The molecular biology of differentiation and proliferation using human myelogenous leukemia cells
Cell lines and cell samples from patients provide opportunities for studying the mechanisms of leukemic cellular differentiation and proliferation. Phorbol esters and 1,25 dihydroxy vitamin D3 can induce differentiation of myeloid leukemic cells to macrophages. Differentiation to granulocytes can be...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1986 |
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| Umfang: |
1 Ill. ; 2 Tab. 4 |
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| Reproduktion: |
Wiley InterScience Backfile Collection 1832-2000 |
|---|---|
| Übergeordnetes Werk: |
in: BioEssays - New York, NY : Wiley-Liss, 5(1986) vom: Jan., Seite 18-21 |
| Übergeordnetes Werk: |
volume:5 ; year:1986 ; month:01 ; pages:18-21 ; extent:4 |
| Links: |
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NLEJ16049477X |
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| 520 | |a Cell lines and cell samples from patients provide opportunities for studying the mechanisms of leukemic cellular differentiation and proliferation. Phorbol esters and 1,25 dihydroxy vitamin D3 can induce differentiation of myeloid leukemic cells to macrophages. Differentiation to granulocytes can be induced by several different compounds. Myeloid differentiation is associated closely with the alteration in expression of several oncogenes. These regulatory events may be associated with the extent of methylation, unfolding or association of chromatin to the nuclear matrix. Oncogene amplification, mutation, or deletion can occur with malignant transformation. Future studies point to the development of specific pharmacological agents which can modify the neoplastic transformation. | ||
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(DE-627)NLEJ16049477X DE-627 ger DE-627 rakwb eng The molecular biology of differentiation and proliferation using human myelogenous leukemia cells 1986 1 Ill. 2 Tab. 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Cell lines and cell samples from patients provide opportunities for studying the mechanisms of leukemic cellular differentiation and proliferation. Phorbol esters and 1,25 dihydroxy vitamin D3 can induce differentiation of myeloid leukemic cells to macrophages. Differentiation to granulocytes can be induced by several different compounds. Myeloid differentiation is associated closely with the alteration in expression of several oncogenes. These regulatory events may be associated with the extent of methylation, unfolding or association of chromatin to the nuclear matrix. Oncogene amplification, mutation, or deletion can occur with malignant transformation. Future studies point to the development of specific pharmacological agents which can modify the neoplastic transformation. Wiley InterScience Backfile Collection 1832-2000 Miller, Carl oth Koeffler, H. Phillip oth in BioEssays New York, NY : Wiley-Liss 5(1986) vom: Jan., Seite 18-21 (DE-627)NLEJ159070902 (DE-600)1473795-4 0265-9247 nnns volume:5 year:1986 month:01 pages:18-21 extent:4 http://dx.doi.org/10.1002/bies.950050106 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 5 1986 1 18-21 4 |
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(DE-627)NLEJ16049477X DE-627 ger DE-627 rakwb eng The molecular biology of differentiation and proliferation using human myelogenous leukemia cells 1986 1 Ill. 2 Tab. 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Cell lines and cell samples from patients provide opportunities for studying the mechanisms of leukemic cellular differentiation and proliferation. Phorbol esters and 1,25 dihydroxy vitamin D3 can induce differentiation of myeloid leukemic cells to macrophages. Differentiation to granulocytes can be induced by several different compounds. Myeloid differentiation is associated closely with the alteration in expression of several oncogenes. These regulatory events may be associated with the extent of methylation, unfolding or association of chromatin to the nuclear matrix. Oncogene amplification, mutation, or deletion can occur with malignant transformation. Future studies point to the development of specific pharmacological agents which can modify the neoplastic transformation. Wiley InterScience Backfile Collection 1832-2000 Miller, Carl oth Koeffler, H. Phillip oth in BioEssays New York, NY : Wiley-Liss 5(1986) vom: Jan., Seite 18-21 (DE-627)NLEJ159070902 (DE-600)1473795-4 0265-9247 nnns volume:5 year:1986 month:01 pages:18-21 extent:4 http://dx.doi.org/10.1002/bies.950050106 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 5 1986 1 18-21 4 |
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(DE-627)NLEJ16049477X DE-627 ger DE-627 rakwb eng The molecular biology of differentiation and proliferation using human myelogenous leukemia cells 1986 1 Ill. 2 Tab. 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Cell lines and cell samples from patients provide opportunities for studying the mechanisms of leukemic cellular differentiation and proliferation. Phorbol esters and 1,25 dihydroxy vitamin D3 can induce differentiation of myeloid leukemic cells to macrophages. Differentiation to granulocytes can be induced by several different compounds. Myeloid differentiation is associated closely with the alteration in expression of several oncogenes. These regulatory events may be associated with the extent of methylation, unfolding or association of chromatin to the nuclear matrix. Oncogene amplification, mutation, or deletion can occur with malignant transformation. Future studies point to the development of specific pharmacological agents which can modify the neoplastic transformation. Wiley InterScience Backfile Collection 1832-2000 Miller, Carl oth Koeffler, H. Phillip oth in BioEssays New York, NY : Wiley-Liss 5(1986) vom: Jan., Seite 18-21 (DE-627)NLEJ159070902 (DE-600)1473795-4 0265-9247 nnns volume:5 year:1986 month:01 pages:18-21 extent:4 http://dx.doi.org/10.1002/bies.950050106 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 5 1986 1 18-21 4 |
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(DE-627)NLEJ16049477X DE-627 ger DE-627 rakwb eng The molecular biology of differentiation and proliferation using human myelogenous leukemia cells 1986 1 Ill. 2 Tab. 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Cell lines and cell samples from patients provide opportunities for studying the mechanisms of leukemic cellular differentiation and proliferation. Phorbol esters and 1,25 dihydroxy vitamin D3 can induce differentiation of myeloid leukemic cells to macrophages. Differentiation to granulocytes can be induced by several different compounds. Myeloid differentiation is associated closely with the alteration in expression of several oncogenes. These regulatory events may be associated with the extent of methylation, unfolding or association of chromatin to the nuclear matrix. Oncogene amplification, mutation, or deletion can occur with malignant transformation. Future studies point to the development of specific pharmacological agents which can modify the neoplastic transformation. Wiley InterScience Backfile Collection 1832-2000 Miller, Carl oth Koeffler, H. Phillip oth in BioEssays New York, NY : Wiley-Liss 5(1986) vom: Jan., Seite 18-21 (DE-627)NLEJ159070902 (DE-600)1473795-4 0265-9247 nnns volume:5 year:1986 month:01 pages:18-21 extent:4 http://dx.doi.org/10.1002/bies.950050106 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 5 1986 1 18-21 4 |
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(DE-627)NLEJ16049477X DE-627 ger DE-627 rakwb eng The molecular biology of differentiation and proliferation using human myelogenous leukemia cells 1986 1 Ill. 2 Tab. 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Cell lines and cell samples from patients provide opportunities for studying the mechanisms of leukemic cellular differentiation and proliferation. Phorbol esters and 1,25 dihydroxy vitamin D3 can induce differentiation of myeloid leukemic cells to macrophages. Differentiation to granulocytes can be induced by several different compounds. Myeloid differentiation is associated closely with the alteration in expression of several oncogenes. These regulatory events may be associated with the extent of methylation, unfolding or association of chromatin to the nuclear matrix. Oncogene amplification, mutation, or deletion can occur with malignant transformation. Future studies point to the development of specific pharmacological agents which can modify the neoplastic transformation. Wiley InterScience Backfile Collection 1832-2000 Miller, Carl oth Koeffler, H. Phillip oth in BioEssays New York, NY : Wiley-Liss 5(1986) vom: Jan., Seite 18-21 (DE-627)NLEJ159070902 (DE-600)1473795-4 0265-9247 nnns volume:5 year:1986 month:01 pages:18-21 extent:4 http://dx.doi.org/10.1002/bies.950050106 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 5 1986 1 18-21 4 |
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the molecular biology of differentiation and proliferation using human myelogenous leukemia cells |
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The molecular biology of differentiation and proliferation using human myelogenous leukemia cells |
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Cell lines and cell samples from patients provide opportunities for studying the mechanisms of leukemic cellular differentiation and proliferation. Phorbol esters and 1,25 dihydroxy vitamin D3 can induce differentiation of myeloid leukemic cells to macrophages. Differentiation to granulocytes can be induced by several different compounds. Myeloid differentiation is associated closely with the alteration in expression of several oncogenes. These regulatory events may be associated with the extent of methylation, unfolding or association of chromatin to the nuclear matrix. Oncogene amplification, mutation, or deletion can occur with malignant transformation. Future studies point to the development of specific pharmacological agents which can modify the neoplastic transformation. |
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Cell lines and cell samples from patients provide opportunities for studying the mechanisms of leukemic cellular differentiation and proliferation. Phorbol esters and 1,25 dihydroxy vitamin D3 can induce differentiation of myeloid leukemic cells to macrophages. Differentiation to granulocytes can be induced by several different compounds. Myeloid differentiation is associated closely with the alteration in expression of several oncogenes. These regulatory events may be associated with the extent of methylation, unfolding or association of chromatin to the nuclear matrix. Oncogene amplification, mutation, or deletion can occur with malignant transformation. Future studies point to the development of specific pharmacological agents which can modify the neoplastic transformation. |
| abstract_unstemmed |
Cell lines and cell samples from patients provide opportunities for studying the mechanisms of leukemic cellular differentiation and proliferation. Phorbol esters and 1,25 dihydroxy vitamin D3 can induce differentiation of myeloid leukemic cells to macrophages. Differentiation to granulocytes can be induced by several different compounds. Myeloid differentiation is associated closely with the alteration in expression of several oncogenes. These regulatory events may be associated with the extent of methylation, unfolding or association of chromatin to the nuclear matrix. Oncogene amplification, mutation, or deletion can occur with malignant transformation. Future studies point to the development of specific pharmacological agents which can modify the neoplastic transformation. |
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