Synthesis and antitumor evaluation of water soluble taxol phosphates
Synthesis and in vivo antitmor evaluation of water soluble 2'- and 7-taxol phosphates is reported. These derivatives were found to be poor prodrugs of taxol based on their marginal in vivo antitumor activity against ip,ip M109 murine tumor model and taxol release studies in vitro.
Gespeichert in:
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1993 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
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| Übergeordnetes Werk: |
in: Bioorganic & Medicinal Chemistry Letters - Amsterdam : Elsevier, 3(1993), 6, Seite 1357-1360 |
| Übergeordnetes Werk: |
volume:3 ; year:1993 ; number:6 ; pages:1357-1360 |
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NLEJ176507280 |
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| 520 | |a Synthesis and in vivo antitmor evaluation of water soluble 2'- and 7-taxol phosphates is reported. These derivatives were found to be poor prodrugs of taxol based on their marginal in vivo antitumor activity against ip,ip M109 murine tumor model and taxol release studies in vitro. | ||
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(DE-627)NLEJ176507280 (DE-599)GBVNLZ176507280 DE-627 ger DE-627 rakwb eng Synthesis and antitumor evaluation of water soluble taxol phosphates 1993 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Synthesis and in vivo antitmor evaluation of water soluble 2'- and 7-taxol phosphates is reported. These derivatives were found to be poor prodrugs of taxol based on their marginal in vivo antitumor activity against ip,ip M109 murine tumor model and taxol release studies in vitro. Water soluble taxol phosphates 3 and 4 are not suitable prodrugs of taxol. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Vyas, D.M. oth Wong, H. oth Crosswell, A.R. oth Casazza, A.M. oth Knipe, J.O. oth Mamber, S.W. oth Doyle, T.W. oth in Bioorganic & Medicinal Chemistry Letters Amsterdam : Elsevier 3(1993), 6, Seite 1357-1360 (DE-627)NLEJ176499342 (DE-600)1501505-1 0960-894X nnns volume:3 year:1993 number:6 pages:1357-1360 http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(00)80348-0 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 3 1993 6 1357-1360 |
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(DE-627)NLEJ176507280 (DE-599)GBVNLZ176507280 DE-627 ger DE-627 rakwb eng Synthesis and antitumor evaluation of water soluble taxol phosphates 1993 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Synthesis and in vivo antitmor evaluation of water soluble 2'- and 7-taxol phosphates is reported. These derivatives were found to be poor prodrugs of taxol based on their marginal in vivo antitumor activity against ip,ip M109 murine tumor model and taxol release studies in vitro. Water soluble taxol phosphates 3 and 4 are not suitable prodrugs of taxol. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Vyas, D.M. oth Wong, H. oth Crosswell, A.R. oth Casazza, A.M. oth Knipe, J.O. oth Mamber, S.W. oth Doyle, T.W. oth in Bioorganic & Medicinal Chemistry Letters Amsterdam : Elsevier 3(1993), 6, Seite 1357-1360 (DE-627)NLEJ176499342 (DE-600)1501505-1 0960-894X nnns volume:3 year:1993 number:6 pages:1357-1360 http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(00)80348-0 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 3 1993 6 1357-1360 |
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(DE-627)NLEJ176507280 (DE-599)GBVNLZ176507280 DE-627 ger DE-627 rakwb eng Synthesis and antitumor evaluation of water soluble taxol phosphates 1993 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Synthesis and in vivo antitmor evaluation of water soluble 2'- and 7-taxol phosphates is reported. These derivatives were found to be poor prodrugs of taxol based on their marginal in vivo antitumor activity against ip,ip M109 murine tumor model and taxol release studies in vitro. Water soluble taxol phosphates 3 and 4 are not suitable prodrugs of taxol. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Vyas, D.M. oth Wong, H. oth Crosswell, A.R. oth Casazza, A.M. oth Knipe, J.O. oth Mamber, S.W. oth Doyle, T.W. oth in Bioorganic & Medicinal Chemistry Letters Amsterdam : Elsevier 3(1993), 6, Seite 1357-1360 (DE-627)NLEJ176499342 (DE-600)1501505-1 0960-894X nnns volume:3 year:1993 number:6 pages:1357-1360 http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(00)80348-0 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 3 1993 6 1357-1360 |
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(DE-627)NLEJ176507280 (DE-599)GBVNLZ176507280 DE-627 ger DE-627 rakwb eng Synthesis and antitumor evaluation of water soluble taxol phosphates 1993 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Synthesis and in vivo antitmor evaluation of water soluble 2'- and 7-taxol phosphates is reported. These derivatives were found to be poor prodrugs of taxol based on their marginal in vivo antitumor activity against ip,ip M109 murine tumor model and taxol release studies in vitro. Water soluble taxol phosphates 3 and 4 are not suitable prodrugs of taxol. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Vyas, D.M. oth Wong, H. oth Crosswell, A.R. oth Casazza, A.M. oth Knipe, J.O. oth Mamber, S.W. oth Doyle, T.W. oth in Bioorganic & Medicinal Chemistry Letters Amsterdam : Elsevier 3(1993), 6, Seite 1357-1360 (DE-627)NLEJ176499342 (DE-600)1501505-1 0960-894X nnns volume:3 year:1993 number:6 pages:1357-1360 http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(00)80348-0 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 3 1993 6 1357-1360 |
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(DE-627)NLEJ176507280 (DE-599)GBVNLZ176507280 DE-627 ger DE-627 rakwb eng Synthesis and antitumor evaluation of water soluble taxol phosphates 1993 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Synthesis and in vivo antitmor evaluation of water soluble 2'- and 7-taxol phosphates is reported. These derivatives were found to be poor prodrugs of taxol based on their marginal in vivo antitumor activity against ip,ip M109 murine tumor model and taxol release studies in vitro. Water soluble taxol phosphates 3 and 4 are not suitable prodrugs of taxol. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Vyas, D.M. oth Wong, H. oth Crosswell, A.R. oth Casazza, A.M. oth Knipe, J.O. oth Mamber, S.W. oth Doyle, T.W. oth in Bioorganic & Medicinal Chemistry Letters Amsterdam : Elsevier 3(1993), 6, Seite 1357-1360 (DE-627)NLEJ176499342 (DE-600)1501505-1 0960-894X nnns volume:3 year:1993 number:6 pages:1357-1360 http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(00)80348-0 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 3 1993 6 1357-1360 |
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Synthesis and in vivo antitmor evaluation of water soluble 2'- and 7-taxol phosphates is reported. These derivatives were found to be poor prodrugs of taxol based on their marginal in vivo antitumor activity against ip,ip M109 murine tumor model and taxol release studies in vitro. Water soluble taxol phosphates 3 and 4 are not suitable prodrugs of taxol. |
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Synthesis and in vivo antitmor evaluation of water soluble 2'- and 7-taxol phosphates is reported. These derivatives were found to be poor prodrugs of taxol based on their marginal in vivo antitumor activity against ip,ip M109 murine tumor model and taxol release studies in vitro. Water soluble taxol phosphates 3 and 4 are not suitable prodrugs of taxol. |
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Synthesis and in vivo antitmor evaluation of water soluble 2'- and 7-taxol phosphates is reported. These derivatives were found to be poor prodrugs of taxol based on their marginal in vivo antitumor activity against ip,ip M109 murine tumor model and taxol release studies in vitro. Water soluble taxol phosphates 3 and 4 are not suitable prodrugs of taxol. |
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