An efficient method for the synthesis of guanidino prodrugs
A new class of guanidino prodrug is efficiently synthesized from an amine and an appropriate N,N'-bis(acyloxymethoxycarbonyl)-S-methylisothiourea. The N,N'-bis(acyloxymethoxycarbonyl)-S-methylisothiourea is readily prepared from S-methylisothiourea and the corresponding acyloxymethyl carbo...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1994 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
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| Übergeordnetes Werk: |
in: Bioorganic & Medicinal Chemistry Letters - Amsterdam : Elsevier, 4(1994), 16, Seite 1985-1990 |
| Übergeordnetes Werk: |
volume:4 ; year:1994 ; number:16 ; pages:1985-1990 |
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| 520 | |a A new class of guanidino prodrug is efficiently synthesized from an amine and an appropriate N,N'-bis(acyloxymethoxycarbonyl)-S-methylisothiourea. The N,N'-bis(acyloxymethoxycarbonyl)-S-methylisothiourea is readily prepared from S-methylisothiourea and the corresponding acyloxymethyl carbonochloridate in good yield. The N,N'-bis(acyloxymethyl carbamate) derivatives of the highly basic guanidino group serve as lipophilic, uncharged, esterase-activatable prodrugs of simple guanidine containing molecules. | ||
| 520 | |a N,N'-bis(acyloxymethyl carbamate) derivatives of the highly basic guanidino group are synthesized from the corresponding amines and function of lipophilic, uncharged, esterase-activatable prodrugs of guanidine-containing molecules. | ||
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| 700 | 1 | |a Deshpande, M.S. |4 oth | |
| 700 | 1 | |a Hansel, S.B. |4 oth | |
| 700 | 1 | |a Vyas, D.M. |4 oth | |
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(DE-627)NLEJ176501754 (DE-599)GBVNLZ176501754 DE-627 ger DE-627 rakwb eng An efficient method for the synthesis of guanidino prodrugs 1994 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A new class of guanidino prodrug is efficiently synthesized from an amine and an appropriate N,N'-bis(acyloxymethoxycarbonyl)-S-methylisothiourea. The N,N'-bis(acyloxymethoxycarbonyl)-S-methylisothiourea is readily prepared from S-methylisothiourea and the corresponding acyloxymethyl carbonochloridate in good yield. The N,N'-bis(acyloxymethyl carbamate) derivatives of the highly basic guanidino group serve as lipophilic, uncharged, esterase-activatable prodrugs of simple guanidine containing molecules. N,N'-bis(acyloxymethyl carbamate) derivatives of the highly basic guanidino group are synthesized from the corresponding amines and function of lipophilic, uncharged, esterase-activatable prodrugs of guanidine-containing molecules. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Saulnier, M.G. oth Frennesson, D.B. oth Deshpande, M.S. oth Hansel, S.B. oth Vyas, D.M. oth in Bioorganic & Medicinal Chemistry Letters Amsterdam : Elsevier 4(1994), 16, Seite 1985-1990 (DE-627)NLEJ176499342 (DE-600)1501505-1 0960-894X nnns volume:4 year:1994 number:16 pages:1985-1990 http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(01)80549-7 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 4 1994 16 1985-1990 |
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(DE-627)NLEJ176501754 (DE-599)GBVNLZ176501754 DE-627 ger DE-627 rakwb eng An efficient method for the synthesis of guanidino prodrugs 1994 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A new class of guanidino prodrug is efficiently synthesized from an amine and an appropriate N,N'-bis(acyloxymethoxycarbonyl)-S-methylisothiourea. The N,N'-bis(acyloxymethoxycarbonyl)-S-methylisothiourea is readily prepared from S-methylisothiourea and the corresponding acyloxymethyl carbonochloridate in good yield. The N,N'-bis(acyloxymethyl carbamate) derivatives of the highly basic guanidino group serve as lipophilic, uncharged, esterase-activatable prodrugs of simple guanidine containing molecules. N,N'-bis(acyloxymethyl carbamate) derivatives of the highly basic guanidino group are synthesized from the corresponding amines and function of lipophilic, uncharged, esterase-activatable prodrugs of guanidine-containing molecules. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Saulnier, M.G. oth Frennesson, D.B. oth Deshpande, M.S. oth Hansel, S.B. oth Vyas, D.M. oth in Bioorganic & Medicinal Chemistry Letters Amsterdam : Elsevier 4(1994), 16, Seite 1985-1990 (DE-627)NLEJ176499342 (DE-600)1501505-1 0960-894X nnns volume:4 year:1994 number:16 pages:1985-1990 http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(01)80549-7 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 4 1994 16 1985-1990 |
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(DE-627)NLEJ176501754 (DE-599)GBVNLZ176501754 DE-627 ger DE-627 rakwb eng An efficient method for the synthesis of guanidino prodrugs 1994 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A new class of guanidino prodrug is efficiently synthesized from an amine and an appropriate N,N'-bis(acyloxymethoxycarbonyl)-S-methylisothiourea. The N,N'-bis(acyloxymethoxycarbonyl)-S-methylisothiourea is readily prepared from S-methylisothiourea and the corresponding acyloxymethyl carbonochloridate in good yield. The N,N'-bis(acyloxymethyl carbamate) derivatives of the highly basic guanidino group serve as lipophilic, uncharged, esterase-activatable prodrugs of simple guanidine containing molecules. N,N'-bis(acyloxymethyl carbamate) derivatives of the highly basic guanidino group are synthesized from the corresponding amines and function of lipophilic, uncharged, esterase-activatable prodrugs of guanidine-containing molecules. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Saulnier, M.G. oth Frennesson, D.B. oth Deshpande, M.S. oth Hansel, S.B. oth Vyas, D.M. oth in Bioorganic & Medicinal Chemistry Letters Amsterdam : Elsevier 4(1994), 16, Seite 1985-1990 (DE-627)NLEJ176499342 (DE-600)1501505-1 0960-894X nnns volume:4 year:1994 number:16 pages:1985-1990 http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(01)80549-7 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 4 1994 16 1985-1990 |
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(DE-627)NLEJ176501754 (DE-599)GBVNLZ176501754 DE-627 ger DE-627 rakwb eng An efficient method for the synthesis of guanidino prodrugs 1994 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A new class of guanidino prodrug is efficiently synthesized from an amine and an appropriate N,N'-bis(acyloxymethoxycarbonyl)-S-methylisothiourea. The N,N'-bis(acyloxymethoxycarbonyl)-S-methylisothiourea is readily prepared from S-methylisothiourea and the corresponding acyloxymethyl carbonochloridate in good yield. The N,N'-bis(acyloxymethyl carbamate) derivatives of the highly basic guanidino group serve as lipophilic, uncharged, esterase-activatable prodrugs of simple guanidine containing molecules. N,N'-bis(acyloxymethyl carbamate) derivatives of the highly basic guanidino group are synthesized from the corresponding amines and function of lipophilic, uncharged, esterase-activatable prodrugs of guanidine-containing molecules. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Saulnier, M.G. oth Frennesson, D.B. oth Deshpande, M.S. oth Hansel, S.B. oth Vyas, D.M. oth in Bioorganic & Medicinal Chemistry Letters Amsterdam : Elsevier 4(1994), 16, Seite 1985-1990 (DE-627)NLEJ176499342 (DE-600)1501505-1 0960-894X nnns volume:4 year:1994 number:16 pages:1985-1990 http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(01)80549-7 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 4 1994 16 1985-1990 |
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(DE-627)NLEJ176501754 (DE-599)GBVNLZ176501754 DE-627 ger DE-627 rakwb eng An efficient method for the synthesis of guanidino prodrugs 1994 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A new class of guanidino prodrug is efficiently synthesized from an amine and an appropriate N,N'-bis(acyloxymethoxycarbonyl)-S-methylisothiourea. The N,N'-bis(acyloxymethoxycarbonyl)-S-methylisothiourea is readily prepared from S-methylisothiourea and the corresponding acyloxymethyl carbonochloridate in good yield. The N,N'-bis(acyloxymethyl carbamate) derivatives of the highly basic guanidino group serve as lipophilic, uncharged, esterase-activatable prodrugs of simple guanidine containing molecules. N,N'-bis(acyloxymethyl carbamate) derivatives of the highly basic guanidino group are synthesized from the corresponding amines and function of lipophilic, uncharged, esterase-activatable prodrugs of guanidine-containing molecules. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Saulnier, M.G. oth Frennesson, D.B. oth Deshpande, M.S. oth Hansel, S.B. oth Vyas, D.M. oth in Bioorganic & Medicinal Chemistry Letters Amsterdam : Elsevier 4(1994), 16, Seite 1985-1990 (DE-627)NLEJ176499342 (DE-600)1501505-1 0960-894X nnns volume:4 year:1994 number:16 pages:1985-1990 http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(01)80549-7 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 4 1994 16 1985-1990 |
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An efficient method for the synthesis of guanidino prodrugs |
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A new class of guanidino prodrug is efficiently synthesized from an amine and an appropriate N,N'-bis(acyloxymethoxycarbonyl)-S-methylisothiourea. The N,N'-bis(acyloxymethoxycarbonyl)-S-methylisothiourea is readily prepared from S-methylisothiourea and the corresponding acyloxymethyl carbonochloridate in good yield. The N,N'-bis(acyloxymethyl carbamate) derivatives of the highly basic guanidino group serve as lipophilic, uncharged, esterase-activatable prodrugs of simple guanidine containing molecules. N,N'-bis(acyloxymethyl carbamate) derivatives of the highly basic guanidino group are synthesized from the corresponding amines and function of lipophilic, uncharged, esterase-activatable prodrugs of guanidine-containing molecules. |
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A new class of guanidino prodrug is efficiently synthesized from an amine and an appropriate N,N'-bis(acyloxymethoxycarbonyl)-S-methylisothiourea. The N,N'-bis(acyloxymethoxycarbonyl)-S-methylisothiourea is readily prepared from S-methylisothiourea and the corresponding acyloxymethyl carbonochloridate in good yield. The N,N'-bis(acyloxymethyl carbamate) derivatives of the highly basic guanidino group serve as lipophilic, uncharged, esterase-activatable prodrugs of simple guanidine containing molecules. N,N'-bis(acyloxymethyl carbamate) derivatives of the highly basic guanidino group are synthesized from the corresponding amines and function of lipophilic, uncharged, esterase-activatable prodrugs of guanidine-containing molecules. |
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A new class of guanidino prodrug is efficiently synthesized from an amine and an appropriate N,N'-bis(acyloxymethoxycarbonyl)-S-methylisothiourea. The N,N'-bis(acyloxymethoxycarbonyl)-S-methylisothiourea is readily prepared from S-methylisothiourea and the corresponding acyloxymethyl carbonochloridate in good yield. The N,N'-bis(acyloxymethyl carbamate) derivatives of the highly basic guanidino group serve as lipophilic, uncharged, esterase-activatable prodrugs of simple guanidine containing molecules. N,N'-bis(acyloxymethyl carbamate) derivatives of the highly basic guanidino group are synthesized from the corresponding amines and function of lipophilic, uncharged, esterase-activatable prodrugs of guanidine-containing molecules. |
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7.399391 |