Growth hormone-releasing hormone and clonidine stimulate biosynthesis of growth hormone in neonatal pituitaries
Comparative studies were performed to verify the effect of growth hormone releasing hormone (GHRH) or clonidine (CLON), a compound thought to act via release of endogenous GHRH, in stimulating GH biosynthesis in the pituitary from neonatal and adult rats. In vitro preincubation for 1 h with GHRH (hp...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1986 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
|---|---|
| Übergeordnetes Werk: |
in: Biochemical and Biophysical Research Communications - Amsterdam : Elsevier, 138(1986), 3, Seite 1223-1230 |
| Übergeordnetes Werk: |
volume:138 ; year:1986 ; number:3 ; pages:1223-1230 |
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NLEJ17694138X |
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| 520 | |a Comparative studies were performed to verify the effect of growth hormone releasing hormone (GHRH) or clonidine (CLON), a compound thought to act via release of endogenous GHRH, in stimulating GH biosynthesis in the pituitary from neonatal and adult rats. In vitro preincubation for 1 h with GHRH (hpGRF-40, 10^-^8M) increased the incorporation of L-[^3H]leucine in the electrophoretic band of GH in the pituitary from 10-day-old rats, but not in the gland from adult rats. Ex-vivo treatment with GHRH or CLON for 5 days was effective in stimulating GH biosynthesis only in the pituitary from neonatal rats. These data demonstrate that neonatal somatotropes are particularly sensitive to the GH-synthesizing activity of GHRH or a GHRH-releasing stimulus. | ||
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(DE-627)NLEJ17694138X (DE-599)GBVNLZ17694138X DE-627 ger DE-627 rakwb eng Growth hormone-releasing hormone and clonidine stimulate biosynthesis of growth hormone in neonatal pituitaries 1986 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Comparative studies were performed to verify the effect of growth hormone releasing hormone (GHRH) or clonidine (CLON), a compound thought to act via release of endogenous GHRH, in stimulating GH biosynthesis in the pituitary from neonatal and adult rats. In vitro preincubation for 1 h with GHRH (hpGRF-40, 10^-^8M) increased the incorporation of L-[^3H]leucine in the electrophoretic band of GH in the pituitary from 10-day-old rats, but not in the gland from adult rats. Ex-vivo treatment with GHRH or CLON for 5 days was effective in stimulating GH biosynthesis only in the pituitary from neonatal rats. These data demonstrate that neonatal somatotropes are particularly sensitive to the GH-synthesizing activity of GHRH or a GHRH-releasing stimulus. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Cozzi, M.G. oth Zanini, A. oth Locatelli, V. oth Cella, S.G. oth Muller, E.E. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 138(1986), 3, Seite 1223-1230 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:138 year:1986 number:3 pages:1223-1230 http://dx.doi.org/10.1016/S0006-291X(86)80413-2 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 138 1986 3 1223-1230 |
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(DE-627)NLEJ17694138X (DE-599)GBVNLZ17694138X DE-627 ger DE-627 rakwb eng Growth hormone-releasing hormone and clonidine stimulate biosynthesis of growth hormone in neonatal pituitaries 1986 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Comparative studies were performed to verify the effect of growth hormone releasing hormone (GHRH) or clonidine (CLON), a compound thought to act via release of endogenous GHRH, in stimulating GH biosynthesis in the pituitary from neonatal and adult rats. In vitro preincubation for 1 h with GHRH (hpGRF-40, 10^-^8M) increased the incorporation of L-[^3H]leucine in the electrophoretic band of GH in the pituitary from 10-day-old rats, but not in the gland from adult rats. Ex-vivo treatment with GHRH or CLON for 5 days was effective in stimulating GH biosynthesis only in the pituitary from neonatal rats. These data demonstrate that neonatal somatotropes are particularly sensitive to the GH-synthesizing activity of GHRH or a GHRH-releasing stimulus. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Cozzi, M.G. oth Zanini, A. oth Locatelli, V. oth Cella, S.G. oth Muller, E.E. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 138(1986), 3, Seite 1223-1230 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:138 year:1986 number:3 pages:1223-1230 http://dx.doi.org/10.1016/S0006-291X(86)80413-2 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 138 1986 3 1223-1230 |
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(DE-627)NLEJ17694138X (DE-599)GBVNLZ17694138X DE-627 ger DE-627 rakwb eng Growth hormone-releasing hormone and clonidine stimulate biosynthesis of growth hormone in neonatal pituitaries 1986 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Comparative studies were performed to verify the effect of growth hormone releasing hormone (GHRH) or clonidine (CLON), a compound thought to act via release of endogenous GHRH, in stimulating GH biosynthesis in the pituitary from neonatal and adult rats. In vitro preincubation for 1 h with GHRH (hpGRF-40, 10^-^8M) increased the incorporation of L-[^3H]leucine in the electrophoretic band of GH in the pituitary from 10-day-old rats, but not in the gland from adult rats. Ex-vivo treatment with GHRH or CLON for 5 days was effective in stimulating GH biosynthesis only in the pituitary from neonatal rats. These data demonstrate that neonatal somatotropes are particularly sensitive to the GH-synthesizing activity of GHRH or a GHRH-releasing stimulus. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Cozzi, M.G. oth Zanini, A. oth Locatelli, V. oth Cella, S.G. oth Muller, E.E. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 138(1986), 3, Seite 1223-1230 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:138 year:1986 number:3 pages:1223-1230 http://dx.doi.org/10.1016/S0006-291X(86)80413-2 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 138 1986 3 1223-1230 |
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(DE-627)NLEJ17694138X (DE-599)GBVNLZ17694138X DE-627 ger DE-627 rakwb eng Growth hormone-releasing hormone and clonidine stimulate biosynthesis of growth hormone in neonatal pituitaries 1986 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Comparative studies were performed to verify the effect of growth hormone releasing hormone (GHRH) or clonidine (CLON), a compound thought to act via release of endogenous GHRH, in stimulating GH biosynthesis in the pituitary from neonatal and adult rats. In vitro preincubation for 1 h with GHRH (hpGRF-40, 10^-^8M) increased the incorporation of L-[^3H]leucine in the electrophoretic band of GH in the pituitary from 10-day-old rats, but not in the gland from adult rats. Ex-vivo treatment with GHRH or CLON for 5 days was effective in stimulating GH biosynthesis only in the pituitary from neonatal rats. These data demonstrate that neonatal somatotropes are particularly sensitive to the GH-synthesizing activity of GHRH or a GHRH-releasing stimulus. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Cozzi, M.G. oth Zanini, A. oth Locatelli, V. oth Cella, S.G. oth Muller, E.E. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 138(1986), 3, Seite 1223-1230 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:138 year:1986 number:3 pages:1223-1230 http://dx.doi.org/10.1016/S0006-291X(86)80413-2 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 138 1986 3 1223-1230 |
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(DE-627)NLEJ17694138X (DE-599)GBVNLZ17694138X DE-627 ger DE-627 rakwb eng Growth hormone-releasing hormone and clonidine stimulate biosynthesis of growth hormone in neonatal pituitaries 1986 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Comparative studies were performed to verify the effect of growth hormone releasing hormone (GHRH) or clonidine (CLON), a compound thought to act via release of endogenous GHRH, in stimulating GH biosynthesis in the pituitary from neonatal and adult rats. In vitro preincubation for 1 h with GHRH (hpGRF-40, 10^-^8M) increased the incorporation of L-[^3H]leucine in the electrophoretic band of GH in the pituitary from 10-day-old rats, but not in the gland from adult rats. Ex-vivo treatment with GHRH or CLON for 5 days was effective in stimulating GH biosynthesis only in the pituitary from neonatal rats. These data demonstrate that neonatal somatotropes are particularly sensitive to the GH-synthesizing activity of GHRH or a GHRH-releasing stimulus. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Cozzi, M.G. oth Zanini, A. oth Locatelli, V. oth Cella, S.G. oth Muller, E.E. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 138(1986), 3, Seite 1223-1230 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:138 year:1986 number:3 pages:1223-1230 http://dx.doi.org/10.1016/S0006-291X(86)80413-2 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 138 1986 3 1223-1230 |
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growth hormone-releasing hormone and clonidine stimulate biosynthesis of growth hormone in neonatal pituitaries |
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Growth hormone-releasing hormone and clonidine stimulate biosynthesis of growth hormone in neonatal pituitaries |
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Comparative studies were performed to verify the effect of growth hormone releasing hormone (GHRH) or clonidine (CLON), a compound thought to act via release of endogenous GHRH, in stimulating GH biosynthesis in the pituitary from neonatal and adult rats. In vitro preincubation for 1 h with GHRH (hpGRF-40, 10^-^8M) increased the incorporation of L-[^3H]leucine in the electrophoretic band of GH in the pituitary from 10-day-old rats, but not in the gland from adult rats. Ex-vivo treatment with GHRH or CLON for 5 days was effective in stimulating GH biosynthesis only in the pituitary from neonatal rats. These data demonstrate that neonatal somatotropes are particularly sensitive to the GH-synthesizing activity of GHRH or a GHRH-releasing stimulus. |
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Comparative studies were performed to verify the effect of growth hormone releasing hormone (GHRH) or clonidine (CLON), a compound thought to act via release of endogenous GHRH, in stimulating GH biosynthesis in the pituitary from neonatal and adult rats. In vitro preincubation for 1 h with GHRH (hpGRF-40, 10^-^8M) increased the incorporation of L-[^3H]leucine in the electrophoretic band of GH in the pituitary from 10-day-old rats, but not in the gland from adult rats. Ex-vivo treatment with GHRH or CLON for 5 days was effective in stimulating GH biosynthesis only in the pituitary from neonatal rats. These data demonstrate that neonatal somatotropes are particularly sensitive to the GH-synthesizing activity of GHRH or a GHRH-releasing stimulus. |
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Comparative studies were performed to verify the effect of growth hormone releasing hormone (GHRH) or clonidine (CLON), a compound thought to act via release of endogenous GHRH, in stimulating GH biosynthesis in the pituitary from neonatal and adult rats. In vitro preincubation for 1 h with GHRH (hpGRF-40, 10^-^8M) increased the incorporation of L-[^3H]leucine in the electrophoretic band of GH in the pituitary from 10-day-old rats, but not in the gland from adult rats. Ex-vivo treatment with GHRH or CLON for 5 days was effective in stimulating GH biosynthesis only in the pituitary from neonatal rats. These data demonstrate that neonatal somatotropes are particularly sensitive to the GH-synthesizing activity of GHRH or a GHRH-releasing stimulus. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ17694138X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706034802.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070505s1986 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ17694138X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVNLZ17694138X</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Growth hormone-releasing hormone and clonidine stimulate biosynthesis of growth hormone in neonatal pituitaries</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1986</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Comparative studies were performed to verify the effect of growth hormone releasing hormone (GHRH) or clonidine (CLON), a compound thought to act via release of endogenous GHRH, in stimulating GH biosynthesis in the pituitary from neonatal and adult rats. In vitro preincubation for 1 h with GHRH (hpGRF-40, 10^-^8M) increased the incorporation of L-[^3H]leucine in the electrophoretic band of GH in the pituitary from 10-day-old rats, but not in the gland from adult rats. Ex-vivo treatment with GHRH or CLON for 5 days was effective in stimulating GH biosynthesis only in the pituitary from neonatal rats. These data demonstrate that neonatal somatotropes are particularly sensitive to the GH-synthesizing activity of GHRH or a GHRH-releasing stimulus.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Elsevier Journal Backfiles on ScienceDirect 1907 - 2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cozzi, M.G.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zanini, A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Locatelli, V.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cella, S.G.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Muller, E.E.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Biochemical and Biophysical Research Communications</subfield><subfield code="d">Amsterdam : Elsevier</subfield><subfield code="g">138(1986), 3, Seite 1223-1230</subfield><subfield code="w">(DE-627)NLEJ176855645</subfield><subfield code="w">(DE-600)1461396-7</subfield><subfield code="x">0006-291X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:138</subfield><subfield code="g">year:1986</subfield><subfield code="g">number:3</subfield><subfield code="g">pages:1223-1230</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1016/S0006-291X(86)80413-2</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_H</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SDJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">138</subfield><subfield code="j">1986</subfield><subfield code="e">3</subfield><subfield code="h">1223-1230</subfield></datafield></record></collection>
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