c-erbB2 amplifications to have positive lymph nodes at surgery (P = 0.09). A somewhat surprising finding however was a very strong association between oncogene amplification and dense lymphocyte infiltration of the tumor (P = .05). This correlation is even stronger when only high levels of amplification are considered, either for each oncogene separately (P = .0048) or in combination (P = .007). We propose that malignant cell cytokine production may help explain this observation. | ||
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| 700 | 1 | |a Kacinski, Barry |4 oth | |
| 700 | 1 | |a Validire, Pierre |4 oth | |
| 700 | 1 | |a Beuvon, Frédéric |4 oth | |
| 700 | 1 | |a Sastre, Xavier |4 oth | |
| 700 | 1 | |a Benoit, Patrick |4 oth | |
| 700 | 1 | |a dela Rochefordière, Anne |4 oth | |
| 700 | 1 | |a Mosseri, Véronique |4 oth | |
| 700 | 1 | |a Pouillart, Pierre |4 oth | |
| 700 | 1 | |a Scholl, Susy |4 oth | |
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(DE-627)NLEJ159853028 DE-627 ger DE-627 rakwb eng Oncogene amplification correlates with dense lymphocyte infiltration in human breast cancers: A role for hematopoietic growth factor release by tumor cells? 1990 3 Ill. 5 Tab. 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier One hundred six primary breast cancer samples were analysed for c-erbB2, int-2, and c-myc gene amplification. Surgically confirmed nodal involvement was observed in 42%. Level of gene amplification was studied by Southern and/or slot blottechniques. Amplified c-erbB2 gene sequences were present in 21.5% of all samples. Int-2 was amplified in 13.1% and c-myc was amplified in 10.3%. In a non-parametric test (Kruskal-Wallis) a strong negative association was found between high levels of c-erbB2 amplification and absence of estrogen receptor (ER) (P = .0009) or progesterone receptor (PR) (P = .011) expression. No correlations were found between all or high levels of amplification of each oncogene separately or combined with T, N, grade, multifocality of tumor, or associated carcinoma in situ. There was a trend approaching statistical significance for patients with c-erbB2 amplifications to have positive lymph nodes at surgery (P = 0.09). A somewhat surprising finding however was a very strong association between oncogene amplification and dense lymphocyte infiltration of the tumor (P = .05). This correlation is even stronger when only high levels of amplification are considered, either for each oncogene separately (P = .0048) or in combination (P = .007). We propose that malignant cell cytokine production may help explain this observation. Wiley InterScience Backfile Collection 1832-2000 Tang, Ruoping oth Kacinski, Barry oth Validire, Pierre oth Beuvon, Frédéric oth Sastre, Xavier oth Benoit, Patrick oth dela Rochefordière, Anne oth Mosseri, Véronique oth Pouillart, Pierre oth Scholl, Susy oth in Journal of Cellular Biochemistry New York, N.Y. : Alan R. Liss, Inc 44(1990) vom: März, Seite 189-198 (DE-627)NLEJ159070694 (DE-600)1479976-5 0730-2312 nnns volume:44 year:1990 month:03 pages:189-198 extent:10 http://dx.doi.org/10.1002/jcb.240440307 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 44 1990 3 189-198 10 |
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(DE-627)NLEJ159853028 DE-627 ger DE-627 rakwb eng Oncogene amplification correlates with dense lymphocyte infiltration in human breast cancers: A role for hematopoietic growth factor release by tumor cells? 1990 3 Ill. 5 Tab. 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier One hundred six primary breast cancer samples were analysed for c-erbB2, int-2, and c-myc gene amplification. Surgically confirmed nodal involvement was observed in 42%. Level of gene amplification was studied by Southern and/or slot blottechniques. Amplified c-erbB2 gene sequences were present in 21.5% of all samples. Int-2 was amplified in 13.1% and c-myc was amplified in 10.3%. In a non-parametric test (Kruskal-Wallis) a strong negative association was found between high levels of c-erbB2 amplification and absence of estrogen receptor (ER) (P = .0009) or progesterone receptor (PR) (P = .011) expression. No correlations were found between all or high levels of amplification of each oncogene separately or combined with T, N, grade, multifocality of tumor, or associated carcinoma in situ. There was a trend approaching statistical significance for patients with c-erbB2 amplifications to have positive lymph nodes at surgery (P = 0.09). A somewhat surprising finding however was a very strong association between oncogene amplification and dense lymphocyte infiltration of the tumor (P = .05). This correlation is even stronger when only high levels of amplification are considered, either for each oncogene separately (P = .0048) or in combination (P = .007). We propose that malignant cell cytokine production may help explain this observation. Wiley InterScience Backfile Collection 1832-2000 Tang, Ruoping oth Kacinski, Barry oth Validire, Pierre oth Beuvon, Frédéric oth Sastre, Xavier oth Benoit, Patrick oth dela Rochefordière, Anne oth Mosseri, Véronique oth Pouillart, Pierre oth Scholl, Susy oth in Journal of Cellular Biochemistry New York, N.Y. : Alan R. Liss, Inc 44(1990) vom: März, Seite 189-198 (DE-627)NLEJ159070694 (DE-600)1479976-5 0730-2312 nnns volume:44 year:1990 month:03 pages:189-198 extent:10 http://dx.doi.org/10.1002/jcb.240440307 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 44 1990 3 189-198 10 |
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(DE-627)NLEJ159853028 DE-627 ger DE-627 rakwb eng Oncogene amplification correlates with dense lymphocyte infiltration in human breast cancers: A role for hematopoietic growth factor release by tumor cells? 1990 3 Ill. 5 Tab. 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier One hundred six primary breast cancer samples were analysed for c-erbB2, int-2, and c-myc gene amplification. Surgically confirmed nodal involvement was observed in 42%. Level of gene amplification was studied by Southern and/or slot blottechniques. Amplified c-erbB2 gene sequences were present in 21.5% of all samples. Int-2 was amplified in 13.1% and c-myc was amplified in 10.3%. In a non-parametric test (Kruskal-Wallis) a strong negative association was found between high levels of c-erbB2 amplification and absence of estrogen receptor (ER) (P = .0009) or progesterone receptor (PR) (P = .011) expression. No correlations were found between all or high levels of amplification of each oncogene separately or combined with T, N, grade, multifocality of tumor, or associated carcinoma in situ. There was a trend approaching statistical significance for patients with c-erbB2 amplifications to have positive lymph nodes at surgery (P = 0.09). A somewhat surprising finding however was a very strong association between oncogene amplification and dense lymphocyte infiltration of the tumor (P = .05). This correlation is even stronger when only high levels of amplification are considered, either for each oncogene separately (P = .0048) or in combination (P = .007). We propose that malignant cell cytokine production may help explain this observation. Wiley InterScience Backfile Collection 1832-2000 Tang, Ruoping oth Kacinski, Barry oth Validire, Pierre oth Beuvon, Frédéric oth Sastre, Xavier oth Benoit, Patrick oth dela Rochefordière, Anne oth Mosseri, Véronique oth Pouillart, Pierre oth Scholl, Susy oth in Journal of Cellular Biochemistry New York, N.Y. : Alan R. Liss, Inc 44(1990) vom: März, Seite 189-198 (DE-627)NLEJ159070694 (DE-600)1479976-5 0730-2312 nnns volume:44 year:1990 month:03 pages:189-198 extent:10 http://dx.doi.org/10.1002/jcb.240440307 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 44 1990 3 189-198 10 |
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(DE-627)NLEJ159853028 DE-627 ger DE-627 rakwb eng Oncogene amplification correlates with dense lymphocyte infiltration in human breast cancers: A role for hematopoietic growth factor release by tumor cells? 1990 3 Ill. 5 Tab. 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier One hundred six primary breast cancer samples were analysed for c-erbB2, int-2, and c-myc gene amplification. Surgically confirmed nodal involvement was observed in 42%. Level of gene amplification was studied by Southern and/or slot blottechniques. Amplified c-erbB2 gene sequences were present in 21.5% of all samples. Int-2 was amplified in 13.1% and c-myc was amplified in 10.3%. In a non-parametric test (Kruskal-Wallis) a strong negative association was found between high levels of c-erbB2 amplification and absence of estrogen receptor (ER) (P = .0009) or progesterone receptor (PR) (P = .011) expression. No correlations were found between all or high levels of amplification of each oncogene separately or combined with T, N, grade, multifocality of tumor, or associated carcinoma in situ. There was a trend approaching statistical significance for patients with c-erbB2 amplifications to have positive lymph nodes at surgery (P = 0.09). A somewhat surprising finding however was a very strong association between oncogene amplification and dense lymphocyte infiltration of the tumor (P = .05). This correlation is even stronger when only high levels of amplification are considered, either for each oncogene separately (P = .0048) or in combination (P = .007). We propose that malignant cell cytokine production may help explain this observation. Wiley InterScience Backfile Collection 1832-2000 Tang, Ruoping oth Kacinski, Barry oth Validire, Pierre oth Beuvon, Frédéric oth Sastre, Xavier oth Benoit, Patrick oth dela Rochefordière, Anne oth Mosseri, Véronique oth Pouillart, Pierre oth Scholl, Susy oth in Journal of Cellular Biochemistry New York, N.Y. : Alan R. Liss, Inc 44(1990) vom: März, Seite 189-198 (DE-627)NLEJ159070694 (DE-600)1479976-5 0730-2312 nnns volume:44 year:1990 month:03 pages:189-198 extent:10 http://dx.doi.org/10.1002/jcb.240440307 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 44 1990 3 189-198 10 |
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(DE-627)NLEJ159853028 DE-627 ger DE-627 rakwb eng Oncogene amplification correlates with dense lymphocyte infiltration in human breast cancers: A role for hematopoietic growth factor release by tumor cells? 1990 3 Ill. 5 Tab. 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier One hundred six primary breast cancer samples were analysed for c-erbB2, int-2, and c-myc gene amplification. Surgically confirmed nodal involvement was observed in 42%. Level of gene amplification was studied by Southern and/or slot blottechniques. Amplified c-erbB2 gene sequences were present in 21.5% of all samples. Int-2 was amplified in 13.1% and c-myc was amplified in 10.3%. In a non-parametric test (Kruskal-Wallis) a strong negative association was found between high levels of c-erbB2 amplification and absence of estrogen receptor (ER) (P = .0009) or progesterone receptor (PR) (P = .011) expression. No correlations were found between all or high levels of amplification of each oncogene separately or combined with T, N, grade, multifocality of tumor, or associated carcinoma in situ. There was a trend approaching statistical significance for patients with c-erbB2 amplifications to have positive lymph nodes at surgery (P = 0.09). A somewhat surprising finding however was a very strong association between oncogene amplification and dense lymphocyte infiltration of the tumor (P = .05). This correlation is even stronger when only high levels of amplification are considered, either for each oncogene separately (P = .0048) or in combination (P = .007). We propose that malignant cell cytokine production may help explain this observation. Wiley InterScience Backfile Collection 1832-2000 Tang, Ruoping oth Kacinski, Barry oth Validire, Pierre oth Beuvon, Frédéric oth Sastre, Xavier oth Benoit, Patrick oth dela Rochefordière, Anne oth Mosseri, Véronique oth Pouillart, Pierre oth Scholl, Susy oth in Journal of Cellular Biochemistry New York, N.Y. : Alan R. Liss, Inc 44(1990) vom: März, Seite 189-198 (DE-627)NLEJ159070694 (DE-600)1479976-5 0730-2312 nnns volume:44 year:1990 month:03 pages:189-198 extent:10 http://dx.doi.org/10.1002/jcb.240440307 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 44 1990 3 189-198 10 |
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Oncogene amplification correlates with dense lymphocyte infiltration in human breast cancers: A role for hematopoietic growth factor release by tumor cells? |
| abstract |
One hundred six primary breast cancer samples were analysed for c-erbB2, int-2, and c-myc gene amplification. Surgically confirmed nodal involvement was observed in 42%. Level of gene amplification was studied by Southern and/or slot blottechniques. Amplified c-erbB2 gene sequences were present in 21.5% of all samples. Int-2 was amplified in 13.1% and c-myc was amplified in 10.3%. In a non-parametric test (Kruskal-Wallis) a strong negative association was found between high levels of c-erbB2 amplification and absence of estrogen receptor (ER) (P = .0009) or progesterone receptor (PR) (P = .011) expression. No correlations were found between all or high levels of amplification of each oncogene separately or combined with T, N, grade, multifocality of tumor, or associated carcinoma in situ. There was a trend approaching statistical significance for patients with c-erbB2 amplifications to have positive lymph nodes at surgery (P = 0.09). A somewhat surprising finding however was a very strong association between oncogene amplification and dense lymphocyte infiltration of the tumor (P = .05). This correlation is even stronger when only high levels of amplification are considered, either for each oncogene separately (P = .0048) or in combination (P = .007). We propose that malignant cell cytokine production may help explain this observation. |
| abstractGer |
One hundred six primary breast cancer samples were analysed for c-erbB2, int-2, and c-myc gene amplification. Surgically confirmed nodal involvement was observed in 42%. Level of gene amplification was studied by Southern and/or slot blottechniques. Amplified c-erbB2 gene sequences were present in 21.5% of all samples. Int-2 was amplified in 13.1% and c-myc was amplified in 10.3%. In a non-parametric test (Kruskal-Wallis) a strong negative association was found between high levels of c-erbB2 amplification and absence of estrogen receptor (ER) (P = .0009) or progesterone receptor (PR) (P = .011) expression. No correlations were found between all or high levels of amplification of each oncogene separately or combined with T, N, grade, multifocality of tumor, or associated carcinoma in situ. There was a trend approaching statistical significance for patients with c-erbB2 amplifications to have positive lymph nodes at surgery (P = 0.09). A somewhat surprising finding however was a very strong association between oncogene amplification and dense lymphocyte infiltration of the tumor (P = .05). This correlation is even stronger when only high levels of amplification are considered, either for each oncogene separately (P = .0048) or in combination (P = .007). We propose that malignant cell cytokine production may help explain this observation. |
| abstract_unstemmed |
One hundred six primary breast cancer samples were analysed for c-erbB2, int-2, and c-myc gene amplification. Surgically confirmed nodal involvement was observed in 42%. Level of gene amplification was studied by Southern and/or slot blottechniques. Amplified c-erbB2 gene sequences were present in 21.5% of all samples. Int-2 was amplified in 13.1% and c-myc was amplified in 10.3%. In a non-parametric test (Kruskal-Wallis) a strong negative association was found between high levels of c-erbB2 amplification and absence of estrogen receptor (ER) (P = .0009) or progesterone receptor (PR) (P = .011) expression. No correlations were found between all or high levels of amplification of each oncogene separately or combined with T, N, grade, multifocality of tumor, or associated carcinoma in situ. There was a trend approaching statistical significance for patients with c-erbB2 amplifications to have positive lymph nodes at surgery (P = 0.09). A somewhat surprising finding however was a very strong association between oncogene amplification and dense lymphocyte infiltration of the tumor (P = .05). This correlation is even stronger when only high levels of amplification are considered, either for each oncogene separately (P = .0048) or in combination (P = .007). We propose that malignant cell cytokine production may help explain this observation. |
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Oncogene amplification correlates with dense lymphocyte infiltration in human breast cancers: A role for hematopoietic growth factor release by tumor cells? |
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Tang, Ruoping Kacinski, Barry Validire, Pierre Beuvon, Frédéric Sastre, Xavier Benoit, Patrick dela Rochefordière, Anne Mosseri, Véronique Pouillart, Pierre Scholl, Susy |
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