Do submaximal InsP"3 concentrations only induce the partial discharge of permeabilized hepatocyte calcium pools because of the concomitant reduction of intraluminal Ca^2^+ concentration?

In several types of cells whose cytoplasmic Ca^2^+ is regulated by inositol phosphate derivatives, low concentrations of InsP"3 added to permeabilized cell suspensions induce the rapid discharge or part of the InsP"3-sensitive Ca^2^+ pool instead of slow monophasic release of Ca^2^+ from t...
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Autor*in:	Combettes, L. Claret, M. Champeil, P.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	1992

Reproduktion:	Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
Übergeordnetes Werk:	in: FEBS Letters - Amsterdam : Elsevier, 301(1992), 3, Seite 287-290
Übergeordnetes Werk:	volume:301 ; year:1992 ; number:3 ; pages:287-290

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Katalog-ID:	NLEJ173421377

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245	1	0	\|a Do submaximal InsP"3 concentrations only induce the partial discharge of permeabilized hepatocyte calcium pools because of the concomitant reduction of intraluminal Ca^2^+ concentration?
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520			\|a In several types of cells whose cytoplasmic Ca^2^+ is regulated by inositol phosphate derivatives, low concentrations of InsP"3 added to permeabilized cell suspensions induce the rapid discharge or part of the InsP"3-sensitive Ca^2^+ pool instead of slow monophasic release of Ca^2^+ from the entire pool. As a tentative explanation for this puzzling observation, sometimes called 'quantal release', it was suggested that the reduced intraluminal Ca^2^+ concentration remaining in the Ca^2^+ pool after a certain amount of Ca^2^+ had been released might allosterically reduce the channels' affinity for InsP"3 and the corresponding InsP"3-dependent Ca^2^+ efflux, and thus result in partial pool discharge (Irvine, R.F. (1990) FEBS Lett. 263, 5-9). We have tested this hypothesis by manipulating the Ca^2^+ pool contents with ionophore, and found that the rate of InsP"3-dependent Ca^2^+ efflux after ionophore-induced partial discharge of the Ca^2^+ pools was much faster than what was predicted on the basis of this hypothesis. Heterogeneity of the Ca^2^+ pools appears to be a more likely reason for the 'quantal release' behavior.
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allfields	(DE-627)NLEJ173421377 (DE-599)GBVNLZ173421377 DE-627 ger DE-627 rakwb eng Do submaximal InsP"3 concentrations only induce the partial discharge of permeabilized hepatocyte calcium pools because of the concomitant reduction of intraluminal Ca^2^+ concentration? 1992 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In several types of cells whose cytoplasmic Ca^2^+ is regulated by inositol phosphate derivatives, low concentrations of InsP"3 added to permeabilized cell suspensions induce the rapid discharge or part of the InsP"3-sensitive Ca^2^+ pool instead of slow monophasic release of Ca^2^+ from the entire pool. As a tentative explanation for this puzzling observation, sometimes called 'quantal release', it was suggested that the reduced intraluminal Ca^2^+ concentration remaining in the Ca^2^+ pool after a certain amount of Ca^2^+ had been released might allosterically reduce the channels' affinity for InsP"3 and the corresponding InsP"3-dependent Ca^2^+ efflux, and thus result in partial pool discharge (Irvine, R.F. (1990) FEBS Lett. 263, 5-9). We have tested this hypothesis by manipulating the Ca^2^+ pool contents with ionophore, and found that the rate of InsP"3-dependent Ca^2^+ efflux after ionophore-induced partial discharge of the Ca^2^+ pools was much faster than what was predicted on the basis of this hypothesis. Heterogeneity of the Ca^2^+ pools appears to be a more likely reason for the 'quantal release' behavior. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Combettes, L. oth Claret, M. oth Champeil, P. oth in FEBS Letters Amsterdam : Elsevier 301(1992), 3, Seite 287-290 (DE-627)NLEJ173141048 (DE-600)1460391-3 0014-5793 nnns volume:301 year:1992 number:3 pages:287-290 http://linkinghub.elsevier.com/retrieve/pii/0014-5793(92)80258-I GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 301 1992 3 287-290
spelling	(DE-627)NLEJ173421377 (DE-599)GBVNLZ173421377 DE-627 ger DE-627 rakwb eng Do submaximal InsP"3 concentrations only induce the partial discharge of permeabilized hepatocyte calcium pools because of the concomitant reduction of intraluminal Ca^2^+ concentration? 1992 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In several types of cells whose cytoplasmic Ca^2^+ is regulated by inositol phosphate derivatives, low concentrations of InsP"3 added to permeabilized cell suspensions induce the rapid discharge or part of the InsP"3-sensitive Ca^2^+ pool instead of slow monophasic release of Ca^2^+ from the entire pool. As a tentative explanation for this puzzling observation, sometimes called 'quantal release', it was suggested that the reduced intraluminal Ca^2^+ concentration remaining in the Ca^2^+ pool after a certain amount of Ca^2^+ had been released might allosterically reduce the channels' affinity for InsP"3 and the corresponding InsP"3-dependent Ca^2^+ efflux, and thus result in partial pool discharge (Irvine, R.F. (1990) FEBS Lett. 263, 5-9). We have tested this hypothesis by manipulating the Ca^2^+ pool contents with ionophore, and found that the rate of InsP"3-dependent Ca^2^+ efflux after ionophore-induced partial discharge of the Ca^2^+ pools was much faster than what was predicted on the basis of this hypothesis. Heterogeneity of the Ca^2^+ pools appears to be a more likely reason for the 'quantal release' behavior. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Combettes, L. oth Claret, M. oth Champeil, P. oth in FEBS Letters Amsterdam : Elsevier 301(1992), 3, Seite 287-290 (DE-627)NLEJ173141048 (DE-600)1460391-3 0014-5793 nnns volume:301 year:1992 number:3 pages:287-290 http://linkinghub.elsevier.com/retrieve/pii/0014-5793(92)80258-I GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 301 1992 3 287-290
allfields_unstemmed	(DE-627)NLEJ173421377 (DE-599)GBVNLZ173421377 DE-627 ger DE-627 rakwb eng Do submaximal InsP"3 concentrations only induce the partial discharge of permeabilized hepatocyte calcium pools because of the concomitant reduction of intraluminal Ca^2^+ concentration? 1992 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In several types of cells whose cytoplasmic Ca^2^+ is regulated by inositol phosphate derivatives, low concentrations of InsP"3 added to permeabilized cell suspensions induce the rapid discharge or part of the InsP"3-sensitive Ca^2^+ pool instead of slow monophasic release of Ca^2^+ from the entire pool. As a tentative explanation for this puzzling observation, sometimes called 'quantal release', it was suggested that the reduced intraluminal Ca^2^+ concentration remaining in the Ca^2^+ pool after a certain amount of Ca^2^+ had been released might allosterically reduce the channels' affinity for InsP"3 and the corresponding InsP"3-dependent Ca^2^+ efflux, and thus result in partial pool discharge (Irvine, R.F. (1990) FEBS Lett. 263, 5-9). We have tested this hypothesis by manipulating the Ca^2^+ pool contents with ionophore, and found that the rate of InsP"3-dependent Ca^2^+ efflux after ionophore-induced partial discharge of the Ca^2^+ pools was much faster than what was predicted on the basis of this hypothesis. Heterogeneity of the Ca^2^+ pools appears to be a more likely reason for the 'quantal release' behavior. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Combettes, L. oth Claret, M. oth Champeil, P. oth in FEBS Letters Amsterdam : Elsevier 301(1992), 3, Seite 287-290 (DE-627)NLEJ173141048 (DE-600)1460391-3 0014-5793 nnns volume:301 year:1992 number:3 pages:287-290 http://linkinghub.elsevier.com/retrieve/pii/0014-5793(92)80258-I GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 301 1992 3 287-290
allfieldsGer	(DE-627)NLEJ173421377 (DE-599)GBVNLZ173421377 DE-627 ger DE-627 rakwb eng Do submaximal InsP"3 concentrations only induce the partial discharge of permeabilized hepatocyte calcium pools because of the concomitant reduction of intraluminal Ca^2^+ concentration? 1992 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In several types of cells whose cytoplasmic Ca^2^+ is regulated by inositol phosphate derivatives, low concentrations of InsP"3 added to permeabilized cell suspensions induce the rapid discharge or part of the InsP"3-sensitive Ca^2^+ pool instead of slow monophasic release of Ca^2^+ from the entire pool. As a tentative explanation for this puzzling observation, sometimes called 'quantal release', it was suggested that the reduced intraluminal Ca^2^+ concentration remaining in the Ca^2^+ pool after a certain amount of Ca^2^+ had been released might allosterically reduce the channels' affinity for InsP"3 and the corresponding InsP"3-dependent Ca^2^+ efflux, and thus result in partial pool discharge (Irvine, R.F. (1990) FEBS Lett. 263, 5-9). We have tested this hypothesis by manipulating the Ca^2^+ pool contents with ionophore, and found that the rate of InsP"3-dependent Ca^2^+ efflux after ionophore-induced partial discharge of the Ca^2^+ pools was much faster than what was predicted on the basis of this hypothesis. Heterogeneity of the Ca^2^+ pools appears to be a more likely reason for the 'quantal release' behavior. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Combettes, L. oth Claret, M. oth Champeil, P. oth in FEBS Letters Amsterdam : Elsevier 301(1992), 3, Seite 287-290 (DE-627)NLEJ173141048 (DE-600)1460391-3 0014-5793 nnns volume:301 year:1992 number:3 pages:287-290 http://linkinghub.elsevier.com/retrieve/pii/0014-5793(92)80258-I GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 301 1992 3 287-290
allfieldsSound	(DE-627)NLEJ173421377 (DE-599)GBVNLZ173421377 DE-627 ger DE-627 rakwb eng Do submaximal InsP"3 concentrations only induce the partial discharge of permeabilized hepatocyte calcium pools because of the concomitant reduction of intraluminal Ca^2^+ concentration? 1992 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In several types of cells whose cytoplasmic Ca^2^+ is regulated by inositol phosphate derivatives, low concentrations of InsP"3 added to permeabilized cell suspensions induce the rapid discharge or part of the InsP"3-sensitive Ca^2^+ pool instead of slow monophasic release of Ca^2^+ from the entire pool. As a tentative explanation for this puzzling observation, sometimes called 'quantal release', it was suggested that the reduced intraluminal Ca^2^+ concentration remaining in the Ca^2^+ pool after a certain amount of Ca^2^+ had been released might allosterically reduce the channels' affinity for InsP"3 and the corresponding InsP"3-dependent Ca^2^+ efflux, and thus result in partial pool discharge (Irvine, R.F. (1990) FEBS Lett. 263, 5-9). We have tested this hypothesis by manipulating the Ca^2^+ pool contents with ionophore, and found that the rate of InsP"3-dependent Ca^2^+ efflux after ionophore-induced partial discharge of the Ca^2^+ pools was much faster than what was predicted on the basis of this hypothesis. Heterogeneity of the Ca^2^+ pools appears to be a more likely reason for the 'quantal release' behavior. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Combettes, L. oth Claret, M. oth Champeil, P. oth in FEBS Letters Amsterdam : Elsevier 301(1992), 3, Seite 287-290 (DE-627)NLEJ173141048 (DE-600)1460391-3 0014-5793 nnns volume:301 year:1992 number:3 pages:287-290 http://linkinghub.elsevier.com/retrieve/pii/0014-5793(92)80258-I GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 301 1992 3 287-290
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topic_title	Do submaximal InsP"3 concentrations only induce the partial discharge of permeabilized hepatocyte calcium pools because of the concomitant reduction of intraluminal Ca^2^+ concentration?
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title	Do submaximal InsP"3 concentrations only induce the partial discharge of permeabilized hepatocyte calcium pools because of the concomitant reduction of intraluminal Ca^2^+ concentration?
spellingShingle	Do submaximal InsP"3 concentrations only induce the partial discharge of permeabilized hepatocyte calcium pools because of the concomitant reduction of intraluminal Ca^2^+ concentration?
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title_full	Do submaximal InsP"3 concentrations only induce the partial discharge of permeabilized hepatocyte calcium pools because of the concomitant reduction of intraluminal Ca^2^+ concentration?
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title_sort	do submaximal insp"3 concentrations only induce the partial discharge of permeabilized hepatocyte calcium pools because of the concomitant reduction of intraluminal ca^2^+ concentration?
title_auth	Do submaximal InsP"3 concentrations only induce the partial discharge of permeabilized hepatocyte calcium pools because of the concomitant reduction of intraluminal Ca^2^+ concentration?
abstract	In several types of cells whose cytoplasmic Ca^2^+ is regulated by inositol phosphate derivatives, low concentrations of InsP"3 added to permeabilized cell suspensions induce the rapid discharge or part of the InsP"3-sensitive Ca^2^+ pool instead of slow monophasic release of Ca^2^+ from the entire pool. As a tentative explanation for this puzzling observation, sometimes called 'quantal release', it was suggested that the reduced intraluminal Ca^2^+ concentration remaining in the Ca^2^+ pool after a certain amount of Ca^2^+ had been released might allosterically reduce the channels' affinity for InsP"3 and the corresponding InsP"3-dependent Ca^2^+ efflux, and thus result in partial pool discharge (Irvine, R.F. (1990) FEBS Lett. 263, 5-9). We have tested this hypothesis by manipulating the Ca^2^+ pool contents with ionophore, and found that the rate of InsP"3-dependent Ca^2^+ efflux after ionophore-induced partial discharge of the Ca^2^+ pools was much faster than what was predicted on the basis of this hypothesis. Heterogeneity of the Ca^2^+ pools appears to be a more likely reason for the 'quantal release' behavior.
abstractGer	In several types of cells whose cytoplasmic Ca^2^+ is regulated by inositol phosphate derivatives, low concentrations of InsP"3 added to permeabilized cell suspensions induce the rapid discharge or part of the InsP"3-sensitive Ca^2^+ pool instead of slow monophasic release of Ca^2^+ from the entire pool. As a tentative explanation for this puzzling observation, sometimes called 'quantal release', it was suggested that the reduced intraluminal Ca^2^+ concentration remaining in the Ca^2^+ pool after a certain amount of Ca^2^+ had been released might allosterically reduce the channels' affinity for InsP"3 and the corresponding InsP"3-dependent Ca^2^+ efflux, and thus result in partial pool discharge (Irvine, R.F. (1990) FEBS Lett. 263, 5-9). We have tested this hypothesis by manipulating the Ca^2^+ pool contents with ionophore, and found that the rate of InsP"3-dependent Ca^2^+ efflux after ionophore-induced partial discharge of the Ca^2^+ pools was much faster than what was predicted on the basis of this hypothesis. Heterogeneity of the Ca^2^+ pools appears to be a more likely reason for the 'quantal release' behavior.
abstract_unstemmed	In several types of cells whose cytoplasmic Ca^2^+ is regulated by inositol phosphate derivatives, low concentrations of InsP"3 added to permeabilized cell suspensions induce the rapid discharge or part of the InsP"3-sensitive Ca^2^+ pool instead of slow monophasic release of Ca^2^+ from the entire pool. As a tentative explanation for this puzzling observation, sometimes called 'quantal release', it was suggested that the reduced intraluminal Ca^2^+ concentration remaining in the Ca^2^+ pool after a certain amount of Ca^2^+ had been released might allosterically reduce the channels' affinity for InsP"3 and the corresponding InsP"3-dependent Ca^2^+ efflux, and thus result in partial pool discharge (Irvine, R.F. (1990) FEBS Lett. 263, 5-9). We have tested this hypothesis by manipulating the Ca^2^+ pool contents with ionophore, and found that the rate of InsP"3-dependent Ca^2^+ efflux after ionophore-induced partial discharge of the Ca^2^+ pools was much faster than what was predicted on the basis of this hypothesis. Heterogeneity of the Ca^2^+ pools appears to be a more likely reason for the 'quantal release' behavior.
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title_short	Do submaximal InsP"3 concentrations only induce the partial discharge of permeabilized hepatocyte calcium pools because of the concomitant reduction of intraluminal Ca^2^+ concentration?
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up_date	2024-07-05T21:52:44.998Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ173421377</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210705185403.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070505s1992 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ173421377</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVNLZ173421377</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Do submaximal InsP"3 concentrations only induce the partial discharge of permeabilized hepatocyte calcium pools because of the concomitant reduction of intraluminal Ca^2^+ concentration?</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1992</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">In several types of cells whose cytoplasmic Ca^2^+ is regulated by inositol phosphate derivatives, low concentrations of InsP"3 added to permeabilized cell suspensions induce the rapid discharge or part of the InsP"3-sensitive Ca^2^+ pool instead of slow monophasic release of Ca^2^+ from the entire pool. As a tentative explanation for this puzzling observation, sometimes called 'quantal release', it was suggested that the reduced intraluminal Ca^2^+ concentration remaining in the Ca^2^+ pool after a certain amount of Ca^2^+ had been released might allosterically reduce the channels' affinity for InsP"3 and the corresponding InsP"3-dependent Ca^2^+ efflux, and thus result in partial pool discharge (Irvine, R.F. (1990) FEBS Lett. 263, 5-9). We have tested this hypothesis by manipulating the Ca^2^+ pool contents with ionophore, and found that the rate of InsP"3-dependent Ca^2^+ efflux after ionophore-induced partial discharge of the Ca^2^+ pools was much faster than what was predicted on the basis of this hypothesis. Heterogeneity of the Ca^2^+ pools appears to be a more likely reason for the 'quantal release' behavior.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Elsevier Journal Backfiles on ScienceDirect 1907 - 2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Combettes, L.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Claret, M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Champeil, P.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">FEBS Letters</subfield><subfield code="d">Amsterdam : Elsevier</subfield><subfield code="g">301(1992), 3, Seite 287-290</subfield><subfield code="w">(DE-627)NLEJ173141048</subfield><subfield code="w">(DE-600)1460391-3</subfield><subfield code="x">0014-5793</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:301</subfield><subfield code="g">year:1992</subfield><subfield code="g">number:3</subfield><subfield code="g">pages:287-290</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://linkinghub.elsevier.com/retrieve/pii/0014-5793(92)80258-I</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_H</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SDJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">301</subfield><subfield code="j">1992</subfield><subfield code="e">3</subfield><subfield code="h">287-290</subfield></datafield></record></collection>
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Do submaximal InsP"3 concentrations only induce the partial discharge of permeabilized hepatocyte calcium pools because of the concomitant reduction of intraluminal Ca^2^+ concentration?

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