Effect of clonidine on the secretion of anterior pituitary hormones in heroin addicts and normal volunteers
Neuroendocrine effects of intravenous injections of clonidine, 0.15 mg, were investigated in 13 heroin addicts and 14 normal control subjects. The study was designed to determine whether continuous opiate administration leads to the development of hypersensitive α"2-adrenergic receptors. The pe...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1984 |
|---|
| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
|---|---|
| Übergeordnetes Werk: |
in: Psychiatry Research - Amsterdam : Elsevier, 13(1984), 4, Seite 295-304 |
| Übergeordnetes Werk: |
volume:13 ; year:1984 ; number:4 ; pages:295-304 |
| Links: |
|---|
| Katalog-ID: |
NLEJ182037541 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLEJ182037541 | ||
| 003 | DE-627 | ||
| 005 | 20210706170103.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 070505s1984 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)NLEJ182037541 | ||
| 035 | |a (DE-599)GBVNLZ182037541 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 245 | 1 | 0 | |a Effect of clonidine on the secretion of anterior pituitary hormones in heroin addicts and normal volunteers |
| 264 | 1 | |c 1984 | |
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Neuroendocrine effects of intravenous injections of clonidine, 0.15 mg, were investigated in 13 heroin addicts and 14 normal control subjects. The study was designed to determine whether continuous opiate administration leads to the development of hypersensitive α"2-adrenergic receptors. The peak increments in levels of plasma growth hormone (GH) and β-endorphin induced by clonidine did not differ between heroin addicts and normal control subjects. At no time interval could the clonidine-induced rise in GH levels in addicts be differentiated from that induced by placebo. Clonidine failed to alter plasma prolactin, gonadotropin, or thyrotropin levels in either heroin addicts or controls. Since clonidine's neuroendocrine effects are reportedly due to the activation of postsynaptic α"2-adrenoceptors, it appears that (1) continuous opiate use does not lead to the development of hypersensitive α"2-adrenergic receptors involved in neuroendocrine mechanisms and (2) brain norepinephrine does not play a role in the regulation of tonic prolactin, gonadotropin, and thyrotropin secretion in man. | ||
| 533 | |f Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 | ||
| 700 | 1 | |a Brambilla, F. |4 oth | |
| 700 | 1 | |a Lampertico, M. |4 oth | |
| 700 | 1 | |a Panerai, A.E. |4 oth | |
| 700 | 1 | |a Sali, L. |4 oth | |
| 700 | 1 | |a Salerno, F. |4 oth | |
| 700 | 1 | |a Muller, E.E. |4 oth | |
| 773 | 0 | 8 | |i in |t Psychiatry Research |d Amsterdam : Elsevier |g 13(1984), 4, Seite 295-304 |w (DE-627)NLEJ177074922 |w (DE-600)1500675-X |x 0165-1781 |7 nnns |
| 773 | 1 | 8 | |g volume:13 |g year:1984 |g number:4 |g pages:295-304 |
| 856 | 4 | 0 | |u http://linkinghub.elsevier.com/retrieve/pii/0165-1781(84)90077-5 |
| 912 | |a GBV_USEFLAG_H | ||
| 912 | |a ZDB-1-SDJ | ||
| 912 | |a GBV_NL_ARTICLE | ||
| 951 | |a AR | ||
| 952 | |d 13 |j 1984 |e 4 |h 295-304 | ||
| matchkey_str |
article:01651781:1984----::fetflndnoteertooatroptiayomnsneond |
|---|---|
| hierarchy_sort_str |
1984 |
| publishDate |
1984 |
| allfields |
(DE-627)NLEJ182037541 (DE-599)GBVNLZ182037541 DE-627 ger DE-627 rakwb eng Effect of clonidine on the secretion of anterior pituitary hormones in heroin addicts and normal volunteers 1984 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Neuroendocrine effects of intravenous injections of clonidine, 0.15 mg, were investigated in 13 heroin addicts and 14 normal control subjects. The study was designed to determine whether continuous opiate administration leads to the development of hypersensitive α"2-adrenergic receptors. The peak increments in levels of plasma growth hormone (GH) and β-endorphin induced by clonidine did not differ between heroin addicts and normal control subjects. At no time interval could the clonidine-induced rise in GH levels in addicts be differentiated from that induced by placebo. Clonidine failed to alter plasma prolactin, gonadotropin, or thyrotropin levels in either heroin addicts or controls. Since clonidine's neuroendocrine effects are reportedly due to the activation of postsynaptic α"2-adrenoceptors, it appears that (1) continuous opiate use does not lead to the development of hypersensitive α"2-adrenergic receptors involved in neuroendocrine mechanisms and (2) brain norepinephrine does not play a role in the regulation of tonic prolactin, gonadotropin, and thyrotropin secretion in man. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Brambilla, F. oth Lampertico, M. oth Panerai, A.E. oth Sali, L. oth Salerno, F. oth Muller, E.E. oth in Psychiatry Research Amsterdam : Elsevier 13(1984), 4, Seite 295-304 (DE-627)NLEJ177074922 (DE-600)1500675-X 0165-1781 nnns volume:13 year:1984 number:4 pages:295-304 http://linkinghub.elsevier.com/retrieve/pii/0165-1781(84)90077-5 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 13 1984 4 295-304 |
| spelling |
(DE-627)NLEJ182037541 (DE-599)GBVNLZ182037541 DE-627 ger DE-627 rakwb eng Effect of clonidine on the secretion of anterior pituitary hormones in heroin addicts and normal volunteers 1984 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Neuroendocrine effects of intravenous injections of clonidine, 0.15 mg, were investigated in 13 heroin addicts and 14 normal control subjects. The study was designed to determine whether continuous opiate administration leads to the development of hypersensitive α"2-adrenergic receptors. The peak increments in levels of plasma growth hormone (GH) and β-endorphin induced by clonidine did not differ between heroin addicts and normal control subjects. At no time interval could the clonidine-induced rise in GH levels in addicts be differentiated from that induced by placebo. Clonidine failed to alter plasma prolactin, gonadotropin, or thyrotropin levels in either heroin addicts or controls. Since clonidine's neuroendocrine effects are reportedly due to the activation of postsynaptic α"2-adrenoceptors, it appears that (1) continuous opiate use does not lead to the development of hypersensitive α"2-adrenergic receptors involved in neuroendocrine mechanisms and (2) brain norepinephrine does not play a role in the regulation of tonic prolactin, gonadotropin, and thyrotropin secretion in man. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Brambilla, F. oth Lampertico, M. oth Panerai, A.E. oth Sali, L. oth Salerno, F. oth Muller, E.E. oth in Psychiatry Research Amsterdam : Elsevier 13(1984), 4, Seite 295-304 (DE-627)NLEJ177074922 (DE-600)1500675-X 0165-1781 nnns volume:13 year:1984 number:4 pages:295-304 http://linkinghub.elsevier.com/retrieve/pii/0165-1781(84)90077-5 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 13 1984 4 295-304 |
| allfields_unstemmed |
(DE-627)NLEJ182037541 (DE-599)GBVNLZ182037541 DE-627 ger DE-627 rakwb eng Effect of clonidine on the secretion of anterior pituitary hormones in heroin addicts and normal volunteers 1984 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Neuroendocrine effects of intravenous injections of clonidine, 0.15 mg, were investigated in 13 heroin addicts and 14 normal control subjects. The study was designed to determine whether continuous opiate administration leads to the development of hypersensitive α"2-adrenergic receptors. The peak increments in levels of plasma growth hormone (GH) and β-endorphin induced by clonidine did not differ between heroin addicts and normal control subjects. At no time interval could the clonidine-induced rise in GH levels in addicts be differentiated from that induced by placebo. Clonidine failed to alter plasma prolactin, gonadotropin, or thyrotropin levels in either heroin addicts or controls. Since clonidine's neuroendocrine effects are reportedly due to the activation of postsynaptic α"2-adrenoceptors, it appears that (1) continuous opiate use does not lead to the development of hypersensitive α"2-adrenergic receptors involved in neuroendocrine mechanisms and (2) brain norepinephrine does not play a role in the regulation of tonic prolactin, gonadotropin, and thyrotropin secretion in man. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Brambilla, F. oth Lampertico, M. oth Panerai, A.E. oth Sali, L. oth Salerno, F. oth Muller, E.E. oth in Psychiatry Research Amsterdam : Elsevier 13(1984), 4, Seite 295-304 (DE-627)NLEJ177074922 (DE-600)1500675-X 0165-1781 nnns volume:13 year:1984 number:4 pages:295-304 http://linkinghub.elsevier.com/retrieve/pii/0165-1781(84)90077-5 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 13 1984 4 295-304 |
| allfieldsGer |
(DE-627)NLEJ182037541 (DE-599)GBVNLZ182037541 DE-627 ger DE-627 rakwb eng Effect of clonidine on the secretion of anterior pituitary hormones in heroin addicts and normal volunteers 1984 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Neuroendocrine effects of intravenous injections of clonidine, 0.15 mg, were investigated in 13 heroin addicts and 14 normal control subjects. The study was designed to determine whether continuous opiate administration leads to the development of hypersensitive α"2-adrenergic receptors. The peak increments in levels of plasma growth hormone (GH) and β-endorphin induced by clonidine did not differ between heroin addicts and normal control subjects. At no time interval could the clonidine-induced rise in GH levels in addicts be differentiated from that induced by placebo. Clonidine failed to alter plasma prolactin, gonadotropin, or thyrotropin levels in either heroin addicts or controls. Since clonidine's neuroendocrine effects are reportedly due to the activation of postsynaptic α"2-adrenoceptors, it appears that (1) continuous opiate use does not lead to the development of hypersensitive α"2-adrenergic receptors involved in neuroendocrine mechanisms and (2) brain norepinephrine does not play a role in the regulation of tonic prolactin, gonadotropin, and thyrotropin secretion in man. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Brambilla, F. oth Lampertico, M. oth Panerai, A.E. oth Sali, L. oth Salerno, F. oth Muller, E.E. oth in Psychiatry Research Amsterdam : Elsevier 13(1984), 4, Seite 295-304 (DE-627)NLEJ177074922 (DE-600)1500675-X 0165-1781 nnns volume:13 year:1984 number:4 pages:295-304 http://linkinghub.elsevier.com/retrieve/pii/0165-1781(84)90077-5 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 13 1984 4 295-304 |
| allfieldsSound |
(DE-627)NLEJ182037541 (DE-599)GBVNLZ182037541 DE-627 ger DE-627 rakwb eng Effect of clonidine on the secretion of anterior pituitary hormones in heroin addicts and normal volunteers 1984 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Neuroendocrine effects of intravenous injections of clonidine, 0.15 mg, were investigated in 13 heroin addicts and 14 normal control subjects. The study was designed to determine whether continuous opiate administration leads to the development of hypersensitive α"2-adrenergic receptors. The peak increments in levels of plasma growth hormone (GH) and β-endorphin induced by clonidine did not differ between heroin addicts and normal control subjects. At no time interval could the clonidine-induced rise in GH levels in addicts be differentiated from that induced by placebo. Clonidine failed to alter plasma prolactin, gonadotropin, or thyrotropin levels in either heroin addicts or controls. Since clonidine's neuroendocrine effects are reportedly due to the activation of postsynaptic α"2-adrenoceptors, it appears that (1) continuous opiate use does not lead to the development of hypersensitive α"2-adrenergic receptors involved in neuroendocrine mechanisms and (2) brain norepinephrine does not play a role in the regulation of tonic prolactin, gonadotropin, and thyrotropin secretion in man. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Brambilla, F. oth Lampertico, M. oth Panerai, A.E. oth Sali, L. oth Salerno, F. oth Muller, E.E. oth in Psychiatry Research Amsterdam : Elsevier 13(1984), 4, Seite 295-304 (DE-627)NLEJ177074922 (DE-600)1500675-X 0165-1781 nnns volume:13 year:1984 number:4 pages:295-304 http://linkinghub.elsevier.com/retrieve/pii/0165-1781(84)90077-5 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 13 1984 4 295-304 |
| language |
English |
| source |
in Psychiatry Research 13(1984), 4, Seite 295-304 volume:13 year:1984 number:4 pages:295-304 |
| sourceStr |
in Psychiatry Research 13(1984), 4, Seite 295-304 volume:13 year:1984 number:4 pages:295-304 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| isfreeaccess_bool |
false |
| container_title |
Psychiatry Research |
| authorswithroles_txt_mv |
Brambilla, F. @@oth@@ Lampertico, M. @@oth@@ Panerai, A.E. @@oth@@ Sali, L. @@oth@@ Salerno, F. @@oth@@ Muller, E.E. @@oth@@ |
| publishDateDaySort_date |
1984-01-01T00:00:00Z |
| hierarchy_top_id |
NLEJ177074922 |
| id |
NLEJ182037541 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ182037541</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706170103.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070505s1984 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ182037541</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVNLZ182037541</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Effect of clonidine on the secretion of anterior pituitary hormones in heroin addicts and normal volunteers</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1984</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Neuroendocrine effects of intravenous injections of clonidine, 0.15 mg, were investigated in 13 heroin addicts and 14 normal control subjects. The study was designed to determine whether continuous opiate administration leads to the development of hypersensitive α"2-adrenergic receptors. The peak increments in levels of plasma growth hormone (GH) and β-endorphin induced by clonidine did not differ between heroin addicts and normal control subjects. At no time interval could the clonidine-induced rise in GH levels in addicts be differentiated from that induced by placebo. Clonidine failed to alter plasma prolactin, gonadotropin, or thyrotropin levels in either heroin addicts or controls. Since clonidine's neuroendocrine effects are reportedly due to the activation of postsynaptic α"2-adrenoceptors, it appears that (1) continuous opiate use does not lead to the development of hypersensitive α"2-adrenergic receptors involved in neuroendocrine mechanisms and (2) brain norepinephrine does not play a role in the regulation of tonic prolactin, gonadotropin, and thyrotropin secretion in man.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Elsevier Journal Backfiles on ScienceDirect 1907 - 2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Brambilla, F.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lampertico, M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Panerai, A.E.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sali, L.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Salerno, F.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Muller, E.E.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Psychiatry Research</subfield><subfield code="d">Amsterdam : Elsevier</subfield><subfield code="g">13(1984), 4, Seite 295-304</subfield><subfield code="w">(DE-627)NLEJ177074922</subfield><subfield code="w">(DE-600)1500675-X</subfield><subfield code="x">0165-1781</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:13</subfield><subfield code="g">year:1984</subfield><subfield code="g">number:4</subfield><subfield code="g">pages:295-304</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://linkinghub.elsevier.com/retrieve/pii/0165-1781(84)90077-5</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_H</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SDJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">13</subfield><subfield code="j">1984</subfield><subfield code="e">4</subfield><subfield code="h">295-304</subfield></datafield></record></collection>
|
| series2 |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ177074922 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| collection |
NL |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
0165-1781 |
| topic_title |
Effect of clonidine on the secretion of anterior pituitary hormones in heroin addicts and normal volunteers |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
f b fb m l ml a p ap l s ls f s fs e m em |
| hierarchy_parent_title |
Psychiatry Research |
| hierarchy_parent_id |
NLEJ177074922 |
| hierarchy_top_title |
Psychiatry Research |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)NLEJ177074922 (DE-600)1500675-X |
| title |
Effect of clonidine on the secretion of anterior pituitary hormones in heroin addicts and normal volunteers |
| spellingShingle |
Effect of clonidine on the secretion of anterior pituitary hormones in heroin addicts and normal volunteers |
| ctrlnum |
(DE-627)NLEJ182037541 (DE-599)GBVNLZ182037541 |
| title_full |
Effect of clonidine on the secretion of anterior pituitary hormones in heroin addicts and normal volunteers |
| journal |
Psychiatry Research |
| journalStr |
Psychiatry Research |
| lang_code |
eng |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
1984 |
| contenttype_str_mv |
zzz |
| container_start_page |
295 |
| container_volume |
13 |
| format_se |
Elektronische Aufsätze |
| title_sort |
effect of clonidine on the secretion of anterior pituitary hormones in heroin addicts and normal volunteers |
| title_auth |
Effect of clonidine on the secretion of anterior pituitary hormones in heroin addicts and normal volunteers |
| abstract |
Neuroendocrine effects of intravenous injections of clonidine, 0.15 mg, were investigated in 13 heroin addicts and 14 normal control subjects. The study was designed to determine whether continuous opiate administration leads to the development of hypersensitive α"2-adrenergic receptors. The peak increments in levels of plasma growth hormone (GH) and β-endorphin induced by clonidine did not differ between heroin addicts and normal control subjects. At no time interval could the clonidine-induced rise in GH levels in addicts be differentiated from that induced by placebo. Clonidine failed to alter plasma prolactin, gonadotropin, or thyrotropin levels in either heroin addicts or controls. Since clonidine's neuroendocrine effects are reportedly due to the activation of postsynaptic α"2-adrenoceptors, it appears that (1) continuous opiate use does not lead to the development of hypersensitive α"2-adrenergic receptors involved in neuroendocrine mechanisms and (2) brain norepinephrine does not play a role in the regulation of tonic prolactin, gonadotropin, and thyrotropin secretion in man. |
| abstractGer |
Neuroendocrine effects of intravenous injections of clonidine, 0.15 mg, were investigated in 13 heroin addicts and 14 normal control subjects. The study was designed to determine whether continuous opiate administration leads to the development of hypersensitive α"2-adrenergic receptors. The peak increments in levels of plasma growth hormone (GH) and β-endorphin induced by clonidine did not differ between heroin addicts and normal control subjects. At no time interval could the clonidine-induced rise in GH levels in addicts be differentiated from that induced by placebo. Clonidine failed to alter plasma prolactin, gonadotropin, or thyrotropin levels in either heroin addicts or controls. Since clonidine's neuroendocrine effects are reportedly due to the activation of postsynaptic α"2-adrenoceptors, it appears that (1) continuous opiate use does not lead to the development of hypersensitive α"2-adrenergic receptors involved in neuroendocrine mechanisms and (2) brain norepinephrine does not play a role in the regulation of tonic prolactin, gonadotropin, and thyrotropin secretion in man. |
| abstract_unstemmed |
Neuroendocrine effects of intravenous injections of clonidine, 0.15 mg, were investigated in 13 heroin addicts and 14 normal control subjects. The study was designed to determine whether continuous opiate administration leads to the development of hypersensitive α"2-adrenergic receptors. The peak increments in levels of plasma growth hormone (GH) and β-endorphin induced by clonidine did not differ between heroin addicts and normal control subjects. At no time interval could the clonidine-induced rise in GH levels in addicts be differentiated from that induced by placebo. Clonidine failed to alter plasma prolactin, gonadotropin, or thyrotropin levels in either heroin addicts or controls. Since clonidine's neuroendocrine effects are reportedly due to the activation of postsynaptic α"2-adrenoceptors, it appears that (1) continuous opiate use does not lead to the development of hypersensitive α"2-adrenergic receptors involved in neuroendocrine mechanisms and (2) brain norepinephrine does not play a role in the regulation of tonic prolactin, gonadotropin, and thyrotropin secretion in man. |
| collection_details |
GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE |
| container_issue |
4 |
| title_short |
Effect of clonidine on the secretion of anterior pituitary hormones in heroin addicts and normal volunteers |
| url |
http://linkinghub.elsevier.com/retrieve/pii/0165-1781(84)90077-5 |
| remote_bool |
true |
| author2 |
Brambilla, F. Lampertico, M. Panerai, A.E. Sali, L. Salerno, F. Muller, E.E. |
| author2Str |
Brambilla, F. Lampertico, M. Panerai, A.E. Sali, L. Salerno, F. Muller, E.E. |
| ppnlink |
NLEJ177074922 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth oth oth |
| up_date |
2024-07-06T08:12:27.343Z |
| _version_ |
1803816583660830720 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ182037541</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706170103.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070505s1984 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ182037541</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVNLZ182037541</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Effect of clonidine on the secretion of anterior pituitary hormones in heroin addicts and normal volunteers</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1984</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Neuroendocrine effects of intravenous injections of clonidine, 0.15 mg, were investigated in 13 heroin addicts and 14 normal control subjects. The study was designed to determine whether continuous opiate administration leads to the development of hypersensitive α"2-adrenergic receptors. The peak increments in levels of plasma growth hormone (GH) and β-endorphin induced by clonidine did not differ between heroin addicts and normal control subjects. At no time interval could the clonidine-induced rise in GH levels in addicts be differentiated from that induced by placebo. Clonidine failed to alter plasma prolactin, gonadotropin, or thyrotropin levels in either heroin addicts or controls. Since clonidine's neuroendocrine effects are reportedly due to the activation of postsynaptic α"2-adrenoceptors, it appears that (1) continuous opiate use does not lead to the development of hypersensitive α"2-adrenergic receptors involved in neuroendocrine mechanisms and (2) brain norepinephrine does not play a role in the regulation of tonic prolactin, gonadotropin, and thyrotropin secretion in man.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Elsevier Journal Backfiles on ScienceDirect 1907 - 2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Brambilla, F.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lampertico, M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Panerai, A.E.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sali, L.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Salerno, F.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Muller, E.E.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Psychiatry Research</subfield><subfield code="d">Amsterdam : Elsevier</subfield><subfield code="g">13(1984), 4, Seite 295-304</subfield><subfield code="w">(DE-627)NLEJ177074922</subfield><subfield code="w">(DE-600)1500675-X</subfield><subfield code="x">0165-1781</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:13</subfield><subfield code="g">year:1984</subfield><subfield code="g">number:4</subfield><subfield code="g">pages:295-304</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://linkinghub.elsevier.com/retrieve/pii/0165-1781(84)90077-5</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_H</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SDJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">13</subfield><subfield code="j">1984</subfield><subfield code="e">4</subfield><subfield code="h">295-304</subfield></datafield></record></collection>
|
| score |
7.401639 |