Novel water soluble phosphate prodrugs of taxol(R) possessing in vivo antitumor activity
Synthesis and biological evaluation of novel taxol derivatives having a phosphonoxyphenylpropionate ester group at the 2'-position or at the 7-position of taxol are described. These were found to have much improved water solubility and both were found to generate taxol upon exposure to alkaline...
Ausführliche Beschreibung
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| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1993 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
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| Übergeordnetes Werk: |
in: Bioorganic & Medicinal Chemistry Letters - Amsterdam : Elsevier, 3(1993), 8, Seite 1761-1766 |
| Übergeordnetes Werk: |
volume:3 ; year:1993 ; number:8 ; pages:1761-1766 |
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| 520 | |a Synthesis and biological evaluation of novel taxol derivatives having a phosphonoxyphenylpropionate ester group at the 2'-position or at the 7-position of taxol are described. These were found to have much improved water solubility and both were found to generate taxol upon exposure to alkaline phosphatase. A particular derivative, 7-phosphonoxyphenylpropionate of taxol 3b exhibited antitumor activity comparable to that of taxol against the ip/ip M109 murine tumor model. | ||
| 520 | |a Synthesis and biological evaluation of novel taxol derivatives 3a and 3b are described. | ||
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| 700 | 1 | |a Rose, W.C. |4 oth | |
| 700 | 1 | |a Casazza, A.M. |4 oth | |
| 700 | 1 | |a Vyas, D.M. |4 oth | |
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(DE-627)NLEJ176509496 (DE-599)GBVNLZ176509496 DE-627 ger DE-627 rakwb eng Novel water soluble phosphate prodrugs of taxol(R) possessing in vivo antitumor activity 1993 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Synthesis and biological evaluation of novel taxol derivatives having a phosphonoxyphenylpropionate ester group at the 2'-position or at the 7-position of taxol are described. These were found to have much improved water solubility and both were found to generate taxol upon exposure to alkaline phosphatase. A particular derivative, 7-phosphonoxyphenylpropionate of taxol 3b exhibited antitumor activity comparable to that of taxol against the ip/ip M109 murine tumor model. Synthesis and biological evaluation of novel taxol derivatives 3a and 3b are described. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Ueda, Y. oth Mikkilineni, A.B. oth Knipe, J.O. oth Rose, W.C. oth Casazza, A.M. oth Vyas, D.M. oth in Bioorganic & Medicinal Chemistry Letters Amsterdam : Elsevier 3(1993), 8, Seite 1761-1766 (DE-627)NLEJ176499342 (DE-600)1501505-1 0960-894X nnns volume:3 year:1993 number:8 pages:1761-1766 http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(00)80058-X GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 3 1993 8 1761-1766 |
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(DE-627)NLEJ176509496 (DE-599)GBVNLZ176509496 DE-627 ger DE-627 rakwb eng Novel water soluble phosphate prodrugs of taxol(R) possessing in vivo antitumor activity 1993 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Synthesis and biological evaluation of novel taxol derivatives having a phosphonoxyphenylpropionate ester group at the 2'-position or at the 7-position of taxol are described. These were found to have much improved water solubility and both were found to generate taxol upon exposure to alkaline phosphatase. A particular derivative, 7-phosphonoxyphenylpropionate of taxol 3b exhibited antitumor activity comparable to that of taxol against the ip/ip M109 murine tumor model. Synthesis and biological evaluation of novel taxol derivatives 3a and 3b are described. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Ueda, Y. oth Mikkilineni, A.B. oth Knipe, J.O. oth Rose, W.C. oth Casazza, A.M. oth Vyas, D.M. oth in Bioorganic & Medicinal Chemistry Letters Amsterdam : Elsevier 3(1993), 8, Seite 1761-1766 (DE-627)NLEJ176499342 (DE-600)1501505-1 0960-894X nnns volume:3 year:1993 number:8 pages:1761-1766 http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(00)80058-X GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 3 1993 8 1761-1766 |
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(DE-627)NLEJ176509496 (DE-599)GBVNLZ176509496 DE-627 ger DE-627 rakwb eng Novel water soluble phosphate prodrugs of taxol(R) possessing in vivo antitumor activity 1993 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Synthesis and biological evaluation of novel taxol derivatives having a phosphonoxyphenylpropionate ester group at the 2'-position or at the 7-position of taxol are described. These were found to have much improved water solubility and both were found to generate taxol upon exposure to alkaline phosphatase. A particular derivative, 7-phosphonoxyphenylpropionate of taxol 3b exhibited antitumor activity comparable to that of taxol against the ip/ip M109 murine tumor model. Synthesis and biological evaluation of novel taxol derivatives 3a and 3b are described. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Ueda, Y. oth Mikkilineni, A.B. oth Knipe, J.O. oth Rose, W.C. oth Casazza, A.M. oth Vyas, D.M. oth in Bioorganic & Medicinal Chemistry Letters Amsterdam : Elsevier 3(1993), 8, Seite 1761-1766 (DE-627)NLEJ176499342 (DE-600)1501505-1 0960-894X nnns volume:3 year:1993 number:8 pages:1761-1766 http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(00)80058-X GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 3 1993 8 1761-1766 |
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(DE-627)NLEJ176509496 (DE-599)GBVNLZ176509496 DE-627 ger DE-627 rakwb eng Novel water soluble phosphate prodrugs of taxol(R) possessing in vivo antitumor activity 1993 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Synthesis and biological evaluation of novel taxol derivatives having a phosphonoxyphenylpropionate ester group at the 2'-position or at the 7-position of taxol are described. These were found to have much improved water solubility and both were found to generate taxol upon exposure to alkaline phosphatase. A particular derivative, 7-phosphonoxyphenylpropionate of taxol 3b exhibited antitumor activity comparable to that of taxol against the ip/ip M109 murine tumor model. Synthesis and biological evaluation of novel taxol derivatives 3a and 3b are described. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Ueda, Y. oth Mikkilineni, A.B. oth Knipe, J.O. oth Rose, W.C. oth Casazza, A.M. oth Vyas, D.M. oth in Bioorganic & Medicinal Chemistry Letters Amsterdam : Elsevier 3(1993), 8, Seite 1761-1766 (DE-627)NLEJ176499342 (DE-600)1501505-1 0960-894X nnns volume:3 year:1993 number:8 pages:1761-1766 http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(00)80058-X GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 3 1993 8 1761-1766 |
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(DE-627)NLEJ176509496 (DE-599)GBVNLZ176509496 DE-627 ger DE-627 rakwb eng Novel water soluble phosphate prodrugs of taxol(R) possessing in vivo antitumor activity 1993 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Synthesis and biological evaluation of novel taxol derivatives having a phosphonoxyphenylpropionate ester group at the 2'-position or at the 7-position of taxol are described. These were found to have much improved water solubility and both were found to generate taxol upon exposure to alkaline phosphatase. A particular derivative, 7-phosphonoxyphenylpropionate of taxol 3b exhibited antitumor activity comparable to that of taxol against the ip/ip M109 murine tumor model. Synthesis and biological evaluation of novel taxol derivatives 3a and 3b are described. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Ueda, Y. oth Mikkilineni, A.B. oth Knipe, J.O. oth Rose, W.C. oth Casazza, A.M. oth Vyas, D.M. oth in Bioorganic & Medicinal Chemistry Letters Amsterdam : Elsevier 3(1993), 8, Seite 1761-1766 (DE-627)NLEJ176499342 (DE-600)1501505-1 0960-894X nnns volume:3 year:1993 number:8 pages:1761-1766 http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(00)80058-X GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 3 1993 8 1761-1766 |
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Novel water soluble phosphate prodrugs of taxol(R) possessing in vivo antitumor activity |
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Synthesis and biological evaluation of novel taxol derivatives having a phosphonoxyphenylpropionate ester group at the 2'-position or at the 7-position of taxol are described. These were found to have much improved water solubility and both were found to generate taxol upon exposure to alkaline phosphatase. A particular derivative, 7-phosphonoxyphenylpropionate of taxol 3b exhibited antitumor activity comparable to that of taxol against the ip/ip M109 murine tumor model. Synthesis and biological evaluation of novel taxol derivatives 3a and 3b are described. |
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Synthesis and biological evaluation of novel taxol derivatives having a phosphonoxyphenylpropionate ester group at the 2'-position or at the 7-position of taxol are described. These were found to have much improved water solubility and both were found to generate taxol upon exposure to alkaline phosphatase. A particular derivative, 7-phosphonoxyphenylpropionate of taxol 3b exhibited antitumor activity comparable to that of taxol against the ip/ip M109 murine tumor model. Synthesis and biological evaluation of novel taxol derivatives 3a and 3b are described. |
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Synthesis and biological evaluation of novel taxol derivatives having a phosphonoxyphenylpropionate ester group at the 2'-position or at the 7-position of taxol are described. These were found to have much improved water solubility and both were found to generate taxol upon exposure to alkaline phosphatase. A particular derivative, 7-phosphonoxyphenylpropionate of taxol 3b exhibited antitumor activity comparable to that of taxol against the ip/ip M109 murine tumor model. Synthesis and biological evaluation of novel taxol derivatives 3a and 3b are described. |
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