Salmon calcitonin inhibits human sperm motility in vitro
We have evaluated by a stroboscopic technique the in vitro effect of salmon calcitonin and human calcitionin on the motility of human migrated spermatozoa. We report here that human calcitonin is uneffective while salmon calcitonin is a potent inhibitor of the sperm motility. This salmon calcitonin...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1984 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
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| Übergeordnetes Werk: |
in: Biochemical and Biophysical Research Communications - Amsterdam : Elsevier, 125(1984), 1, Seite 199-204 |
| Übergeordnetes Werk: |
volume:125 ; year:1984 ; number:1 ; pages:199-204 |
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NLEJ176939482 |
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| 520 | |a We have evaluated by a stroboscopic technique the in vitro effect of salmon calcitonin and human calcitionin on the motility of human migrated spermatozoa. We report here that human calcitonin is uneffective while salmon calcitonin is a potent inhibitor of the sperm motility. This salmon calcitonin action is abolished by the preincubation of the peptide with an anti-salmon calcitonin antiserum, demonstrating the specificity of the effect. In addition, we provide evidence that the release of intracellular calcium represents a necessary step for the action of the peptide. In fact, the salmon calcitonin effect is prevented in a dose-dependent way by dantrolene sodium which inhibits the release of calcium from intracellular stores while the calcium channel blocker verapamil is unefficacious. These results suggest a potential role for calcitonin in regulating human sperm motility. | ||
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| 700 | 1 | |a Moretti, C. |4 oth | |
| 700 | 1 | |a Panerai, A.E. |4 oth | |
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| 700 | 1 | |a Fraioli, F. |4 oth | |
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(DE-627)NLEJ176939482 (DE-599)GBVNLZ176939482 DE-627 ger DE-627 rakwb eng Salmon calcitonin inhibits human sperm motility in vitro 1984 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We have evaluated by a stroboscopic technique the in vitro effect of salmon calcitonin and human calcitionin on the motility of human migrated spermatozoa. We report here that human calcitonin is uneffective while salmon calcitonin is a potent inhibitor of the sperm motility. This salmon calcitonin action is abolished by the preincubation of the peptide with an anti-salmon calcitonin antiserum, demonstrating the specificity of the effect. In addition, we provide evidence that the release of intracellular calcium represents a necessary step for the action of the peptide. In fact, the salmon calcitonin effect is prevented in a dose-dependent way by dantrolene sodium which inhibits the release of calcium from intracellular stores while the calcium channel blocker verapamil is unefficacious. These results suggest a potential role for calcitonin in regulating human sperm motility. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Gnessi, L. oth Silvestroni, L. oth Fabbri, A. oth Moretti, C. oth Panerai, A.E. oth Bonifacio, V. oth Fraioli, F. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 125(1984), 1, Seite 199-204 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:125 year:1984 number:1 pages:199-204 http://dx.doi.org/10.1016/S0006-291X(84)80354-X GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 125 1984 1 199-204 |
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(DE-627)NLEJ176939482 (DE-599)GBVNLZ176939482 DE-627 ger DE-627 rakwb eng Salmon calcitonin inhibits human sperm motility in vitro 1984 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We have evaluated by a stroboscopic technique the in vitro effect of salmon calcitonin and human calcitionin on the motility of human migrated spermatozoa. We report here that human calcitonin is uneffective while salmon calcitonin is a potent inhibitor of the sperm motility. This salmon calcitonin action is abolished by the preincubation of the peptide with an anti-salmon calcitonin antiserum, demonstrating the specificity of the effect. In addition, we provide evidence that the release of intracellular calcium represents a necessary step for the action of the peptide. In fact, the salmon calcitonin effect is prevented in a dose-dependent way by dantrolene sodium which inhibits the release of calcium from intracellular stores while the calcium channel blocker verapamil is unefficacious. These results suggest a potential role for calcitonin in regulating human sperm motility. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Gnessi, L. oth Silvestroni, L. oth Fabbri, A. oth Moretti, C. oth Panerai, A.E. oth Bonifacio, V. oth Fraioli, F. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 125(1984), 1, Seite 199-204 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:125 year:1984 number:1 pages:199-204 http://dx.doi.org/10.1016/S0006-291X(84)80354-X GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 125 1984 1 199-204 |
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(DE-627)NLEJ176939482 (DE-599)GBVNLZ176939482 DE-627 ger DE-627 rakwb eng Salmon calcitonin inhibits human sperm motility in vitro 1984 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We have evaluated by a stroboscopic technique the in vitro effect of salmon calcitonin and human calcitionin on the motility of human migrated spermatozoa. We report here that human calcitonin is uneffective while salmon calcitonin is a potent inhibitor of the sperm motility. This salmon calcitonin action is abolished by the preincubation of the peptide with an anti-salmon calcitonin antiserum, demonstrating the specificity of the effect. In addition, we provide evidence that the release of intracellular calcium represents a necessary step for the action of the peptide. In fact, the salmon calcitonin effect is prevented in a dose-dependent way by dantrolene sodium which inhibits the release of calcium from intracellular stores while the calcium channel blocker verapamil is unefficacious. These results suggest a potential role for calcitonin in regulating human sperm motility. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Gnessi, L. oth Silvestroni, L. oth Fabbri, A. oth Moretti, C. oth Panerai, A.E. oth Bonifacio, V. oth Fraioli, F. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 125(1984), 1, Seite 199-204 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:125 year:1984 number:1 pages:199-204 http://dx.doi.org/10.1016/S0006-291X(84)80354-X GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 125 1984 1 199-204 |
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(DE-627)NLEJ176939482 (DE-599)GBVNLZ176939482 DE-627 ger DE-627 rakwb eng Salmon calcitonin inhibits human sperm motility in vitro 1984 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We have evaluated by a stroboscopic technique the in vitro effect of salmon calcitonin and human calcitionin on the motility of human migrated spermatozoa. We report here that human calcitonin is uneffective while salmon calcitonin is a potent inhibitor of the sperm motility. This salmon calcitonin action is abolished by the preincubation of the peptide with an anti-salmon calcitonin antiserum, demonstrating the specificity of the effect. In addition, we provide evidence that the release of intracellular calcium represents a necessary step for the action of the peptide. In fact, the salmon calcitonin effect is prevented in a dose-dependent way by dantrolene sodium which inhibits the release of calcium from intracellular stores while the calcium channel blocker verapamil is unefficacious. These results suggest a potential role for calcitonin in regulating human sperm motility. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Gnessi, L. oth Silvestroni, L. oth Fabbri, A. oth Moretti, C. oth Panerai, A.E. oth Bonifacio, V. oth Fraioli, F. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 125(1984), 1, Seite 199-204 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:125 year:1984 number:1 pages:199-204 http://dx.doi.org/10.1016/S0006-291X(84)80354-X GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 125 1984 1 199-204 |
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(DE-627)NLEJ176939482 (DE-599)GBVNLZ176939482 DE-627 ger DE-627 rakwb eng Salmon calcitonin inhibits human sperm motility in vitro 1984 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We have evaluated by a stroboscopic technique the in vitro effect of salmon calcitonin and human calcitionin on the motility of human migrated spermatozoa. We report here that human calcitonin is uneffective while salmon calcitonin is a potent inhibitor of the sperm motility. This salmon calcitonin action is abolished by the preincubation of the peptide with an anti-salmon calcitonin antiserum, demonstrating the specificity of the effect. In addition, we provide evidence that the release of intracellular calcium represents a necessary step for the action of the peptide. In fact, the salmon calcitonin effect is prevented in a dose-dependent way by dantrolene sodium which inhibits the release of calcium from intracellular stores while the calcium channel blocker verapamil is unefficacious. These results suggest a potential role for calcitonin in regulating human sperm motility. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Gnessi, L. oth Silvestroni, L. oth Fabbri, A. oth Moretti, C. oth Panerai, A.E. oth Bonifacio, V. oth Fraioli, F. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 125(1984), 1, Seite 199-204 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:125 year:1984 number:1 pages:199-204 http://dx.doi.org/10.1016/S0006-291X(84)80354-X GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 125 1984 1 199-204 |
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Salmon calcitonin inhibits human sperm motility in vitro |
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We have evaluated by a stroboscopic technique the in vitro effect of salmon calcitonin and human calcitionin on the motility of human migrated spermatozoa. We report here that human calcitonin is uneffective while salmon calcitonin is a potent inhibitor of the sperm motility. This salmon calcitonin action is abolished by the preincubation of the peptide with an anti-salmon calcitonin antiserum, demonstrating the specificity of the effect. In addition, we provide evidence that the release of intracellular calcium represents a necessary step for the action of the peptide. In fact, the salmon calcitonin effect is prevented in a dose-dependent way by dantrolene sodium which inhibits the release of calcium from intracellular stores while the calcium channel blocker verapamil is unefficacious. These results suggest a potential role for calcitonin in regulating human sperm motility. |
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We have evaluated by a stroboscopic technique the in vitro effect of salmon calcitonin and human calcitionin on the motility of human migrated spermatozoa. We report here that human calcitonin is uneffective while salmon calcitonin is a potent inhibitor of the sperm motility. This salmon calcitonin action is abolished by the preincubation of the peptide with an anti-salmon calcitonin antiserum, demonstrating the specificity of the effect. In addition, we provide evidence that the release of intracellular calcium represents a necessary step for the action of the peptide. In fact, the salmon calcitonin effect is prevented in a dose-dependent way by dantrolene sodium which inhibits the release of calcium from intracellular stores while the calcium channel blocker verapamil is unefficacious. These results suggest a potential role for calcitonin in regulating human sperm motility. |
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We have evaluated by a stroboscopic technique the in vitro effect of salmon calcitonin and human calcitionin on the motility of human migrated spermatozoa. We report here that human calcitonin is uneffective while salmon calcitonin is a potent inhibitor of the sperm motility. This salmon calcitonin action is abolished by the preincubation of the peptide with an anti-salmon calcitonin antiserum, demonstrating the specificity of the effect. In addition, we provide evidence that the release of intracellular calcium represents a necessary step for the action of the peptide. In fact, the salmon calcitonin effect is prevented in a dose-dependent way by dantrolene sodium which inhibits the release of calcium from intracellular stores while the calcium channel blocker verapamil is unefficacious. These results suggest a potential role for calcitonin in regulating human sperm motility. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ176939482</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706034743.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070505s1984 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ176939482</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVNLZ176939482</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Salmon calcitonin inhibits human sperm motility in vitro</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1984</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">We have evaluated by a stroboscopic technique the in vitro effect of salmon calcitonin and human calcitionin on the motility of human migrated spermatozoa. We report here that human calcitonin is uneffective while salmon calcitonin is a potent inhibitor of the sperm motility. This salmon calcitonin action is abolished by the preincubation of the peptide with an anti-salmon calcitonin antiserum, demonstrating the specificity of the effect. In addition, we provide evidence that the release of intracellular calcium represents a necessary step for the action of the peptide. In fact, the salmon calcitonin effect is prevented in a dose-dependent way by dantrolene sodium which inhibits the release of calcium from intracellular stores while the calcium channel blocker verapamil is unefficacious. These results suggest a potential role for calcitonin in regulating human sperm motility.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Elsevier Journal Backfiles on ScienceDirect 1907 - 2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gnessi, L.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Silvestroni, L.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fabbri, A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Moretti, C.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Panerai, A.E.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bonifacio, V.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fraioli, F.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Biochemical and Biophysical Research Communications</subfield><subfield code="d">Amsterdam : Elsevier</subfield><subfield code="g">125(1984), 1, Seite 199-204</subfield><subfield code="w">(DE-627)NLEJ176855645</subfield><subfield code="w">(DE-600)1461396-7</subfield><subfield code="x">0006-291X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:125</subfield><subfield code="g">year:1984</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:199-204</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1016/S0006-291X(84)80354-X</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_H</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SDJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">125</subfield><subfield code="j">1984</subfield><subfield code="e">1</subfield><subfield code="h">199-204</subfield></datafield></record></collection>
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