Inhibition of the tissue reaction to a biodegradable biomaterial by monoclonal antibodies to IFN-γ
Biomaterials are increasingly used for clinical applications. However, loss of function may occur owing to tissue reactions, which are mainly caused by a variety of inflammatory reactions. Recently, we demonstrated that macrophages (MØ) and T cells play key roles in these reactions. Since immunologi...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1998 |
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| Umfang: |
8 Ill. 9 |
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| Reproduktion: |
Wiley InterScience Backfile Collection 1832-2000 |
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| Übergeordnetes Werk: |
in: Journal of Biomedical Materials Research - Hoboken, NJ : Wiley, 41(1998) vom: Feb., Seite 202-210 |
| Übergeordnetes Werk: |
volume:41 ; year:1998 ; month:02 ; pages:202-210 ; extent:9 |
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| 520 | |a Biomaterials are increasingly used for clinical applications. However, loss of function may occur owing to tissue reactions, which are mainly caused by a variety of inflammatory reactions. Recently, we demonstrated that macrophages (MØ) and T cells play key roles in these reactions. Since immunological studies showed that the T cell-derived cytokine interferon-γ (IFN-γ) activates MØ, the aim of this study was to investigate the possibility of modulating tissue reactions to biodegradable biomaterials by inactivating IFN-γ. Dermal sheep collagen (DSC) was used as a test biomaterial. DSC impregnated with anti-IFN-γ or phosphate-buffered saline (control) was implanted in rats. The results showed that cellular ingrowth and formation and function of giant cells were strongly delayed by anti-IFN-γ. Also, MHC class II expression was strongly inhibited. In the treated DSC, some huge giant cells were formed at the interface but association with the DSC bundles did not occur. Finally, in both the control and treated DSC, T cells and NK cells were rarely detected. This study demonstrates that IFN-γ plays an important role in the inflammatory reaction to biomaterials. This reaction can be modulated by anti-IFN-γ, which warrants further studies of anti-IFN-γ for clinical application to prevent unwanted tissue reactions to biomaterials. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 41, 202-210, 1998. | ||
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(DE-627)NLEJ160202361 DE-627 ger DE-627 rakwb eng Inhibition of the tissue reaction to a biodegradable biomaterial by monoclonal antibodies to IFN-γ 1998 8 Ill. 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Biomaterials are increasingly used for clinical applications. However, loss of function may occur owing to tissue reactions, which are mainly caused by a variety of inflammatory reactions. Recently, we demonstrated that macrophages (MØ) and T cells play key roles in these reactions. Since immunological studies showed that the T cell-derived cytokine interferon-γ (IFN-γ) activates MØ, the aim of this study was to investigate the possibility of modulating tissue reactions to biodegradable biomaterials by inactivating IFN-γ. Dermal sheep collagen (DSC) was used as a test biomaterial. DSC impregnated with anti-IFN-γ or phosphate-buffered saline (control) was implanted in rats. The results showed that cellular ingrowth and formation and function of giant cells were strongly delayed by anti-IFN-γ. Also, MHC class II expression was strongly inhibited. In the treated DSC, some huge giant cells were formed at the interface but association with the DSC bundles did not occur. Finally, in both the control and treated DSC, T cells and NK cells were rarely detected. This study demonstrates that IFN-γ plays an important role in the inflammatory reaction to biomaterials. This reaction can be modulated by anti-IFN-γ, which warrants further studies of anti-IFN-γ for clinical application to prevent unwanted tissue reactions to biomaterials. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 41, 202-210, 1998. Wiley InterScience Backfile Collection 1832-2000 Khouw, I. M. S. L. oth van Wachem, P. B. oth de Leij, L. F. M. H. oth van Luyn, M. J. A. oth in Journal of Biomedical Materials Research Hoboken, NJ : Wiley 41(1998) vom: Feb., Seite 202-210 (DE-627)NLEJ159070848 (DE-600)2176174-7 0021-9304 nnns volume:41 year:1998 month:02 pages:202-210 extent:9 http://dx.doi.org/10.1002/(SICI)1097-4636(199808)41:2<202::AID-JBM4>3.0.CO;2-M text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 41 1998 2 202-210 9 |
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(DE-627)NLEJ160202361 DE-627 ger DE-627 rakwb eng Inhibition of the tissue reaction to a biodegradable biomaterial by monoclonal antibodies to IFN-γ 1998 8 Ill. 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Biomaterials are increasingly used for clinical applications. However, loss of function may occur owing to tissue reactions, which are mainly caused by a variety of inflammatory reactions. Recently, we demonstrated that macrophages (MØ) and T cells play key roles in these reactions. Since immunological studies showed that the T cell-derived cytokine interferon-γ (IFN-γ) activates MØ, the aim of this study was to investigate the possibility of modulating tissue reactions to biodegradable biomaterials by inactivating IFN-γ. Dermal sheep collagen (DSC) was used as a test biomaterial. DSC impregnated with anti-IFN-γ or phosphate-buffered saline (control) was implanted in rats. The results showed that cellular ingrowth and formation and function of giant cells were strongly delayed by anti-IFN-γ. Also, MHC class II expression was strongly inhibited. In the treated DSC, some huge giant cells were formed at the interface but association with the DSC bundles did not occur. Finally, in both the control and treated DSC, T cells and NK cells were rarely detected. This study demonstrates that IFN-γ plays an important role in the inflammatory reaction to biomaterials. This reaction can be modulated by anti-IFN-γ, which warrants further studies of anti-IFN-γ for clinical application to prevent unwanted tissue reactions to biomaterials. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 41, 202-210, 1998. Wiley InterScience Backfile Collection 1832-2000 Khouw, I. M. S. L. oth van Wachem, P. B. oth de Leij, L. F. M. H. oth van Luyn, M. J. A. oth in Journal of Biomedical Materials Research Hoboken, NJ : Wiley 41(1998) vom: Feb., Seite 202-210 (DE-627)NLEJ159070848 (DE-600)2176174-7 0021-9304 nnns volume:41 year:1998 month:02 pages:202-210 extent:9 http://dx.doi.org/10.1002/(SICI)1097-4636(199808)41:2<202::AID-JBM4>3.0.CO;2-M text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 41 1998 2 202-210 9 |
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(DE-627)NLEJ160202361 DE-627 ger DE-627 rakwb eng Inhibition of the tissue reaction to a biodegradable biomaterial by monoclonal antibodies to IFN-γ 1998 8 Ill. 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Biomaterials are increasingly used for clinical applications. However, loss of function may occur owing to tissue reactions, which are mainly caused by a variety of inflammatory reactions. Recently, we demonstrated that macrophages (MØ) and T cells play key roles in these reactions. Since immunological studies showed that the T cell-derived cytokine interferon-γ (IFN-γ) activates MØ, the aim of this study was to investigate the possibility of modulating tissue reactions to biodegradable biomaterials by inactivating IFN-γ. Dermal sheep collagen (DSC) was used as a test biomaterial. DSC impregnated with anti-IFN-γ or phosphate-buffered saline (control) was implanted in rats. The results showed that cellular ingrowth and formation and function of giant cells were strongly delayed by anti-IFN-γ. Also, MHC class II expression was strongly inhibited. In the treated DSC, some huge giant cells were formed at the interface but association with the DSC bundles did not occur. Finally, in both the control and treated DSC, T cells and NK cells were rarely detected. This study demonstrates that IFN-γ plays an important role in the inflammatory reaction to biomaterials. This reaction can be modulated by anti-IFN-γ, which warrants further studies of anti-IFN-γ for clinical application to prevent unwanted tissue reactions to biomaterials. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 41, 202-210, 1998. Wiley InterScience Backfile Collection 1832-2000 Khouw, I. M. S. L. oth van Wachem, P. B. oth de Leij, L. F. M. H. oth van Luyn, M. J. A. oth in Journal of Biomedical Materials Research Hoboken, NJ : Wiley 41(1998) vom: Feb., Seite 202-210 (DE-627)NLEJ159070848 (DE-600)2176174-7 0021-9304 nnns volume:41 year:1998 month:02 pages:202-210 extent:9 http://dx.doi.org/10.1002/(SICI)1097-4636(199808)41:2<202::AID-JBM4>3.0.CO;2-M text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 41 1998 2 202-210 9 |
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(DE-627)NLEJ160202361 DE-627 ger DE-627 rakwb eng Inhibition of the tissue reaction to a biodegradable biomaterial by monoclonal antibodies to IFN-γ 1998 8 Ill. 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Biomaterials are increasingly used for clinical applications. However, loss of function may occur owing to tissue reactions, which are mainly caused by a variety of inflammatory reactions. Recently, we demonstrated that macrophages (MØ) and T cells play key roles in these reactions. Since immunological studies showed that the T cell-derived cytokine interferon-γ (IFN-γ) activates MØ, the aim of this study was to investigate the possibility of modulating tissue reactions to biodegradable biomaterials by inactivating IFN-γ. Dermal sheep collagen (DSC) was used as a test biomaterial. DSC impregnated with anti-IFN-γ or phosphate-buffered saline (control) was implanted in rats. The results showed that cellular ingrowth and formation and function of giant cells were strongly delayed by anti-IFN-γ. Also, MHC class II expression was strongly inhibited. In the treated DSC, some huge giant cells were formed at the interface but association with the DSC bundles did not occur. Finally, in both the control and treated DSC, T cells and NK cells were rarely detected. This study demonstrates that IFN-γ plays an important role in the inflammatory reaction to biomaterials. This reaction can be modulated by anti-IFN-γ, which warrants further studies of anti-IFN-γ for clinical application to prevent unwanted tissue reactions to biomaterials. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 41, 202-210, 1998. Wiley InterScience Backfile Collection 1832-2000 Khouw, I. M. S. L. oth van Wachem, P. B. oth de Leij, L. F. M. H. oth van Luyn, M. J. A. oth in Journal of Biomedical Materials Research Hoboken, NJ : Wiley 41(1998) vom: Feb., Seite 202-210 (DE-627)NLEJ159070848 (DE-600)2176174-7 0021-9304 nnns volume:41 year:1998 month:02 pages:202-210 extent:9 http://dx.doi.org/10.1002/(SICI)1097-4636(199808)41:2<202::AID-JBM4>3.0.CO;2-M text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 41 1998 2 202-210 9 |
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Inhibition of the tissue reaction to a biodegradable biomaterial by monoclonal antibodies to IFN-γ |
| abstract |
Biomaterials are increasingly used for clinical applications. However, loss of function may occur owing to tissue reactions, which are mainly caused by a variety of inflammatory reactions. Recently, we demonstrated that macrophages (MØ) and T cells play key roles in these reactions. Since immunological studies showed that the T cell-derived cytokine interferon-γ (IFN-γ) activates MØ, the aim of this study was to investigate the possibility of modulating tissue reactions to biodegradable biomaterials by inactivating IFN-γ. Dermal sheep collagen (DSC) was used as a test biomaterial. DSC impregnated with anti-IFN-γ or phosphate-buffered saline (control) was implanted in rats. The results showed that cellular ingrowth and formation and function of giant cells were strongly delayed by anti-IFN-γ. Also, MHC class II expression was strongly inhibited. In the treated DSC, some huge giant cells were formed at the interface but association with the DSC bundles did not occur. Finally, in both the control and treated DSC, T cells and NK cells were rarely detected. This study demonstrates that IFN-γ plays an important role in the inflammatory reaction to biomaterials. This reaction can be modulated by anti-IFN-γ, which warrants further studies of anti-IFN-γ for clinical application to prevent unwanted tissue reactions to biomaterials. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 41, 202-210, 1998. |
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Biomaterials are increasingly used for clinical applications. However, loss of function may occur owing to tissue reactions, which are mainly caused by a variety of inflammatory reactions. Recently, we demonstrated that macrophages (MØ) and T cells play key roles in these reactions. Since immunological studies showed that the T cell-derived cytokine interferon-γ (IFN-γ) activates MØ, the aim of this study was to investigate the possibility of modulating tissue reactions to biodegradable biomaterials by inactivating IFN-γ. Dermal sheep collagen (DSC) was used as a test biomaterial. DSC impregnated with anti-IFN-γ or phosphate-buffered saline (control) was implanted in rats. The results showed that cellular ingrowth and formation and function of giant cells were strongly delayed by anti-IFN-γ. Also, MHC class II expression was strongly inhibited. In the treated DSC, some huge giant cells were formed at the interface but association with the DSC bundles did not occur. Finally, in both the control and treated DSC, T cells and NK cells were rarely detected. This study demonstrates that IFN-γ plays an important role in the inflammatory reaction to biomaterials. This reaction can be modulated by anti-IFN-γ, which warrants further studies of anti-IFN-γ for clinical application to prevent unwanted tissue reactions to biomaterials. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 41, 202-210, 1998. |
| abstract_unstemmed |
Biomaterials are increasingly used for clinical applications. However, loss of function may occur owing to tissue reactions, which are mainly caused by a variety of inflammatory reactions. Recently, we demonstrated that macrophages (MØ) and T cells play key roles in these reactions. Since immunological studies showed that the T cell-derived cytokine interferon-γ (IFN-γ) activates MØ, the aim of this study was to investigate the possibility of modulating tissue reactions to biodegradable biomaterials by inactivating IFN-γ. Dermal sheep collagen (DSC) was used as a test biomaterial. DSC impregnated with anti-IFN-γ or phosphate-buffered saline (control) was implanted in rats. The results showed that cellular ingrowth and formation and function of giant cells were strongly delayed by anti-IFN-γ. Also, MHC class II expression was strongly inhibited. In the treated DSC, some huge giant cells were formed at the interface but association with the DSC bundles did not occur. Finally, in both the control and treated DSC, T cells and NK cells were rarely detected. This study demonstrates that IFN-γ plays an important role in the inflammatory reaction to biomaterials. This reaction can be modulated by anti-IFN-γ, which warrants further studies of anti-IFN-γ for clinical application to prevent unwanted tissue reactions to biomaterials. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 41, 202-210, 1998. |
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Inhibition of the tissue reaction to a biodegradable biomaterial by monoclonal antibodies to IFN-γ |
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Khouw, I. M. S. L. van Wachem, P. B. de Leij, L. F. M. H. van Luyn, M. J. A. |
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