Structural requirements for mitochondrial mutagenesis
Ethidium bromide (3, 8-diamino-5-ethyl-6-phenylphenanthridinium bromide) and euflavine (3, 6-diamino-10-methylacridinium chloride) are superficially similar in structure and ability to intercalate into DNA. However, they exhibit qualitative differences in their ability to bring about a mitochondrial...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1973 |
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| Umfang: |
4 Ill. ; 1 Tab. 12 |
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| Reproduktion: |
Wiley InterScience Backfile Collection 1832-2000 |
|---|---|
| Übergeordnetes Werk: |
in: Journal of Supramolecular Structure - New York, N.Y. : Alan R. Liss, Inc, 1(1973) vom: Juni, Seite 449-460 |
| Übergeordnetes Werk: |
volume:1 ; year:1973 ; month:06 ; pages:449-460 ; extent:12 |
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NLEJ159891590 |
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| 520 | |a Ethidium bromide (3, 8-diamino-5-ethyl-6-phenylphenanthridinium bromide) and euflavine (3, 6-diamino-10-methylacridinium chloride) are superficially similar in structure and ability to intercalate into DNA. However, they exhibit qualitative differences in their ability to bring about a mitochondrial mutation (ρ+ → ρ-) in Saccharomyces cerevisiae. This investigation tried to establish and compare the essential structural prerequisites in three series of planar, heterocyclic dyes: the phenanthridines (P series), the acridines (A series), and molecules with different heteroatoms related to acridines (X series). Compounds capable of bringing about the mutation in the complete absence of growth and energy sources are restricted to di-primary amines in the P series: quaternization of the ring nitrogen, and an aromatic side chain at C-6 also appear essential. Compounds in the A series are mutagenic only with growing cells; quaternization (C1 through C4) is essential. The 10-allyl derivative is unusual; it is highly effective even in buffer supplemented only with an energy source. The results are interpreted in terms of a model that requires interaction of the mutagen with the mitochondrial inner membrane as well as with its DNA. | ||
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(DE-627)NLEJ159891590 DE-627 ger DE-627 rakwb eng Structural requirements for mitochondrial mutagenesis 1973 4 Ill. 1 Tab. 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Ethidium bromide (3, 8-diamino-5-ethyl-6-phenylphenanthridinium bromide) and euflavine (3, 6-diamino-10-methylacridinium chloride) are superficially similar in structure and ability to intercalate into DNA. However, they exhibit qualitative differences in their ability to bring about a mitochondrial mutation (ρ+ → ρ-) in Saccharomyces cerevisiae. This investigation tried to establish and compare the essential structural prerequisites in three series of planar, heterocyclic dyes: the phenanthridines (P series), the acridines (A series), and molecules with different heteroatoms related to acridines (X series). Compounds capable of bringing about the mutation in the complete absence of growth and energy sources are restricted to di-primary amines in the P series: quaternization of the ring nitrogen, and an aromatic side chain at C-6 also appear essential. Compounds in the A series are mutagenic only with growing cells; quaternization (C1 through C4) is essential. The 10-allyl derivative is unusual; it is highly effective even in buffer supplemented only with an energy source. The results are interpreted in terms of a model that requires interaction of the mutagen with the mitochondrial inner membrane as well as with its DNA. Wiley InterScience Backfile Collection 1832-2000 Mahler, Henry R. oth in Journal of Supramolecular Structure New York, N.Y. : Alan R. Liss, Inc 1(1973) vom: Juni, Seite 449-460 (DE-627)NLEJ159070716 0091-7419 nnns volume:1 year:1973 month:06 pages:449-460 extent:12 http://dx.doi.org/10.1002/jss.400010602 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 1 1973 6 449-460 12 |
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(DE-627)NLEJ159891590 DE-627 ger DE-627 rakwb eng Structural requirements for mitochondrial mutagenesis 1973 4 Ill. 1 Tab. 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Ethidium bromide (3, 8-diamino-5-ethyl-6-phenylphenanthridinium bromide) and euflavine (3, 6-diamino-10-methylacridinium chloride) are superficially similar in structure and ability to intercalate into DNA. However, they exhibit qualitative differences in their ability to bring about a mitochondrial mutation (ρ+ → ρ-) in Saccharomyces cerevisiae. This investigation tried to establish and compare the essential structural prerequisites in three series of planar, heterocyclic dyes: the phenanthridines (P series), the acridines (A series), and molecules with different heteroatoms related to acridines (X series). Compounds capable of bringing about the mutation in the complete absence of growth and energy sources are restricted to di-primary amines in the P series: quaternization of the ring nitrogen, and an aromatic side chain at C-6 also appear essential. Compounds in the A series are mutagenic only with growing cells; quaternization (C1 through C4) is essential. The 10-allyl derivative is unusual; it is highly effective even in buffer supplemented only with an energy source. The results are interpreted in terms of a model that requires interaction of the mutagen with the mitochondrial inner membrane as well as with its DNA. Wiley InterScience Backfile Collection 1832-2000 Mahler, Henry R. oth in Journal of Supramolecular Structure New York, N.Y. : Alan R. Liss, Inc 1(1973) vom: Juni, Seite 449-460 (DE-627)NLEJ159070716 0091-7419 nnns volume:1 year:1973 month:06 pages:449-460 extent:12 http://dx.doi.org/10.1002/jss.400010602 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 1 1973 6 449-460 12 |
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(DE-627)NLEJ159891590 DE-627 ger DE-627 rakwb eng Structural requirements for mitochondrial mutagenesis 1973 4 Ill. 1 Tab. 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Ethidium bromide (3, 8-diamino-5-ethyl-6-phenylphenanthridinium bromide) and euflavine (3, 6-diamino-10-methylacridinium chloride) are superficially similar in structure and ability to intercalate into DNA. However, they exhibit qualitative differences in their ability to bring about a mitochondrial mutation (ρ+ → ρ-) in Saccharomyces cerevisiae. This investigation tried to establish and compare the essential structural prerequisites in three series of planar, heterocyclic dyes: the phenanthridines (P series), the acridines (A series), and molecules with different heteroatoms related to acridines (X series). Compounds capable of bringing about the mutation in the complete absence of growth and energy sources are restricted to di-primary amines in the P series: quaternization of the ring nitrogen, and an aromatic side chain at C-6 also appear essential. Compounds in the A series are mutagenic only with growing cells; quaternization (C1 through C4) is essential. The 10-allyl derivative is unusual; it is highly effective even in buffer supplemented only with an energy source. The results are interpreted in terms of a model that requires interaction of the mutagen with the mitochondrial inner membrane as well as with its DNA. Wiley InterScience Backfile Collection 1832-2000 Mahler, Henry R. oth in Journal of Supramolecular Structure New York, N.Y. : Alan R. Liss, Inc 1(1973) vom: Juni, Seite 449-460 (DE-627)NLEJ159070716 0091-7419 nnns volume:1 year:1973 month:06 pages:449-460 extent:12 http://dx.doi.org/10.1002/jss.400010602 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 1 1973 6 449-460 12 |
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(DE-627)NLEJ159891590 DE-627 ger DE-627 rakwb eng Structural requirements for mitochondrial mutagenesis 1973 4 Ill. 1 Tab. 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Ethidium bromide (3, 8-diamino-5-ethyl-6-phenylphenanthridinium bromide) and euflavine (3, 6-diamino-10-methylacridinium chloride) are superficially similar in structure and ability to intercalate into DNA. However, they exhibit qualitative differences in their ability to bring about a mitochondrial mutation (ρ+ → ρ-) in Saccharomyces cerevisiae. This investigation tried to establish and compare the essential structural prerequisites in three series of planar, heterocyclic dyes: the phenanthridines (P series), the acridines (A series), and molecules with different heteroatoms related to acridines (X series). Compounds capable of bringing about the mutation in the complete absence of growth and energy sources are restricted to di-primary amines in the P series: quaternization of the ring nitrogen, and an aromatic side chain at C-6 also appear essential. Compounds in the A series are mutagenic only with growing cells; quaternization (C1 through C4) is essential. The 10-allyl derivative is unusual; it is highly effective even in buffer supplemented only with an energy source. The results are interpreted in terms of a model that requires interaction of the mutagen with the mitochondrial inner membrane as well as with its DNA. Wiley InterScience Backfile Collection 1832-2000 Mahler, Henry R. oth in Journal of Supramolecular Structure New York, N.Y. : Alan R. Liss, Inc 1(1973) vom: Juni, Seite 449-460 (DE-627)NLEJ159070716 0091-7419 nnns volume:1 year:1973 month:06 pages:449-460 extent:12 http://dx.doi.org/10.1002/jss.400010602 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 1 1973 6 449-460 12 |
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(DE-627)NLEJ159891590 DE-627 ger DE-627 rakwb eng Structural requirements for mitochondrial mutagenesis 1973 4 Ill. 1 Tab. 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Ethidium bromide (3, 8-diamino-5-ethyl-6-phenylphenanthridinium bromide) and euflavine (3, 6-diamino-10-methylacridinium chloride) are superficially similar in structure and ability to intercalate into DNA. However, they exhibit qualitative differences in their ability to bring about a mitochondrial mutation (ρ+ → ρ-) in Saccharomyces cerevisiae. This investigation tried to establish and compare the essential structural prerequisites in three series of planar, heterocyclic dyes: the phenanthridines (P series), the acridines (A series), and molecules with different heteroatoms related to acridines (X series). Compounds capable of bringing about the mutation in the complete absence of growth and energy sources are restricted to di-primary amines in the P series: quaternization of the ring nitrogen, and an aromatic side chain at C-6 also appear essential. Compounds in the A series are mutagenic only with growing cells; quaternization (C1 through C4) is essential. The 10-allyl derivative is unusual; it is highly effective even in buffer supplemented only with an energy source. The results are interpreted in terms of a model that requires interaction of the mutagen with the mitochondrial inner membrane as well as with its DNA. Wiley InterScience Backfile Collection 1832-2000 Mahler, Henry R. oth in Journal of Supramolecular Structure New York, N.Y. : Alan R. Liss, Inc 1(1973) vom: Juni, Seite 449-460 (DE-627)NLEJ159070716 0091-7419 nnns volume:1 year:1973 month:06 pages:449-460 extent:12 http://dx.doi.org/10.1002/jss.400010602 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 1 1973 6 449-460 12 |
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Structural requirements for mitochondrial mutagenesis |
| abstract |
Ethidium bromide (3, 8-diamino-5-ethyl-6-phenylphenanthridinium bromide) and euflavine (3, 6-diamino-10-methylacridinium chloride) are superficially similar in structure and ability to intercalate into DNA. However, they exhibit qualitative differences in their ability to bring about a mitochondrial mutation (ρ+ → ρ-) in Saccharomyces cerevisiae. This investigation tried to establish and compare the essential structural prerequisites in three series of planar, heterocyclic dyes: the phenanthridines (P series), the acridines (A series), and molecules with different heteroatoms related to acridines (X series). Compounds capable of bringing about the mutation in the complete absence of growth and energy sources are restricted to di-primary amines in the P series: quaternization of the ring nitrogen, and an aromatic side chain at C-6 also appear essential. Compounds in the A series are mutagenic only with growing cells; quaternization (C1 through C4) is essential. The 10-allyl derivative is unusual; it is highly effective even in buffer supplemented only with an energy source. The results are interpreted in terms of a model that requires interaction of the mutagen with the mitochondrial inner membrane as well as with its DNA. |
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Ethidium bromide (3, 8-diamino-5-ethyl-6-phenylphenanthridinium bromide) and euflavine (3, 6-diamino-10-methylacridinium chloride) are superficially similar in structure and ability to intercalate into DNA. However, they exhibit qualitative differences in their ability to bring about a mitochondrial mutation (ρ+ → ρ-) in Saccharomyces cerevisiae. This investigation tried to establish and compare the essential structural prerequisites in three series of planar, heterocyclic dyes: the phenanthridines (P series), the acridines (A series), and molecules with different heteroatoms related to acridines (X series). Compounds capable of bringing about the mutation in the complete absence of growth and energy sources are restricted to di-primary amines in the P series: quaternization of the ring nitrogen, and an aromatic side chain at C-6 also appear essential. Compounds in the A series are mutagenic only with growing cells; quaternization (C1 through C4) is essential. The 10-allyl derivative is unusual; it is highly effective even in buffer supplemented only with an energy source. The results are interpreted in terms of a model that requires interaction of the mutagen with the mitochondrial inner membrane as well as with its DNA. |
| abstract_unstemmed |
Ethidium bromide (3, 8-diamino-5-ethyl-6-phenylphenanthridinium bromide) and euflavine (3, 6-diamino-10-methylacridinium chloride) are superficially similar in structure and ability to intercalate into DNA. However, they exhibit qualitative differences in their ability to bring about a mitochondrial mutation (ρ+ → ρ-) in Saccharomyces cerevisiae. This investigation tried to establish and compare the essential structural prerequisites in three series of planar, heterocyclic dyes: the phenanthridines (P series), the acridines (A series), and molecules with different heteroatoms related to acridines (X series). Compounds capable of bringing about the mutation in the complete absence of growth and energy sources are restricted to di-primary amines in the P series: quaternization of the ring nitrogen, and an aromatic side chain at C-6 also appear essential. Compounds in the A series are mutagenic only with growing cells; quaternization (C1 through C4) is essential. The 10-allyl derivative is unusual; it is highly effective even in buffer supplemented only with an energy source. The results are interpreted in terms of a model that requires interaction of the mutagen with the mitochondrial inner membrane as well as with its DNA. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ159891590</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707021307.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070201s1973 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ159891590</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Structural requirements for mitochondrial mutagenesis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1973</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="b">4 Ill.</subfield><subfield code="b">1 Tab.</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">12</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Ethidium bromide (3, 8-diamino-5-ethyl-6-phenylphenanthridinium bromide) and euflavine (3, 6-diamino-10-methylacridinium chloride) are superficially similar in structure and ability to intercalate into DNA. However, they exhibit qualitative differences in their ability to bring about a mitochondrial mutation (ρ+ → ρ-) in Saccharomyces cerevisiae. This investigation tried to establish and compare the essential structural prerequisites in three series of planar, heterocyclic dyes: the phenanthridines (P series), the acridines (A series), and molecules with different heteroatoms related to acridines (X series). Compounds capable of bringing about the mutation in the complete absence of growth and energy sources are restricted to di-primary amines in the P series: quaternization of the ring nitrogen, and an aromatic side chain at C-6 also appear essential. Compounds in the A series are mutagenic only with growing cells; quaternization (C1 through C4) is essential. The 10-allyl derivative is unusual; it is highly effective even in buffer supplemented only with an energy source. The results are interpreted in terms of a model that requires interaction of the mutagen with the mitochondrial inner membrane as well as with its DNA.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Wiley InterScience Backfile Collection 1832-2000</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mahler, Henry R.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Journal of Supramolecular Structure</subfield><subfield code="d">New York, N.Y. : Alan R. Liss, Inc</subfield><subfield code="g">1(1973) vom: Juni, Seite 449-460</subfield><subfield code="w">(DE-627)NLEJ159070716</subfield><subfield code="x">0091-7419</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:1</subfield><subfield code="g">year:1973</subfield><subfield code="g">month:06</subfield><subfield code="g">pages:449-460</subfield><subfield code="g">extent:12</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1002/jss.400010602</subfield><subfield code="q">text/html</subfield><subfield code="z">Deutschlandweit zugänglich</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-WIS</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">1</subfield><subfield code="j">1973</subfield><subfield code="c">6</subfield><subfield code="h">449-460</subfield><subfield code="g">12</subfield></datafield></record></collection>
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7.402916 |