Inhibition of the RNA dependent DNA polymerase and the malignant transforming ability of Rous sarcoma virus by thiosemicarbazone-transition metal complexes
Several thiosemicarbazone-metal complexes inhibit the RNA dependent DNA polymerase and the transforming ability of Rous sarcoma virus. Some complexes are equally as active as the free ligand whereas the activity of others is greatly enhanced. The 2-formyl pyridine thiosemicarbazone copper (II) compl...
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| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1978 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
|---|---|
| Übergeordnetes Werk: |
in: Bioinorganic Chemistry - Amsterdam : Elsevier, 8(1978), 3, Seite 245-254 |
| Übergeordnetes Werk: |
volume:8 ; year:1978 ; number:3 ; pages:245-254 |
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NLEJ174781539 |
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| 245 | 1 | 0 | |a Inhibition of the RNA dependent DNA polymerase and the malignant transforming ability of Rous sarcoma virus by thiosemicarbazone-transition metal complexes |
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| 520 | |a Several thiosemicarbazone-metal complexes inhibit the RNA dependent DNA polymerase and the transforming ability of Rous sarcoma virus. Some complexes are equally as active as the free ligand whereas the activity of others is greatly enhanced. The 2-formyl pyridine thiosemicarbazone copper (II) complex is the most potent compound of this class that we tested. Some copper complexes of salicylaldehyde derivatives are very active also, particularly N-n-butyl, N-n-hexyl and N-benzylsalicylaldimine; no nickel complex of any salicylaldehyde compound is active. In addition, other metal ligands, such as dithizone, diacetyl bis (mercaptoethylimine), N-butyl thiocarbamate, 0,0' dimethyl dithiophosphate, potassium dithiooxalate, and cis-Pt^I^I(NH"3)"2Cl"2 were tested with varying results. | ||
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(DE-627)NLEJ174781539 (DE-599)GBVNLZ174781539 DE-627 ger DE-627 rakwb eng Inhibition of the RNA dependent DNA polymerase and the malignant transforming ability of Rous sarcoma virus by thiosemicarbazone-transition metal complexes 1978 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Several thiosemicarbazone-metal complexes inhibit the RNA dependent DNA polymerase and the transforming ability of Rous sarcoma virus. Some complexes are equally as active as the free ligand whereas the activity of others is greatly enhanced. The 2-formyl pyridine thiosemicarbazone copper (II) complex is the most potent compound of this class that we tested. Some copper complexes of salicylaldehyde derivatives are very active also, particularly N-n-butyl, N-n-hexyl and N-benzylsalicylaldimine; no nickel complex of any salicylaldehyde compound is active. In addition, other metal ligands, such as dithizone, diacetyl bis (mercaptoethylimine), N-butyl thiocarbamate, 0,0' dimethyl dithiophosphate, potassium dithiooxalate, and cis-Pt^I^I(NH"3)"2Cl"2 were tested with varying results. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Kaska, W.C. oth Carrano, C. oth Michalowski, J. oth Jackson, J. oth Levinson, W. oth in Bioinorganic Chemistry Amsterdam : Elsevier 8(1978), 3, Seite 245-254 (DE-627)NLEJ174780230 (DE-600)2196599-7 0006-3061 nnns volume:8 year:1978 number:3 pages:245-254 http://linkinghub.elsevier.com/retrieve/pii/S0006-3061(00)80198-2 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 8 1978 3 245-254 |
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(DE-627)NLEJ174781539 (DE-599)GBVNLZ174781539 DE-627 ger DE-627 rakwb eng Inhibition of the RNA dependent DNA polymerase and the malignant transforming ability of Rous sarcoma virus by thiosemicarbazone-transition metal complexes 1978 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Several thiosemicarbazone-metal complexes inhibit the RNA dependent DNA polymerase and the transforming ability of Rous sarcoma virus. Some complexes are equally as active as the free ligand whereas the activity of others is greatly enhanced. The 2-formyl pyridine thiosemicarbazone copper (II) complex is the most potent compound of this class that we tested. Some copper complexes of salicylaldehyde derivatives are very active also, particularly N-n-butyl, N-n-hexyl and N-benzylsalicylaldimine; no nickel complex of any salicylaldehyde compound is active. In addition, other metal ligands, such as dithizone, diacetyl bis (mercaptoethylimine), N-butyl thiocarbamate, 0,0' dimethyl dithiophosphate, potassium dithiooxalate, and cis-Pt^I^I(NH"3)"2Cl"2 were tested with varying results. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Kaska, W.C. oth Carrano, C. oth Michalowski, J. oth Jackson, J. oth Levinson, W. oth in Bioinorganic Chemistry Amsterdam : Elsevier 8(1978), 3, Seite 245-254 (DE-627)NLEJ174780230 (DE-600)2196599-7 0006-3061 nnns volume:8 year:1978 number:3 pages:245-254 http://linkinghub.elsevier.com/retrieve/pii/S0006-3061(00)80198-2 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 8 1978 3 245-254 |
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(DE-627)NLEJ174781539 (DE-599)GBVNLZ174781539 DE-627 ger DE-627 rakwb eng Inhibition of the RNA dependent DNA polymerase and the malignant transforming ability of Rous sarcoma virus by thiosemicarbazone-transition metal complexes 1978 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Several thiosemicarbazone-metal complexes inhibit the RNA dependent DNA polymerase and the transforming ability of Rous sarcoma virus. Some complexes are equally as active as the free ligand whereas the activity of others is greatly enhanced. The 2-formyl pyridine thiosemicarbazone copper (II) complex is the most potent compound of this class that we tested. Some copper complexes of salicylaldehyde derivatives are very active also, particularly N-n-butyl, N-n-hexyl and N-benzylsalicylaldimine; no nickel complex of any salicylaldehyde compound is active. In addition, other metal ligands, such as dithizone, diacetyl bis (mercaptoethylimine), N-butyl thiocarbamate, 0,0' dimethyl dithiophosphate, potassium dithiooxalate, and cis-Pt^I^I(NH"3)"2Cl"2 were tested with varying results. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Kaska, W.C. oth Carrano, C. oth Michalowski, J. oth Jackson, J. oth Levinson, W. oth in Bioinorganic Chemistry Amsterdam : Elsevier 8(1978), 3, Seite 245-254 (DE-627)NLEJ174780230 (DE-600)2196599-7 0006-3061 nnns volume:8 year:1978 number:3 pages:245-254 http://linkinghub.elsevier.com/retrieve/pii/S0006-3061(00)80198-2 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 8 1978 3 245-254 |
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(DE-627)NLEJ174781539 (DE-599)GBVNLZ174781539 DE-627 ger DE-627 rakwb eng Inhibition of the RNA dependent DNA polymerase and the malignant transforming ability of Rous sarcoma virus by thiosemicarbazone-transition metal complexes 1978 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Several thiosemicarbazone-metal complexes inhibit the RNA dependent DNA polymerase and the transforming ability of Rous sarcoma virus. Some complexes are equally as active as the free ligand whereas the activity of others is greatly enhanced. The 2-formyl pyridine thiosemicarbazone copper (II) complex is the most potent compound of this class that we tested. Some copper complexes of salicylaldehyde derivatives are very active also, particularly N-n-butyl, N-n-hexyl and N-benzylsalicylaldimine; no nickel complex of any salicylaldehyde compound is active. In addition, other metal ligands, such as dithizone, diacetyl bis (mercaptoethylimine), N-butyl thiocarbamate, 0,0' dimethyl dithiophosphate, potassium dithiooxalate, and cis-Pt^I^I(NH"3)"2Cl"2 were tested with varying results. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Kaska, W.C. oth Carrano, C. oth Michalowski, J. oth Jackson, J. oth Levinson, W. oth in Bioinorganic Chemistry Amsterdam : Elsevier 8(1978), 3, Seite 245-254 (DE-627)NLEJ174780230 (DE-600)2196599-7 0006-3061 nnns volume:8 year:1978 number:3 pages:245-254 http://linkinghub.elsevier.com/retrieve/pii/S0006-3061(00)80198-2 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 8 1978 3 245-254 |
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(DE-627)NLEJ174781539 (DE-599)GBVNLZ174781539 DE-627 ger DE-627 rakwb eng Inhibition of the RNA dependent DNA polymerase and the malignant transforming ability of Rous sarcoma virus by thiosemicarbazone-transition metal complexes 1978 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Several thiosemicarbazone-metal complexes inhibit the RNA dependent DNA polymerase and the transforming ability of Rous sarcoma virus. Some complexes are equally as active as the free ligand whereas the activity of others is greatly enhanced. The 2-formyl pyridine thiosemicarbazone copper (II) complex is the most potent compound of this class that we tested. Some copper complexes of salicylaldehyde derivatives are very active also, particularly N-n-butyl, N-n-hexyl and N-benzylsalicylaldimine; no nickel complex of any salicylaldehyde compound is active. In addition, other metal ligands, such as dithizone, diacetyl bis (mercaptoethylimine), N-butyl thiocarbamate, 0,0' dimethyl dithiophosphate, potassium dithiooxalate, and cis-Pt^I^I(NH"3)"2Cl"2 were tested with varying results. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Kaska, W.C. oth Carrano, C. oth Michalowski, J. oth Jackson, J. oth Levinson, W. oth in Bioinorganic Chemistry Amsterdam : Elsevier 8(1978), 3, Seite 245-254 (DE-627)NLEJ174780230 (DE-600)2196599-7 0006-3061 nnns volume:8 year:1978 number:3 pages:245-254 http://linkinghub.elsevier.com/retrieve/pii/S0006-3061(00)80198-2 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 8 1978 3 245-254 |
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inhibition of the rna dependent dna polymerase and the malignant transforming ability of rous sarcoma virus by thiosemicarbazone-transition metal complexes |
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Inhibition of the RNA dependent DNA polymerase and the malignant transforming ability of Rous sarcoma virus by thiosemicarbazone-transition metal complexes |
| abstract |
Several thiosemicarbazone-metal complexes inhibit the RNA dependent DNA polymerase and the transforming ability of Rous sarcoma virus. Some complexes are equally as active as the free ligand whereas the activity of others is greatly enhanced. The 2-formyl pyridine thiosemicarbazone copper (II) complex is the most potent compound of this class that we tested. Some copper complexes of salicylaldehyde derivatives are very active also, particularly N-n-butyl, N-n-hexyl and N-benzylsalicylaldimine; no nickel complex of any salicylaldehyde compound is active. In addition, other metal ligands, such as dithizone, diacetyl bis (mercaptoethylimine), N-butyl thiocarbamate, 0,0' dimethyl dithiophosphate, potassium dithiooxalate, and cis-Pt^I^I(NH"3)"2Cl"2 were tested with varying results. |
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Several thiosemicarbazone-metal complexes inhibit the RNA dependent DNA polymerase and the transforming ability of Rous sarcoma virus. Some complexes are equally as active as the free ligand whereas the activity of others is greatly enhanced. The 2-formyl pyridine thiosemicarbazone copper (II) complex is the most potent compound of this class that we tested. Some copper complexes of salicylaldehyde derivatives are very active also, particularly N-n-butyl, N-n-hexyl and N-benzylsalicylaldimine; no nickel complex of any salicylaldehyde compound is active. In addition, other metal ligands, such as dithizone, diacetyl bis (mercaptoethylimine), N-butyl thiocarbamate, 0,0' dimethyl dithiophosphate, potassium dithiooxalate, and cis-Pt^I^I(NH"3)"2Cl"2 were tested with varying results. |
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Several thiosemicarbazone-metal complexes inhibit the RNA dependent DNA polymerase and the transforming ability of Rous sarcoma virus. Some complexes are equally as active as the free ligand whereas the activity of others is greatly enhanced. The 2-formyl pyridine thiosemicarbazone copper (II) complex is the most potent compound of this class that we tested. Some copper complexes of salicylaldehyde derivatives are very active also, particularly N-n-butyl, N-n-hexyl and N-benzylsalicylaldimine; no nickel complex of any salicylaldehyde compound is active. In addition, other metal ligands, such as dithizone, diacetyl bis (mercaptoethylimine), N-butyl thiocarbamate, 0,0' dimethyl dithiophosphate, potassium dithiooxalate, and cis-Pt^I^I(NH"3)"2Cl"2 were tested with varying results. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ174781539</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506112139.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070505s1978 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ174781539</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVNLZ174781539</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Inhibition of the RNA dependent DNA polymerase and the malignant transforming ability of Rous sarcoma virus by thiosemicarbazone-transition metal complexes</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1978</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Several thiosemicarbazone-metal complexes inhibit the RNA dependent DNA polymerase and the transforming ability of Rous sarcoma virus. Some complexes are equally as active as the free ligand whereas the activity of others is greatly enhanced. The 2-formyl pyridine thiosemicarbazone copper (II) complex is the most potent compound of this class that we tested. Some copper complexes of salicylaldehyde derivatives are very active also, particularly N-n-butyl, N-n-hexyl and N-benzylsalicylaldimine; no nickel complex of any salicylaldehyde compound is active. In addition, other metal ligands, such as dithizone, diacetyl bis (mercaptoethylimine), N-butyl thiocarbamate, 0,0' dimethyl dithiophosphate, potassium dithiooxalate, and cis-Pt^I^I(NH"3)"2Cl"2 were tested with varying results.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Elsevier Journal Backfiles on ScienceDirect 1907 - 2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kaska, W.C.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Carrano, C.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Michalowski, J.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jackson, J.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Levinson, W.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Bioinorganic Chemistry</subfield><subfield code="d">Amsterdam : Elsevier</subfield><subfield code="g">8(1978), 3, Seite 245-254</subfield><subfield code="w">(DE-627)NLEJ174780230</subfield><subfield code="w">(DE-600)2196599-7</subfield><subfield code="x">0006-3061</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:8</subfield><subfield code="g">year:1978</subfield><subfield code="g">number:3</subfield><subfield code="g">pages:245-254</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://linkinghub.elsevier.com/retrieve/pii/S0006-3061(00)80198-2</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_H</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SDJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">8</subfield><subfield code="j">1978</subfield><subfield code="e">3</subfield><subfield code="h">245-254</subfield></datafield></record></collection>
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