Flexible association of hemopoietic differentiation programs in multilineage colonies
Pluripotent hemopoietic progenitors lose potentialities during the process of differentiation. We have examined events that lead to lineage restriction by determining the cellular composition of 785 multilineage colonies grown from peripheral blood samples of glucose-6-phosphate-dehydrogenase (G-6-P...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1984 |
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| Umfang: |
2 Ill. ; 4 Tab. 7 |
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| Reproduktion: |
Wiley InterScience Backfile Collection 1832-2000 |
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| Übergeordnetes Werk: |
in: Journal of Cellular Physiology - New York, NY [u.a.] : Wiley-Liss, 121(1984) vom: Feb., Seite 291-297 |
| Übergeordnetes Werk: |
volume:121 ; year:1984 ; month:02 ; pages:291-297 ; extent:7 |
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| 520 | |a Pluripotent hemopoietic progenitors lose potentialities during the process of differentiation. We have examined events that lead to lineage restriction by determining the cellular composition of 785 multilineage colonies grown from peripheral blood samples of glucose-6-phosphate-dehydrogenase (G-6-PD) heterozygous volunteers. Of these colonies, 762 contained only one isoenzyme type and were considered to be of clonal origin. A considerable heterogenity was observed. Some colonies were composed of cells belonging to two different lineages, while other colonies contained three or more different cell types. A small number of colonies consisted - in addition to myeloid cells - of T-lymphocytes. The variable association within individual colonies of members belonging to different hemopoietic lineages suggests a flexible determination and expression of differentiation programs by early progenitors. | ||
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(DE-627)NLEJ160785162 DE-627 ger DE-627 rakwb eng Flexible association of hemopoietic differentiation programs in multilineage colonies 1984 2 Ill. 4 Tab. 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Pluripotent hemopoietic progenitors lose potentialities during the process of differentiation. We have examined events that lead to lineage restriction by determining the cellular composition of 785 multilineage colonies grown from peripheral blood samples of glucose-6-phosphate-dehydrogenase (G-6-PD) heterozygous volunteers. Of these colonies, 762 contained only one isoenzyme type and were considered to be of clonal origin. A considerable heterogenity was observed. Some colonies were composed of cells belonging to two different lineages, while other colonies contained three or more different cell types. A small number of colonies consisted - in addition to myeloid cells - of T-lymphocytes. The variable association within individual colonies of members belonging to different hemopoietic lineages suggests a flexible determination and expression of differentiation programs by early progenitors. Wiley InterScience Backfile Collection 1832-2000 Lim, B. oth Jamal, N. oth Messner, H. A. oth in Journal of Cellular Physiology New York, NY [u.a.] : Wiley-Liss 121(1984) vom: Feb., Seite 291-297 (DE-627)NLEJ15907097X (DE-600)1478143-8 0021-9541 nnns volume:121 year:1984 month:02 pages:291-297 extent:7 http://dx.doi.org/10.1002/jcp.1041210205 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 121 1984 2 291-297 7 |
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(DE-627)NLEJ160785162 DE-627 ger DE-627 rakwb eng Flexible association of hemopoietic differentiation programs in multilineage colonies 1984 2 Ill. 4 Tab. 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Pluripotent hemopoietic progenitors lose potentialities during the process of differentiation. We have examined events that lead to lineage restriction by determining the cellular composition of 785 multilineage colonies grown from peripheral blood samples of glucose-6-phosphate-dehydrogenase (G-6-PD) heterozygous volunteers. Of these colonies, 762 contained only one isoenzyme type and were considered to be of clonal origin. A considerable heterogenity was observed. Some colonies were composed of cells belonging to two different lineages, while other colonies contained three or more different cell types. A small number of colonies consisted - in addition to myeloid cells - of T-lymphocytes. The variable association within individual colonies of members belonging to different hemopoietic lineages suggests a flexible determination and expression of differentiation programs by early progenitors. Wiley InterScience Backfile Collection 1832-2000 Lim, B. oth Jamal, N. oth Messner, H. A. oth in Journal of Cellular Physiology New York, NY [u.a.] : Wiley-Liss 121(1984) vom: Feb., Seite 291-297 (DE-627)NLEJ15907097X (DE-600)1478143-8 0021-9541 nnns volume:121 year:1984 month:02 pages:291-297 extent:7 http://dx.doi.org/10.1002/jcp.1041210205 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 121 1984 2 291-297 7 |
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(DE-627)NLEJ160785162 DE-627 ger DE-627 rakwb eng Flexible association of hemopoietic differentiation programs in multilineage colonies 1984 2 Ill. 4 Tab. 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Pluripotent hemopoietic progenitors lose potentialities during the process of differentiation. We have examined events that lead to lineage restriction by determining the cellular composition of 785 multilineage colonies grown from peripheral blood samples of glucose-6-phosphate-dehydrogenase (G-6-PD) heterozygous volunteers. Of these colonies, 762 contained only one isoenzyme type and were considered to be of clonal origin. A considerable heterogenity was observed. Some colonies were composed of cells belonging to two different lineages, while other colonies contained three or more different cell types. A small number of colonies consisted - in addition to myeloid cells - of T-lymphocytes. The variable association within individual colonies of members belonging to different hemopoietic lineages suggests a flexible determination and expression of differentiation programs by early progenitors. Wiley InterScience Backfile Collection 1832-2000 Lim, B. oth Jamal, N. oth Messner, H. A. oth in Journal of Cellular Physiology New York, NY [u.a.] : Wiley-Liss 121(1984) vom: Feb., Seite 291-297 (DE-627)NLEJ15907097X (DE-600)1478143-8 0021-9541 nnns volume:121 year:1984 month:02 pages:291-297 extent:7 http://dx.doi.org/10.1002/jcp.1041210205 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 121 1984 2 291-297 7 |
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(DE-627)NLEJ160785162 DE-627 ger DE-627 rakwb eng Flexible association of hemopoietic differentiation programs in multilineage colonies 1984 2 Ill. 4 Tab. 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Pluripotent hemopoietic progenitors lose potentialities during the process of differentiation. We have examined events that lead to lineage restriction by determining the cellular composition of 785 multilineage colonies grown from peripheral blood samples of glucose-6-phosphate-dehydrogenase (G-6-PD) heterozygous volunteers. Of these colonies, 762 contained only one isoenzyme type and were considered to be of clonal origin. A considerable heterogenity was observed. Some colonies were composed of cells belonging to two different lineages, while other colonies contained three or more different cell types. A small number of colonies consisted - in addition to myeloid cells - of T-lymphocytes. The variable association within individual colonies of members belonging to different hemopoietic lineages suggests a flexible determination and expression of differentiation programs by early progenitors. Wiley InterScience Backfile Collection 1832-2000 Lim, B. oth Jamal, N. oth Messner, H. A. oth in Journal of Cellular Physiology New York, NY [u.a.] : Wiley-Liss 121(1984) vom: Feb., Seite 291-297 (DE-627)NLEJ15907097X (DE-600)1478143-8 0021-9541 nnns volume:121 year:1984 month:02 pages:291-297 extent:7 http://dx.doi.org/10.1002/jcp.1041210205 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 121 1984 2 291-297 7 |
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(DE-627)NLEJ160785162 DE-627 ger DE-627 rakwb eng Flexible association of hemopoietic differentiation programs in multilineage colonies 1984 2 Ill. 4 Tab. 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Pluripotent hemopoietic progenitors lose potentialities during the process of differentiation. We have examined events that lead to lineage restriction by determining the cellular composition of 785 multilineage colonies grown from peripheral blood samples of glucose-6-phosphate-dehydrogenase (G-6-PD) heterozygous volunteers. Of these colonies, 762 contained only one isoenzyme type and were considered to be of clonal origin. A considerable heterogenity was observed. Some colonies were composed of cells belonging to two different lineages, while other colonies contained three or more different cell types. A small number of colonies consisted - in addition to myeloid cells - of T-lymphocytes. The variable association within individual colonies of members belonging to different hemopoietic lineages suggests a flexible determination and expression of differentiation programs by early progenitors. Wiley InterScience Backfile Collection 1832-2000 Lim, B. oth Jamal, N. oth Messner, H. A. oth in Journal of Cellular Physiology New York, NY [u.a.] : Wiley-Liss 121(1984) vom: Feb., Seite 291-297 (DE-627)NLEJ15907097X (DE-600)1478143-8 0021-9541 nnns volume:121 year:1984 month:02 pages:291-297 extent:7 http://dx.doi.org/10.1002/jcp.1041210205 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-WIS GBV_NL_ARTICLE AR 121 1984 2 291-297 7 |
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Flexible association of hemopoietic differentiation programs in multilineage colonies |
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Pluripotent hemopoietic progenitors lose potentialities during the process of differentiation. We have examined events that lead to lineage restriction by determining the cellular composition of 785 multilineage colonies grown from peripheral blood samples of glucose-6-phosphate-dehydrogenase (G-6-PD) heterozygous volunteers. Of these colonies, 762 contained only one isoenzyme type and were considered to be of clonal origin. A considerable heterogenity was observed. Some colonies were composed of cells belonging to two different lineages, while other colonies contained three or more different cell types. A small number of colonies consisted - in addition to myeloid cells - of T-lymphocytes. The variable association within individual colonies of members belonging to different hemopoietic lineages suggests a flexible determination and expression of differentiation programs by early progenitors. |
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Pluripotent hemopoietic progenitors lose potentialities during the process of differentiation. We have examined events that lead to lineage restriction by determining the cellular composition of 785 multilineage colonies grown from peripheral blood samples of glucose-6-phosphate-dehydrogenase (G-6-PD) heterozygous volunteers. Of these colonies, 762 contained only one isoenzyme type and were considered to be of clonal origin. A considerable heterogenity was observed. Some colonies were composed of cells belonging to two different lineages, while other colonies contained three or more different cell types. A small number of colonies consisted - in addition to myeloid cells - of T-lymphocytes. The variable association within individual colonies of members belonging to different hemopoietic lineages suggests a flexible determination and expression of differentiation programs by early progenitors. |
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Pluripotent hemopoietic progenitors lose potentialities during the process of differentiation. We have examined events that lead to lineage restriction by determining the cellular composition of 785 multilineage colonies grown from peripheral blood samples of glucose-6-phosphate-dehydrogenase (G-6-PD) heterozygous volunteers. Of these colonies, 762 contained only one isoenzyme type and were considered to be of clonal origin. A considerable heterogenity was observed. Some colonies were composed of cells belonging to two different lineages, while other colonies contained three or more different cell types. A small number of colonies consisted - in addition to myeloid cells - of T-lymphocytes. The variable association within individual colonies of members belonging to different hemopoietic lineages suggests a flexible determination and expression of differentiation programs by early progenitors. |
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