HOW NEUTROPHILS KILL MICROBES
Neutrophils provide the first line of defense of the innate immune system by phagocytosing, killing, and digesting bacteria and fungi. Killing was previously believed to be accomplished by oxygen free radicals and other reactive oxygen species generated by the NADPH oxidase, and by oxidized halides...
Ausführliche Beschreibung
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2005 |
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27 |
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Annual Reviews Electronic Back Volume Collection 1932-2005ff |
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in: Annual review of immunology - Palo Alto, Calif. : Annual Reviews Inc., 1983, 23(2005), Seite 197-223 |
Übergeordnetes Werk: |
volume:23 ; year:2005 ; pages:197-223 ; extent:27 |
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520 | |a Neutrophils provide the first line of defense of the innate immune system by phagocytosing, killing, and digesting bacteria and fungi. Killing was previously believed to be accomplished by oxygen free radicals and other reactive oxygen species generated by the NADPH oxidase, and by oxidized halides produced by myeloperoxidase. We now know this is incorrect. The oxidase pumps electrons into the phagocytic vacuole, thereby inducing a charge across the membrane that must be compensated. The movement of compensating ions produces conditions in the vacuole conducive to microbial killing and digestion by enzymes released into the vacuole from the cytoplasmic granules. | ||
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(DE-627)NLEJ16411131X DE-627 ger DE-627 rakwb HOW NEUTROPHILS KILL MICROBES 2005 27 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Neutrophils provide the first line of defense of the innate immune system by phagocytosing, killing, and digesting bacteria and fungi. Killing was previously believed to be accomplished by oxygen free radicals and other reactive oxygen species generated by the NADPH oxidase, and by oxidized halides produced by myeloperoxidase. We now know this is incorrect. The oxidase pumps electrons into the phagocytic vacuole, thereby inducing a charge across the membrane that must be compensated. The movement of compensating ions produces conditions in the vacuole conducive to microbial killing and digestion by enzymes released into the vacuole from the cytoplasmic granules. Annual Reviews Electronic Back Volume Collection 1932-2005ff Segal, Anthony W. oth in Annual review of immunology Palo Alto, Calif. : Annual Reviews Inc., 1983 23(2005), Seite 197-223 Online-Ressource (DE-627)NLEJ164018891 (DE-600)1470451-1 1545-3278 nnns volume:23 year:2005 pages:197-223 extent:27 http://dx.doi.org/10.1146/annurev.immunol.23.021704.115653 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-ANR GBV_NL_ARTICLE AR 23 2005 197-223 27 |
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(DE-627)NLEJ16411131X DE-627 ger DE-627 rakwb HOW NEUTROPHILS KILL MICROBES 2005 27 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Neutrophils provide the first line of defense of the innate immune system by phagocytosing, killing, and digesting bacteria and fungi. Killing was previously believed to be accomplished by oxygen free radicals and other reactive oxygen species generated by the NADPH oxidase, and by oxidized halides produced by myeloperoxidase. We now know this is incorrect. The oxidase pumps electrons into the phagocytic vacuole, thereby inducing a charge across the membrane that must be compensated. The movement of compensating ions produces conditions in the vacuole conducive to microbial killing and digestion by enzymes released into the vacuole from the cytoplasmic granules. Annual Reviews Electronic Back Volume Collection 1932-2005ff Segal, Anthony W. oth in Annual review of immunology Palo Alto, Calif. : Annual Reviews Inc., 1983 23(2005), Seite 197-223 Online-Ressource (DE-627)NLEJ164018891 (DE-600)1470451-1 1545-3278 nnns volume:23 year:2005 pages:197-223 extent:27 http://dx.doi.org/10.1146/annurev.immunol.23.021704.115653 text/html Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-ANR GBV_NL_ARTICLE AR 23 2005 197-223 27 |
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HOW NEUTROPHILS KILL MICROBES |
abstract |
Neutrophils provide the first line of defense of the innate immune system by phagocytosing, killing, and digesting bacteria and fungi. Killing was previously believed to be accomplished by oxygen free radicals and other reactive oxygen species generated by the NADPH oxidase, and by oxidized halides produced by myeloperoxidase. We now know this is incorrect. The oxidase pumps electrons into the phagocytic vacuole, thereby inducing a charge across the membrane that must be compensated. The movement of compensating ions produces conditions in the vacuole conducive to microbial killing and digestion by enzymes released into the vacuole from the cytoplasmic granules. |
abstractGer |
Neutrophils provide the first line of defense of the innate immune system by phagocytosing, killing, and digesting bacteria and fungi. Killing was previously believed to be accomplished by oxygen free radicals and other reactive oxygen species generated by the NADPH oxidase, and by oxidized halides produced by myeloperoxidase. We now know this is incorrect. The oxidase pumps electrons into the phagocytic vacuole, thereby inducing a charge across the membrane that must be compensated. The movement of compensating ions produces conditions in the vacuole conducive to microbial killing and digestion by enzymes released into the vacuole from the cytoplasmic granules. |
abstract_unstemmed |
Neutrophils provide the first line of defense of the innate immune system by phagocytosing, killing, and digesting bacteria and fungi. Killing was previously believed to be accomplished by oxygen free radicals and other reactive oxygen species generated by the NADPH oxidase, and by oxidized halides produced by myeloperoxidase. We now know this is incorrect. The oxidase pumps electrons into the phagocytic vacuole, thereby inducing a charge across the membrane that must be compensated. The movement of compensating ions produces conditions in the vacuole conducive to microbial killing and digestion by enzymes released into the vacuole from the cytoplasmic granules. |
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