Isolation of a Heregulin-like Growth-Factor Secreted by Estrogen Receptor-Negative MDA-MB-231 Human Breast-Cancer Cells That Stimulates Estrogen Receptor-Positive Cells
A 52 kDa peptide growth factor secreted by the estrogen receptor (ER)-negative human breast cancer cell line MDA-MB-231 was purified to homogeneity. It induced transient membrane ruffling, lamellipodia formation, cell motility and proliferation exclusively of ER-positive human breast cancer cells. P...
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| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1994 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
|---|---|
| Übergeordnetes Werk: |
in: Biochemical and Biophysical Research Communications - Amsterdam : Elsevier, 202(1994), 3, Seite 1357-1365 |
| Übergeordnetes Werk: |
volume:202 ; year:1994 ; number:3 ; pages:1357-1365 |
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NLEJ183476085 |
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| 520 | |a A 52 kDa peptide growth factor secreted by the estrogen receptor (ER)-negative human breast cancer cell line MDA-MB-231 was purified to homogeneity. It induced transient membrane ruffling, lamellipodia formation, cell motility and proliferation exclusively of ER-positive human breast cancer cells. Partial sequencing revealed a high homology to the protein family of heregulins. However, the obtained amino acid sequences of the new factor were not completely identical to any of the members of the heregulin family. This finding together with the observation that the successful purification protocol was significantly different from that used to isolate other members of the heregulin family indicate the isolation of a novel heregulin-like proliferation factor for ER-positive human breast cancer cells. | ||
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(DE-627)NLEJ183476085 (DE-599)GBVNLZ183476085 DE-627 ger DE-627 rakwb eng Isolation of a Heregulin-like Growth-Factor Secreted by Estrogen Receptor-Negative MDA-MB-231 Human Breast-Cancer Cells That Stimulates Estrogen Receptor-Positive Cells 1994 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A 52 kDa peptide growth factor secreted by the estrogen receptor (ER)-negative human breast cancer cell line MDA-MB-231 was purified to homogeneity. It induced transient membrane ruffling, lamellipodia formation, cell motility and proliferation exclusively of ER-positive human breast cancer cells. Partial sequencing revealed a high homology to the protein family of heregulins. However, the obtained amino acid sequences of the new factor were not completely identical to any of the members of the heregulin family. This finding together with the observation that the successful purification protocol was significantly different from that used to isolate other members of the heregulin family indicate the isolation of a novel heregulin-like proliferation factor for ER-positive human breast cancer cells. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Kung, W. oth David, F. oth Langen, H. oth Weyer, K.A. oth Schlaeger, E.J. oth Lahm, H.W. oth Silber, E. oth Mueller, H. oth Eppenberger, U. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 202(1994), 3, Seite 1357-1365 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:202 year:1994 number:3 pages:1357-1365 http://dx.doi.org/10.1006/bbrc.1994.2080 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 202 1994 3 1357-1365 |
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(DE-627)NLEJ183476085 (DE-599)GBVNLZ183476085 DE-627 ger DE-627 rakwb eng Isolation of a Heregulin-like Growth-Factor Secreted by Estrogen Receptor-Negative MDA-MB-231 Human Breast-Cancer Cells That Stimulates Estrogen Receptor-Positive Cells 1994 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A 52 kDa peptide growth factor secreted by the estrogen receptor (ER)-negative human breast cancer cell line MDA-MB-231 was purified to homogeneity. It induced transient membrane ruffling, lamellipodia formation, cell motility and proliferation exclusively of ER-positive human breast cancer cells. Partial sequencing revealed a high homology to the protein family of heregulins. However, the obtained amino acid sequences of the new factor were not completely identical to any of the members of the heregulin family. This finding together with the observation that the successful purification protocol was significantly different from that used to isolate other members of the heregulin family indicate the isolation of a novel heregulin-like proliferation factor for ER-positive human breast cancer cells. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Kung, W. oth David, F. oth Langen, H. oth Weyer, K.A. oth Schlaeger, E.J. oth Lahm, H.W. oth Silber, E. oth Mueller, H. oth Eppenberger, U. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 202(1994), 3, Seite 1357-1365 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:202 year:1994 number:3 pages:1357-1365 http://dx.doi.org/10.1006/bbrc.1994.2080 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 202 1994 3 1357-1365 |
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(DE-627)NLEJ183476085 (DE-599)GBVNLZ183476085 DE-627 ger DE-627 rakwb eng Isolation of a Heregulin-like Growth-Factor Secreted by Estrogen Receptor-Negative MDA-MB-231 Human Breast-Cancer Cells That Stimulates Estrogen Receptor-Positive Cells 1994 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A 52 kDa peptide growth factor secreted by the estrogen receptor (ER)-negative human breast cancer cell line MDA-MB-231 was purified to homogeneity. It induced transient membrane ruffling, lamellipodia formation, cell motility and proliferation exclusively of ER-positive human breast cancer cells. Partial sequencing revealed a high homology to the protein family of heregulins. However, the obtained amino acid sequences of the new factor were not completely identical to any of the members of the heregulin family. This finding together with the observation that the successful purification protocol was significantly different from that used to isolate other members of the heregulin family indicate the isolation of a novel heregulin-like proliferation factor for ER-positive human breast cancer cells. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Kung, W. oth David, F. oth Langen, H. oth Weyer, K.A. oth Schlaeger, E.J. oth Lahm, H.W. oth Silber, E. oth Mueller, H. oth Eppenberger, U. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 202(1994), 3, Seite 1357-1365 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:202 year:1994 number:3 pages:1357-1365 http://dx.doi.org/10.1006/bbrc.1994.2080 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 202 1994 3 1357-1365 |
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(DE-627)NLEJ183476085 (DE-599)GBVNLZ183476085 DE-627 ger DE-627 rakwb eng Isolation of a Heregulin-like Growth-Factor Secreted by Estrogen Receptor-Negative MDA-MB-231 Human Breast-Cancer Cells That Stimulates Estrogen Receptor-Positive Cells 1994 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A 52 kDa peptide growth factor secreted by the estrogen receptor (ER)-negative human breast cancer cell line MDA-MB-231 was purified to homogeneity. It induced transient membrane ruffling, lamellipodia formation, cell motility and proliferation exclusively of ER-positive human breast cancer cells. Partial sequencing revealed a high homology to the protein family of heregulins. However, the obtained amino acid sequences of the new factor were not completely identical to any of the members of the heregulin family. This finding together with the observation that the successful purification protocol was significantly different from that used to isolate other members of the heregulin family indicate the isolation of a novel heregulin-like proliferation factor for ER-positive human breast cancer cells. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Kung, W. oth David, F. oth Langen, H. oth Weyer, K.A. oth Schlaeger, E.J. oth Lahm, H.W. oth Silber, E. oth Mueller, H. oth Eppenberger, U. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 202(1994), 3, Seite 1357-1365 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:202 year:1994 number:3 pages:1357-1365 http://dx.doi.org/10.1006/bbrc.1994.2080 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 202 1994 3 1357-1365 |
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(DE-627)NLEJ183476085 (DE-599)GBVNLZ183476085 DE-627 ger DE-627 rakwb eng Isolation of a Heregulin-like Growth-Factor Secreted by Estrogen Receptor-Negative MDA-MB-231 Human Breast-Cancer Cells That Stimulates Estrogen Receptor-Positive Cells 1994 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A 52 kDa peptide growth factor secreted by the estrogen receptor (ER)-negative human breast cancer cell line MDA-MB-231 was purified to homogeneity. It induced transient membrane ruffling, lamellipodia formation, cell motility and proliferation exclusively of ER-positive human breast cancer cells. Partial sequencing revealed a high homology to the protein family of heregulins. However, the obtained amino acid sequences of the new factor were not completely identical to any of the members of the heregulin family. This finding together with the observation that the successful purification protocol was significantly different from that used to isolate other members of the heregulin family indicate the isolation of a novel heregulin-like proliferation factor for ER-positive human breast cancer cells. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Kung, W. oth David, F. oth Langen, H. oth Weyer, K.A. oth Schlaeger, E.J. oth Lahm, H.W. oth Silber, E. oth Mueller, H. oth Eppenberger, U. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 202(1994), 3, Seite 1357-1365 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:202 year:1994 number:3 pages:1357-1365 http://dx.doi.org/10.1006/bbrc.1994.2080 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 202 1994 3 1357-1365 |
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isolation of a heregulin-like growth-factor secreted by estrogen receptor-negative mda-mb-231 human breast-cancer cells that stimulates estrogen receptor-positive cells |
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Isolation of a Heregulin-like Growth-Factor Secreted by Estrogen Receptor-Negative MDA-MB-231 Human Breast-Cancer Cells That Stimulates Estrogen Receptor-Positive Cells |
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A 52 kDa peptide growth factor secreted by the estrogen receptor (ER)-negative human breast cancer cell line MDA-MB-231 was purified to homogeneity. It induced transient membrane ruffling, lamellipodia formation, cell motility and proliferation exclusively of ER-positive human breast cancer cells. Partial sequencing revealed a high homology to the protein family of heregulins. However, the obtained amino acid sequences of the new factor were not completely identical to any of the members of the heregulin family. This finding together with the observation that the successful purification protocol was significantly different from that used to isolate other members of the heregulin family indicate the isolation of a novel heregulin-like proliferation factor for ER-positive human breast cancer cells. |
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A 52 kDa peptide growth factor secreted by the estrogen receptor (ER)-negative human breast cancer cell line MDA-MB-231 was purified to homogeneity. It induced transient membrane ruffling, lamellipodia formation, cell motility and proliferation exclusively of ER-positive human breast cancer cells. Partial sequencing revealed a high homology to the protein family of heregulins. However, the obtained amino acid sequences of the new factor were not completely identical to any of the members of the heregulin family. This finding together with the observation that the successful purification protocol was significantly different from that used to isolate other members of the heregulin family indicate the isolation of a novel heregulin-like proliferation factor for ER-positive human breast cancer cells. |
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A 52 kDa peptide growth factor secreted by the estrogen receptor (ER)-negative human breast cancer cell line MDA-MB-231 was purified to homogeneity. It induced transient membrane ruffling, lamellipodia formation, cell motility and proliferation exclusively of ER-positive human breast cancer cells. Partial sequencing revealed a high homology to the protein family of heregulins. However, the obtained amino acid sequences of the new factor were not completely identical to any of the members of the heregulin family. This finding together with the observation that the successful purification protocol was significantly different from that used to isolate other members of the heregulin family indicate the isolation of a novel heregulin-like proliferation factor for ER-positive human breast cancer cells. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ183476085</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706203327.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070506s1994 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ183476085</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVNLZ183476085</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Isolation of a Heregulin-like Growth-Factor Secreted by Estrogen Receptor-Negative MDA-MB-231 Human Breast-Cancer Cells That Stimulates Estrogen Receptor-Positive Cells</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1994</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">A 52 kDa peptide growth factor secreted by the estrogen receptor (ER)-negative human breast cancer cell line MDA-MB-231 was purified to homogeneity. It induced transient membrane ruffling, lamellipodia formation, cell motility and proliferation exclusively of ER-positive human breast cancer cells. Partial sequencing revealed a high homology to the protein family of heregulins. However, the obtained amino acid sequences of the new factor were not completely identical to any of the members of the heregulin family. This finding together with the observation that the successful purification protocol was significantly different from that used to isolate other members of the heregulin family indicate the isolation of a novel heregulin-like proliferation factor for ER-positive human breast cancer cells.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Elsevier Journal Backfiles on ScienceDirect 1907 - 2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kung, W.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">David, F.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Langen, H.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Weyer, K.A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Schlaeger, E.J.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lahm, H.W.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Silber, E.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mueller, H.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Eppenberger, U.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Biochemical and Biophysical Research Communications</subfield><subfield code="d">Amsterdam : Elsevier</subfield><subfield code="g">202(1994), 3, Seite 1357-1365</subfield><subfield code="w">(DE-627)NLEJ176855645</subfield><subfield code="w">(DE-600)1461396-7</subfield><subfield code="x">0006-291X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:202</subfield><subfield code="g">year:1994</subfield><subfield code="g">number:3</subfield><subfield code="g">pages:1357-1365</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1006/bbrc.1994.2080</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_H</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SDJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">202</subfield><subfield code="j">1994</subfield><subfield code="e">3</subfield><subfield code="h">1357-1365</subfield></datafield></record></collection>
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