Differential effect of cytochalasin B on the aggregation of melanosomes in cultured mouse melanoma cells
Mouse B16 melanoma cells in culture were treated with 2 μg/ml cytochalasin B. Melanosomes, localized in dendrites as well as those in the peripheral cell body, formed aggregates which then showed centripetal migration. After 24 hr of treatment, melanosomes were found as large aggregates near the nuc...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1980 |
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| Umfang: |
20 Ill. 11 |
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| Reproduktion: |
Wiley InterScience Backfile Collection 1832-2000 |
|---|---|
| Übergeordnetes Werk: |
in: The Anatomical Record - New York, NY [u.a.] : Wiley, 196(1980) vom: Apr., Seite 449-459 |
| Übergeordnetes Werk: |
volume:196 ; year:1980 ; month:04 ; pages:449-459 ; extent:11 |
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| 520 | |a Mouse B16 melanoma cells in culture were treated with 2 μg/ml cytochalasin B. Melanosomes, localized in dendrites as well as those in the peripheral cell body, formed aggregates which then showed centripetal migration. After 24 hr of treatment, melanosomes were found as large aggregates near the nucleus. However, cytochalasin B showed no effect on the distribution of mitochondria and endoplasmic reticulum. When cells were released from the 24 hr-treatment with cytochalasin B, each melanosome began centrifugal migration. In this process, melanosomes were situated in the periphery, and were in close association with microtubules. Side arm-like structures were observed between microtubules and melanosomes, or mitochondria. These results seem to indicate the presence of a mechanism(s) specific to melanosome migration, and possible participation of microtubules in this melanosome migration. | ||
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(DE-627)NLEJ16072659X DE-627 ger DE-627 rakwb eng Differential effect of cytochalasin B on the aggregation of melanosomes in cultured mouse melanoma cells 1980 20 Ill. 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Mouse B16 melanoma cells in culture were treated with 2 μg/ml cytochalasin B. Melanosomes, localized in dendrites as well as those in the peripheral cell body, formed aggregates which then showed centripetal migration. After 24 hr of treatment, melanosomes were found as large aggregates near the nucleus. However, cytochalasin B showed no effect on the distribution of mitochondria and endoplasmic reticulum. When cells were released from the 24 hr-treatment with cytochalasin B, each melanosome began centrifugal migration. In this process, melanosomes were situated in the periphery, and were in close association with microtubules. Side arm-like structures were observed between microtubules and melanosomes, or mitochondria. These results seem to indicate the presence of a mechanism(s) specific to melanosome migration, and possible participation of microtubules in this melanosome migration. Wiley InterScience Backfile Collection 1832-2000 Koyama, Yoh-Ichi oth Takeuchi, Takuji oth in The Anatomical Record New York, NY [u.a.] : Wiley 196(1980) vom: Apr., Seite 449-459 (DE-627)NLEJ159070961 (DE-600)2205803-5 0003-276X nnns volume:196 year:1980 month:04 pages:449-459 extent:11 http://dx.doi.org/10.1002/ar.1091960410 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 196 1980 4 449-459 11 |
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(DE-627)NLEJ16072659X DE-627 ger DE-627 rakwb eng Differential effect of cytochalasin B on the aggregation of melanosomes in cultured mouse melanoma cells 1980 20 Ill. 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Mouse B16 melanoma cells in culture were treated with 2 μg/ml cytochalasin B. Melanosomes, localized in dendrites as well as those in the peripheral cell body, formed aggregates which then showed centripetal migration. After 24 hr of treatment, melanosomes were found as large aggregates near the nucleus. However, cytochalasin B showed no effect on the distribution of mitochondria and endoplasmic reticulum. When cells were released from the 24 hr-treatment with cytochalasin B, each melanosome began centrifugal migration. In this process, melanosomes were situated in the periphery, and were in close association with microtubules. Side arm-like structures were observed between microtubules and melanosomes, or mitochondria. These results seem to indicate the presence of a mechanism(s) specific to melanosome migration, and possible participation of microtubules in this melanosome migration. Wiley InterScience Backfile Collection 1832-2000 Koyama, Yoh-Ichi oth Takeuchi, Takuji oth in The Anatomical Record New York, NY [u.a.] : Wiley 196(1980) vom: Apr., Seite 449-459 (DE-627)NLEJ159070961 (DE-600)2205803-5 0003-276X nnns volume:196 year:1980 month:04 pages:449-459 extent:11 http://dx.doi.org/10.1002/ar.1091960410 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 196 1980 4 449-459 11 |
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(DE-627)NLEJ16072659X DE-627 ger DE-627 rakwb eng Differential effect of cytochalasin B on the aggregation of melanosomes in cultured mouse melanoma cells 1980 20 Ill. 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Mouse B16 melanoma cells in culture were treated with 2 μg/ml cytochalasin B. Melanosomes, localized in dendrites as well as those in the peripheral cell body, formed aggregates which then showed centripetal migration. After 24 hr of treatment, melanosomes were found as large aggregates near the nucleus. However, cytochalasin B showed no effect on the distribution of mitochondria and endoplasmic reticulum. When cells were released from the 24 hr-treatment with cytochalasin B, each melanosome began centrifugal migration. In this process, melanosomes were situated in the periphery, and were in close association with microtubules. Side arm-like structures were observed between microtubules and melanosomes, or mitochondria. These results seem to indicate the presence of a mechanism(s) specific to melanosome migration, and possible participation of microtubules in this melanosome migration. Wiley InterScience Backfile Collection 1832-2000 Koyama, Yoh-Ichi oth Takeuchi, Takuji oth in The Anatomical Record New York, NY [u.a.] : Wiley 196(1980) vom: Apr., Seite 449-459 (DE-627)NLEJ159070961 (DE-600)2205803-5 0003-276X nnns volume:196 year:1980 month:04 pages:449-459 extent:11 http://dx.doi.org/10.1002/ar.1091960410 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 196 1980 4 449-459 11 |
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(DE-627)NLEJ16072659X DE-627 ger DE-627 rakwb eng Differential effect of cytochalasin B on the aggregation of melanosomes in cultured mouse melanoma cells 1980 20 Ill. 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Mouse B16 melanoma cells in culture were treated with 2 μg/ml cytochalasin B. Melanosomes, localized in dendrites as well as those in the peripheral cell body, formed aggregates which then showed centripetal migration. After 24 hr of treatment, melanosomes were found as large aggregates near the nucleus. However, cytochalasin B showed no effect on the distribution of mitochondria and endoplasmic reticulum. When cells were released from the 24 hr-treatment with cytochalasin B, each melanosome began centrifugal migration. In this process, melanosomes were situated in the periphery, and were in close association with microtubules. Side arm-like structures were observed between microtubules and melanosomes, or mitochondria. These results seem to indicate the presence of a mechanism(s) specific to melanosome migration, and possible participation of microtubules in this melanosome migration. Wiley InterScience Backfile Collection 1832-2000 Koyama, Yoh-Ichi oth Takeuchi, Takuji oth in The Anatomical Record New York, NY [u.a.] : Wiley 196(1980) vom: Apr., Seite 449-459 (DE-627)NLEJ159070961 (DE-600)2205803-5 0003-276X nnns volume:196 year:1980 month:04 pages:449-459 extent:11 http://dx.doi.org/10.1002/ar.1091960410 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 196 1980 4 449-459 11 |
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(DE-627)NLEJ16072659X DE-627 ger DE-627 rakwb eng Differential effect of cytochalasin B on the aggregation of melanosomes in cultured mouse melanoma cells 1980 20 Ill. 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Mouse B16 melanoma cells in culture were treated with 2 μg/ml cytochalasin B. Melanosomes, localized in dendrites as well as those in the peripheral cell body, formed aggregates which then showed centripetal migration. After 24 hr of treatment, melanosomes were found as large aggregates near the nucleus. However, cytochalasin B showed no effect on the distribution of mitochondria and endoplasmic reticulum. When cells were released from the 24 hr-treatment with cytochalasin B, each melanosome began centrifugal migration. In this process, melanosomes were situated in the periphery, and were in close association with microtubules. Side arm-like structures were observed between microtubules and melanosomes, or mitochondria. These results seem to indicate the presence of a mechanism(s) specific to melanosome migration, and possible participation of microtubules in this melanosome migration. Wiley InterScience Backfile Collection 1832-2000 Koyama, Yoh-Ichi oth Takeuchi, Takuji oth in The Anatomical Record New York, NY [u.a.] : Wiley 196(1980) vom: Apr., Seite 449-459 (DE-627)NLEJ159070961 (DE-600)2205803-5 0003-276X nnns volume:196 year:1980 month:04 pages:449-459 extent:11 http://dx.doi.org/10.1002/ar.1091960410 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 196 1980 4 449-459 11 |
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differential effect of cytochalasin b on the aggregation of melanosomes in cultured mouse melanoma cells |
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Differential effect of cytochalasin B on the aggregation of melanosomes in cultured mouse melanoma cells |
| abstract |
Mouse B16 melanoma cells in culture were treated with 2 μg/ml cytochalasin B. Melanosomes, localized in dendrites as well as those in the peripheral cell body, formed aggregates which then showed centripetal migration. After 24 hr of treatment, melanosomes were found as large aggregates near the nucleus. However, cytochalasin B showed no effect on the distribution of mitochondria and endoplasmic reticulum. When cells were released from the 24 hr-treatment with cytochalasin B, each melanosome began centrifugal migration. In this process, melanosomes were situated in the periphery, and were in close association with microtubules. Side arm-like structures were observed between microtubules and melanosomes, or mitochondria. These results seem to indicate the presence of a mechanism(s) specific to melanosome migration, and possible participation of microtubules in this melanosome migration. |
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Mouse B16 melanoma cells in culture were treated with 2 μg/ml cytochalasin B. Melanosomes, localized in dendrites as well as those in the peripheral cell body, formed aggregates which then showed centripetal migration. After 24 hr of treatment, melanosomes were found as large aggregates near the nucleus. However, cytochalasin B showed no effect on the distribution of mitochondria and endoplasmic reticulum. When cells were released from the 24 hr-treatment with cytochalasin B, each melanosome began centrifugal migration. In this process, melanosomes were situated in the periphery, and were in close association with microtubules. Side arm-like structures were observed between microtubules and melanosomes, or mitochondria. These results seem to indicate the presence of a mechanism(s) specific to melanosome migration, and possible participation of microtubules in this melanosome migration. |
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Mouse B16 melanoma cells in culture were treated with 2 μg/ml cytochalasin B. Melanosomes, localized in dendrites as well as those in the peripheral cell body, formed aggregates which then showed centripetal migration. After 24 hr of treatment, melanosomes were found as large aggregates near the nucleus. However, cytochalasin B showed no effect on the distribution of mitochondria and endoplasmic reticulum. When cells were released from the 24 hr-treatment with cytochalasin B, each melanosome began centrifugal migration. In this process, melanosomes were situated in the periphery, and were in close association with microtubules. Side arm-like structures were observed between microtubules and melanosomes, or mitochondria. These results seem to indicate the presence of a mechanism(s) specific to melanosome migration, and possible participation of microtubules in this melanosome migration. |
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