Serum levels of neuroleptics measured by dopamine radioreceptor assay and some clinical observations
A new dopamine radioreceptor assay was used to measure serum concentrations of neuroleptics during treatment of 58 patients. Results of this assay are expressed as chlorpromazine equivalents. Serum concentrations varied with different drugs, with extremely high levels in patients receiving thioridaz...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1979 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
|---|---|
| Übergeordnetes Werk: |
in: Psychiatry Research - Amsterdam : Elsevier, 1(1979), 1, Seite 39-44 |
| Übergeordnetes Werk: |
volume:1 ; year:1979 ; number:1 ; pages:39-44 |
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| 520 | |a A new dopamine radioreceptor assay was used to measure serum concentrations of neuroleptics during treatment of 58 patients. Results of this assay are expressed as chlorpromazine equivalents. Serum concentrations varied with different drugs, with extremely high levels in patients receiving thioridazine or mesoridazine. No detectable serum levels were found in 11 patients, probably either due to low drug doses or noncompliance in taking medication. Best results with the assay were obtained in the 22 patients treated with haloperidol. Serum concentrations of haloperidol were correlated with dose and were related to the Brief Psychiatric Rating Scale (BPRS) total pathology score, as well as to BPRS factor scores for thinking disturbance and paranoid disturbance. Serum concentrations of haloperidol were not different among patients with or without the presence of extrapyramidal symptoms or among patients receiving or not receiving concurrent antiparkinson medication. | ||
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(DE-627)NLEJ182049078 (DE-599)GBVNLZ182049078 DE-627 ger DE-627 rakwb eng Serum levels of neuroleptics measured by dopamine radioreceptor assay and some clinical observations 1979 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A new dopamine radioreceptor assay was used to measure serum concentrations of neuroleptics during treatment of 58 patients. Results of this assay are expressed as chlorpromazine equivalents. Serum concentrations varied with different drugs, with extremely high levels in patients receiving thioridazine or mesoridazine. No detectable serum levels were found in 11 patients, probably either due to low drug doses or noncompliance in taking medication. Best results with the assay were obtained in the 22 patients treated with haloperidol. Serum concentrations of haloperidol were correlated with dose and were related to the Brief Psychiatric Rating Scale (BPRS) total pathology score, as well as to BPRS factor scores for thinking disturbance and paranoid disturbance. Serum concentrations of haloperidol were not different among patients with or without the presence of extrapyramidal symptoms or among patients receiving or not receiving concurrent antiparkinson medication. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Calil, H.M. oth Avery, D.H. oth Hollister, L.E. oth Creese, I. oth Snyder, S.H. oth in Psychiatry Research Amsterdam : Elsevier 1(1979), 1, Seite 39-44 (DE-627)NLEJ177074922 (DE-600)1500675-X 0165-1781 nnns volume:1 year:1979 number:1 pages:39-44 http://linkinghub.elsevier.com/retrieve/pii/0165-1781(79)90026-X GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 1 1979 1 39-44 |
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(DE-627)NLEJ182049078 (DE-599)GBVNLZ182049078 DE-627 ger DE-627 rakwb eng Serum levels of neuroleptics measured by dopamine radioreceptor assay and some clinical observations 1979 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A new dopamine radioreceptor assay was used to measure serum concentrations of neuroleptics during treatment of 58 patients. Results of this assay are expressed as chlorpromazine equivalents. Serum concentrations varied with different drugs, with extremely high levels in patients receiving thioridazine or mesoridazine. No detectable serum levels were found in 11 patients, probably either due to low drug doses or noncompliance in taking medication. Best results with the assay were obtained in the 22 patients treated with haloperidol. Serum concentrations of haloperidol were correlated with dose and were related to the Brief Psychiatric Rating Scale (BPRS) total pathology score, as well as to BPRS factor scores for thinking disturbance and paranoid disturbance. Serum concentrations of haloperidol were not different among patients with or without the presence of extrapyramidal symptoms or among patients receiving or not receiving concurrent antiparkinson medication. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Calil, H.M. oth Avery, D.H. oth Hollister, L.E. oth Creese, I. oth Snyder, S.H. oth in Psychiatry Research Amsterdam : Elsevier 1(1979), 1, Seite 39-44 (DE-627)NLEJ177074922 (DE-600)1500675-X 0165-1781 nnns volume:1 year:1979 number:1 pages:39-44 http://linkinghub.elsevier.com/retrieve/pii/0165-1781(79)90026-X GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 1 1979 1 39-44 |
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(DE-627)NLEJ182049078 (DE-599)GBVNLZ182049078 DE-627 ger DE-627 rakwb eng Serum levels of neuroleptics measured by dopamine radioreceptor assay and some clinical observations 1979 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A new dopamine radioreceptor assay was used to measure serum concentrations of neuroleptics during treatment of 58 patients. Results of this assay are expressed as chlorpromazine equivalents. Serum concentrations varied with different drugs, with extremely high levels in patients receiving thioridazine or mesoridazine. No detectable serum levels were found in 11 patients, probably either due to low drug doses or noncompliance in taking medication. Best results with the assay were obtained in the 22 patients treated with haloperidol. Serum concentrations of haloperidol were correlated with dose and were related to the Brief Psychiatric Rating Scale (BPRS) total pathology score, as well as to BPRS factor scores for thinking disturbance and paranoid disturbance. Serum concentrations of haloperidol were not different among patients with or without the presence of extrapyramidal symptoms or among patients receiving or not receiving concurrent antiparkinson medication. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Calil, H.M. oth Avery, D.H. oth Hollister, L.E. oth Creese, I. oth Snyder, S.H. oth in Psychiatry Research Amsterdam : Elsevier 1(1979), 1, Seite 39-44 (DE-627)NLEJ177074922 (DE-600)1500675-X 0165-1781 nnns volume:1 year:1979 number:1 pages:39-44 http://linkinghub.elsevier.com/retrieve/pii/0165-1781(79)90026-X GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 1 1979 1 39-44 |
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(DE-627)NLEJ182049078 (DE-599)GBVNLZ182049078 DE-627 ger DE-627 rakwb eng Serum levels of neuroleptics measured by dopamine radioreceptor assay and some clinical observations 1979 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A new dopamine radioreceptor assay was used to measure serum concentrations of neuroleptics during treatment of 58 patients. Results of this assay are expressed as chlorpromazine equivalents. Serum concentrations varied with different drugs, with extremely high levels in patients receiving thioridazine or mesoridazine. No detectable serum levels were found in 11 patients, probably either due to low drug doses or noncompliance in taking medication. Best results with the assay were obtained in the 22 patients treated with haloperidol. Serum concentrations of haloperidol were correlated with dose and were related to the Brief Psychiatric Rating Scale (BPRS) total pathology score, as well as to BPRS factor scores for thinking disturbance and paranoid disturbance. Serum concentrations of haloperidol were not different among patients with or without the presence of extrapyramidal symptoms or among patients receiving or not receiving concurrent antiparkinson medication. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Calil, H.M. oth Avery, D.H. oth Hollister, L.E. oth Creese, I. oth Snyder, S.H. oth in Psychiatry Research Amsterdam : Elsevier 1(1979), 1, Seite 39-44 (DE-627)NLEJ177074922 (DE-600)1500675-X 0165-1781 nnns volume:1 year:1979 number:1 pages:39-44 http://linkinghub.elsevier.com/retrieve/pii/0165-1781(79)90026-X GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 1 1979 1 39-44 |
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(DE-627)NLEJ182049078 (DE-599)GBVNLZ182049078 DE-627 ger DE-627 rakwb eng Serum levels of neuroleptics measured by dopamine radioreceptor assay and some clinical observations 1979 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A new dopamine radioreceptor assay was used to measure serum concentrations of neuroleptics during treatment of 58 patients. Results of this assay are expressed as chlorpromazine equivalents. Serum concentrations varied with different drugs, with extremely high levels in patients receiving thioridazine or mesoridazine. No detectable serum levels were found in 11 patients, probably either due to low drug doses or noncompliance in taking medication. Best results with the assay were obtained in the 22 patients treated with haloperidol. Serum concentrations of haloperidol were correlated with dose and were related to the Brief Psychiatric Rating Scale (BPRS) total pathology score, as well as to BPRS factor scores for thinking disturbance and paranoid disturbance. Serum concentrations of haloperidol were not different among patients with or without the presence of extrapyramidal symptoms or among patients receiving or not receiving concurrent antiparkinson medication. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Calil, H.M. oth Avery, D.H. oth Hollister, L.E. oth Creese, I. oth Snyder, S.H. oth in Psychiatry Research Amsterdam : Elsevier 1(1979), 1, Seite 39-44 (DE-627)NLEJ177074922 (DE-600)1500675-X 0165-1781 nnns volume:1 year:1979 number:1 pages:39-44 http://linkinghub.elsevier.com/retrieve/pii/0165-1781(79)90026-X GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 1 1979 1 39-44 |
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serum levels of neuroleptics measured by dopamine radioreceptor assay and some clinical observations |
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Serum levels of neuroleptics measured by dopamine radioreceptor assay and some clinical observations |
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A new dopamine radioreceptor assay was used to measure serum concentrations of neuroleptics during treatment of 58 patients. Results of this assay are expressed as chlorpromazine equivalents. Serum concentrations varied with different drugs, with extremely high levels in patients receiving thioridazine or mesoridazine. No detectable serum levels were found in 11 patients, probably either due to low drug doses or noncompliance in taking medication. Best results with the assay were obtained in the 22 patients treated with haloperidol. Serum concentrations of haloperidol were correlated with dose and were related to the Brief Psychiatric Rating Scale (BPRS) total pathology score, as well as to BPRS factor scores for thinking disturbance and paranoid disturbance. Serum concentrations of haloperidol were not different among patients with or without the presence of extrapyramidal symptoms or among patients receiving or not receiving concurrent antiparkinson medication. |
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A new dopamine radioreceptor assay was used to measure serum concentrations of neuroleptics during treatment of 58 patients. Results of this assay are expressed as chlorpromazine equivalents. Serum concentrations varied with different drugs, with extremely high levels in patients receiving thioridazine or mesoridazine. No detectable serum levels were found in 11 patients, probably either due to low drug doses or noncompliance in taking medication. Best results with the assay were obtained in the 22 patients treated with haloperidol. Serum concentrations of haloperidol were correlated with dose and were related to the Brief Psychiatric Rating Scale (BPRS) total pathology score, as well as to BPRS factor scores for thinking disturbance and paranoid disturbance. Serum concentrations of haloperidol were not different among patients with or without the presence of extrapyramidal symptoms or among patients receiving or not receiving concurrent antiparkinson medication. |
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A new dopamine radioreceptor assay was used to measure serum concentrations of neuroleptics during treatment of 58 patients. Results of this assay are expressed as chlorpromazine equivalents. Serum concentrations varied with different drugs, with extremely high levels in patients receiving thioridazine or mesoridazine. No detectable serum levels were found in 11 patients, probably either due to low drug doses or noncompliance in taking medication. Best results with the assay were obtained in the 22 patients treated with haloperidol. Serum concentrations of haloperidol were correlated with dose and were related to the Brief Psychiatric Rating Scale (BPRS) total pathology score, as well as to BPRS factor scores for thinking disturbance and paranoid disturbance. Serum concentrations of haloperidol were not different among patients with or without the presence of extrapyramidal symptoms or among patients receiving or not receiving concurrent antiparkinson medication. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ182049078</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506093115.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070505s1979 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ182049078</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVNLZ182049078</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Serum levels of neuroleptics measured by dopamine radioreceptor assay and some clinical observations</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1979</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">A new dopamine radioreceptor assay was used to measure serum concentrations of neuroleptics during treatment of 58 patients. Results of this assay are expressed as chlorpromazine equivalents. Serum concentrations varied with different drugs, with extremely high levels in patients receiving thioridazine or mesoridazine. No detectable serum levels were found in 11 patients, probably either due to low drug doses or noncompliance in taking medication. Best results with the assay were obtained in the 22 patients treated with haloperidol. Serum concentrations of haloperidol were correlated with dose and were related to the Brief Psychiatric Rating Scale (BPRS) total pathology score, as well as to BPRS factor scores for thinking disturbance and paranoid disturbance. Serum concentrations of haloperidol were not different among patients with or without the presence of extrapyramidal symptoms or among patients receiving or not receiving concurrent antiparkinson medication.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Elsevier Journal Backfiles on ScienceDirect 1907 - 2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Calil, H.M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Avery, D.H.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hollister, L.E.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Creese, I.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Snyder, S.H.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Psychiatry Research</subfield><subfield code="d">Amsterdam : Elsevier</subfield><subfield code="g">1(1979), 1, Seite 39-44</subfield><subfield code="w">(DE-627)NLEJ177074922</subfield><subfield code="w">(DE-600)1500675-X</subfield><subfield code="x">0165-1781</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:1</subfield><subfield code="g">year:1979</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:39-44</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://linkinghub.elsevier.com/retrieve/pii/0165-1781(79)90026-X</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_H</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SDJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">1</subfield><subfield code="j">1979</subfield><subfield code="e">1</subfield><subfield code="h">39-44</subfield></datafield></record></collection>
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